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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | The Raman modes of the Aurivillius phases: temperature and polarization dependence 显示文摘 | GRAVES P R HUA G MYHRA S | 1995 | J Solid State Chem1995，114，： | 3 |
| 5 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 6 | Asymptotic performance of optimal gain-and-phase estimators of sensor arrays显示文摘 | CHENG Q HUA Y B STOICA P | 2000 | IEEE Transactions on Signal Processing2000，48，12： | 1 |
| 7 | Integrated optical dull Mach-Zehnder interferometer sensor显示文摘 | Hua P Jonathan L B Quigley G Q | 2002 | Sensors and Actuators B2002，87，2： | 1 |
| 8 | Lossy-to-lossless compressionof medical volumetric data using three-dimensionalinteger wavelet transforms显示文摘 | Xiong Z X Wu X L Cheng S Hua J P | 2003 | IEEE Transactions on MedicalImaging2003，22，3： | 1 |
| 9 | Effect of oxide vscale ontemperature-dependent interfacial heat transfer in hotstamping process显示文摘 | Hua P Ying L Li Y | 2013 | Journal of Materials ProcessingTechnology2013，213，9： | 1 |
| 10 | Degrada- tion of chlorpyrifos alone and in combillation with chlorotha- lonil and their effects on soil microbial populations 显示文摘 | Xiaoqiang C H U Hua F Xuedong P A N | | Jour- nal of Environmental Sciences0，20，4： | 1 |
| 11 | Predictors of early postischemic stroke apathy and depression:a cross-sectional study显示文摘 | Yang SR Hua P Shang XY | 2013 | BMC Psychiatry2013，13，： | 1 |
| 12 | The Raman modes of the aurivillius phases:temperature and polarization dependence显示文摘 | Graves P R Hua G Myhra S | 1995 | Journal of Solid State Chemistry1995，114，1： | 1 |
| 13 | Linear Matrix equations from all inverse problem of vibration theory显示文摘 | Dai Hua Lancaster P | 1996 | Linear Algebra Appl1996，246，： | 1 |
| 14 | Human glomerular endothelium : interplay among glucose, free fatty acids, angiotensin II, and oxidative stress 显示文摘 | Jaimes EA Hua P Tian RX | 2010 | Am J Physiol Renal Physiol2010，298，1： | 1 |
| 15 | Statistical propert ies of logarithmically transformed speckle显示文摘 | Hua X Leland E P Fawwaz T U | | 0，，03： | 1 |
| 16 | Double lookbacks显示文摘 | HE Hua KEIRSTEAD W P REBBOLZ J | 1998 | Mathematical Finance1998，8，3： | 1 |
| 17 | Delay-dependent stability criteria of teleoperation systems with asymmetric time-varying delays 显示文摘 | HUA C LIU X P | 2010 | IEEE Transactions on Robotics2010，26，5： | 1 |
| 18 | Titanium dioxide nanoparticles co-doped with Fe^3+ and Eu^3 + ions for photocatalysis 显示文摘 | Yang P Lu C Hua N P | 2002 | Materials Letters2002，57，： | 1 |
| 19 | Real exchange rate aod employment in China显示文摘 | Hua P | 2007 | China Economic Review2007，，2： | 1 |
| 20 | Identification of plate rigidities of a circular plate with cylindrical orthotropy using vibration data 显示文摘 | HUA Hongxing SOL H de WILDE W P | 2000 | Computers and Structures2000，77，1： | 1 |
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