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| 1 | Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review显示文摘AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our institution.RESULTS: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant therapy.The mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow up.CONCLUSION: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable. | Hsueh-Lien Huang Shou-Chuan Shih Wen-Hsiung Chang Tsang-En Wang Ming-Jen Chen Yu-Jan Chan | 2005 | World Journal of Gastroenterology2005，11，9： | 57 |
| 2 | Structural and functional properties of SARS-CoV-2 spike protein:potential antivirus drug development for COVID-19显示文摘Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world.It is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The spike(S)protein of SARS-CoV-2,which plays a key role in the receptor recognition and cell membrane fusion process,is composed of two subunits,S1 and S2.The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2,while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain.In this review,we highlight recent research advance in the structure,function and development of antivirus drugs targeting the S protein. | Yuan Huang Chan Yang Xin-feng Xu Wei Xu Shu-wen Liu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 25 |
| 3 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 4 | Benefits of Conservation Agriculture on Soil and Water Conservation and Its Progress in China显示文摘Conservation agriculture has been practised for three decades and has been spread widely. There are many nomenclatures surrounding conservation agriculture and differ to each other lightly. Conservation agriculture (CA) is a system approach to soil and water conservation, high crop productivity and profitability, in one word, it is a system approach to sustainable agriculture. Yet, because conservation agriculture is a knowledge-intensive and a complex system to learn and implement, and also because of traditions of intensive cultivation, adoption rates have been low, since to date, only about seven percent of the world's arable and permanent cropland area is farmed under conservation agriculture. The practice and wider extention of conservation agriculture thus requires a deeper understanding of its ecological underpinnings in order to manage its various elements for sustainable intensification, where the aim is to conserve soil and water and improve sustainability over the long term. This paper described terms related to conservation agriculture, presented the effects of conservation agriculture on soil and water conservation, crop productivity, progress and adoption of CA worldwide, emphasized obstacles and possible ways to increase CA adoption to accelerate sustainable development of China agriculture. | LI Ling-ling HUANG Gao-bao ZHANG Ren-zhi Bill Bellotti Guangdi Li Kwong Yin Chan | 2011 | Agricultural Sciences in China2011，10，6： | 15 |
| 5 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 6 | The PCA3 test for guiding repeat biopsy of prostate cancer and its cut-off score: a systematic review and meta-analysis显示文摘为在重复活体检视的早干预的前列腺特定的抗原(PSA ) 的特性是不能令人满意的。(PCA3 ) 前列腺癌症抗原 3 可能比为前列腺癌症(PCa ) 的早察觉的另外的方法在结果预言是更精确的。然而,结果在重复活体检视是不一致的。因此,我们执行了系统的评论和元分析在结果预言评估 PCA3 的角色。系统的文献的搜索为在 2013 年 4 月前出版的文章被进行,用从健康技术评价机构的 PubMed, Medline,科学的网, Embase 和另外的数据库。研究的质量根据 QUADAS 标准被估计。诊断测试与的十一研究对高质量中等被选择。元分析被执行综合结果。元分析的结果在研究之中是异构的。我们执行了亚群分析(与或没有高级 prostatic intraepithelial 瘤形成(HGPIN ) 和不正常的小 acinar 增长的包括(尽快)) 。用 20 或 35 的 PCA3 截止,在二亚群,全球敏感价值是 0.93 或 0.80 和 0.79 或 0.75 ,特性是 0.65 或 0.44 和 0.78 或 0.70 ,积极可能性的比率是 1.86 或 1.58 和 2.49 或 1.78 ,否定可能性的比率是 0.81 或 0.43 和 0.91 或 0.82 ,诊断奇怪的比率( ORs )分别地是 5.73 或 3.45 和 7.13 或 4.11 。在操作典型曲线的概括接收装置的曲线(AUC ) 下面的区域分别地是 0.85 或 0.72 和 0.81 或 0.69。PCA3 能被用于前列腺的重复活体检视改进 PCa 察觉的精确性。不必要的活体检视能被使用 20 的一个 PCa 截止分数避免。 | Yong Luo Xin Gou Peng Huang Chan Mou | 2014 | Asian Journal of Andrology2014，16，3： | 13 |
