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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 4 | MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB显示文摘 | Guijun Yan Lianxiao Zhang Ting Fang Qun Zhang Shaogen Wu Yue Jiang Haixiang Sun Yali Hu | 2012 | FEBS Letters2012，，19： | 2 |
| 5 | Small molecule gas sorption and diffusion in coal: molecular simulation 显示文摘 | Hu Haixiang Li Xiaochun Fang Zhiming Wei Ning Li Qianshu | 2010 | Energy2010，35，： | 1 |
| 6 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 7 | Smart luminescent solar concentrator as a BICPV window显示文摘Building integrated concentrating photovoltaic(BICPV)windows have attracted numerous studies in recent years.However,there is a tradeoff between the light transmittance and power generation efficiency in the design of BICPV window.In this paper,a smart luminescent solar concentrator(LSC)is introduced as the BICPV window.The proposed smart LSC system features on the combination of fluorescent dyes with thermochromic materials to enhance photoelectric conversion efficiency as well as form a dynamic response mechanism to ambient solar radiation and environmental temperature.In this study,a BICPV smart window system consists of the waveguide doped with organic dye Lumogen F Red-305(BASF)and the thermochromic hydrogel membrane has been developed.The research on analytic design parameters is executed through optical simulation by ray tracing technology along with outdoor comparative experiments.From simulations for a smart LSC of 100 mm×100 mm×3 mm with a bottom-mounted solar cell of 100 mm×10 mm,the optical effective concentration is found to be with the range of 1.23 to 1.31 when a highest gain of 1.26 in power over the bare solar cell is obtained from experiments. | Ying Nie Wei He Xianghua Liu Zhongting Hu Hancheng Yu Haixiang Liu | 2022 | Building Simulation2022，15，10： | 1 |
| 8 | Delay-induced inward and outward spiral waves in oscillatory medium显示文摘 | HU Haixiang JI Lin LI Shuqian | 2008 | J ChemPhys2008，128，04： | 1 |
| 9 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 10 | The mRNA–miRNA–lncRNA Regulatory Network and Factors Associated with Prognosis Prediction of Hepatocellular Carcinoma显示文摘The aim of this study was to identify novel prognostic mRNA and microRNA(miRNA)biomarkers for hepatocellular carcinoma(HCC)using methods in systems biology.Differentially expressed mRNAs,miRNAs,and long non-coding RNAs(lncRNAs)were compared between HCC tumor tissues and normal liver tissues in The Cancer Genome Atlas(TCGA)database.Subsequently,a prognosis-associated mRNA co-expression network,an mRNA–miRNA reg-ulatory network,and an mRNA–miRNA–lncRNA regulatory network were constructed to identify prognostic biomarkers for HCC through Cox survival analysis.Seven prognosis-associated mRNA co-expression modules were obtained by analyzing these differentially expressed mRNAs.An expression module including 120 mRNAs was significantly corre-lated with HCC patient survival.Combined with patient survival data,several mRNAs and miRNAs,including CHST4,SLC22A8,STC2,hsa-miR-326,and hsa-miR-21 were identified from the network to predict HCC patient prognosis.Clinical significance was investigated using tissue microarray analysis of samples from 258 patients with HCC.Functional annotation of hsa-miR-326 and hsa-miR-21-5p indicated specific associations with several cancer-related pathways.The present study provides a bioinformatics method for biomarker screening,leading to the identification of an integrated mRNA–miRNA–lncRNA regulatory network and their co-expression patterns in relation to predicting HCC patient survival. | Bo Hu Xiaolu Ma Peiyao Fu Qiman Sun Weiguo Tang Haixiang Sun Zhangfu Yang Mincheng Yu Jian Zhou Jia Fan Yang Xu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，6： | 0 |
| 11 | Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial显示文摘Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe. | Hui Zhu Taishun Li Peizhen Xu Lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan Li Pengfeng Zhu Huiyan Wang Chenyan Dai Haixiang Sun Jianwu Dai Yali Hu | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 12 | Calcium-based polymers for suppression of soil acidification by improving acid-buffering capacity and inhibiting nitrification显示文摘Soil acidification is a major threat to agricultural sustainability in tropical and subtropical regions.Biodegradable and environmentally friendly materials,such as calcium lignosulfonate(CaLS),calcium poly(aspartic acid)(PASP-Ca),and calcium polyγ-glutamic acid(γ-PGA-Ca),are known to effectively ameliorate soil acidity.However,their effectiveness in inhibiting soil acidification has not been studied.This study aimed to evaluate the effect of CaLS,PASP-Ca,andγ-PGA-Ca on the resistance of soil toward acidification as directly and indirectly(i.e.,via nitrification)caused by the application of HNO_(3)and urea,respectively.For comparison,Ca(OH)_(2)and lignin were used as the inorganic and organic controls,respectively.Among the materials,γ-PGA-Ca drove the substantial improvements in the pH buffering capacity(pHBC)of the soil and exhibited the greatest potential in inhibiting HNO_(3)-induced soil acidification via protonation of carboxyl,complexing with Al~(3+),and cation exchange processes.Under acidification induced by urea,CaLS was the optimal one in inhibiting acidification and increasing exchangeable acidity during incubation.Furthermore,the sharp reduction in the population sizes of ammonia-oxidizing bacteria(AOB)and ammonia-oxidizing archaea(AOA)confirmed the inhibition of nitrification via CaLS application.Therefore,compared to improving soil pHBC,CaLS may play a more important role in suppressing indirect acidification.Overall,γ-PGA-Ca was superior to PASP-Ca and CaLS in enhancing the soil pHBC and the its resistance to acidification induced by HNO_(3) addition,whereas CaLS was the best at suppressing