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| 1 | Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment显示文摘Although progress has been indeed made by nanomedicines, their efficacies for cancer treatment remain low, consequently leading to failures in translation to clinic. To improve the drug delivery efficiency,nanoparticles need to change size so as to fully utilize the enhanced permeability and retention(EPR) effect of solid tumor, which is the golden principle of nanoparticles used for cancer treatment. Herein, we employed cationic small-sized red emission bovine serum albumin(BSA) protected gold nanocluster(Au NC@CBSA,21.06 nm) to both load indocyanine green(ICG) and act as imaging probe to realize theranostic. Then Au NC@CBSA-ICG was fabricated with negatively charged hyaluronic acid(HA) to form Au NC@CBSAICG@HA, which was about 200 nm to easily retain at tumor site and could be degraded by tumor-specific hyaluronidase into small nanoparticles for deep tumor penetration. The HA shell also endowed Au NC@CBSA-ICG@HA with actively targeting ability and hyaluronidase-dependent drug release. Furthermore, the quenching and recovery of fluorescence revealed the interaction between ICG and carrier, which was essential for the investigation of pharmacokinetic profiles. No matter in vitro or in vivo, Au NC@CBSAICG@HA showed markedly anti-tumor effect, and could suppress 95.0% of tumor growth on mice breast cancer model. All results demonstrated Au NC@CBSA-ICG@HA was potential for breast cancer therapy. | Rui Liu Chuan Hu Yuanyuan Yang Jingqing Zhang Huile Gao | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 24 |
| 2 | Flexible fiber-shaped supercapacitors based on hierarchically nanostructured composite electrodes显示文摘新奇所有固态的、同轴的、塑造纤维的不对称的 supercapacitor 被在 MnO 上包一张进行的复写纸制作了 < 潜水艇 class= “ a-plus-plus ” > 2 -modified nanoporous 金牌电线。这根精力电线展出 12 mF | Henghui Xu Xianluo Hu Yongming Sun Huiling Yang Xiaoxiao Liu Yunhui Huang | 2015 | Nano Research2015，8，4： | 14 |
| 3 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 4 | The maximum coseismic vertical surface displacement and surface deformation pattern accompanying the Ms 8.0 Wenchuan earthquake显示文摘The amount of coseismic deformation and its distribution of the Wenchuan earthquake provide important scientific bases for revealing the mechanisms of earthquake preparation and characterizing the rupture propagation of the Wenchuan earthquake. The previous studies have indicated that the earthquake ruptured the middle-to-north segment of the Longmenshan central fault and the middle segment of the Longmenshan range-front fault, which are characterized by two surface rupture zones of 240 km and 90 km in length, respectively. Based on the pre-earthquake information and photos of landforms and buildings obtained through ge-ologic and geomorphic survey of the area around Shaba Village of Beichuan County, Sichuan Province and the extensive interview with local villagers, we measured the displacements of the major terrain features and the dislocated buildings by total station instruments and differential GPS and obtained the maximum vertical displacement of 9±0.5 m and right-lateral displacement of 2±0.5 m around the Zou’s house in Shaba Village. Though the near-surface deformation exhibits a normal faulting around Shaba Village, the dynamic environment has not changed on the whole. The NW wall of the fault uplifted but without gravity gliding as normally occurring on the hanging wall of a normal fault, which proves that the 9±0.5 m displacement should be the maximum coseismic vertical displacement of the May 12, 2008 Ms 8.0 Wenchuan earthquake. | Ran YongKang Shi Xiang Wang Hu Chen LiChun Chen Jie Liu RuiChun Gong Huiling | 2010 | Chinese Science Bulletin2010，55，9： | 9 |
| 5 | Small Interfering RNA-mediated Caveolin-1 Knockout on Plasminogen Activator Inhibitor-1 Expression in Insulin-stimulated Human Vascular Endothelial Cells显示文摘把人的脉管的 endothelial 房间(ECV304 ) 用作目标,我们学习了 caveolin (CAV ) 的效果在 plasminogen 的刺激胰岛素的表示期间的 -1 禁止者(白族)-1。代表 RNAi CAV-1 基因的适当搁浅单人赛的 oligonucleotides 被 Ambion 软件分析。在退火产生双 stranded oligonucleotides (dsoligo ) 以后,它被克隆进由 T4 DNA 连接酶包含 RNA 聚合酶 III 表示元素的 pENTR/U6 入口向量。从 pENTR/U6 入口转移的短发卡(shRNA ) 序列与 LR 再结合反应被克隆进 pLenti6/BLOCK-iT-DEST 向量。由定序的 Afteridentification,我们成功地用网关技术构造了 CAV-1 RNAi lentiviral 表达式系统。Silencing 效率是由即时 reversetranscription 聚合酶链反应,免疫荧光染色并且西方的弄污的 assayed。ECV304cells 在包含胰岛素的不同集中的媒介是有教养的(1x10 ^( 有 CAV-1 基因 silenced 的 -9)to1x10^(-7) M ) 。表示水平和潜水艇 PAI-1 和 CAV-1 的细胞的本地化用反向的抄写聚合酶链反应,免疫荧光染色和蛋白质印迹试金被比较。结果证明有势力抑制 ofCAV-1 表示能到达 85% ,并且它对 CAV-1-derived shRNA,不是导出 theS100A13 的 shRNA 特定。在蛋白质确实在房间膜下面积累了的在与生理的胰岛素,而是 PAI-1 孵化的 RNAi^+andRNAi^- ECV304 房间之间的 PAI-1 表示没有戏剧的差别。当胰岛素的集中增加了, PAI-1 的表示是起来调整的,而 CAV-1 的表示稀释了。而且, PAI-1 清楚地在 CAV-1knockdown 以后扩充了。这些结果显示 hyperinsulinism 能由 inhibitingCAV-1 支持 PAI-1 表示,并且稳定或在 endothelial 房间的起来调整的 CAV-1 表示可能在糖尿病减少大容器和毛状的容器的复杂并发症。 | Huiling YANG Shuya HE Zhihua QUAN Weixia PENG Bin YAN Jianghua LIU Fang WEN Renxian CAO Yangyan XU Gebo WEN Weixin HU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 7 |
