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| 1 | Transplant outcomes of 100 cases of living-donor ABO-incompatible kidney transplantation显示文摘Background:Although ABO-incompatible(ABOi)kidney transplantation(KT)has been performed successfully,a standard preconditioning regimen has not been established.Based on the initial antidonor ABO antibody titers,an individualized preconditioning regimen is developed,and this study explored the efficacy and safety of the regimen.Methods:From September 1,2014,to September 1,2020,we performed 1668 consecutive living-donor KTs,including 100 ABOi and 1568 ABO-compatible(ABOc)KTs.ABOi KT recipients(KTRs)with a lower antibody titer(≤1:8)were administered oral immunosuppressive drugs(OIs)before KT,while patients with a medium titer(1:16)received OIs plus antibody-removal therapy(plasma exchange/double-filtration plasmapheresis),patients with a higher titer(≥1:32)were in addition received rituximab(Rit).Competing risk analyses were conducted to estimate the cumulative incidence of infection,acute rejection(AR),graft loss,and patient death.Results:After propensity score analyses,100 ABOi KTRs and 200 matched ABOc KTRs were selected.There were no significant differences in graft and patient survival between the ABOi and ABOc groups(P=0.787,P=0.386,respectively).After using the individualized preconditioning regimen,ABOi KTRs showed a similar cumulative incidence of AR(10.0%vs.10.5%,P=0.346).Among the ABOi KTRs,the Rit-free group had a similar cumulative incidence of AR(P=0.714)compared to that of the Rittreated group.Multivariate competing risk analyses revealed that a Rit-free regimen reduced the risk of infection(HR:0.31;95%CI:0.12–0.78,P=0.013).Notably,antibody titer rebound was more common in ABOi KTRs receiving a Rit-free preconditioning regimen(P=0.013)than those receiving Rit.ABOi KTRs with antibody titer rebound had a 2.72-fold risk of AR(HR:2.72,95%CI:1.01–7.31,P=0.048).ABOi KTRs had similar serum creatinine and estimated glomerular filtration rate compared to those of ABOc KTRs after the first year.Conclusions:An individualized preconditioning regimen can achieve comparable graft and patient survival rates in ABOi KT with ABOc KT.Rit-free preconditioning effectively prevented AR without increasing the risk of infectious events in those with lower initial titers;however,antibody titer rebound should be monitored. | Saifu Yin Qiling Tan Youmin Yang Fan Zhang Turun Song Yu Fan Zhongli Huang Tao Lin Xianding Wang | 2022 | Chinese Medical Journal2022，135，19： | 7 |
| 2 | Screening high-quality fetal bovine serum for porcine oocyte maturation in vitro显示文摘Fetal bovine serum(FBS) is widely used in cell cultures due to its high stability and easy access. It was also used as a substitute for porcine follicular fluid(PFF) in previous studies. However, FBS components are unclear, and the presence of FBS in culture media may introduce a variation from batch to batch. This study aimed to establish an effective method to screen FBS in place of PFF in the culture media for porcine oocytes in vitro. We screened FBS from different sources by using porcine fetal fibroblast cells. The effects of six FBS samples on porcine fetal fibroblast cell growth were tested via frozen cell survival assay, cell clone formation assay, cell growth curve, and cell passage activity assay. The best serum that we called GFBS(heat-inactivated FBS, cat. no. 10500-64;Gibco) showed a similar effect on the maturation and development of porcine oocytes to that of PFF and can be used as a good substitute for PFF. These results suggested that the porcine fetal fibroblast cell culture test can be used as a valuable method to screen FBS for porcine oocyte maturation and embryonic development in vitro. | Xueqing Liu Qiaoli Lang Meng Wu Xiaoyan You Qiling He Ling Luo Zijia Liu Puying Xiao Nan Huang Xi Yang Liangpeng Ge | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 3 | d(GC)n repeats form Z-DNA within promoter region and repress the promoter activity in Escherichia coil显示文摘 | Shenghe Huang Chuxin Wu Dongming Li Haizhou Wang Zechang Rao Qiling Shen Chunxiang Chen Yong Liu Xun Xu Chengyu Hu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 1 |
| 4 | Identi-fication and characterization of the causal agent of bacterialcanker of kiwifruit in the Shaanxi Province of China 显示文摘 | ZHAO Zhibo’GAO Xiaoning HUANG Qiling ef al | 2013 | Journal of Plant Pathology2013，95，1： | 1 |
| 5 | Effects of Fe–EDDHA application on iron chlorosis of citrus trees and comparison of evaluations on nutrient balance with three approaches显示文摘 | Hong Huang Cheng Xiao Hu Qiling Tan Xiaoming Hu Xuecheng Sun Lei Bi | 2012 | Scientia Horticulturae2012，，： | 1 |
