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| 1 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 2 | Vertiginous syndrome显示文摘 | Janice C Salma F Helena B | 2008 | Australi-an Family Physician2008，37，5： | 1 |
| 3 | Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine显示文摘 | Helena Domeij Xiang Hua Jun Su Alexandra B?cklund Zhongqun Yan Anna G. Frosteg?rd Jesper Z. Haeggstr?m Tomas Modéer Johan Frosteg?rd | 2013 | Prostaglandins and Other Lipid Mediators2013，，： | 1 |
| 4 | Enzymatic characterization of lipid2based drug delivery systems显示文摘 | Helena L W Flemming S N Mattias B | 2005 | Int J Pharm2005，298，32： | 1 |
| 5 | Regulation of gene expression by low levels of ultraviolet-B radiation in Pisum sativum:isolation of novel genes by suppression subtractive hybridisation显示文摘 | HELENA SAVENSTRAND MIKAEL B AKE S | 2002 | Plant and Cell Physiology2002，4，4： | 1 |
| 6 | Evaluation of an aroma similar to that of sparkling wine:Sensory and gas chromatography analyses of fermented grape musts显示文摘 | Maria E O Mamede Helena M A B Cardello Glaucia M Pastore | 2005 | Food Chemistry2005，89，： | 1 |
| 7 | Health care professionals'experiences of parental presence and participation in neonatal intensive care unit 显示文摘 | Helena W Marie B | 2007 | Int J Qualitative Studies Health and Well-being2007，2，2： | 1 |
| 8 | Health care professionals ' ex- periences of parental presence and participation in neonatal inten- sive care unit显示文摘 | Helena W Marie B Anna - lena H | 2007 | International Journal of Qualitative Studies on Health and Well - being2007，2，： | 1 |
| 9 | Search for genes involved in the temperature - induced gonadal sex differentiation in the tilapia, Oreochromis niloticus显示文摘 | Helena D Jean - Francois B | 2001 | Journal of Experimental Zoology2001，290，： | 1 |
| 10 | Enzymatic characterization of lipid-based drug delivery systems显示文摘 | Helena L W Flemming S N Mattias B | 2005 | Int J Pharm2005，298，2： | 1 |
| 11 | Younger women with breast carcinoma have a poorer prognosis the Han older women 显示文摘 | Maureen C Helena R Kirby B | 1996 | Caneer1996，77，3： | 1 |
| 12 | Food properties affecting the digestion and absorption of carbohydrates 显示文摘 | Inger B Yvonne B Helena L | 1994 | American Journal of Clinical Nutrition1994，，： | 1 |
| 13 | Changes occurring in phenoliccontent,tocopherol composition and oxidative stability of Camelinasativa oil during storage显示文摘 | HELENA A BOJAN B VOJKO N | 2007 | Food Chemistry2007，104，3： | 1 |
| 14 | Temporal evolution of groundwater composition in an alluvial aquifer (Pisuerga River, Spain) by principal component analysis显示文摘 | Helena B Pardo R Vega M | 2000 | Water Research2000，34，80： | 1 |
| 15 | The presence of banana streak virus has been confirmed in plantain(Musa AAB Simmonds),sugarcane:(Saccharum officinarum)and edible canna(Canna edulis)in Colombia显示文摘 | Helena R Sylvio B Gladys M | 1997 | Infomusa1997，6，1： | 1 |
| 16 | Standards of medical care in diabetes--2009 显示文摘 | Helena WR Lawrence B Susan SB | 2009 | Diabetes Care2009，32，1： | 1 |
| 17 | Identification and partial characterisation of hyaluronidases in Lonomia obliqua venom显示文摘 | Ana Isabel da C B Gouveia Rafael B da Silveira Helena B Nader et a/ | 2005 | Toxicon2005，45，： | 1 |
| 18 | Tumor necrosis factorαandβup-regulate the levels of osteoprotegerin m RNA in human osteosarcoma MG-63 cell显示文摘 | Helena B Kenweth B J Olle V | 1998 | Biochem Biophys Res Commun1998，248，3： | 1 |
| 19 | Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential显示文摘Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(P.capillacea) and Osmundaria obtusiloba.Methods:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content quantification.Antimicrobial activity was tested using the method of disc diffusion on Mueller-Hinton medium.The ability of algal extracts to agglutinate bacterial cells was also tested.Results:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex extract.The results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of P.capillacea(33.04%and 40.81%) at a concentration of 1 000 μg/mL.As for the ferrous ion chelating,there was an opposite behavior,extracts of P.capillacea had a higher activity.The extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to 0.180.Antioxidant activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains tested.However,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio harveyi.Conclusions This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells. | Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 1 |
| 20 | Changes occurring in phenolic content, tocopherol composition and oxidative stability of Camelina sativa oil during storage 显示文摘 | Helena A Bojan B Vojko N | 2007 | Food Chemistry2007，104，： | 1 |
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