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| 1 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 2 | Clinical,Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau显示文摘Objective To analyze characteristics of high altitude pulmonary edema(HAPE)in Chinese patients.Methods We performed a retrospective study of 98 patients with HAPE.We reviewed the medical records and summarized the clinical,laboratory and imaging characteristics of these cases,and compared the results on admission with those determined before discharge.Results Forty-eight(49.0%)patients developed HAPE at the altitude of 2800 m to 3000 m.Ninty-five(96.9%)patients were man.Moist rales were audible from the both lungs,and moist rales over the right lung were clearer than those over the left lung in fourteen patients.The white blood cells[(12.83±5.55)versus(8.95±3.23)×109/L,P=0.001)]as well as neutrophil counts[(11.34±3.81)versus(7.49±2.83)×109/L,P=0.001)]were higher,whereas the counts of other subsets of white blood cells were lower on admission than those after recovery(all P<0.05).Serum levels of alkaline phosphatase(115.8±37.6 versus 85.7±32.4 mmol/L,P=0.020),cholinesterase(7226.2±1631.8 versus 6285.3±1693.3 mmol/L,P=0.040),creatinine(85.2±17.1 versus 75.1±12.8 mmol/L,P=0.021),uric acid(401.9±114.2 versus 326.0±154.3 mmol/L,P=0.041),and uric glucose(7.20±1.10 versus 5.51±1.11 mmol/L,P=0.001)were higher,but carbondioxide combining power(CO2CP,26.7±4.4 versus 28.9±4.5 mmol/L,P=0.042)and serous calcium(2.32±0.13 versus 2.41±0.10 mmol/L,P=0.006)were lower on admission.Arterial blood gas results showed hypoxemia and respiratory alkalosis on admission.Conclusions In the present research,men were more susceptible to HAPE than women,and in the process of HAPE,the lesions of the right lung were more serious than those of the left lung.Some indicators of routine blood test and blood biochemistry of HAPE patients changed. | Zongbin Li Hongyan Chen Jiayue Li Gaoyuan Li Chunwei Liu Yundai Chen | 2018 | Chinese Medical Sciences Journal2018，33，3： | 9 |
| 3 | Early Warning of Acute Altitude Sickness by Physiological Variables and Noninvasive Cardiovascular Indicators显示文摘Objective To examine if the variations at sea level would be able to predict subsequent susceptibility to acute altitude sickness in subjects upon a rapid ascent to high altitude.Methods One hundred and six Han nationality male individuals were recruited to this research.Dynamic electrocardiogram,treadmill exercise test,echocardiography,routine blood examination and biochemical analysis were performed when subjects at sea level and entering the plateau respectively.Then multiple regression analysis was performed to construct a multiple linear regression equation using the Lake Louise Score as dependent variable to predict the risk factors at sea level related to acute mountain sickness(AMS).Results Approximately 49.05%of the individuals developed AMS.The tricuspid annular plane systolic excursion(22.0+2.66 vs.23.2+3.19 mm,t=l.998,P=0.048)was significantly lower in the AMS group at sea level,while count of eosinophil[(0.264+0.393)×109/L vs.(0.126+0.084)×109/L,t=-2.040,P—0.045],percentage of diflerences exceeding 50 ms between adjacent normal number of intervals(PNN50,9.66%±5.40%vs.6.98%±5.66%,t=-2.229,P=0.028)and heart rate variability triangle index(57.1+16.1 vs.50.6+12.7,t=-2.271,P=0.025)were significantly higher.After acute exposure to high altitude,C-reactive protein(0.098+0.103 vs.0.062+0.045 g/L,t=-2.132,P=0.037),aspartate aminotransferase(19.7+6.7275.17,3±3.95 U/L,t=-2.231,P=0.028)and creatinine(85.1±12.9 vs.77.7±11.2 mmol/L,t=3.162,P=0.002)were significantly higher in the AMS group,while alkaline phosphatase(71.7+18.2 vs.80.6+20.2 U/L,t=2.389,P=0.019),standard deviation of normal-to-normal RR intervals(126.5+35.9 vs.143.3+36.4 ms,t—2.320,P—0.022),ejection time(276.9+50.8 vs.313.8+48.9 ms,t—3.641,P—0.001)and heart rate variability triangle index(37.1+12.9 vs.41.9+11.1,t=2.O2O,P=0.047)were significantly lower.Using the Lake Louise Score as the dependent variable,prediction equation were established to estimate AMS:Lake Louise Score=3.783+0.281Xeosinophil-0.219Xalkaline phosphatase+O.O32XPNN50.Conclusions We elucidated the differences of pl^siological variables as well as noninvasive cardiovascular indicators for subjects after high altitude exposure compared with those at sea level.We also created an acute high altitude reaction early warning equation based on the physiological variables and noninvasive cardiovascular indicators at sea level. | Zongbin Li Chunwei Liu Jun Guo Yajun Shi Yang Li Jinli Wang Jing Wang Yundai Chen | 2020 | Chinese Medical Sciences Journal2020，35，1： | 8 |
