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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | The German emergency and disaster medicine and management system--history and present显示文摘也为在至于在灾难管理,直接走近病人的医学博士的原则到这个事件的地点的及时、平结束的优化的集体药的单个情况中的优化紧急情况管理,在德国是为照顾和耐心的幸存的质量的一个长期的标记。包括医疗服务,职业营救和紧急情况力量是紧急情况管理系统的金色的标准。管理法律,资源的合适的组织,设备,训练并且医药措施的足够的交货是在系统的途径的关键因素管理紧急情况,灾难同样地并且这样救命。在灾难期间,命令,通讯,协作和合作是必要的应付极端状况,甚至更这样在一个全球化的世界上。在这篇文章,我们描述主要历史的里程碑,在进更宽广的欧洲途径的紧急情况和灾难管理和它的集成的德国系统的当前的状态。 | Norman Hecker Bernd Dieter Domres | 2018 | Chinese Journal of Traumatology2018，21，2： | 9 |
| 3 | 羟乙基甲基纤维素对硫铝酸盐水泥早期水化的影响显示文摘采用超声/电声谱仪、低场核磁共振仪、量热仪研究了羟乙基甲基纤维素(HEMC)对硅酸盐水泥和快硬硫铝酸盐水泥(CSA)早期水化的影响。测试了砂浆的保水性、含气量等宏观性能。结果表明:HEMC均显著提高了新拌砂浆的保水性和含气量,但对水泥浆体ζ电位的影响截然不同——HEMC的掺入大幅缩短了硅酸盐水泥浆体ζ电位变正的时间,却仅使快硬CSA浆体ζ电位的绝对值略微减小。此外,HEMC掺入后,水泥浆体横向弛豫时间分布曲线在100~1000 ms内出现新的弛豫峰。对硅酸盐水泥水化而言,3 d后此峰基本消失;而快硬CSA浆体120 min时此峰便已消失,表明HEMC在快硬CSA颗粒表面的吸附作用弱,因此不同于HEMC对硅酸盐水泥水化反应显著的延缓作用,HEMC几乎不影响快硬CSA早期水化放热。 | 吴凯 康旺 徐玲琳 Andreas HECKER Horst-Michael LUDWIG 王培铭 | 2020 | 硅酸盐学报2020，48，5： | 8 |
| 4 | Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomized phase 2 study显示文摘 | Donald Richards Darren M. Kocs Alexander I. Spira A. David McCollum Sami Diab Lanny I. Hecker Allen Cohn Feng Zhan Lina Asmar | 2013 | European Journal of Cancer2013，，： | 3 |
| 5 | Polymersomes scalably fabricated via flash nano- precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration显示文摘 | Sean D. Allen Yu-Gang Liu Sharan Bobbala Lei Cai Peter I. Hecker Ryan Temel Evan A. Scott | 2018 | Nano Research2018，11，10： | 3 |
| 6 | Contraindications for video capsule endoscopy显示文摘Video capsule endoscopy(VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication. Endoscopic placement of the capsule should be considered in patients with swallowing disorders to avoid aspiration. Esophageal or gastric motility disorders may require endoscopic capsule transport or application of prokinetics if the real-time viewer proofs delayed transit. In pregnant women, VCE should be restricted to urgent cases where diagnosis cannot be postponed after delivery, as data on safety are missing. There is theoretical and clinical evidence that patients with implanted cardiac devices such as a pacemaker, cardioverters or left heart assist devices, can safely undergo VCE in spite of still existing contraindication by manufacturers. Children from the age of 2 years have safely undergone VCE. Although video capsules are not proven safe with magnetic resonance imaging(MRI), first single cases of patients incidentally undergoing MRI with an incorporated capsule have been reported, showing susceptibility artifacts but no signs of clinical harm. | Dirk Bandorski Niehls Kurniawan Peter Baltes Reinhard Hoeltgen Matthias Hecker Dominik Stunder Martin Keuchel | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 7 | Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study显示文摘 | J. Tischendorf H. Wasmuth A. Koch H. Hecker C. Trautwein R. Winograd | 2007 | Endoscopy2007，，12： | 2 |
