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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | Surrounding rock control mechanism of deep coal roadways and its application显示文摘Aiming at the surrounding rock control problem of mining and preparation entries in Xingdong mine with large mining depth, and the comprehensive control countermeasures including high pre-stress cable truss system, this study put forward powerful anchor support system and anchor cable adaption technology to surrounding rock deformation. Furthermore, the control measures possess the supporting performance with ‘‘primary rigid-following flexible-new rigid, and primary resistance-following yield-new resistance'', which suits deep roadway surrounding rock control. The mechanical model of truss anchor supporting roof beams was established, and the inverted arch deflection produced by the cable pre-stress with stress increment effect and roof beam deflection were obtained. And then the system working mechanism was illustrated. Finally, the surrounding rock support parameters were determined by means of comprehensive methods, and put into practice. The results show that surrounding rock deformation realized secondary stability after three months. The roadway sides convergence value was less than 245mm, and roof subsidence was less than 124mm. In addition, there was no expansion and renovation during service period. | Xie Shengrong Li Erpeng Li Shijun Wang Jinguang He Chongchong Yang Yafeng | 2015 | International Journal of Mining Science and Technology2015，25，3： | 10 |
| 3 | The carbon nanotubes-based materials and their applications for organic pollutant removal: A critical review显示文摘The carbon nanotubes(CNTs) as the emerging materials for organic pollutant removal have gradually become a burgeoning research field.Herein,a mini-review of CNTs-based materials curre ntly studies for organic pollutant elimination is presented.This review summarizes the preparation methods of CNTsbased materials.CNTs-based materials can be used as adsorbents to remove organic pollutants in wastewater.The adsorption mechanisms mainly include surface diffusio n,pore diffusion and adsorption reaction.Most importantly,an in-depth overview of CNTs-based materials currently available in advanced oxidation processes(AOPs) applications for wastewater treatment is proposed.CNTs-based materials can catalyze different oxidants(e.g.,hydrogen peroxide(H2 O2),persulfates(PMS/PDS),ozone(O3) and ferrate/permanganate(Fe(Ⅵ)/Mn(Ⅶ)) to generate more reactive oxygen species(ROS) for organic pollutant elimination.Moreover,the possible reaction mechanisms of removing organic pollutants by CNTs-based materials are summarized systematically and discussed in detail.Finally,application potential and future research directions of CNTs-based materials in the environmental remediation field are proposed. | Jiali Peng Yongli He Chenying Zhou Shijun Su Bo Lai | 2021 | Chinese Chemical Letters2021，32，5： | 7 |
| 4 | Deer Body Adaptive Threshold Segmentation Algorithm Based on Color Space显示文摘In large-scale deer farming image analysis,K-means or maximum between-class variance(Otsu)algorithms can be used to distinguish the deer from the background.However,in an actual breeding environment,the barbed wire or chain-link fencing has a certain isolating effect on the deer which greatly interferes with the identification of the individual deer.Also,when the target and background grey values are similar,the multiple background targets cannot be completely separated.To better identify the posture and behaviour of deer in a deer shed,we used digital image processing to separate the deer from the background.To address the problems mentioned above,this paper proposes an adaptive threshold segmentation algorithm based on color space.First,the original image is pre-processed and optimized.On this basis,the data are enhanced and contrasted.Next,color space is used to extract the several backgrounds through various color channels,then the adaptive space segmentation of the extracted part of the color space is performed.Based on the segmentation effect of the traditional Otsu algorithm,we designed a comparative experiment that divided the four postures of turning,getting up,lying,and standing,and successfully separated multiple target deer from the background.Experimental results show that compared with K-means,Otsu and hue saturation value(HSV)+K-means,this method is better in performance and accuracy for adaptive segmentation of deer in artificial breeding scenes and can be used to separate artificially cultivated deer from their backgrounds.Both the subjective and objective aspects achieved good segmentation results.This article lays a foundation for the effective identification of abnormal behaviour in sika deer. | Yuheng Sun Ye Mu Qin Feng Tianli Hu He Gong Shijun Li Jing Zhou | 2020 | Computers, Materials & Continua2020，，8： | 5 |
| 5 | A comparison of pilot scale electron beam and bench scale gamma irradiations of cyanide aqueous in solution显示文摘 | YE Longfei HE Shijun YANG Chunping WANG Jianlong YU Jiang | 2013 | Nuclear Science and Techniques2013，24，B12： | 4 |
| 6 | Evolvement behavior of microstructure and H_2O adsorption of lignite pyrolysis显示文摘The effect of pyrolysis on the microstructure and moisture adsorption of lignite was investigated with low field nuclear magnetic resonance spectroscopy. Changes in oxygen-containing groups were analyzed by Fourier transform infrared spectroscopy(FTIR), and H2 O adsorption mechanism on the surface of lignite pyrolysis was inferred. Two major changes in the pore structure of lignite char were observed as temperature increased in 105–200 °C and500–700 °C. Pyrolysis temperature is a significant factor in removing carboxyl and phenolic hydroxyl from lignite.Variation of ether bond content can be divided into three stages; the content initially increased, then decreased,and finally increased. The equilibrium adsorption ratio, content of oxygen-containing groups, and variation of pore volume below 700° were closely correlated with each other. The amount of adsorbed water on char pyrolyzed at700 °C increased. Moreover, the adsorption capacity of the lignite decreased, and the adsorption state changed. | Yingyue Teng Shijun Lian Quansheng Liu Yuzhe Liu Yinmin Song Runxia He Keduan Zhi | 2016 | Chinese Journal of Chemical Engineering2016，24，6： | 3 |