| 7 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 8 | Single photon sources with single semiconductor quantum dots显示文摘在这贡献,我们简短记起量光学的基本概念和对有单个 QD 的单个光子的产生的物理的理解必要的半导体量点(QD ) 的性质。第一,我们象 QD 的光性质一样探讨量发射极洞系统,荧光和半导体 QD,和光子统计的光性质的理论。我们然后在以强壮的联合政体,效率, directionality,和极化完成他们的全面光性质和表演的限制光 microcavity 系统控制的量考察单个半导体 QD 的本地化。而且,我们将在单个光子来源的制造上讨论最近的进步,并且为嵌入的各种各样的途径挑选 QD 进 microcavities 或 photonic 水晶 nanocavities 并且显示出怎么扩大波长范围。我们特别地集中于在提高的温度操作导致高重复率,强壮的联合政体,和高收集效率的电子上驾驶的 QD 单个光子来源的新一代。而且,在强壮的联合政体的房间温度单身者光子排放的新开发被考察。为实际单个光子的来源的难区分的光子和留下的挑战的产生也被讨论。 | Guang-Cun Shant Zhang-Qi Yin Chan Hung Shek Wei Huang | 2014 | Frontiers of physics2014，9，2： | 9 |
| 9 | Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay:optimization,standardization and diagnostic criteria显示文摘Serologicaldiagnosisofnasopharyngealcarcinomabyenzymelinkedimmunosorbantasay:optimization,standardizationanddiagnosticcriteri... | M.H. Ng, H.L. Chen, R.X. Luo, K.H. Chan, P.C.Y. Woo, J.S.T. Sham, J. Huang, W.H.Seto P. Smith and B.E. Griffin | 1998 | Chinese Medical Journal1998，，6： | 8 |
| 10 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 11 | THREE-DIMENSIONAL NUMERICAL MODELING OF SECONDARY FLOWS IN A WIDE CURVED CHANNEL显示文摘Most natural rivers are curved channels, where the turbulent flows have a complex helical pattern, as has been extensively studied both numerically and experimentally. The helical flow structure in curved channels has an important bearing on sediment transport, riverbed evolution, and pollutant transport study. In this article, different turbulence closure schemes i.e., the mixing-length model and the k-ε model with different pressure solution techniques i. e., hydrostatic assumptions and dynamic pressure treatments are applied to study the helical secondary flows in an experiment curved channel. The agreements of vertically-averaged velocities between the simulated results obtained by using different turbulence models with different pressure solution techniques and the measured data are satisfactory. Their discrepancies with respect to surface elevations, superelevations and secondary flow patterns are discussed. | HUANG Sui-liang JLA Ya-fei CHAN Hsun-Chuan WANG Sam S. Y. | 2009 | Journal of Hydrodynamics2009，21，6： | 8 |
| 12 | A NUMERICAL ANALYSIS OF THE VENTILATION PERFORMANCE FOR DIFFERENT VENTILATION STRATEGIES IN A SUBWAY TUNNEL显示文摘An unsteady three-dimensional analysis of the ventilation performance is carried out for different ventilation strategies to find out a ventilation method with a high performance in a subway tunnel.The natural ventilation performance associated with a train-induced air flow in a subway tunnel is examined.The dynamic layering method is used to consider the moving boundary of a train in the current CFD method.The geometries of the modeled tunnel and the subway train are partially based on those of the Seoul subway.The effects of the structure of the ventilation duct and the geometry of the partitions on the ventilation performance are evaluated.The results show that the combined ventilation ducts (to be designed),and the partitioning blocks installed along the middle of tunnel (already in existences) are helpful for air exchange.This study can provide some guidance for the design of ventilation ducts in a subway system. | HUANG Yuan-dong LI Chan KIM Chang Nyung | 2012 | Journal of Hydrodynamics2012，24，2： | 8 |
| 13 | Overexpression of the Suaeda salsa SsNHX1 gene confers enhanced salt and drought tolerance to transgenic Zea mays显示文摘Maize is one of the most important crops worldwide, but it suffers from salt stress when grown in saline-alkaline soil. There is therefore an urgent need to improve maize salt tolerance and crop yield. In this study, the SsNHX1 gene of Suaeda salsa, which encodes a vacuolar membrane Na^+/H^+ antiporter, was transformed into the maize inbred line 18-599 by Agrobacterium-mediated transformation. Transgenic maize plants overexpressing the SsNHX1 gene showed less growth retardation when treated with an increasing NaCl gradient of up to 1%, indicating