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| 1 | The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3显示文摘增加的庄稼收益被要求支持世界范围的快速的人口生长。谷物重量是米饭产量的一个关键部件,但是控制它的内在的分子的机制留下逃犯。这里,我们报导为米饭谷物长度,重量和产量的控制克隆和一个新量的特点地点(QTL ) 的描述。这个地点, GL3.1,编码蛋白质磷酸酶 kelch (PPKL ) 家庭 —Ser/Thr 磷酸酶。GL3.1 是大谷物 WY3 变化的一个成员,它比小谷物 FAZ1 变化与更弱的 dephosphorylation 活动被联系。GL3.1-WY3 在小穗状花小穗影响蛋白质 phosphorylation 加速房间分割,从而导致更长的谷物和更高的收益。进一步的研究直接显示出那 GL3.1 dephosphorylates 它的底层, Cyclin-T1; 3,它很少仅仅在植物被学习了。Cyclin-T1 的 downregulation; 3 在更短的谷物导致了米饭,它在房间周期规定为 Cyclin-T 显示新奇功能。我们的调查结果为通过影响 Cyclin-T1 的 phosphorylation 的新奇调停磷酸酶的进程被驾驶的谷物尺寸和产量的规定建议新机制; 3 在房间周期前进期间,并且这样提供新卓见进位于庄稼种子开发下面的机制。我们引起了包含表明了增加的谷物产量的自然 GL3.1 等位基因的一个新变化,它显示 GL3.1 是为引起产量很高的庄稼的一个强大的工具。 | Peng Qi You-Shun Lin Xian-Jun Song Jin-Bo Shen Wei Huang Jun-Xiang Shan Mei-Zhen Zhu Liwen Jiang Ji-Ping Gao Hong-Xuan Lin | 2012 | Cell Research2012，22，12： | 132 |
| 2 | Panax notogiseng saponin inhibits ischemia-induced apoptosis by activating PI3K/Akt signal pathway in cardiomyocytes显示文摘The panax notoginseng saponin(PNS) had been clinically used for the treatment of cardiovascular diseases and stroke in China.It had been demonstrated that PNS could protect cardiomyocytes from injury induced by ischemi- a,but the underlying molecular mechanisms of this protective effect were still unclear.This study was aimed to investigate the protective effect and molecular mechanisms of PNS on apoptosis in H9c2 cells in vitro and rat myocardial ischemia injury model in vivo.Annexin-V/PI assay shew that PNS could protect H9c2 cells from apoptosis induced by serum, glucose and oxygen deprivation(SGOD) in a dose-dependent manner.However,the anti-apoptotic effect of PNS was reversed by LY294002,a specific PI3K inhibitor.This antiapoptotic effect of PNS was confirmed by JC-1,a specific probe of mitochondrial membrane potential staining.PNS could significantly increase phos-Akt in H9c2 cells by Western blot assays and its effect could be inhibited by LY294002.Furthermore,PNS could improve ischemic-induced left ventricular function as reflected by EF,LVDd and LVDs.PNS could also inhibited cellular apoptosis in myocardial tissues in ischemic rats by TUNEL assay.PNS administration also increased the expression of phos-Akt in rat ischemic myocardial tissues.These results suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in vitro model and in vivo model through activating-PI3K/Akt signal pathway which may be meaningful for further understanding the molecular mechanisms of cardiac protection of PNS.And the results might be useful in treatment of myocardial ischemia in future. | YANG Min,CHEN Shao-Xian,LIU Ju-Li,LIU Xiao-Ying,FU Yong-Heng,ZHANGMeng-zhen,LIN Qiu-Xiong,ZHU Jie-Ning, SHAN Zhi-Xin,YU Xi-yong (Medical Research Center,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 47 |
| 3 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 4 | DK crush technique: modified treatment of bifurcation lesions in coronary artery显示文摘 | CHEN Shao-liang YE Fei ZHANG Jun-jie ZHU Zhong-sheng LIN Song SHAN Shou-jie LIU Zhi-zhong LIU Yan DUAN Bao-xiang GE Jun-bo | 2005 | Chinese Medical Journal2005，，20： | 35 |
