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| 1 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 2 | Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation显示文摘Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets. However, little is known about the precise roles of intracellular cholesterol metabolism in the development of craniofacial bones, the majority of which are formed through intramembranous ossification. Here, we show that an altered cholesterol metabolic status results in abnormal osteogenesis through dysregulation of primary cilium formation during bone formation. We found that cholesterol metabolic aberrations, induced through disruption of either Dhcr7(which encodes an enzyme involved in cholesterol synthesis) or Insig1 and Insig2(which provide a negative feedback mechanism for cholesterol biosynthesis), result in osteoblast differentiation abnormalities. Notably, the primary cilia responsible for sensing extracellular cues were altered in number and length through dysregulated ciliary vesicle fusion in Dhcr7 and Insig1/2 mutant osteoblasts. As a consequence, WNT/β-catenin and hedgehog signaling activities were altered through dysregulated primary cilium formation.Strikingly, the normalization of defective cholesterol metabolism by simvastatin, a drug used in the treatment of cholesterol metabolic aberrations, rescued the abnormalities in both ciliogenesis and osteogenesis in vitro and in vivo. Thus, our results indicate that proper intracellular cholesterol status is crucial for primary cilium formation during skull formation and homeostasis. | Akiko Suzuki Kenichi Ogata Hiroki Yoshioka Junbo Shim Christopher AWassif Forbes DPorter Junichi Iwata | 2020 | Bone Research2020，8，1： | 5 |
| 3 | Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells显示文摘Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 cells.Recently,the roles of Sox(SRY-related high-mobility-group(HMG)-box)family members in various immune responses have been investigated.However,the roles of Sox12,a member of the SoxC group,in Th2 cell differentiation and allergic airway inflammation,remain unknown.We showed that Sox12 mRNA was significantly increased during Th2 cell differentiation.In vivo,HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12−/−mice compared with those in control Sox12+/−mice.In vitro,Sox12−/−CD4^(+)T cells that were cultured under Th2 conditions had increased production of Th2 cytokines and GATA3 protein compared with those of control Sox12+/−CD4^(+)T cells.Importantly,forced expression of Sox12 decreased the protein levels of GATA3 in CD4^(+)T cells under Th2 conditions without affecting mRNA expression.Furthermore,Sox12 induced degradation of GATA3 through the proteasome pathway in CD4^(+)T cells.Consistently,Sox12 enhanced ubiquitination of GATA3,which was mediated by the E3 ligase Fbw7.Finally,we found that Fbw7 knockdown partly abrogated Sox12-mediated GATA3 suppression in CD4^(+)T cells.Taken together,these results suggest that Sox12 suppresses Th2 cell differentiation by accelerating Fbw7-mediated GATA3 degradation,and attenuates HDM-induced allergic inflammation. | Ken-Ichi Suehiro Akira Suto Kensuke Suga Hiroki Furuya Arifumi Iwata Taro Iwamoto Shigeru Tanaka Takahiro Kageyama Kotaro Suzuki Koichi Hirose Véronique Lefebvre Hiroshi Nakajima | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 4 | How does environmental performance affect financial performance Evidence from Japanese manufacturing rms显示文摘 | Hiroki Iwata Keisuke Okada | 2011 | Ecological Economics2011，70，： | 1 |
| 5 | Enhancement of Runx2 Expression Is Potentially Linked to β‐Catenin Accumulation in Canine Intervertebral Disc Degeneration显示文摘 | Munetaka Iwata Takeshi Aikawa Takaharu Hakozaki Kiyotaka Arai Hiroki Ochi Hirotaka Haro Masahiro Tagawa Yoshinori Asou Yasushi Hara | 2015 | J. Cell. Physiol2015，，1： | 1 |
| 6 | Empirical study on the environmental Kuznets curve for CO2 in France: The role of nuclear energy 显示文摘 | Hiroki Iwata Keisuke Okada Sovannroeun Samreth | 2010 | Energy Policy2010，38，： | 1 |
| 7 | Empirical Study on the Environmental Kuznets Curve for CO2 in Prance: The Role of nuclear Energy显示文摘 | Hiroki Iwata Keisuke Okada Sovannroeun Samreth | 2010 | Energy Policy2010，38，8： | 1 |
| 8 | How Does Environmental Performance Affect Financial Performance?Evidence from Japanese Manufacturing Firms显示文摘 | Hiroki Iwata Keisuke Okada | 2010 | Munich Personal Re PEc Archive2010，，29： | 1 |