| 8 | Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis显示文摘Cellular therapies are becoming a major focus for the treatment of demyelinating diseases such as multiple sclerosis (MS), therefore it is important to identify the most effective cell types that promote myelin repair. Several components contribute to the relative benefits of specific cell types including the overall efficacy of the cell therapy, the reproducibility of treatment, the mechanisms of action of distinct cell types and the ease of isolation and generation of therapeutic populations. A range of distinct cell populations promote functional recovery in animal models of MS including neural stem cells and mesenchymal stem cells derived from different tissues. Each of these cell populations has advantages and disadvantages and likely works through distinct mechanisms. The relevance of such mechanisms to myelin repair in the adult central nervous system is unclear since the therapeutic cells are generally derived from developing animals. Here we describe the isolation and characterization of a population of neural cells from the adult spinal cord that are characterized by the expression of the cell surface glycoprotein NG2. In functional studies, injection of adult NG2^+ cells into mice with ongoing MOG_35-55-induced experimental autoimmune encephalomyelitis (EAE) enhanced remyelination in the CNS while the number of CD3^+ T cells in areas of spinal cord demyelination was reduced approximately three-fold. In vivostudies indicated that in EAE, NG2^+ cells stimulated endogenous repair while in vitro they responded to signals in areas of induced inflammation by differentiating into oligodendrocytes. These results suggested that adult NG2^+ cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS. | Lianhua Bai Jordan Hecker Amber Kerstetter Robert H.Miller | 2013 | Neuroscience Bulletin2013，29，2： | 2 |
| 9 | Basic theory and experimental techniques of the strain-gradient method显示文摘 | J. T. Pindera F. W. Hecker | 1987 | Experimental Mechanics1987，，3： | 2 |
| 10 | High-pressure Intrinsic Oxidation Kinetics of Two Coal Chars显示文摘 | William C Hecker Peter M | 2007 | Energy and Fuels2007，17，2： | 1 |
| 11 | Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ显示文摘 | Wagner AH Schwabe O Hecker M | 2002 | Br J Pharmacol2002，136，1： | 1 |
| 12 | Anterior cruciate ligament graft fixation:comparison of hamstring and patellar tendon graft 显示文摘 | Steiner ME Hecker AT Brown CH Jr | 1994 | Am J Sports Med1994，22，： | 1 |
| 13 | Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein显示文摘 | Konradi C and Heckers S | 1995 | Neurosci1995，65，： | 1 |
| 14 | MicroRNAs in multiplesclerosis and experimental autoimmune encephalomyelitis 显示文摘 | Thamilarasan M Koczan D Hecker M | 2012 | Autoimmun Rev2012，11，3： | 1 |
| 15 | Anterior cingulate cortex activation during cognitive interference in schizophrenia显示文摘 | Heckers S Weiss A P Deckersbach T | 2004 | Am J Psychiatry2004，161，4： | 1 |
| 16 | The magic of plutonium: 5 f electrons and phase instability显示文摘 | S. S. Hecker | 2004 | Metallurgical and Materials Transactions A2004，，8： | 1 |
| 17 | CD 95(APO-1/FAS)-mediated apotosis in cytokine-activated hematopoietic cells显示文摘 | Hecker S Kohne E | 1998 | Exp Hematol1998，26，： | 1 |
| 18 | Structure and thermal stability of graded Ta-TaN diffusion barriers between Cu and SiO2 显示文摘 | H ~i bner R Hecker M Mattern N | 2003 | Thin Solid Films2003，437，： | 1 |
| 19 | Infusion thrombophlebitis显示文摘 | Iewisg BH Hecker JF | 1985 | Br J Anaesth1985，57，2： | 1 |
| 20 | A 24-week,randomized double-blind study of donepezil in moderate to severe Alzheimer's disesse显示文摘 | Feldman H Gauthier S Hecker J | 2001 | Neurology2001，57，： | 1 |
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