| 5 | Palaeogeothermal response and record of the effusing of Emeishan basalts in the Sichuan basin显示文摘Thermal history of the Sichuan basin is reconstructed based on vitrinite reflectance from boreholes in the basin using a paleo-heat flow method.The results show that the Sichuan basin experienced a relatively low heat flow period in the Early Paleozoic,and an elevated paleo-heat flow,ranging 60-80 mW/m2 with a maximum as high as 100 mW/m2 around 259 Ma,from the beginning of the Late Paleozoic to the end of the early Permian,and a decreased paleo-heat flow from the late Permian to the late Triassic,and then maintained nearly stable to the present.The Late Paleozoic paleo-heat flow was quite high where there were extensive Emeishan flood basalts or concealed basalts which erupted between the early and the late Permian,such as the southwestern and northeastern areas of the Sichuan basin.According to the distribution of paleo-heat flow,it can be inferred that,the northeastern Sichuan basin was also influenced by the Emeishan magmatic activity during the Dongwu movement though there was lack of Emeishan flood basalts.In addition,the results of thermal history reconstruction of the Sichuan basin provide paleogeothermal evidence for the existence and onset of the Emaishan mantle plume. | ZHU ChuanQing XU Ming YUAN YuSon ZHAO YongQing SHAN JingNan HE ZhiGuo TIAN YunTao HU ShengBiao | 2010 | Chinese Science Bulletin2010，55，10： | 30 |
| 6 | Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer显示文摘背景分子的指向的药现在广泛地在临床的 treatment.lcotinib hydrochloride 是的非小的房间肺癌症(NSCLC ) 被使用口头的表皮的生长的一种新类型因素受体(EGFR ) tyresine kinase 禁止者(EGFR-TKIs ) 。在这研究,我们作为我们分析了的 icotinib hydrochlodde.Methods 的功效的 predicators 从先进 NSCLC 病人在肿瘤标本检验了 EGFR ,K地岬,B皇家空军体的变化和 EGFR mRNAexpression 的角色肿瘤嵌入石蜡的标本,它与先进 NSCLC 从 40 个病人中的 14 个被获得在阶段注册了 icotinib hydrochloride 的临床的试用。体的变化被充实异种的 liquidchip (MEL ) 评估技术,和 EGFR mRNA 表示被分叉的 DNA liquidchip (MBL ) 测量在 14 个标本的 technology.Results,七个病人显示出 EGFR 变化, exon 19 删除(3/7 ) 和 exon 21 点变化(4/7 ) ;并且二个病人显示出 K 地岬变化。在 EGFR exon 的没有变化 20。或 B 皇家空军被检测。在有 EGFR 变化的病人,一个病人得了进步疾病(PD ) ,三个病人有稳定的疾病(SD ) ,二个病人有部分回答(PR ) ,一个病人有完全的回答(CR ) 。在有野类型的 EGFR 的病人,四个病人有 PD,三个病人获得了 SD,并且任何一个都没有 PR/CR (P=0.0407 ) 。EGFR 变化与更好没有进步的幸存(PFS )(141 天对 61 天) ,但是没有统计上重要的差别(P=0.8597 ) 被联系,并且中部的全面幸存(OS )(449 天对 140 天) 。 EGFR mRNA 表示层次被评估(三高度,八中等,一个低,并且二那不能由于不够的肿瘤织物被测量)并且没有统计上重要的关系与 EGFR 变化率是的反应, PFS 或 OS.Conclusions 被观察与在亚洲人口报导了那一致, MEL 技术因此为与高产量和快测量 EGFR 变化是可靠的。EGFR exon 19 删除和 exon 21 点变化作为第二线治疗以上是为对 icotinib hydrochloride 的反应的预兆的 biomarkers。 | REN Guan-jun ZHAO Yuan-yua ZHU Yu-jia XIAO Yi XU Jia-sen SHAN Bin ZHANG Li | 2011 | Chinese Medical Journal2011，，1： | 30 |
| 7 | ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis显示文摘叶绿素(Chl ) 降级是叶老朽的一个不可分的过程,并且 NYE1/SGR1 在多样的工厂种类作为 Chl 分解代谢的一个关键管理者被表明了。在这研究,用屏蔽的酵母一个混血儿,我们识别了三 abscisic 酸(骆驼毛的织物) 应答的元素(ABRE ) 绑定抄写因素, ABF2 (AREB1 ) , ABF3,和 ABF4 (AREB2 ) , NYE1 倡导者的通常认为的有约束力的蛋白质。通过 transactivation 分析, electrophoretic 活动性移动试金,和染色质 immunoprecipitation,我们表明了直接跳到并且在 vitro 并且在 vivo 激活 NYE1 倡导者的那 ABF2, ABF3,和 ABF4。骆驼毛的织物是叶老朽的一个积极管理者,并且外长地适用骆驼毛的织物能加速 Chl 降级。ABF, abf2abf3abf4,以及二骆驼毛的织物感觉迟钝的异种, abi1-1 和 snrk2.2/2.3/2.6 的三倍的异种,在骆驼毛的织物处理以后的展出停留绿色显型,与 NYE1 和 NYE2 表示的减少的正式就职一起。相反, ABF4 的 overexpression 在骆驼毛的织物处理之上加速了 Chl 降级。有趣地, ABF2/3/4 能也激活二 Chl 分解代谢的酶基因, PAO 和 NYC1 的表达式,由对他们的倡导者直接有约束力。另外, abf2abf3abf4 展出了功能的停留绿色显型,和联系老朽的基因(下垂) 例如 SAG29 (SWEET15 ) ,可能被 ABF 直接调整。一起拿,我们的结果在调停作为关键管理者建议那 ABF2, ABF3,和 ABF4 可能的行为被触发骆驼毛的织物的 Chl 降级和叶老朽一般来说在 Arabidopsis。 | Shan Gao Jiong Gao Xiaoyu Zhu Yi Song Zhongpeng Li Guodong Ren Xin Zhou Benke Kuai | 2016 | Molecular Plant2016，9，9： | 27 |
| 8 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 9 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 10 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 11 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 12 | Comprehensive analysis of nitrogen distributions and ammonia nitrogen release fluxes in the sediments of Baiyangdian Lake, China显示文摘The condition of Baiyangdian Lake(BYDL) will improve as the Xiongan New Area evolves and fulfills its role of easing overcrowding and supporting economic growth. Water and sediment samples from BYDL were analyzed to provide information