| 6 | Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications显示文摘Considering that hydrogen peroxide(H2O2)plays significant roles in oxidative stress,the cellular signal transduction and essential biological process regulation,the detection and imaging of H2O2 in living systems undertakes critical responsibility.Herein,we have developed a novel two-photon fluorescence turn on probe,named as Pyp-B for mitochondria H2O2 detection in living systems.Selectivity studies show that probe Pyp-B exhibit highly sensitive response toward H2O2 than other reactive oxygen species(ROS)and reactive nitrogen species(RNS)as well as biologically relevant species.The fluorescence colocalization studies demonstrate that the probe can localize in the mitochondria solely.Furthermore,as a bio-compatibility molecule,the highly selective and sensitive of fluorescence probe Pyp-B have been confirmed by its cell imaging application of H2O2 in living A549 cells and zebrafishes under the physiological conditions. | Kangnan Wang Wen Ma Yuchun Xu Xin Liu Gui Chen Meng Yu Qiling Pan Chaobo Huang Xiaochuan Li Qingchun Mu Yongbing Sun Zhiqiang Yu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 7 | Effects of Fe-EDDHA application on iron chlorosis of citrus trees and comparison of evaluations on nutrient balance with three approaches显示文摘 | Hong Huang Cheng Xiao Hu Qiling Tan | 2012 | Scientia Horticulturae2012，，146： | 1 |
| 8 | One-stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via posterior-only approach显示文摘 | Hongqi Zhang Bin Sheng Mingxing Tang Chaofeng Guo Shaohua Liu Shu Huang Qile Gao Jinyang Liu Jianhuang Wu | 2013 | European Spine Journal2013，，3： | 1 |
| 9 | A TWO-GRID FINITE ELEMENT APPROXIMATION FOR NONLINEAR TIME FRACTIONAL TWO-TERM MIXED SUB-DIFFUSION AND DIFFUSION WAVE EQUATIONS显示文摘In this paper,we develop a two-grid method(TGM)based on the FEM for 2D nonlinear time fractional two-term mixed sub-diffusion and diffusion wave equations.A two-grid algorithm is proposed for solving the nonlinear system,which consists of two steps:a nonlinear FE system is solved on a coarse grid,then the linearized FE system is solved on the fine grid by Newton iteration based on the coarse solution.The fully discrete numerical approximation is analyzed,where the Galerkin finite element method for the space derivatives and the finite difference scheme for the time Caputo derivative with orderα∈(1,2)andα1∈(0,1).Numerical stability and optimal error estimate O(h^(r+1)+H^(2r+2)+τ^(min{3−α,2−α1}))in L^(2)-norm are presented for two-grid scheme,where t,H and h are the time step size,coarse grid mesh size and fine grid mesh size,respectively.Finally,numerical experiments are provided to confirm our theoretical results and effectiveness of the proposed algorithm. | Yanping Chen Qiling Gu Qingfeng Li Yunqing Huang | 2022 | Journal of Computational Mathematics2022，40，6： | 0 |
| 10 | Underdetermined direction of arrival estimation with nonuniform linear motion sampling based on a small unmanned aerial vehicle platform显示文摘Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suffers from significant performance degradation owing to the limited number of physical elements.To improve the underdetermined DOA estimation performance of a ULA radar mounted on a small UAV platform,we propose a nonuniform linear motion sampling underdetermined DOA estimation method.Using the motion of the UAV platform,the echo signal is sampled at different positions.Then,according to the concept of difference co-array,a virtual ULA with multiple array elements and a large aperture is synthesized to increase the degrees of freedom(DOFs).Through position analysis of the original and motion arrays,we propose a nonuniform linear motion sampling method based on ULA for determining the optimal DOFs.Under the condition of no increase in the aperture of the physical array,the proposed method obtains a high DOF with fewer sampling runs and greatly improves the underdetermined DOA estimation performance of ULA.The results of numerical simulations conducted herein verify the superior performance of the proposed method. | Xinwei Wang Xiaopeng Yan Tai An Qile Chen Dingkun Huang | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
| 11 | Enrichment of Cd and Pb and associations with grain size in sediments in Nanjing alluvial island of Yangtze River显示文摘 | Hongrui MA Yuqian MAO Junfeng JI Qiling LIAO Shunsheng HUANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 12 | Optimization of Solid-state Fermentation Conditions of Sophora japonica cv.jinhuai by Response Surface Methodology显示文摘[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material. | Miao YANG Chaohao GU Qiling LI Zhiqiang HUANG Hao LIU Yanxi LAI Zongyou CHEN Kaimei ZHU | 2023 | Medicinal Plant2023，14，5： | 0 |
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