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| 1 | 急性缺血性卒中的血管内治疗:神经介入外科学学会实践标准委员会的报告显示文摘目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会(American Heart Association,AHA)以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上,进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。 | K A Blackham P M Meyers T A Abruzzo F C Alberquerque D Fiorella J Fraser D Frei C D Gandhi D V Heck J A Hirsch D P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) | 2012 | 国际脑血管病杂志2012，20，12： | 28 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 4 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 5 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 6 | Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling显示文摘 | Jennifer L Strande Hsu A | 2008 | Pharmacol Exp Ther Mar2008，324，： | 1 |
| 7 | Rate control for robust video trgnsmission over burst-error wireless channels显示文摘 | C Hsu A Ortega M Khansari | 1999 | IEEE Journal on Selected Areas in Communications1999，17，5： | 1 |
| 8 | Ischemic preconditioning in the intact rat heart is mediated by deltal but not mu-or kappa-opioid receptors显示文摘 | Schultz J E Hsu A K Gross G J | 1998 | Circulation1998，97，13： | 1 |
| 9 | FIFE: the variation in energy partition at surface flux sites显示文摘 | SHUTTLEWORH W J GURNEY R J HSU A Y | 1989 | IAHS Publication1989，186，： | 1 |
| 10 | Constitutive laws of softened concrete in biaxial tension compression 显示文摘 | Belarbi A Hsu T T C | 1995 | ACI Structural Journal1995，92，5： | 1 |
| 11 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 12 | Gender differences and age-related white matter changes of the human brain: a diffu- sion tensor imaging study 显示文摘 | Hsu JL Leemans A Bai CH | 2008 | Neuroimage2008，39，2： | 1 |
| 13 | Immuno- prophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization显示文摘 | HSU C H CHUA K Y TAO M H et a | 1996 | Nat Med1996，2，： | 1 |
| 14 | Computing eolian sand transport from shear velocity measurements显示文摘 | Hsu S A | 1973 | Journal of Geology1973，81，： | 1 |
| 15 | High-perfoimance carbon nanotube transparent conductive films by scablable dip coating显示文摘 | MIRRI F MA A W K HSU T T | 2012 | Acs Nano2012，6，79： | 1 |
| 16 | Anti-inflammatory activity of soy and tea in prostate cancer prevention显示文摘 | Hsu A Bray T M So E | 2010 | Exp Biol Med2010，235，6： | 1 |
| 17 | Sleep disruptions and noc- turnal nursing interactions in the intensive care unit 显示文摘 | Le A Friese RS Hsu CH | 2012 | J Surg Res2012，177，2： | 1 |
| 18 | Phar-macokinetic interactions between two human immunodeficiency virus protease inhibitors,ritonavir and saquinavir显示文摘 | HSU A GRANNEMAN G R CAO G | 1998 | Clin Pharmacol Ther1998，63，4： | 1 |
| 19 | IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF显示文摘 | Kikuchi K Lai A Y Hsu C L | 2007 | J Exp Med2007，201，： | 1 |
| 20 | Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase 显示文摘 | Yoshida A Hsu LC Dave' V | 1992 | Enzyme1992，46，45： | 1 |
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