on nitrogen(N) contamination in BYDL. The mean ammonium N(NH_4^+-N), nitrate N, and total N concentrations in the water samples were 0.36, 0.12, and 2.22 mg/L, respectively, and the ranges were 0.003–8.38, 0.06–0.30,and 1.25–10.34 mg/L, respectively. The N concentrations in water gradually increased from the north to the south of BYDL. Sediment at 90% of the sampling sites was in or above the moderately contaminated class(1000–2000 mg/kg) defined in US Environmental Protection Agency total N pollution standards. Positive NH_4^+-N fluxes were found for 28 of the 34 sediment core samples, so the potential for NH_4^+-N being released from sediment was relatively high. The NH_4^+-N fluxes were 5.35–48.76 mg/m^2/day, and the mean and maximum fluxes were 8.71 and 48.76 mg/m^2/day, respectively. Benthic organisms will be affected more by NH_4^+-N and NH_3·H_2O in the surface sediment pore water(mean concentrations 4.93 and 0.13 mg/L, respectively) than by the other forms of N. | Yaoyao Zhu Xin Jin Wenzhong Tang Xin Meng Baoqing Shan | 2019 | Journal of Environmental Sciences2019，31，2： | 20 |
| 13 | Effect of surface modification of activated carbon on its adsorption capacity for NH_3显示文摘To investigate the effects of carbon surface characteristics on NH3 adsorption,coal-based and coconut shell activated carbons were modified by treatment with oxidants.The surface properties of the carbons were characterized by low temperature nitrogen sorption,by Boehm's titrations and by XPS techniques.NH3 adsorption isotherms of the original and the modified carbons were determined.The results show that the carbons were oxidized by HNO3 and(NH4)2S2O8,and that there was an increase in oxygen containing functional groups on the surface.However,the pore-size distribution of the coal-based carbons was changed after KMnO4 treatment.It was found that the NH3 adsorption capacity of the modified carbons was enhanced and that the most pronounced enhancement results from(NH4)2S2O8 oxidation.Under our experimental conditions,the capacity is positively cor- rected to the number of surface functional groups containing oxygen,and to the number of micro-pores.Furthermore,an empirical model of the relationship between NH3 adsorption and multiple factors on the carbon surface was fit using a complex regression method. | SHAN Xiao-mei ZHU Shu-quan ZHANG Wen-hui | 2008 | Journal of China University of Mining and Technology2008，18，2： | 18 |
| 14 | Proton accumulation accelerated by heavy chemical nitrogen fertilization and its long-term impact on acidifying rate in a typical arable soil in the Huang-Huai-Hai Plain显示文摘Cropland productivity has been significantly impacted by soil acidification resulted from nitrogen(N) fertilization, especially as a result of excess ammoniacal N input. With decades' intensive agricultural cultivation and heavy chemical N input in the Huang-Huai-Hai Plain, the impact extent of induced proton input on soil p H in the long term was not yet clear. In this study, acidification rates of different soil layers in the soil profile(0–120 cm) were calculated by p H buffer capacity(p HBC) and net input of protons due to chemical N incorporation. Topsoil(0–20 cm) p H changes of a long-term fertilization field(from 1989) were determined to validate the predicted values. The results showed that the acid and alkali buffer capacities varied significantly in the soil profile, averaged 692 and 39.8 mmolc kg–1 p H–1, respectively. A significant(P<0.05) correlation was found between p HBC and the content of calcium carbonate. Based on the commonly used application rate of urea(500 kg N ha–1 yr–1), the induced proton input in this region