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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 3 | A comparison of several vector quantization codebook generation approaches显示文摘 | Huang C M Harris R W | 1993 | IEEE Transactions on Image Processing1993，2，1： | 1 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | The efficacy of spinosad against the western flower thrips,Frankliniella occidentalis,and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Jones T Scott D C Harris R | 2005 | Pest Manag Sci2005，61，： | 1 |
| 6 | Angiotensin actions in the kidney:renewed insight into the old hormone显示文摘 | ICHIKAWI I HARRIS R C | 1991 | Kidney Int1991，40，： | 1 |
| 7 | Review and assessment of methane emissions form wetlands显示文摘 | Bartlett K B Harris R C | 1993 | Chemosl0here1993，26，： | 1 |
| 8 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 9 | Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1显示文摘 | Keenan C R Mok J S Harris T | 2014 | Respir Res2014，15，1： | 1 |
| 10 | Citrus peel use is associated with reduced risk of squamous/ cell carcinoma of the skin显示文摘 | Hakim I A Harris R B Ritenbaugh C | 2000 | Nutr Cancer2000，37，： | 1 |
| 11 | Post electrophoresis staining of proteins by two-dimensional gel electrophoresis using SYPRO dyes显示文摘 | Yan J X Harry R A Spibey C | 2000 | Electrophoresis2000，21，： | 1 |
| 12 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 13 | Self-organizing Hierarchical Particle Swarm Optimizer with Time- varying Acceleration Coefficients显示文摘 | Asanga R Saman K H Harry C W | 2004 | IEEE Transac- tions on Evolutionary Computation2004，8，3： | 1 |
| 14 | Fac tors that influence mechanical failure of sapphire at high temperature显示文摘 | Harris D C Schmid Frederick Black David R | 1997 | Proc SPIE1997，3060，： | 1 |
| 15 | Abdominal compartment syndrome in patients with isolated extraperitoneal injuries 显示文摘 | Kopelman T Harris C Miller R | 2000 | J Trauma2000，49，4： | 1 |
| 16 | Journal of the Less-Common Metals显示文摘 | Harris I R Noble C | 1985 | 106:L1-L41985，106，： | 1 |
| 17 | Diarrheal epidemics in Dhaka,Bangladesh, during three consecutive floods: 1988,1998,and 2004显示文摘 | Schwartz B S Harris J B Khan A I Larocque R C Sack D A Malek M A | 2006 | Am J Trop Med Hyg2006，74，： | 1 |
| 18 | IGF-1 and p- AKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells 显示文摘 | Wine R N McPherson C A Harry G J | 2009 | Neurotoxicity Research2009，16，3： | 1 |
| 19 | Posttraumatic growth among American former prisoners of war显示文摘 | Erbes C Eberly R Dikel T Johnsen E Harris 1 & Engdahl B | | 0，，04： | 1 |
| 20 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
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