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| 1 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 2 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 3 | The TBK1-OPTN Axis Mediates Crosstalk Between Mitophagy and the Innate Immune Response: A Potential Therapeutic Target for Neurodegenerative Diseases显示文摘Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1(TBK1)and the autophagy receptor optineurin(OPTN).The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy[2,3].Indeed,TBK1 can phosphorylate OPTN at Ser177,Ser473,or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin(poly-UB)chains.Conversely,binding of poly-UB chains to OPTN | Lu He Linxi Chen Lanfang Li | 2017 | Neuroscience Bulletin2017，33，3： | 5 |
| 4 | The application of the high-frequency electromagnetic sounding method in the exploration of underground thermal water显示文摘高周波的电磁的发出声音作为地来源是用自然的高周波的电磁的地的一个电磁的探索方法。它比直接当前的方法有更高的分辨率和更大的深度穿入并且为地热的精力探索是特别合适的并且低 -- 并且中间水平的地下水察觉。我们介绍为评估地热的水资源的高周波的电磁的发出声音的成功的应用。高频率电磁的系统(有到 1 Hz 的从 10 KHz 的一个频率范围的 MT-U5A ) 首先被使用从中国取样域数据。一个遥远的参考车站被用来保证取样的数据质量。我们然后执行 2D 倒置图象与电的方法数据处理。结果基本上显示地下的地热的水的空间分发并且提供有利线索给在这个区域发现表面下的地热的水的来源。 | Cao Hui He Lanfang He Zhanxiang Zhao Xiaoming | 2006 | Applied Geophysics2006，3，4： | 4 |
| 5 | Pannexin-1 channels and their emerging functions in cardiovascular diseases显示文摘Pannexin-1, Pannexin-2,和 Pannexin-3 是形成隧道的 glycoprotein 的 Pannexin 家庭的三个成员。他们的主要功能是由他们形成单个膜的隧道的能力的 dened。Pannexin-1 无所不在地在整个身体在许多房间和机关存在并且在循环系统是特殊分布式的,当 Pannexin-2 和 Pannexin-3 的表情主要被限制为机关和纸巾时。Pannexin-1 oligomers 被显示了是连接细胞内部、细胞外的分隔空间的功能的单个膜隧道并且不是在同位格的膜的细胞间的隧道。Pannexin-1 的生理的函数是连接到充当一个 paracrine 信号的腺苷 triphosphate 流出,并且在许多房间类型调整细胞的 inflammasomes 在下面生理并且 pathophysiological 条件。然而,仍然有要探索的许多功能。这评论总结最近的报告并且在心血管的疾病讨论 Pannexin-1 的角色,包括局部缺血,心律不齐,心脏的纤维变性,和高血压。Pannexin-1 在心血管的疾病作为一个令人激动的、临床上相关的目标被建议了。 | Lanfang Li Lu He Di Wu Linxi Chen Zhisheng Jiang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 4 |
| 6 | Distribution and origin of high magnetic anomalies at Luobusa Ophiolite in Southern Tibet显示文摘The Luobusa Ophiolite,Southern Tibet,lies in the eastern portion of Indus–Yarlung Zangbo suture zone that separates Eurasia from the Indian continent.An aeromagnetic reconnaissance survey has revealed an EWtrending Yarlung Zangbo River aeromagnetic anomaly zone,and it is considered to be caused mainly by the Indus–Yarlung Zangbo Ophiolite.The Luobusa Ophiolite reflects the eastern portion of the Yarlung Zangbo River aeromagnetic anomaly zone.Conventionally,the ultramafic rock in the Luobusa Ophiolite is considered as the origin of the high magnetic anomalies.However,results from the surface magnetic survey and the magnetic susceptibility measurements from drill cores indicate that the high magnetic anomalies are distributed inhomogeneously in the Luobusa Ophiolite.In some cases,the susceptibility exhibits more than 30 times difference between two sides of the same sample.A fact emerged that the susceptibility of dunite with serpentinization is higher than that of fresh dunite,harzburgite and chromite when we analyzed the measurement results.In order to understand the origin of the high magnetic anomalies,we measured the density and susceptibility of 17 samples,microscopic and electron probe analyses have been performed as well.The result indicates the presence of dunite with serpentinization containing an abundant of micro-fissures filled with magnetite.Olivine has a susceptibility of about 2.7–351(910-5SI),pyroxene about 16–320,and chromite about200–800.All these units feature relatively low susceptibility in ultramafic rock,and only the magnetite is characterized by a high susceptibility of about 200,000(910-5SI).Based on these observations,we conclude that the precipitation of magnetite in the process of serpentinization of the olivine caused by the geological process in the Luobusa Ophiolite is the origin of high magnetic anomalies. | Lanfang He Xiumian Hu Yabing Zha Ligui Xu Yaohui Wang | 2014 | Chinese Science Bulletin2014，59，23： | 2 |