| 4 | Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients显示文摘BACKGROUND: Post-stroke fatigue has received much attention recently. Three evaluation scales are available,including the Fatigue Impact Scale (FIS). Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue. OBJECTIVE: To introduce FIS into China,and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN: Scale evaluation. SETTING: Department of Rehabilitation,Beijing Friendship Hospital,Capital Medical University. PARTICIPANTS: A total of 330 patients with cerebral infarction were selected from the Department of Neurology,Beijing Friendship Hospital,Capital Medical University from June 2005 to December 2006. All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination. Patients who were not willing to accept scale evaluation were excluded. METHODS: The English version of FIS was translated into Chinese and subsequently translated back to English again. FIS was given to the discharged patients,and they returned them upon completion. In-patients completed and immediately returned the FIS. Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES: Total scores and subscale scores of FIS. RESULTS: Out of 330 questionnaires,214 valid questionnaires were deemed valid in total. Six components were extracted in factor analysis,and the total cumulative contribution was 73.919%,which suggested the questionnaire was valid. After correlation analysis,6 components were divided into 3 subscales,including cognitive,physical,and social,which was the same as the English version. The Cronbach α value for the three subscales was 0.937 7,0.918 8,and 0.940 6,respectively (> 0.7). CONCLUSION: The reliability and validity of the Chinese version of FIS met with satisfaction and ap-peared to be adaptable to cerebral infarction patients in China. | Chunwei Wu Zhandong Liu Yongbo Zhang Jimei Li Dexin Wang | 2008 | Neural Regeneration Research2008，3，2： | 6 |
| 5 | Development of an aero-thermal coupled through-flow method for cooled turbines显示文摘The influence of complicated interaction between the flow field and heat transfer in cooled turbines becomes more and more significant with the increasing turbine inlet temperature. However, classical through-flow methods did not take into account the influence of the interaction caused by air cooling. The aerodynamic design and cooling design of cooled turbines were carried out separately, and the iterations between the aerodynamic design and cooling design led to a long design period and raised the design cost. To shorten the design period and decrease the design cost, this paper proposes a concise aero-thermal coupled through-flow method for the design of cooled turbines, taking into account the influence of the complicated interaction between the flow field and heat transfer in cooled turbines. The governing equations, such as energy equation and continuity equation in classical through-flow method are re-derived theoretically by considering the historical influence of cooling with the same method that deals with viscous losses in this paper. A cooling model is developed in this method. The cooled blade is split into a number of heat transfer elements, and the heat transfer is studied element by element along both the span and the chord in detail. This paper applies the method in the design of a two-stage axial turbine, of which the first stator is cooled with convective cooling. With the prescribed blade temperature limitation and the knowledge of the flow variables of the mainstream at the turbine inlet, such as the total pressure, total temperature and mass flow rate, the convergence of the calculation is then obtained and the properties of the flow field, velocity triangles and coolant requirement are well predicted. The calculated results prove that the aero-thermal coupled through-flow method is a reliable tool for flow analysis and coolant requirement prediction in the design of cooled turbines. | GU ChunWei LI HaiBo SONG Yin | 2015 | Science China(Technological Sciences)2015，58，12： | 3 |
