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| 1 | Drag reduction in ultrahydrophobic channels with micro-nano structured surfaces显示文摘A series of experiments have been performed to demonstrate the significant drag reduction of the laminar flow in the ultrahydrophobic channels with dual-scale micro-nano structured surfaces.However,in previous experiments,the ultrahydrophobic surfaces were fabricated with micro-structures or nano-structures and the channels were on the microscale.For the drag reduction in macro-scale channels few reports are available.Here a new method was developed to fabricate ultrahydrophobic surfaces with micro-nano hierarchical structures made from carbon nanotubes.The drag reductions up to 36.3% were observed in the macro-channels with ultrahydrophobic surfaces.The micro-PIV was used to measure the flow velocity in channels.Compared with the traditional no-slip theory at walls,a significant slip velocity was observed on the ultrahydrophobic surfaces. | LU Si,YAO ZhaoHui *,HAO PengFei & FU ChengSong School of Aerospace,Tsinghua University,Beijing 100084,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 11 |
| 2 | ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome显示文摘OBJECTIVES:Anti-citrullinated protein antibodies(ACPAs)are a group of autoantibodies targeted against citrullinated proteins/peptides and are informative rheumatoid arthritis(RA)biomarkers.ACPAs also play a crucial role in RA pathogenesis,and their underlying mechanism merits investigation.METHODS:Immunohistochemical(IHC)assays were carried out to determine IL-1βlevels in ACPA+and ACPA−RA patients.PBMCderived monocytes were differentiated into macrophages before stimulation with ACPAs purified from RA patients.The localization and interaction of molecules were analyzed by confocal microscopy,co-IP,and surface plasmon resonance.RESULTS:In our study,we found that IL-1βlevels were elevated in ACPA+RA patients and that ACPAs promoted IL-1βproduction by PBMC-derived macrophages.ACPAs interacted with CD147 to enhance the interaction between CD147 and integrinβ1 and,in turn,activate the Akt/NF-κB signaling pathway.The nuclear localization of p65 promoted the expression of NLRP3 and pro-IL-1β,resulting in priming.Moreover,ACPA stimulation activated pannexin channels,leading to ATP release.The accumulated ATP bound to the P2X7 receptor,leading to NLRP3 inflammasome activation.CONCLUSIONS:Our study suggests a new hypothesis regarding IL-1βproduction in RA involving ACPAs,which may be a potential therapeutic target in RA treatment. | Xiwen Dong Zhaohui Zheng Peng Lin Xianghui Fu Fanni Li Jianli Jiang Ping Zhu | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 3 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 4 | Preparation of luminescent CdTe quantum dots doped core-shell nanoparticles and their application in cell recognition显示文摘Based on the reverse microemulsion technique, luminescent quantum dots doped core-shell nanoparticles have been prepared by employing silica as the shell and CdTe quantum dots as the core of the nanoparticles, which have an excellent solubility and dispersibility, especially amine and phosphonate groups have been modified on their surface synchronously. In comparison with CdTe quantum dots, these nanoparticles show superiority in chemical and photo-chemical stability. The quantum dots doped core-shell nanoparticles were successfully linked with lactobionic acid by amine group on it, which was used to recognize living liver cells. | LI Zhaohui WANG Kemin TAN Weihong LI Jun FU Zhiying WANG Yilin LIU Jianbo YANG Xiaohai | 2005 | Chinese Science Bulletin2005，50，16： | 5 |
| 5 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 6 | High-performance polarization management devices based on thin-film lithium niobate显示文摘High-speed polarization management is highly desirable for many applications,such as remote sensing,telecommunication,and medical diagnosis.However,most of the approaches for polarization management rely on bulky optical components that are slow to respond,cumbersome to use,and sometimes with high drive voltages.Here,we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate platform.We successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities,including arbitrary polarization generation,fast polarization measurement,polarization scrambling,and automatic polarization control.The present devices feature ultra-fast control speeds,low drive voltages,low optical losses and compact footprints.Using these devices,we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB and fast polarization scrambling with a scrambling rate up to 65 Mrad s−1,both of which are best results in integrated optics.We also demonstrate the endless polarization state tracking operation in our devices.The demonstrated devices unlock a drastically new level of performance and scales in polarization management devices,leading to a paradigm shift in polarization management. | Zhongjin Lin Yanmei Lin Hao Li Mengyue Xu Mingbo He Wei Ke Heyun Tan Ya Han Zhaohui Li Dawei Wang X.Steve Yao Songnian Fu Siyuan Yu Xinlun Cai | 2022 | Light(Science & Applications)2022，11，5： | 3 |