was predicted to be 16.1 kmol ha–1 yr–1, and nitrification and plant uptake of nitrate were the most important mechanisms for proton producing and consuming, respectively. The acidification rate of topsoil(0–20 cm) was estimated to be 0.01 unit p H yr–1 at the assumed N fertilization level. From 1989 to 2009, topsoil p H(0–20 cm) of the long-term fertilization field decreased from 8.65 to 8.50 for the PK(phosphorus, 150 kg P2O5 ha–1 yr–1; potassium, 300 kg K2 O ha–1 yr–1; without N fertilization), and 8.30 for NPK(nitrogen, 300 kg N ha–1 yr–1; phosphorus, 150 kg P2O5 ha–1 yr–1; potassium, 300 kg K2 O ha–1 yr–1), respectively. Therefore, the apparent soil acidification rate induced by N fertilization equaled to 0.01 unit p H yr–1, which can be a reference to the estimated result, considering the effect of atmospheric N deposition, crop biomass, field management and plant uptake of other nutrients and cations. As protons could be consumed by some field practices, such as stubble return and coupled water and nutrient management, soil p H would maintain relatively stable if proper management practices can be adopted in this region. | HUANG P ing ZHANG Jia-bao XIN Xiu-li ZHU An-ning ZHANG Cong-zhi MA Dong-hao ZHU Qiang-gen YANG Shan WU Sheng-jun | 2015 | Journal of Integrative Agriculture2015，14，1： | 18 |
| 15 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 16 | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats显示文摘Objective:To investigate the effects of puerarin on the activity of superoxide dismutase(SOD), and expressions of advanced glycation end-product(AGE) receptor(RAGE) and vascular endothelial growth factor(VEGF) in retinas of streptozotocin(STZ)-induced early diabetic rats. Methods:Diabetic rat models were established by inducing diabetes via intra-peritoneal injection of STZ.Rats were randomly divided into normal(control),diabetic(DM),and DM+ puerarin groups.After intra-gastric administration of puerarin(500 mg/kg/day for 4 weeks),levels of SOD and malondialdehyde(MDA) were determined in serum and retina.mRNA and protein expression levels of RAGE and VEGF in retinas were determined by real-lime polymerase chain reaction(RT-PCR)(mRNA) and Western blot analysis(protein levels).Results:There was significantly lower SOD activity and significantly higher MDA in serum and retinas of the DM group compared with the two other groups(P<0.05).After treatment with puerarin,SOD activity increased and MDA content decreased in this group(P<0.05).mRNA and protein expression levels of RACE and VECF in the DM group were significantly higher than those of the other groups (P<0.05),and decreased after puerarin treatment(P<0.05).Conclusions:Puerarin is able to enhance SOD activity,and inhibit RAGE and VEGF expressions in retinas of STZ-induced early diabetic ruts. | Fang Chen Hong-Quan Zhang Jun Zhu Kai-Yang Liu Hong Cheng Guo-Li Li Shan Xu Wei-Hong Lv Zheng-Gao Xie | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，11： | 16 |
| 17 | Clinical significance of multislice spiral CT scans in hepatic veins occlusion in Budd-Chiari syndrome显示文摘有肝的静脉吸藏(HVBCS ) 的背景 Budd-Chiari 症候群能导致严重的门高血压和肝损坏。我们回顾地分析了 HVBCS 的肝的 CT 特征并且在它的 diagnosis.Methods 评估了 CT 考试和 CT angiography (CTA ) 的 triphasic 改进的实用性有 HVBCS 的 25 个盒子,由数字减法 angiography (DSA ) 证实了,在 DSA 前在一个星期以内收到了 triphasic 改进 CT 扫描。相关的血容器的 CTA 图象与最大的紧张设计被重建,显示的体积并且倾斜与 DSA ,横向的 CT 的察觉率和 CTA 图象相比重新格式化 techniques.Results 因为反常肝的静脉是81.7%( 58/71 )并且95.8%( 68/71 )( 2=7.044 , P=0.008 ),为膜的阻塞是47.4%( 9/19 )并且84.2%( 16/19 )分别地( 2 =5.729 , P=0.017 )因为部分阻塞是88.0%( 22/25 )并且100%( 25/25 )分别地( 2=1.418 , P=0.234 )。为肝的静脉狭窄的察觉率是有每个方法的 100% 。弥漫的肝肿大在尖锐阶段在所有 6 个盒子中被发现并且在长期的阶段的 19 个盒子中的 3 个没有专利 intrahepatic 担保,有三根肝的静脉的严重阻塞。在长期的阶段的另外的 16 个盒子有 hepatatrophia 到与妨碍的肝的静脉有关的不同程度。都在尖锐阶段并且 15 开始在有尾的脑叶和 perihilar 区域在长期的阶段介绍了典型补缀的改进并且与时间扩大了延期。在所有情况中,有萎缩,坏死和拥挤的实质区域表明了更低、以后的改进。在所有部分,它有正常改进,至少一获流出专利肝的静脉,附件肝的静脉或并行的容器被检测。由 multislice 螺线 CT 的结论动态改进 CT 检查能不仅由 CTA 技术改进 HVBCS 的诊断,而且能 noninvasively 提供解剖信息并且揭示损坏到肝的实质。 | MENG Xiao-chun ZHU Kang-shun QIN Jie ZHANG Jian-sheng WANG Xiao-hong ZOU Yan ZHANG Ya-qin SHAN Hong | 2007 | Chinese Medical Journal2007，，2： | 15 |