| 6 | Two-port network model and startup criteria for thermoacoustic oscillators显示文摘The startup process of a thermoacoustic engine is a self-excited oscillation process generated in inhomogeneous acoustic media. To reveal these coupling relations between various influential factors is an important task of basic research on thermoacoustics. In this paper thermoacoustic engines are regarded as thermoacoustic oscillators consisting of the active network and the passive network. Accordingly, the two-port Y-parameter for relevant component is derived, and standing wave and traveling wave thermoacoustic engine are described by the negative-resistance and feedback model, respectively. The relevant two-port network topology is given as well. The startup criteria for thermoacoustic oscillators are obtained by using Nyquist instability criterion. The model prediction of startup parameters, particularly, startup frequency and mode characteristic are in agreement with that of experimental results reported in the literature. Moreover, with topological graphs it is verified that standing wave engines would start up in a negative-resistance state and there would exist high frequency modes in thermoacoustic-Stirling engines. By investigating into the frequency response of thermoacoustic system, this method proposed can achieve such an objective that these effects of operating and structural parameters of engine on startup modes and startup temperature can be revealed in an analytical way. Thus this approach to test and check thermal stability can be provided in a design phase, instead of using empirical frequency to design thermoacoustic systems. | HU XingHua ZHANG XiaoQing WANG HuiLing SHU ShuiMing | 2009 | Chinese Science Bulletin2009，54，2： | 6 |
| 7 | Tandem catalysis in electrochemical CO_(2) reduction reaction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)is an attractive pathway for closing the anthropogenic carbon cycle and storing intermittent renewable energy by converting CO_(2) to valuable chemicals and fuels.The production of highly reduced carbon compounds beyond CO and formate,such as hydrocarbon and oxygenate products with higher energy density,is particularly desirable for practical applications.However,the productivity towards highly reduced chemicals is typically limited by high overpotential and poor selectivity due to the multiple electron-proton transfer steps.Tandem catalysis,which is extensively utilized by nature for producing biological macromolecules with multiple enzymes via coupled reaction steps,represents a promising strategy for enhancing the CO_(2)RR performance.Improving the efficiency of CO_(2)RR via tandem catalysis has recently emerged as an exciting research frontier and achieved significant advances.Here we describe the general principles and also considerations for designing tandem catalysis for CO_(2)RR.Recent advances in constructing tandem catalysts,mainly including bimetallic alloy nanostructures,bimetallic heterostructures,bimetallic core-shell nanostructures,bimetallic mixture catalysts,metal-metal organic framework(MOF)and metal-metallic complexes,metal-nonmetal hybrid nanomaterials and copper-free hybrid nanomaterials for boosting the CO_(2)RR performance are systematically summarized.The study of tandem catalysis for CO_(2)RR is still at the early stage,and future research challenges and opportunities are also discussed. | Yating Zhu Xiaoya Cui Huiling Liu Zhenguo Guo Yanfeng Dang Zhanxi Fan Zhicheng Zhang Wenping Hu | 2021 | Nano Research2021，14，12： | 5 |
| 8 | The progress and perspective of strategies to improve tumor penetration of nanomedicines显示文摘Tumor penetration is important for effectively tumor targeting drug delivery.Recently,many researches are published to overcome the barriers that restrict tumor penetration and improve drug delivery efficiency.In the mini review,we first analyzed the barriers influence the tumor penetration,including tumor microenvironment barriers,nanoparticle properties,and interaction barriers between tumor and nanoparticles.To overcome the barrier,several strategies are developed,including modulating tumor microenvironment,changing particle size,transcytosis enabled tumor penetration,cell penetrating peptide modification and overcoming binding site barrier,which could effectively improve tumor penetration,and finally enhance tumor treatment outcome. | Jiang Hu Xinwei Yuan Fei Wang Huile Gao Xilin Liu Wei Zhang | 2021 | Chinese Chemical Letters2021，32，4： | 4 |