| 9 | A note on the environmental Kuznets curve forCO2: A pooled mean group approach显示文摘 | HIROKI IWATA KEISUKEOKADA SOVANNROEUN SAMRETH | 2011 | Applied Energy2011，88，： | 1 |
| 10 | Empirical study on the environmental Kuznets curve for CO 2 in France: The role of nuclear energy显示文摘 | Hiroki Iwata Keisuke Okada Sovannroeun Samreth | 2010 | Energy Policy2010，，： | 1 |
| 11 | Ultrastructural changes in porcine liver sinusoidal endothelial cells of machine perfused liver donated after cardiac death显示文摘BACKGROUND The machine perfusion(MP)preservation including hypothermic MP(HMP)and midthermic MP(MMP)has been considered as a promising strategy to preserve the functions of liver donated after cardiac death.The importance of understanding liver sinusoidal endothelial cells(LSEC)damage in regulating liver injury during MP has been emphasized.However,the ultrastructural changes in the LSEC and sinusoids around them after MP are unclear.AIM To investigate the ultrastructural changes in the LSEC and sinusoids around them after MP.METHODS Porcine liver grafts undergo a warm ischemia time of 60 minutes perfused for 4 h with modified University of Wisconsin gluconate solution.Group A grafts were preserved with HMP at 8℃ constantly for 4 h.Group B grafts were preserved with a rewarming solution at 22℃ by MMP for 4 h.Then the ultrastructural changes in the LSEC and sinusoids in Group A and B were comparatively analyzed by using osmium-maceration scanning electron microscopy with complementary transmission electron microscopy methods.RESULTS An analysis of the LSEC after warm ischemia revealed that mitochondria with condensed-shaped cristae,abnormal vesicles,reduction of ribosomes and the endoplasmic reticulum(ER)surround the mitochondria appeared.The MP subsequent after warm ischemia alleviate the abnormal vesicles and reduction of ribosomes in LSEC,which indicated the reduction of the ER damage.However,MMP could restore the tubular mitochondrial cristae,while after HMP the condensed and narrow mitochondrial cristae remained.In addition,the volume of the sinusoidal space in the liver grafts after MMP were restored,which indicated a lower risk of pressure injury than HMP.CONCLUSION MMP alleviates the ER damage of LSEC by warm ischemia,additionally restore the metabolism of LSEC via the normalization of mitochondria and prevent the share stress damage of liver grafts. | Hiroki Bochimoto Yo Ishihara Nur Khatijah Mohd Zin Hiroyoshi Iwata Daisuke Kondoh Hiromichi Obara Naoto Matsuno | 2022 | World Journal of Gastroenterology2022，28，19： | 0 |
| 12 | Development of risky varices in alcoholic cirrhosis with a well-maintained nutritional status显示文摘AIM: To compare the nutritional status between alcoholic compensated cirrhotic patients and hepatitis C virus(HCV)-related cirrhotic patients with portal hypertension.METHODS: A total of 21 patients with compensated cirrhosis(14 with HCV-related cirrhosis and seven with alcoholic cirrhosis) who had risky esophageal varices were investigated. In addition to physical variables, including the body mass index, triceps skinfold thickness, and arm-muscle circumference, the nutritional status was also assessed using the levels of pre-albumin(pre-ALB), retinol-binding protein(RBP) and non-protein respiratory quotient(NPRQ) measured with an indirect calorimeter.RESULTS: A general assessment for the nutritional status with physical examinations did not show a significant difference between HCV-related cirrhosis and alcoholic cirrhosis. However, the levels of pre-ALB and RBP in alcoholic compensated cirrhotic patients were significantly higher than those in HCV-related compensated cirrhotic patients. In addition, the frequency of having a normal nutritional status(NPRQ ≥ 0.85 and ALB value > 3.5 g/d L) in alcoholic compensated cirrhotic patients was significantly higher than that in HCV-related compensated cirrhotic patients.CONCLUSION: According to our small scale study, alcoholic compensated cirrhotic patients can develop severe portal hypertension even with a relatively well-maintained liver function and nutritional status compared with HCV-related cirrhosis. | Hirayuki Enomoto Yoshiyuki Sakai Yoshinori Iwata Ryo Takata Nobuhiro Aizawa Naoto Ikeda Kunihiro Hasegawa Chikage Nakano Takashi Nishimura Kazunori Yoh Akio Ishii Tomoyuki Takashima Hiroki Nishikawa Hiroko Iijima Shuhei Nishiguchi | 2015 | World Journal of Hepatology2015，7，21： | 0 |
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