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| 1 | Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic显示文摘Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD. | Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader | 2014 | World Journal of Gastroenterology2014，20，34： | 36 |
| 2 | Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4显示文摘AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. | Mona F Schaalan Waleed A Mohamed Hesham H Amin | 2012 | World Journal of Gastroenterology2012，18，28： | 12 |
| 3 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 4 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 5 | Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE显示文摘 | Xia K Manning M Hesham H | 2007 | Proceed- ings of the National Academy of Sciences2007，104，17： | 1 |
| 6 | Time varying load analysis to reduce distribution losses through reconfiguration显示文摘 | Robert P Broaderwater Asif H Khan Hesham E Shaalan | 1993 | IEEE Transactions on Power Delivery1993，8，1： | 1 |
| 7 | Pest control expert system for tomato (PCEST)显示文摘 | EL-SAYED EL-AZHARY HESHAM A H RAFEA A | 2000 | Knowlegde and Information System2000，2，： | 1 |
| 8 | Radiation-induced grafting of glycidyl methacrylate onto cotton fabric waste and its modification for anchoring hazardous wastes from their solutions 显示文摘 | HESHAM H SAYED M EHAB M | 2009 | Journal of Hazardous Materials2009，168，： | 1 |
| 9 | Benzo(a)pyrene,3-methylcholanthrene and β-naphthoflavone induce oxidative stress in hepatoma hepa1c1c7 cells by an AHR-dependent pathway显示文摘 | REEM H ELBEK A I HESHAM M | 2004 | Free Radical Res2004，38，11： | 1 |
| 10 | Radiation-induced grafting of glycidyl methacrylate onto cotton fabric waste and its mod- ification for anchoring hazardous wastes from their solutions显示文摘 | HESHAM H S SAYED M B EHAB M Z et a/ | 2009 | Jour- nal of Hazardous Materials2009，168，1： | 1 |
| 11 | Application of cleaner production technology in chemical industry: A near zero emission显示文摘 | Sohair I A Hesham A H Enns A T | 2007 | Journal ofCleanerProduction2007，15，18： | 1 |
| 12 | Time varying load analysis to reduce distribution losses through reconfiguration显示文摘 | Robert P Broaderwater Asif H Khan Hesham E Shaalan | 1993 | IEEE Trans on Power Delivery1993，8，1： | 1 |
| 13 | Developing passenger car equivalents for heavy vehicles during congestion 显示文摘 | AHMED F A YOUNG H J HESHAM R | 2005 | Journal of Transportation Engineering2005，131，7： | 1 |
| 14 | The distribution-free newsboy problem: Extensions to the shortage penalty case 显示文摘 | Hesham K A Hassan H E | 2005 | International Journal of Production Economics2005，9394，： | 1 |
| 15 | A neural network approach for predicting the structural behavior of concrete slabs显示文摘 | Tarek H Susan T Hesham M | 1998 | Canadian Journal of Civil Engineering1998，25，4： | 1 |
| 16 | Pest control expert system for tomato (PCEST)显示文摘 | EL-SAYED E A HESHAM A H RAFEA A | 2000 | Knowledge and Information Systems2000，，2： | 1 |
| 17 | Laparoscopic conmmn bile duct exploration: the past, the present, and the future显示文摘 | Muhammed AM Hesham H Mohammed IM | 2000 | Am J Surg2000，179，4： | 1 |
| 18 | Close accord on DWT performance and real-time implementation for protection applications显示文摘 | Darwish H A Hesham M Taalab A I | 2012 | IEEE Transactions on Power Delivery2012，25，4： | 1 |
| 19 | An evolutionary approach to vehicle routing problem with dynamic time and precedence relationships显示文摘 | PLUM D HESHAM H A | 2005 | Journal of Computational Methods in Science and Engineering2005，，： | 1 |
| 20 | Two-dimensional modeling of contaminant transport in porous media in the presence of colloids显示文摘 | HESHAM M B AHMED E H | 2005 | Advances in Water Resources2005，28，12： | 1 |
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