enhanced salt tolerance. The improved salt tolerance of transgenic plants was also demonstrated by a significantly elevated seed germination rate(79%) and a reduction in seminal root length inhibition. Moreover, transgenic plants under salt stress exhibited less physiological damage. SsNHX1-overexpressing transgenic maize accumulated more Na^+ and K^+ than wild-type(WT) plants particularly in the leaves, resulting in a higher ratio of K^+/Na^+ in the leaves under salt stress. This result revealed that the improved salt tolerance of SsNHX1-overexpressing transgenic maize plants was likely attributed to SsNHX1-mediated localization of Na^+ to vacuoles and subsequent maintenance of the cytosolic ionic balance. In addition, SsNHX1 overexpression also improved the drought tolerance of the transgenic maize plants, as rehydrated transgenic plants were restored to normal growth while WT plants did not grow normally after dehydration treatment. Therefore, based on our engineering approach, SsNHX1 represents a promising candidate gene for improving the salt and drought tolerance of maize and other crops. | HUANG Ying ZHANG Xiao-xia LI Yi-hong DING Jian-zhou DU Han-mei ZHAO Zhuo ZHOU Li-na LIU Chan GAO Shi-bin CAO Mo-ju LU Yan-li ZHANG Su-zhi | 2018 | Journal of Integrative Agriculture2018，17，12： | 8 |
| 14 | Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats显示文摘背景肺的动脉的高血压(哼) 被压制 apoptosis 并且在脉管的墙中提高房间增长描绘。导致肺的动脉光滑的肌肉房间(PASMC ) apoptosis 被认为是一条治疗学的途径为哼。Oridonin 能在许多房间线引起 apoptosis,当很少被做了在三十只男 Sprague-Dawley 老鼠随机被分到三个组的 PASMC.Methods 上评估它的效果时:正常控制(NC ) ;组织缺氧血碳酸过多症(HH ) ;组织缺氧血碳酸过多症 + oridonin (HHO ) 。公寓暴露于组织缺氧血碳酸过多症四个星期。有教养的人的 PASMC (HPASMC ) 被分到三个组:normoxia (没有) ;组织缺氧(HY ) ;hypoxia+ oridonin (惊讶) 。吝啬的肺的动脉压力,在加中隔(RV/( LV+S ))的左室上的正确的室的集体比率,到脉管的外部直径(WT%)的肺的小动脉墙的厚度的比率和到全部的区域(WA%)的容器墙区域的比率被测量。肺的动脉的词法变化在光和电子显微镜下面被观察。在 vitro 并且在 vivo 的 apoptotic 特征被检测。mPAP, RV/(LV+S ) , WT% ,和在 HH 的 WA% 组织的结果比在 NC 的那些显著地大(P < 0.01 ) 并且 HHO 组(P < 0.01 ) ;caspase-3 和 caspase-9 的活动,和在组 HH 的 Bex, cyt-C 和 apoptotic 索引(AI ) 的表情是在 NC 和 HHO 组的不到那些;并且在组 HH 的 Bcl-2 的表示在 NC 和 HHO 组比那大。在组的 HPASMC mitochondrial 膜潜力惊讶比在组 HY 低( P < 0.01 ),并且在在 HO 组的细胞质, AI ,和 caspase-9 的 cyt-C 在 HY 组比那大( P < 0.01 ),但是在 HO 组的 Bcl-2 的表示是不到那在 HY 组( P < 0.05 )。结果建议那个 oridonin 罐头的结论有效地降低肺的动脉压力,并且禁止肺的动脉由经由一条线粒体依赖者小径导致光滑的房间 apoptosis 的结构的改变。 | WANG Liang-xing SUN Yu CHEN Chan HUANG Xiao-ying LIN Quan QIAN Guo-qing DONG Wei CHEN Yan-fan | 2009 | Chinese Medical Journal2009，，12： | 6 |
| 15 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 16 | Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars显示文摘D-Psicose 3-epimerase(DPEase)is demonstrated to be useful in the bioproduction of D-psicose,a rare hexose sugar,from D-fructose,found plenty in nature.Clostridium cellulolyticum H10 has recently been identified as a DPEase that can epimerize D-fructose to yield D-psicose with a much higher conversion rate when compared with the conventionally used DTEase.In this study,the crystal structure of the C.cellulolyticum DPEase was determined.The enzyme assembles into a tetramer and each subunit shows a(β/α)8 TIM barrel fold with a Mn2+metal ion in the active site.Additional crystal structures of the enzyme in complex with substrates/products(D-psicose,D-fructose,D-tagatose and D-sorbose)were also determined.From the complex structures of C.cellulolyticum DPEase with D-psicose and D-fructose,the enzyme has much more interactions with D-psicose than D-fructose by forming more hydrogen bonds between the substrate and the active site residues.Accordingly,based on these ketohexosebound complex structures,a C3-O3 proton-exchange mechanism for the conversion between D-psicose and D-fructose is proposed here.These results provide a clear idea for the deprotonation/protonation roles of E150 and E244 in catalysis. | Hsiu-Chien Chan Yueming Zhu Yumei Hu Tzu-Ping Ko Chun-Hsiang Huang Feifei Ren Chun-Chi Chen Yanhe Ma Rey-Ting Guo Yuanxia Sun | 2012 | Protein & Cell2012，3，2： | 6 |