| 18 | Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study显示文摘BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome. | Zhu-Jun Cao Yu-Han Liu Chuan-Wu Zhu Shan Yin Wei-Jing Wang Wei-Liang Tang Gang-De Zhao Yu-Min Xu Lu Chen Tian-Hui Zhou Ming-Hao Cai Hui Wang Wei Cai Shi-San Bao Hai Li Qing Xie | 2020 | World Journal of Gastroenterology2020，26，6： | 15 |
| 19 | Radiofrequency ablation for hepatic hemangiomas: A consensus from a Chinese panel of experts显示文摘Recent studies have shown that radiofrequency(RF) ablation therapy is a safe, feasible, and effective procedure for hepatic hemangiomas, even huge hepatic hemangiomas. RF ablation has the following advantages in the treatment of hepatic hemangiomas: minimal invasiveness, definite efficacy, high safety, fast recovery, relatively simple operation, and wide applicability. It is necessary to formulate a widely accepted consensus among the experts in China who have extensive expertise and experience in the treatment of hepatic hemangiomas using RF ablation, which is important to standardize the application of RF ablation for the management of hepatic hemangiomas, regarding the selection of patients with suitable indications to receive RF ablation treatment, the technical details of the techniques, therapeutic effect evaluations, management of complications, etc. A final consensus by a Chinese panel of experts who have the expertise of using RF ablation to treat hepatic hemangiomas was reached by means of literature review, comprehensive discussion, and draft approval. | Jun Gao Rui-Fang Fan Jia-Yin Yang Yan Cui Jian-Song Ji Kuan-Sheng Ma Xiao-Long Li Long Zhang Chong-Liang Xu Xin-Liang Kong Shan Ke Xue-Mei Ding Shao-Hong Wang Meng-Meng Yang Jin-Jin Song Bo Zhai Chun-Ming Nin Shi-Gang Guo Zong-Hai Xin Jun Lu Yong-Hong Dong Hua-Qiang Zhu Wen-Bing Sun | 2017 | World Journal of Gastroenterology2017，23，39： | 15 |
| 20 | Rapid growth cost in “all-fish” growth hormone gene transgenic carp:Reduced critical swimming speed显示文摘Evidence has accumulated that there is a trade-off between benefits and costs associated with rapid growth. A trade-off between growth rates and critical swimming speed (Ucrit) had been also reported to be common in teleost fish. We hypothesize that growth acceleration in the F3 generation of 'all-fish' growth hormone gene (GH) transgenic common carp (Cyprinus carpio L.) would reduce the swimming abilities. Growth and swimming performance between transgenic fish and non-transgenic controls were compared. The results showed that transgenic fish had a mean body weight 1.4―1.9-fold heavier,and a mean specific growth rate (SGR) value 6%―10% higher than the controls. Transgenic fish,however,had a mean absolute Ucrit (cm/s) value 22% or mean relative Ucrit (BL/s) value 24% lower than the controls. It suggested that fast-growing 'all-fish' GH-transgenic carp were inferior swimmers. It is also supported that there was a trade-off between growth rates and swimming performance,i.e. faster-growing individuals had lower critical swimming speed. | LI DeLiang FU CuiZhang HU Wei ZHONG Shan WANG YaPing ZHU ZuoYan | 2007 | Chinese Science Bulletin2007，52，11： | 14 |
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