| 7 | Transforming growth factor β1 is a differentially expressed candidate protein of congestive heart failure with Qi-deficiency-blood-stasis syndrome显示文摘OBJECTIVE: To investigate the role of tongue coating fluid protein in regulation of congestive heart failure(CHF) in Qi-deficiency-blood-stasis syndrome.METHODS: We studied patients with CHF(3 patients with Qi-deficiency-blood-stasis syndrome and 3 without Qi-deficiency-blood-stasis syndrome) to investigate differentially expressed proteins. We also included a control group. A biotin label-based antibody array was used for testing tongue coating fluid samples from patients. Net-work analysis of these differentially expressed proteins was conducted using the STRING database,which can predict the relations between differentially expressed proteins and CHF with Qi-deficiency-blood-stasis syndrome.RESULTS: A total of seven differentially expressed proteins were identified, and among these, transforming growth factor β1(TGF-β1) gets a particular attention for us has drawn specific attention.Network analysis showed a homologous relationship of TGF-β1 with bone morphogenetic protein15, which is associated with myocardial fibrosis.CONCLUSION: Occurrence and development of CHF may result from certain DE-proteins and associated signaling pathways. TGF-β1 protein may be a candidate marker for assessing the risk of CHF in Qideficiency-blood-stasis syndrome. | Li Xiaoqian Huang Pinxian Wang Shijun Cao Xuebin He Jiancheng | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 8 | A single nucleotide substitution at 5'-UTR of GSN1 represses its translation and leads to an increase of grain length in rice显示文摘Rice grain size is an important trait that affects rice yield and quality, and thus the identification of genes related to grain size is of great significance for improving rice yield and quality. Many genes related to grain size, such as DEP1(Huang et al., 2009),GW5(Liu et al., 2017). | Xia Zhang Peng Qin Youlin Peng Bo Ma Jiangbo Hu Shijun Fan Binhua Hu Guohua Zhang Hua Yuan Wei Yan Weilan Chen Bin Tu Hang He Bingtian Ma Yuping Wang Shigui Li | 2019 | Journal of Genetics and Genomics2019，46，2： | 2 |
| 9 | Potential Off-Grid User Prediction System Based on Spark显示文摘With the increasingly fierce competition among communication operators,it is more and more important to make an accurate prediction of potential off grid users.To solve the above problem,it is inevitable to consider the effectiveness of learning algo rithms,the efficiency of data processing,and other factors.Therefore,in this paper,we,from the practical application point of view,propose a potential customer off grid predic tion system based on Spark,including data pre processing,feature selection,model build ing,and effective display.Furthermore,in the research of off grid system,we use the Spark parallel framework to improve the gcForest algorithm which is a novel decision tree ensemble approach.The new parallel gcForest algorithm can be used to solve practical problems,such as the off grid prediction problem.Experiments on two real world datasets demonstrate that the proposed prediction system can handle large scale data for the off grid user prediction problem and the proposed parallel gcForest can achieve satisfying per formance. | LI Xuebing SUN Ying ZHUANG Fuzhen HE Jia ZHANG Zhao ZHU Shijun HE Qing | 2019 | ZTE Communications2019，17，2： | 2 |
| 10 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 11 | Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution显示文摘Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic interest.Despite numerous studies,the mechanisms underlying its adaptation and evolution remain enigmatic.Here,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded geographically.We complete a chromosome-level assembly and annotation of the E.onukii genome,showing notable expansions of gene families associated with adaptation to chemoreception and detoxification.Genomic signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse regions.Patterns of genetic variations among 54 E.onukii samples unveil the population structure and evolutionary history across different tea-growing regions in China.Our results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of E.onukii.This work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management. | Qian Zhao Longqing Shi Weiyi He Jinyu Li Shijun You Shuai Chen Jing Lin Yibin Wang Liwen Zhang Guang Yang Liette Vasseur Minsheng You | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 12 | Paleoecology of Oligocarpia gothanii Halle from the Middle Permian of Southeastern Shanxi,North China显示文摘Fossil ferns are abundant and diverse in the Permian Cathaysian Flora of Shanxi, North China. Although plants assemblages of the Carboniferous and Permian have been extensively investigated, their palaeoecology and especially the paleoecology of ferns has not been studied in detail. Recent reinvestigation of Oligocarpia gothanii has revealed its growth habit and cloning reproduction strategy, but most previous studies lack integrated sedimentological and taphonomic data. In this study, new materials of O. gothanii have been collected from a floodplain setting in the middle Permian Lower Shihhotse Formation of southeastern Shanxi. These plant fossils were found in a lenticular claystone associated with rooting