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| 1 | Cytomegalovirus in human brain tumors:Role in pathogenesis and potential treatment options显示文摘During the last years increasing evidence implies that human cytomegalovirus(CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths. | Cecilia Soderberg-Nauclér John Inge Johnsen | 2015 | World Journal of Experimental Medicine2015，5，1： | 4 |
| 2 | The Global Stratotype Section and Point (GSSP) for the base of the Holocene Series/Epoch (Quaternary System/Period) in the NGRIP ice core显示文摘 | Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar Konrad Hughen Peter Kershaw Bernd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob Schwander | 2008 | Episodes2008，31，2： | 3 |
| 3 | Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease显示文摘 | Stein Harald Johnsen Ellisiv B. Mathiesen | 2009 | Current Cardiology Reports2009，，1： | 2 |
| 4 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 5 | Using RGB displays to portray colorrealistic imagery to animal eyes显示文摘RGB displays effectively simulate millions of colors in the eyes of humans by modulating the rela-tive amount of light emitted by 3 differently colored juxtaposed lights (red, green, and blue). Therelationship between the ratio of red, green, and blue light and the perceptual experience of thatlight has been well defined by psychophysical experiments in humans, but is unknown in animals.The perceptual experience of an animal looking at an RGB display of imagery designed for humansis likely to poorly represent an animal's experience of the same stimulus in the real world. This isdue, in part, to the fact that many animals have different numbers of photoreceptor classes thanhumans do and that their photoreceptor classes have peak sensitivities centered over differentparts of the ultraviolet and visible spectrum. However, it is sometimes possible to generate videosthat accurately mimic natural stimuli in the eyes of another animal, even if that animal's sensitivityextends into the ultraviolet portion of the spectrum. How independently each RGB phosphor stimu-lates each of an animal's photoreceptor classes determines the range of colors that can be simu-lated for that animal. What is required to determine optimal color rendering for another animal is adevice capable of measuring absolute or relative quanta of light across the portion of the spectrumvisible to the animal (i.e., a spectrometer), and data on the spectral sensitivities of the animal'sphotoreceptor classes. In this article, we outline how to use such equipment and information togenerate video stimuli that mimic, as closely as possible, an animal's color perceptual experienceof real-world objects. | Cynthia TEDORE Sonke JOHNSEN | 2017 | Current Zoology2017，63，1： | 2 |
| 6 | Morphology‐function relationships and repeatability in the sperm of Passer sparrows显示文摘 | Emily R.A. Cramer Terje Laskemoen Even Stensrud Melissah Rowe Fredrik Haas Jan T. Lifjeld Glenn‐Peter S?tre Arild Johnsen | 2015 | Journal of Morphology2015，，： | 2 |
| 7 | Release and persistence of extracellular DNA in the environment显示文摘 | Nielsen K M Johnsen P J Bensasson D | 2007 | Environ Biosafety Res2007，6，12： | 1 |
| 8 | Evidence for general instability of past climate from a 250 kyr ice-core record显示文摘 | Dansgaard W Johnsen S J Clausen H B | 1993 | Nature1993，364，： | 1 |
| 9 | Evidence for general instability of past climate from a 250-kyr ice-core record显示文摘 | Dansgaard W Johnsen S J Clausen H B | 1993 | Nature1993，364，： | 1 |
| 10 | Synchronized terrestrial atmospheric deglacial records around the North Atlantic显示文摘 | Bjorck S Kromer B Johnsen S | 1996 | Science1996，274，： | 1 |
| 11 | Flow cytometry standands for CD34+ cell enumeration in blood and leukapheresis products:report from Second Nordic Workshop显示文摘 | Johnsen H E Nordic | 1996 | J Hematoth1996，5，： | 1 |
| 12 | Correlations between climate records from North Atlantic sediments and Greenland ice显示文摘 | Bond G Broecker W Johnsen S | 1993 | Nature1993，365，： | 1 |
| 13 | To see or not to see-beetter dis- patcher-assisted CPR with video-calls? A qualitative study based on simulated trials显示文摘 | Johnsen E Bolle S | 2008 | Resuscitation2008，78，3： | 1 |
| 14 | Evaluation of a standardized protocol for processing adrenal tumor samples: preparation for a European adrenal tumor bank显示文摘 | Johnsen IK Hahner S Briere JJ | 2010 | Horm Metab Res2010，42，2： | 1 |
| 15 | Nurse Edu- cator Competence: A Study of Norwegian Nurse Educators' Opinions of the Importance and Application of Different Nurse Educator Competence Domains显示文摘 | Johnsen K O Aasgaard H S Wahl A K | 2002 | J Nurs Educ2002，41，7： | 1 |
| 16 | Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs显示文摘 | JOHNSEN S P MONSTER T B OLSEN M L | 2006 | Am J Ther2006，13，2： | 1 |
| 17 | Pesticide effects on bacterial diversity in agricultural soils-a review显示文摘 | Johnsen K Jacobsen C S Torsvik V | 2001 | Biology and Fertility of Soils2001，33，6： | 1 |
| 18 | Hip fracture risk in statin users-a population-based Danish case-control study 显示文摘 | REJNMARK L OLSEN ML JOHNSEN SP | 2004 | Osteoporos lnt2004，15，： | 1 |
| 19 | Helicobacterpylori infec-tion and gastroesophageal reflux in a population-based study(TheHUNT study)显示文摘 | Nordenstede H Nilsson M Johnsen R | 2007 | Helicobacter2007，12，1： | 1 |
| 20 | Correlations between climate records from North Atlantic sediments and Greenland ice显示文摘 | Bond G Broecker W Johnsen S | 1993 | Nature1993，365，： | 1 |
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