urea-driven soil acidification by inhibiting nitrification.In conclusion,these results provide a reference for inhibiting soil re-acidification in intensive agricultural systems. | Fei Kang Yunshan Meng Yanning Ge Yun Zhang Haixiang Gao Xueqin Ren Jie Wang Shuwen Hu | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 13 | Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling显示文摘Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular development.Angiogenesis plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure. | Lu Xu Yanjun Yang Lingling Zhang Guijun Yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 14 | CCS Technology Helpful for China to Improve Capability of Treaty Execution显示文摘The International Energy Agency (IEA) Report 2008 illustrated that the CO2 emissions from energy consumption in China was 5.6 billion tons in 2006,accounting for 20% of the global total (28 billion tons). | LI Xiaochun WEI Ning FANG Zhiming LI Qi HU Haixiang | 2009 | Bulletin of the Chinese Academy of Sciences2009，23，4： | 0 |
| 15 | CO_(2) gas stripped off membranous residual oil from pore surfaces: Effects of temperature, pressure and wettability显示文摘The threshold values of CO_(2) gas stripped off membranous residual oil from the pore walls are not clear under different temperatures, pressures and wettability conditions. The extent to which temperature, pressure and wettability influence CO_(2) flooding for enhancing the recovery of residual oil in membranous formations also remains uncertain. Therefore, further quantitative characterization is entailed. In this study, the molecular dynamics method was employed to explore CO_(2) flooding under different temperatures, pressures and wettability conditions, aiming to enhance the production of membranous residual oil. The results reveal that the interaction energy between CO_(2), decane molecules and pore walls exhibits a decrease with increasing temperature and an increase with increasing pressure, respectively, in distinct wettability scenarios. When the temperature was at or below 363 K and the pressure was not lower than 40 MPa, CO_(2) gas could detach the membranous residual oil from the pore walls in the water-wet systems. When the temperature was equal to 363 K and the pressure remained under 40 MPa, or the temperature surpassed 363 K, CO_(2) gas failed to detach the membranous residual oil from the pore walls in the water-wet systems. For the mixed-wet and oil-wet systems, CO_(2) molecules could not detach the membranous residual oil from the pore walls. The hierarchy of influence regarding temperature, pressure and wettability on the competitive adsorption capacity of CO_(2) and decane molecules on the pore walls emerged as follows: wettability > temperature > pressure. The findings of this study offer valuable insights into the application of CO_(2) gas flooding for the exploitation of membranous residual oil on pore walls. | Tao Yu Haixiang Hu Qi Li Yongsheng Tan Liang Xu Xiaomin Cao | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，12： | 0 |
| 16 | Bioinspired Hydrogels with Muscle-Like Structure for AIEgen-Guided Selective Self-Healing显示文摘Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being damaged.The self-healing is usually selective,which means that the healing efficiency is related to the spatial distribution of dynamic interfacial interactions of the two rupturing surfaces.Current artificial systems use noncovalent interactions or dynamic covalent bonds to prepare self-healing materials.However,they can only show nonselective self-healing due to their homogeneous internal structures.Herein,we report the construction of a composite hydrogel Gel-C consisting of three different self-healing hydrogels(Gel-Y,Gel-G,and Gel-O)through the use of classic bilayer hydrogel technology.When the composite hydrogel was cut into two pieces,the relative orientation of the parts was rotated through different angles to study the differences in self-healing.Owing to the heterogeneous internal structure of the composite hydrogel and the recognition specificity of each included hydrogel,the interfacial dynamic interactions distribution of the two rupturing surfaces is diverse.The results of tensile tests demonstrated that these rotated samples exhibited different self-healing efficiencies.This system realized the transformation of artificial materials from nonselective self-healing to selective selfhealing,providing inspiration for the development of novel biological materials and engineering materials. | Xiaofan Ji Zhao Li Yubing Hu Huilin Xie Wenjie Wu Fengyan Song Haixiang Liu Jianguo Wang Meijuan Jiang Jacky WYLam Ben Zhong Tang | 2021 | CCS Chemistry2021，3，4： | 0 |
| 17 | MXene Ti_(3)C_(2) decorated g-C_(3)N_(4)/ZnO photocatalysts with improved photocatalytic performance for CO_(2) reduction显示文摘Photocatalytic reduction of CO_(2) is considered as a kind of promising technologies for solving the greenhouse effect.Herein,a novel hybrid structure of g-C_(3)N_(4)/ZnO/Ti_(3)C_(2) photocatalysts was designed and fabricated to investigate their abilities for CO_(2) reduction.As demonstration,heterojunction of g-C_(3)N_(4)/ZnO can improve photogenerated carriers’separation,the addition of Ti_(3)C_(2) fragments can further facilitate the photocatalytic performance from CO_(2) to CO.Hence,g-C_(3)N_(4)/ZnO/Ti_(3)C_(2) has efficiently increased CO production by 8 and 12 times than pristine g-C_(3)N_(4) and ZnO,respectively.Which is ascribed to the photogenerated charge migration promoted by metallic Ti_(3)C_(2).This work provides a guideline for designing efficient hybrid catalysts on other applications in the renewable energy fields. | Jianxin Li Yuhua Wang Yitong Wang Yao Guo Shiding Zhang Haixiang Song Xianchang Li Qianqian Gao Wanyu Shang Shuaishuai Hu Huibin Zheng Xifei Li | 2023 | Nano Materials Science2023，5，2： | 0 |
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