| 17 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 18 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 19 | Statistical extremes and peak factors in wind-induced vibration of tall buildings显示文摘In the structural design of tall buildings,peak factors have been widely used to predict mean extreme responses of tall buildings under wind excitations.Vanmarcke's peak factor is directly related to an explicit measure of structural reliability against a Gaussian response process.We review the use of this factor for time-variant reliability design by comparing it to the conventional Davenport's peak factor.Based on the asymptotic theory of statistical extremes,a new closed-form peak factor,the so-called Gamma peak factor,can be obtained for a non-Gaussian resultant response characterized by a Rayleigh distribution process.Using the Gamma peak factor,a combined peak factor method was developed for predicting the expected maximum resultant responses of a building undergoing lateral-torsional vibration.The effects of the standard deviation ratio of two sway components and the inter-component correlation on the evaluation of peak resultant response were also investigated.Utilizing wind tunnel data derived from synchronous multi-pressure measurements,we carried out a wind-induced time history response analysis of the Commonwealth Advisory Aeronautical Research Council(CAARC) standard tall building to validate the applicability of the Gamma peak factor to the prediction of the peak resultant acceleration.Results from the building example indicated that the use of the Gamma peak factor enables accurate predictions to be made of the mean extreme resultant acceleration responses for dynamic serviceability performance design of modern tall buildings. | Ming-feng HUANG Chun-man CHAN Wen-juan LOU Kenny Chung-Siu KWOK | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，1： | 4 |
| 20 | Building metallurgical bonding interfaces in an immiscible Mo/Cu system by irradiation damage alloying (IDA)显示文摘For the immiscible Mo/Cu system with a positive heat of mixing(△H_m > 0), building metallurgical bonding interfaces directly between immiscible Mo and Cu and preparing Mo/Cu laminar metal matrix composites(LMMCs) are very difficult. To solve the problem, a new alloying method for immiscible systems, which is named as irradiation damage alloying(IDA), is presented in this paper. The IDA primarily consists of three steps. Firstly, Mo is damaged by irradiation with multi-energy(186, 62 keV) Cu ion beams at a dose of 2 × 10^(17) ions/cm^2. Secondly, Cu layers are superimposed on the surfaces of the irradiation-damaged Mo to obtain Mo/Cu laminated specimens. Thirdly, the irradiation damage induces the diffusion alloying between Mo and Cu when the laminated specimens are annealed at 950℃ in a protective atmosphere.Through IDA, Mo/Cu LMMCs are prepared in this paper. The tensile tests carried out for the Mo/Cu LMMCs specimens show that the Mo/Cu interfaces constructed via IDA have high normal and shear strengths.Additionally, the microstructure of the Mo/Cu interface is characterized by High Resolution Transmission Electron Microscopy(HRTEM), X-ray diffraction(XRD) and Energy Dispersive X-ray(EDX) attached in HRTEM. The microscopic characterization results show that the expectant diffusion between Mo and Cu occurs through the irradiation damage during the process of IDA. Thus a Mo/Cu metallurgical bonding interface successfully forms. Moreover, the microscopic test results show that the Mo/Cu metallurgical interface is mainly constituted of crystalline phases with twisted and tangled lattices, and amorphous phase is not observed. Finally, based on the positron annihilation spectroscopy(PAS) and HRTEM results,the diffusion mechanism of IDA is discussed and determined to be vacancy assisted diffusion. | Jinlong Du Yuan Huang Chan Xiao Yongchang Liu | 2018 | Journal of Materials Science & Technology2018，34，4： | 4 |
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