| 9 | Simultaneous Removal of SO2 and NO from Flue Gas with Calcium-based Sorbent at Low Temperature显示文摘 | Zhang Hu Tong Huiling Wang Sujuan | 2006 | Industrial and Engineering Chemistry Research2006，45，18： | 1 |
| 10 | Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditinons in mice显示文摘 | Zhaoyong Hu Huiling Wang In Hee Lee | | 0，，10： | 1 |
| 11 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 12 | Bundling strategy and product differentiation显示文摘 | Huiling Chung Yanshu Lin Jinli Hu | 2013 | Journal of Economics2013，108，3： | 1 |
| 13 | Simultaneous removal of SO2 and NO from flue gas with calcium-based sorbent at low temperature 显示文摘 | Hu Z Huiling T Sujuan W | 2006 | Ind Eng Chem Res2006，45，： | 1 |
| 14 | Simultaneous removal of SO2 and NO from flue gas with calcium-based sorbent at low temperature显示文摘 | Zhang Hu Tong Huiling Wang Sujuan | 2006 | Industrial & Engineering Chemistry Research2006，45，18： | 1 |
| 15 | A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein显示文摘 | Gao Huile Pan Shuaiqi Yang Zhi Cao Shijie Chen Chen Jiang Xinguo Shen Shun Pang Zhiqing Hu Yu | 2011 | Biomaterials2011，，33： | 1 |
| 16 | CoSe_(2)/MoS_(2) Heterostructures to Couple Polysulfide Adsorption and Catalysis in Lithium-Sulfur Batteries显示文摘Lithium-sulfur batteries have been regarded as one of most promising next-generation energy storage devices because of their high energy density and low cost.However,polysulfide shuttling and slow kinetics hinder the practical application.We fabricated hierarchically heterostructured CoSe_(2)/MoS_(2) nanoarrays on carbon clothes as the sulfur cathode host.The resulting heterostructures facilitate electron conduction and improve electrolyte wetting.More importantly,the composite heterostructures couple the strong poly-sulfide adsorption of CoSe_(2) and high catalytic activity of MoS_(2) to synergistically accelerate polysulfide conversion,demonstrating higher catalytic activity than their individual components. | Zihan Shen Qingwen Zhou Huiling Yu Jiaming Tian Man Shi Chaoquan Hu Huigang Zhang | 2021 | Chinese Journal of Chemistry2021，39，5： | 1 |
| 17 | A co-word analysis of digital library field in China显示文摘 | Liu Gaoyong Hu Jiming Wang Huiling | 2012 | Scientometrics2012，91，1： | 1 |
| 18 | Soft,stretchable,wireless intelligent three-lead electrocardiograph monitors with feedback functions for warning of potential heart attack显示文摘Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky formats,discontinuous monitoring,and no safety alarm system significantly limit their practical applications.Herein,we present a soft,and stretchable,three-lead ECG device allowing continuous monitoring and wireless transmission of ECG signals.A newly developed organohydrogel patch with a strong adhesive ability(~9.9 kPa)and higher conductivity(~6.5 kΩ)is applied for high-quality ECG signals collection.With a long operation duration(6.5 h)and wireless transmission distance(20.9 m),it could fulfill most of the daily applications.Machine learning algorithms and the graphical user interface are used for real-time ECG monitoring and cardiac abnormalities diagnosis.The vibratory flexible actuator,which is triggered by cardiac abnormalities that need immediate medical treatment,is also integrated as a warning system for the user.As a newly reported stretchable multi-lead ECG device for long-term ECG signal monitoring,there is a high potential for improving users'life quality with the high-risk population of CVDs. | Chunki Yiu Yiming Liu Chao Zhang Jingkun Zhou Huiling Jia Tsz H.Wong Xingcan Huang Jian Li Kuanming Yao Ming K.Yau Ling Zhao Hu Li Binbin Zhang Wooyoung Park Yuanting Zhang Zuankai Wang Xinge Yu | 2022 | SmartMat2022，3，4： | 1 |
| 19 | A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein显示文摘 | Gao Huile Pan Shuaiqi Yang Zhi Cao Shijie Chen Chen Jiang Xinguo Shen Shun Pang Zhiqing Hu Yu | 2011 | Biomaterials2011，，33： | 1 |
| 20 | Stimulation of the P2X 7 receptor kills rat retinal ganglion cells in vivo显示文摘 | Huiling Hu Wennan Lu Mei Zhang Xiulan Zhang Arthur J. Argall Shaun Patel Ga Eun Lee Yong-Chul Kim Kenneth A. Jacobson Alan M. Laties Claire H. Mitchell | 2010 | Experimental Eye Research2010，，3： | 1 |
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