| 7 | Lithospheric structures across the Qiman Tagh and western Qaidam Basin revealed by magnetotelluric data collected using a self-developed SEP system显示文摘Geophysics offers an important means to investigate the physical processes occurring inside the earth.In particular,since the 1960s,electromagnetic(EM)methods have played important roles in mineral exploration and engineering investigation.Such investigation requires extensive data acquisition and experimental analysis based on geophysical techniques.However,high-performance geophysical equipment,particularly EM exploration equipment,has been dominated by large geophysical companies from the United States,Canada,Germany,and other European countries for decades.This has limited the development of deep exploration technology in China.Recently,we have developed a high-resolution acquisition system with a wireless control unit and a high-power transmitting system for surface EM prospecting(SEP).The new system has been tested in the high-intensity,noisy environment in Jian-sanjiang area,Heilongjiang Province.We then conducted a field survey on the western edge of Qaidam Basin,Qinghai Province.A highly conductive anomaly was found in the upper mantle below the Qinmantage Mountains,which indicates a possible northward fluid channel that runs from below the Qinmantage Mountains to the bottom of the western crust of the Qaidam Basin.Identification of this significant feature was made possible by the new SEP for its better resolution than the previous systems.Also,geophysical analysis confirmed that the thick Cenozoic sediments of the Qaidam Basin are underlain by rigid Precambrian basement rocks and are characterized by a series of folds.The resistivity profile indicates that the Qaidam Basin was formed due to the folding structures in the northern part of the Qinghai-Tibet Plateau which provided an additional evidence for the uplifting of the Qinghai-Tibet Plateau. | Qingyun DI Guoqiang XUE Zhongxing WANG Lanfang HE Renzhong PEI Tianxin ZHANG Guangyou FANG | 2021 | Science China Earth Sciences2021，64，10： | 2 |
| 8 | Thermal properties of harzburgite and dunite at 0.8–3 GPa and 300–823 K and implications for the thermal evolution of Tibet显示文摘Thermal diffusivity(D)and thermal conductivity(κ)of harzburgite and dunite from Luobusha ophiolite were simultaneously measured up to 3 GPa and 823 K using the transient plane-source method in a multi anvil apparatus.The results show that the values of D andκof both samples systematically decrease with increasing temperature and increase with increasing pressure.By combination of the thermal physical data of rocks and minerals and geophysical constraints,we performed numerical simulation on the thermal evolution of Tibet vary over depth,distance and geologic ages.The present results provide new constraints on occurrence of partial melting and its geophysical significance beneath Tibetan crust. | Jianhua Ge Baohua Zhang Zili Xiong Lanfang He Heping Li | 2021 | Geoscience Frontiers2021，12，2： | 1 |
| 9 | NOX3-derived reactive oxygen species promote TNF-α-induced reductions in hepatocyte glycogen levels via a JNK pathway显示文摘 | Lanfang Li Qinghua He Xiuqing Huang Yong Man Yingsheng Zhou Shu Wang Jianye Wang Jian Li | 2010 | FEBS Letters2010，，5： | 1 |
| 10 | Relationship Between Electrical Properties and Sedimentary Environment of the Longmaxi Formation Shale,Southern Sichuan显示文摘The Lower Silurian Longmaxi Formation in the south of Sichuan is a key player in the exploration and development of shale gas in China.Due to a highly complex topographic area,electromagnetic methods(EM)become important exploration means in this area.Many studies have been conducted on the shale mineral composition and electrical properties of shale,however,the correlation between sedimentary environments and the electrical properties of shale remain poorly understood.The electrical properties and sedimentary environment of the organic-rich shale of the Longmaxi Formation have been studied by means of X-ray diffraction,organic geochemistry,scanning electron microscopy and complex resistivity measurements.The discovered high quartz content of the Longmaxi Formation shale results in low resistivity.Deep-water shelf biogenic