structures. They are characterized by aphlebia at the base of the penultimate rachis. Sedimentological, taphonomic and morphological analyses were conducted to understand the growth habit and ecology of the fern. The result indicates that the Oligocarpia gothanii had a prostrate, ground cover growth habit, and was dominant in pioneer floras that colonized disturbed floodplains. | HE Xuezhi WAN Mingli YAN Mengxiao CHENG Chen WANG Shijun WANG Jun | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 13 | A Novel Hybrid Tag Identification Protocol for Large-Scale RFID Systems显示文摘Radio frequency identification technology is one of the main technologies of Internet of Things(IoT).Through the transmission and reflection of wireless radio frequency signals,non-contact identification is realized,and multiple objects identification can be realized.However,when multiple tags communicate with a singleton reader simultaneously,collision will occur between the signals,which hinders the successful transmissions.To effectively avoid the tag collision problem and improve the reading performance of RFID systems,two advanced tag identification algorithms namely Adaptive M-ary tree slotted Aloha(AMTS)based on the characteristics of Aloha-based and Query tree-based algorithms are proposed.In AMTS,the reader firstly uses the framed slotted Aloha protocol to map the tag set to different time slots,and then identify the collided tags using binary search method based on collision factor or mapping table.Both performance analysis and extensive experimental results indicate that our proposed algorithms significantly outperforms most existing anti-collision approaches in tag dense RFID systems. | Ye Mu Ruiwen Ni Yuheng Sun Tong Zhang Ji Li Tianli Hu He Gong Shijun Li Thobela Louis Tyasi | 2021 | Computers, Materials & Continua2021，，8： | 1 |
| 14 | CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer显示文摘Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of patients.Thus,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic outcome.Methods:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with MLN8237.Then,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with MLN8237.For mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of MLN8237.Mechanistic studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic catastrophe.We further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor growth.Conclusions:These findings establish Haspin as a synthetic lethal target and demonstrate CHR-6494 as a potential combinational drug for promoting the therapeutic effects of MLN8237 on breast cancer. | Ailin Chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu | 2021 | Cancer Communications2021，41，2： | 1 |
| 15 | Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus显示文摘Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021 by the Food and Drug Administration(FDA)in the US.The launch of Saphnelo marked the only new treatment approved for systemic lupus erythematosus(SLE)in more than 10 years. | Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 16 | Coordination-driven self-assembly of dibenzo-18-crown-6 functionalized Pt(Ⅱ) metallacycles显示文摘Coordination-driven self-assembly was used to construct two metallacycles of a dicarboxylatefunctionalized dibenzo-18-crown-6 in combination with either a 0° anthracene-based clip-type acceptor or a 60° phenanthrene-based acceptor. The angularities of these moieties make them suitable for the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization and host-guest chemistry of two metallacycles were described and supported by31P{1H},1H NMR spectra and electrospray mass spectrometry. | Zibin Zhang Yu Yao Lang He Tao Hong Shijun Li Feihe Huang Peter J.Stang | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 17 | Global Epigenomic Reconfiguration During Mammalian Brain Development显示文摘 | Ryan Lister Eran A. Mukamel Joseph R. Nery Mark Urich Clare A. Puddifoot Nicholas D. Johnson Jacinta Lucero Yun Huang Andrew J. Dwork Matthew D. Schultz Miao Yu Julian Tonti-Filippini Holger Heyn Shijun Hu Joseph C. Wu Anjana Rao Manel Esteller Chuan He F | 2013 | Science2013，，6146： | 1 |
| 18 | Use of RNAi silencing to target preconditioned glial cell line-derived neurotrophic factor in neuronal apoptosis显示文摘Several studies have suggested that exogenous glial cell line-derived neurotrophic factor may pro-tect neurons from cerebral ischemic injury. However, the mechanisms underlying the neuroprotec-tive effects of endogenous glial cell line-derived neurotrophic factor remain unclear. The present experiments sought to elucidate the influence of various conditioned media on neuronal apoptosis, using a normal culture medium for astrocytes, an astrocyte medium highly expressing glial cell line-derived neurotrophic factor, and an astrocyte medium in which glial cell line-derived neurotro-phic factor expression was silenced using RNAi technology. The results confirmed that the use of RNAi silencing to target pretreated glial cell line-derived neurotrophic factor expression promoted neuronal apoptosis. In addition, oxygen and glucose deprivation preconditioning was found to upregulate glial cell line-derived neurotrophic factor expression, and significantly reduce neuronal apoptosis. | Hongliang Guo Xinhua Li Jing Mang Ying Xing Jinting He Guihua Xu Shijun Yan LifengLiu Chunli Mei Zhongxin Xu | 2011 | Neural Regeneration Research2011，6，7： | 1 |
| 19 | Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice显示文摘 | Min He Shijun Zhang Yang Jiao Xing Lin Jianchun Huang Chunxia Chen Zhaoni Chen Renbin Huang | 2012 | Food and Chemical Toxicology2012，，9： | 1 |
| 20 | Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats显示文摘 | Quanfang Huang Renbin Huang Shijun Zhang Jun Lin Ling Wei Min He Lang Zhuo Xing Lin | 2012 | Toxicology Letters2012，，： | 1 |
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