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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Maps preserving numerical radius of products of self-adjoint operators显示文摘 | He K Hou J C Zhang X L | 2010 | Acta Math Sinca-Eng-lish Series2010，6，： | 1 |
| 3 | Composi tion and preservation of the Cheng jiang fauna-lower Cambrian soft-bodied biota显示文摘 | Hou Xian guang Ramskold L Bergstrom J | 1991 | Zoologica Scripta1991，20，： | 1 |
| 4 | Identification of miRNomes inhuman liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma 显示文摘 | Hou J Lin L Zhou W | 2011 | Cancer cell2011，19，2： | 1 |
| 5 | 1,8-Naphthalimides for non-doping OLEDs:the tunable emission color from blue,green to red显示文摘 | Gan J A Song Q L Hou X Y | 2004 | J Photochem Photobiol A:Chem2004，162，： | 1 |
| 6 | Medical meth- ods for cervical ripening before the removal of in- trauterine devices in postmenopausal women: a systematic review 显示文摘 | Hou S P C'hen 0 J Huang L H | 2013 | Eur J Obstet Gynecol Reprod Biol2013，169，2： | 1 |
| 7 | Linear maps preserving the closure of numerical range on nest algebras with maximal atomic nest显示文摘 | Cui J L Hou J C | | 0，，： | 1 |
| 8 | The Brassica rapa FLC homologue FLC 2is a key regulator of flowering time,identified through transcriptional co-expression networks显示文摘 | Xiao D Zhao J J Hou X L | 2013 | Journal of Experimental Botany2013，64，14： | 1 |
| 9 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 10 | Effects of Lactobacillusjohn- sonii XS4 supplementation on reproductive performance, gut environment,and blood biochemical and immunological index in lactating sows显示文摘 | Wang J Ji H F Hou C L | 2014 | Livestock Sci2014，164，6： | 1 |
| 11 | Cystain C, association with hemorrhagic and ischemic stroke,is a strong predictor of the risk of cardiovascular event and death in Chinese显示文摘 | Ni L Ltl J Hou LB | 2007 | Stroke2007，38，12： | 1 |
| 12 | Simple and rapid docetaxel assay in plasma by protein precipitation and high-performance liquid chromatography -tandem mass spectrometry 显示文摘 | HOU Weiying WATTERS J W MCLEOD H L | 2004 | J Chromatogr: B2004，804，2： | 1 |
| 13 | Non-Linear numerical radius isometries on atomic nest algebras and diagonal algebras显示文摘 | Cui J L Hou J C | | 0，，： | 1 |
| 14 | Cutting balloon combined with paclitax-el-cluting balloon for treatment of In-stent restenosis 显示文摘 | Kong J Hou J Ma L | 2013 | Arch Car-diovasc Dis2013，106，： | 1 |
| 15 | Anaerobic ammonium oxidation (Anammox) bacterial diversity, abundance, and activity in marsh sediments of the Yangtze Estuary 显示文摘 | Hou L J Zheng Y L Liu M | 2013 | Journal of Geophysical Research: Biogeosciences2013，118，3： | 1 |
| 16 | Scanning tunneling spectroscopy of individual C60 molecules adsorbed on Si ( 111 )-7 × 7 surface 显示文摘 | Wang H Q Zeng C G Li Q X Wang B Yang J L Hou J G Zhu Q Sh | 1999 | Surface Science1999，442，： | 1 |
| 17 | Are fluorinated boron nitride nanotubes n-type semiconductors 显示文摘 | XIANG H J YANG J L HOU J G | 2005 | Appl Phys Lett2005，87，24： | 1 |
| 18 | Identification of mi- RNomes in Human Liver and Hepatocellular Carci- noma Reveals miR-199a/b-3p as Therapeutic Target for H epatocellular Carcinoma显示文摘 | Hou J Lin L Zhou WP | 2011 | Cancer Cell2011，19，2： | 1 |
| 19 | Coordination with a Backup supplier through buy-back contract under supply disruption 显示文摘 | HOU J ZENG A Z ZHAO L | 2010 | Transportation Research Part E2010，46，： | 1 |
| 20 | Oxygen istope composi- tions of quartz grains (4 16 p,m) from Chinese eolian de- posits and their implications for provenance 显示文摘 | Hou S S Yang S L Sun J M etal | 2003 | Science in China (Series D)2003，46，10： | 1 |
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