quartz contributes lower resistivity more than that of shallow-water terrigenous quartz.The deep-water anoxic and organic sedimentary environment led to major enrichment of pyrite,leading to a high polarization effect in shale.We present the correlation between the lithofacies types and electrical properties of Longmaxi Formation.The mixed siliceous shale lithofacies is the most favorable among the three lithofacies,which is characterized by high total organic carbon(TOC)content,high brittleness mineral content,high polarization and low resistivity('three high and one low').This feature is an effective identification of shale gas reservoirs by electromagnetic prospecting.Our study can provide constraints on electrical parameters of rocks for electromagnetic'sweet spot'exploration of shale gas,and so this has important geological significance to shale gas exploration and development. | YANG Kai ZHANG Bing WANG Xuben HE Lanfang YANG Hongyu WANG Pengwan TANG Jialin DENG Jixin ZHANG Cong | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 0 |
| 11 | Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state显示文摘During homeostasis and after injury,adult muscle stem cells(MuSCs)activate to mediate muscle regeneration.However,much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and regeneration.Here,we show that Lin28a is expressed in embryonic limb bud muscle progenitors,and that a rare reserve subset of Lin28a^(+)Pax7^(-)skeletal MuSCs can respond to injury at adult stage by replenishing the Pax7^(+)MuSC pool to drive muscle regeneration.Compared with adult Pax7^(+)MuSCs,Lin28a^(+)MuSCs displayed enhanced myogenic potency in vitro and in vivo upon transplantation.The epigenome of adult Lin28a^(+)MuSCs showed resemblance to embryonic muscle progenitors.In addition,RNA-sequencing revealed that Lin28a^(+)MuSCs co-expressed higher levels of certain embryonic limb bud transcription factors,telomerase components and the p53 inhibitor Mdm4,and lower levels of myogenic differentiation markers compared to adult Pax7^(+)MuSCs,resulting in enhanced self-renewal and stress-response signatures.Functionally,conditional ablation and induction of Lin28a^(+)MuSCs in adult mice revealed that these cells are necessary and sufficient for efficient muscle regeneration.Together,our findings connect the embryonic factor Lin28a to adult stem cell self-renewal and juvenile regeneration. | Peng Wang Xupeng Liu Ziyue Yao Yu Chen Lanfang Luo Kun Liang Jun-Hao Elwin Tan Min-Wen Jason Chua Yan-Jiang Benjamin Chua Shilin Ma Liping Zhang Wenwu Ma Shuqing Liu Wenhua Cao Luyao Guo Lu Guang Yuefan Wang He Zhao Na Ai Yun Li Chunwei Li Ruiqi Rachel Wang Bin Tean Teh Lan Jiang Kang Yu Ng Shyh-Chang | 2023 | Cell Research2023，33，9： | 0 |
| 12 | From agricultural cellulosic waste to food delivery packaging: A mini-review显示文摘The growing food delivery service market has boosted the consumption of packaging materials, and this trend is projected to continue in the following years. The gap between industrial supply and consumer demand from a sustainable viewpoint leads to a need for agricultural cellulosic waste-based materials that bring the idea of trash-to-treasure to fruition. In this paper, we review up-to-date advancements surrounding the food delivery packaging that are derived from agricultural cellulosic waste. Two scenarios in which agricultural feedstock is used as a host or guest material are summarized, and sketch on the individual processing routine is depicted. We further evaluate how the chemical compositions and processing parameters influence the properties of the final products. Current challenges and gaps in developing sustainable packaging materials are identified, with perspectives on these important issues highlighting the importance of process innovation as well as economic and environmental-impact assessment for agricultural cellulosic waste to food delivery packaging. | Jinxing Ma Jiazhou He Xiangtong Kong Junjian Zheng Lanfang Han Yi Liu Zhenchang Zhu Zhong Zhang | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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