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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle显示文摘 | Ho R C Alcazar O Fujii N | 2004 | Am J Physiol Regul Integr Comp Physiol2004，286，2： | 1 |
| 3 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 4 | Peonidin 3- glucoside inhibits lung cancer metastasis by downregulation of proteinases activities and MAPK pathway 显示文摘 | Ho M L Chen P N Chu S C | 2010 | Nutrition and Cancer2010，62，4： | 1 |
| 5 | Response of Vietnam coastal upwelling to the 1997-1998 ENSO event observed by multisensor data显示文摘 | Kuo N J Zheng Q Ho C | 2004 | Remote Sensing of Environment2004，87，： | 1 |
| 6 | Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification显示文摘 | Toyota M Ho C Ahuja N | 1999 | Cancer Res1999，59，： | 1 |
| 7 | Regulation of stress granule dynamicsby Grb7 and FAK signalling pathway显示文摘 | Tsai N P Ho P C Wei L N | 2008 | EMBO J2008，27，5： | 1 |
| 8 | Satellite observation of upwelling along the western coast of the South China Sea显示文摘 | Kuo N J Zheng Q Ho C | 2000 | Remote Sensing of Environment2000，74，： | 1 |
| 9 | The markets for non-deliverable forwards in Asian currencies显示文摘 | Ma G N C Ho R N McCauley | 2004 | BIS Quarterly Review2004，6，： | 1 |
| 10 | Modeling of mercury sorption by activated carbon in a confined, a semi-fluidized, and a fluidized bed显示文摘 | Ho T C Kobayashi N Lee Y K | 2002 | Waste Management2002，22，4： | 1 |
| 11 | Aptamer-Based Optical Probes with Separated Molecular Recognition and Signal Transduction Modules显示文摘 | Li N Ho C M | 2008 | J Am Chem Soc2008，130，8： | 1 |
| 12 | Modeling the Psychology of Consumer and Firm Behavior Using Behavioral Economics 显示文摘 | HO T H LIM N CAMERER C F | 2006 | Journal of Market Research2006，43，8： | 1 |
| 13 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 14 | Exploring the high lipid produc- tion potential of a thermotolerant microalga using statistical optimi- zation and semi-continuous cultivation 显示文摘 | Ho S H Chen C N Lai Y Y | 2014 | Bioresource Technolo- gy2014，163，： | 1 |
| 15 | Residence time distribution analysis in controllable flow conditions : Case of rotating disc reactor 显示文摘 | Myung J K Yong S G Ho N C | 1984 | Chemical Engineering Science1984，39，5： | 1 |
| 16 | A longitudinal magnetic resonance imaging study early in schizophrenia显示文摘 | Ho B C Andreasen N C Nopoulos P | 2003 | Arch Gen Psychiatry2003，60，6： | 1 |
| 17 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 18 | Modeling the psychology of consumer and firm behavior with behaviouraleconomics 显示文摘 | Ho T H Lim N Camerer C F | 2006 | Journal of Marketing Research 20062006，，： | 1 |
| 19 | Morbidity, mortality, and technical factors of distal pancreatectomy 显示文摘 | Fahy B N Frey C H Ho H S | 2002 | Am J Surg2002，183，3： | 1 |
| 20 | Framework of a fuzzy quality function deployment system显示文摘 | KHOO L P HO N C | 1996 | International Journal of Production Research1996，34，2： | 1 |
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