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| 1 | Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway显示文摘Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluated in vitro and in vivo for the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis.In in vivo study, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model. More importantly, we found lycorine had less toxicity than first-line chemotherapy drug paclitaxel at the same effective dose in vivo. Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK(focal adhesion kinase)-involved pathway. In conclusion, our study implied lycorine was a potential candidate for the treatment of breast cancer by inhibition of tumor growth and metastasis. | Xuexiang Ying Anling Huang Yajing Xing Liping Lan Zhengfang Yi Pingqing He | 2017 | Science China(Life Sciences)2017，60，4： | 15 |
| 2 | Further study on augmented Lagrangian duality theory 显示文摘 | HUANG Xuexiang YANG Xiaoqi | 2005 | Journal of Global Optimiza- tion2005，31，： | 1 |
| 3 | Potential molecular materials based on organic-inorganic salts derived from2-isopolyoxoanion and hemicyanine dyes:synthesis,spectraproperties and X-ray stucture显示文摘 | XU Xuexiang YOU Xiaozeng HUANG Xiaoying | 1995 | Polyhedron1995，14，13： | 1 |
| 4 | Potential molecular materials based on organic-inorganic charge-transfer salts derived from 2- isopolyoxoanion and hemicyanine dyes: synthesis, spectra properties and X-ray structure 显示文摘 | You Xiaozeng Huang Xiaoying | 1995 | Polyhedron1995，14，13： | 1 |
| 5 | Rapid determination of aflatoxins in corn and peanuts 显示文摘 | FU Zhaohui HUANG Xuexiang MIN Shungeng | 2008 | J Chromatogr A2008，1209，12： | 1 |
| 6 | Potenial molecula rmaterials based on organic-inorganic salts derived from 2- isopolyoxoanion and hemicyanine dyes: Synthesis, spectra properties and X-ray stucture显示文摘 | Xu Xuexiang You Xiaozeng Huang Xiaoying | 1995 | Polyhedron1995，14，1314： | 1 |
| 7 | Potential molecular materials based on organic-inorganic salts derived from 2- isopolyoxoanion and hemicyanine dyes: synthesis, spectraproperties and X-ray stucture显示文摘 | YOU Xiaozeng HUANG Xiaoying | 1995 | Polyhedron1995，14，1314： | 1 |
| 8 | A DIFFERENTIAL GAME MODEL FOR A DEVELOPING AND A DEVELOPED COUNTRY显示文摘A differential game (DG) model for a developing and a developed country is considered.Each player makes decisions about how much resource to be used to restrict the opponent's developmentso as to maximize his weighted sum of current consumption and final output.Current consumption isassumed to be preferred to final output for both players.The developing country is assumed to havea higher economic growth rate and a higher preference to final output,whereas the developed countryis assumed to have a higher initial income and a higher efficiency in restricting his opponent.Thisproblem is investigated under three kinds of information structures,i.e.,a zerosum,a nonzero-sum,anda Stackelberg game.Open-loop equilibrium solutions are obtained for all the three cases.Economicimplications of the result are provided. | Rong ZHANG Xuexiang HUANG | 2009 | Journal of Systems Science & Complexity2009，22，2： | 0 |
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