| 6 | Design and Analysis of S-CO_2 Cycle and Radial Turbine for SOFC Vehicle Waste-Heat Recovery显示文摘Solid oxide fuel cell(SOFC) vehicles are considered to have broad prospects for development, and the high operating temperature of SOFC results in great potential for waste-heat recovery. Many concepts for utilizing waste heat of SOFC have been suggested and studied, and most of them directly couple an SOFC to a gas turbine, which require the SOFC to operate at an elevated pressure and make the system less flexible and thus harder to operate. In recent years, with the development of turbine and heat exchanger technology, the supercritical carbon dioxide(S-CO_2) power cycle has raised widespread attractions for the waste recovery. This study explores the potential of S-CO_2 Brayton cycle to realize waste-heat recovery for an SOFC vehicle. The SOFC can operate at atmospheric pressure, and the hybrid system is easier to operate than the directly coupled systems. In this paper, a simple recuperated S-CO_2 Brayton cycle is proposed and the key component, radial inflow turbine is designed and focused. The flow state of the designed turbine is analyzed in detail based on computational fluid dynamics(CFD) numerical simulation. Five cases with different impeller tip clearances are numerically simulated to study its influence on the turbine performance. In addition, off-design performance analysis of the radial inflow turbine is conducted considering the temperature fluctuation of SOFC in practical applications. | XIA Liu LI Xuesong SONG Jian REN Xiaodong GU Chunwei | 2019 | Journal of Thermal Science2019，28，3： | 3 |
| 7 | Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis显示文摘RNF20,an E3 ligase critical for monoubiquitination of histone H2B at lysine 120(H2Bub),has been implicated in the regulation of various cellar processes;however,its physiological roles in adipocytes remain poorly characterized.Here,we report that the adipocyte-specific knockout of Rnf20(ASKO)in mice led to progressive fat toss,organomegaly and hyperinsulinemia.Despite signs of hyperinsulinemia,normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice.In addition,high-fat diet-fed ASKO mice developed severe liver steatosis.Moreover,we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue(BAT)selective genes,including uncoupling protein 1(l/cpf),and impaired mitochondrial functions.Significantly decreased levels of peroxisome proliterator-activated receptor gamma(Ppary)were observed in the gonadal white adipose tissues(gWAT)from the ASKO mice,suggesting that Rnf20 regulates adipogenesis,at least in part,through Ppary.Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice.Collectively,our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function. | Xiaojuan Liang Cong Tao Jianfei Pan Lilan Zhang Lulu Liu Ying Zhao Yiping Fan Chunwei Cao Jiali Liu Jin Zhang Sin Man Lam Guanghou Shui Wanzhu Jin Wei Li Jianguo Zhao Kui Li Yanfang Wang | 2021 | Protein & Cell2021，12，6： | 1 |
| 8 | Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice显示文摘 | Ying Chen Cuiying Li Dong Weng Laiyu Song Wen Tang Wujing Dai Ye Yu Fangwei Liu Ming Zhao Chunwei Lu Jie Chen | 2013 | Toxicology and Applied Pharmacology2013，，： | 1 |
| 9 | Preconditioning method and engineering application of large eddy simulation显示文摘On applying large eddy simulation (LES) to engineering interest, one of the keys is to obtain two-order low-dissipation shock-capturing schemes adapted to LES. Therefore, the preconditioning method for all speed flows is adopted. However, the accuracy of preconditioned schemes is not satisfactory because of the poor per-formance of stability of preconditioning techniques especially in viscous flows. The reason of unstability is attributed to the unstability structure in the preconditioned eigenvalue matrix. Based on Roe scheme and two assumptions for low-Mach- Number flows, the new scheme named Low-Speed-Roe scheme is deduced for removing the unstability structure. Numerical experiments show that this scheme has the reasonable computational stability. For general-precision problems, Low-Speed-Roe scheme has similar behavior as the classical preconditioned Roe scheme. For simulations of high-accuracy requirement such as LES, Low-Speed- Roe scheme can obtain better results of complex flows, such as the laminar sepa-ration bubble on the suction surface of the high-loaded turbine blade T106. | LI XueSong XU JianZhong GU ChunWei | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，6： | 1 |
| 10 | Photocatalytic degradation of X-3B dye by visible light using lanthanide ion modified titanium dioxide hydrosol system显示文摘 | Xie Yibinging Yuan Chunwei Li Xiangzhong | | 0，，： | 1 |
| 11 | The properties of dust aerosol and reducing tendency of the dust storms in northwest China显示文摘 | Peijian Fu Jianping Huang Chunwei Li Sharon Zhong | 2008 | Atmospheric Environment2008，，23： | 1 |
| 12 | Photocatalytic degradation of X-3B dye by visible light using lanthanide ion modified titanium dioxide hydrosol system显示文摘 | Xie Yibing Yuan Chunwei Li Xiangzhong | 2005 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2005，252，1： | 1 |
| 13 | Study on the toxic effects induced by different arsenicals in primary cultured rat astroglia显示文摘 | Yaping Jin Guifan Sun Xin Li Gexin Li Chunwei Lu Long Qu | 2004 | Toxicology and Applied Pharmacology2004，，3： | 1 |
| 14 | Fluorescent probe for copper( ] ) ion based on a rhodamine spirolactame derivative,and its application to fluorescent imaging in living cells显示文摘 | Yu Chunwei Zhang Jun Li Jinhua | 2011 | Microchim Acta2011，174，34： | 1 |
| 15 | An all-speed Roe-type schemeand its asymptotic analysis of low Mach number behaviour显示文摘 | LI Xuesong GU Chunwei | 2008 | Journal of Computational Physics2008，227，10： | 1 |
| 16 | Photocatalytic degradation of X-3B dye by visible light using lanthanide ion modified titanium dioxide hydrosol system显示文摘 | Yibing Xie Chunwei Yuan Xiangzhong Li | 2004 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2004，，1： | 1 |
| 17 | Improvement of part-load performance of gas turbine by adjusting compressor inlet air temperature and IGV opening显示文摘A novel adjusting method for improving gas turbine(GT)efficiency and surge margin(SM)under partload conditions is proposed.This method adopts the inlet air heating technology,which uses the waste heat of lowgrade heat source and the inlet guide vane(IGV)opening adjustment.Moreover,the regulation rules of the compressor inlet air temperature and the IGV opening are studied comprehensively to optimize GT performance.A model and calculation method for an equilibrium running line is adopted based on the characteristic curves of the compressor and turbine.The equilibrium running lines calculated through the calculation method involve three part-load conditions and three IGVopenings with different inlet air temperatures.The results show that there is an optimal matching relationship between IGV opening and inlet air temperature.For the best GT performance of a given load,the IGV could be adjusted according to inlet air temperature.In addition,inlet air heating has a considerable potential for the improvement of part-load performance of GT due to the increase in compressor efficiency,combustion efficiency,and turbine efficiency as well as turbine inlet temperature,when inlet air temperature is lower than the optimal value with different IGV openings.Further,when the IGV is in a full opening state and an optimal inlet air temperature is achieved by using the inlet air heating technology,GT efficiency and SM can be obviously higher than other IGVopenings.The IGV can be left unadjusted,even when the load is as low as 50%.These findings indicate that inlet air heating has a great potential to replace the IGV to regulate load because GT efficiency and SM can be remarkably improved,which is different from the traditional viewpoints. | Wei ZHU Xiaodong REN Xuesong LI Chunwei GU Zhitan LIU Zhiyuan YAN Hongfei ZHU Tao ZHANG | 2022 | Frontiers in Energy2022，16，6： | 1 |
| 18 | Microstructure and Mechanical Properties of Ti N/Ti Al N Multilayer Coatings Deposited by Arc Ion Plating with Separate Targets显示文摘 | Wei Yongqiang Li Chunwei Gong Chunzhi | 2011 | Transactions of Nonferrous Metals Society of China2011，21，： | 1 |
| 19 | A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment显示文摘Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies. | Xiao Wang Chunwei Cao Yongshun Li Tang Hai Qitao Jia Ying Zhang Qiantao Zheng Jing Yao Guosong Qin Hongyong Zhang Ruigao Song Yanfang Wang Guanghou Shui Sin Man Lam Zhonghua Liu Hong Wei Anming Meng Qi Zhou Jianguo Zhao | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
| 20 | 显示文摘 | Xie Yibing Yuan Chunwei Li Xiangzhong | 2005 | Colloids Surf A2005，，252： | 1 |
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