| 7 | Separation-and-Recovery Technology for Organic Waste Liquid with a High Concentration of Inorganic Particles显示文摘 | Hualin Wang Pengbo Fu Jianping Li Yuan Huang Ying Zhao Lai Jiang Xiangchen Fang Tao Yang Zhaohui Huang Cheng Huang | 2018 | Engineering2018，4，3： | 3 |
| 8 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 9 | Experiments on ring wave packet generated by water drop显示文摘The propagation of ring wave packet (composed of carrier waves modulated by an envelope) generated by a water drop was studied experimentally. It is a localized wave packet propagating with constant velocity and low diffusion. The wavelength, the amplitude and the waveform of the carrier waves, the velocity of the carrier waves and the packet have been measured. The measured wavelength λe of the carrier waves and the measured group velocity Cge of the packet are near the minimum point of the dispersion curve of group velocity, which may be the main reason why the packet can propagate with low diffusion. | ZHU GuoZhen LI ZhaoHui FU DeYong | 2008 | Chinese Science Bulletin2008，53，11： | 2 |
| 10 | A solution on identification and rearing files in smallhold production显示文摘 | Xiong Benhai Fu Runting Lin Zhaohui | 2009 | Computer and Computing Technologies in Agriculture 2/springer2009，，3： | 1 |
| 11 | Flexlble Uretteroscopy and Laser Lithotripsy for Bilateral Multiple Intrarenal Stones:Is This a Valuable Choice? 显示文摘 | Zhichao Huang Fajun Fu Zhaohui Zhong | 2012 | Urology2012，80，4： | 1 |
| 12 | Solution to the bulging problem in the open-die extrusion of a spline shaft and relevant photoplastic theoretical study显示文摘 | Zhaohui Huang Peifu Fu | | 0，，： | 1 |
| 13 | Effects of exogenic chloride on oxidative degradation of chlorinated azo dye by UV-activated peroxodisulfate显示文摘Recently,the degradation of organic compounds in saline dye wastewater by sulfate radicals(SO4·-)-based advanced oxidation processes(AOPs) have attracted much attention.However,previous studies on these systems have selected non-chlorinated dyes as model compounds,and little is known about the transformation of chlorinated dyes in such systems.In this study,acid yellow 17(AY-17) was selected as a model of chlorinated contaminants,and the degradation kinetics and evolution of oxidation byproducts were investigated in the UV/PDS system.AY-17 can be efficiently degraded(over 98% decolorization)under 90 min irradiation at pH 2.0-3.0,and the reaction follows pseudo-first order kinetics.Cl-accelerated the degradation of AY-17,but simultaneously led to an undesirable increase of absorbable organic halogen(AOX).Several chlorinated byproducts were identified by liquid chromatography-mass spectrometry(LC-MS/MS) in the UV/PDS system.It indicates that endogenic chlorine and exogenic Cl-reacted with SO_(4)·- to form chloride radicals,which are involved in the dechlorination and rechlorination of AY-17 and intermediates.The possible degradation mechanisms of AY-17 photooxidative degradation are proposed.This work provides valuable information for further studies on the role of exogenic chloride in the degradation of chlorinated azo dyes and the kinetic parameters in the PDS-based oxidation process. | Wenya Peng Yu Fu Lingli Wang Yifan Wang Yongxia Dong Ying Huang Zhaohui Wang | 2021 | Chinese Chemical Letters2021，32，8： | 1 |
| 14 | Simple solvothermal routes to synthesize nanocrystalline Bi 2 MoO 6 photocatalysts with different morphologies显示文摘 | Jinhong Bi Ling Wu Jie Li Zhaohui Li Xuxu Wang Xianzhi Fu | 2007 | Acta Materialia2007，，： | 1 |
| 15 | Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients:A randomized,open-label,parallel-group,noninferiority phase III trial显示文摘Background:This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection(recombinant human erythropoietin injection,rHuEPO)for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis.Method:This study was a multicenter,randomized,open-label,intergroup parallel control phase III noninferiority trial from April 19,2013 to September 9,2014 at 25 sites.In this study,the members of the darbepoetin alfa group underwent intravenous administration once per week or once every two weeks.The members of the control drug epoetin alfa group underwent intravenous administration two or three times per week.All subjects underwent epoetin alfa administration during the 8-week baseline period.After that,subjects were randomly assigned to the darbepoetin alfa group or epoetin alfa group.The noninferiority in the changes of the average Hb concentrations from the baseline to the end of the evaluation period(noninferiority threshold:-1.0 g/dl)was tested between the two treatments.The time-dependent hemoglobin(Hb)concentration and the maintenance rate of the target Hb concentration(the proportion of subjects with Hb concentrations between 10.0 and 12.0 g/dl)were also evaluated.Iron metabolism,including changes in the serum iron,total iron-binding capacity,ferritin,transferrin saturation,and comparisons of the dose adjustments between the two groups during the treatment period were analyzed further.Adverse events(AEs)were also observed and compared,and the safety was analyzed between the two treatment groups.The conversion rate switching from epoetin alfa to darbepoetin alfa was also discussed.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:Four hundred and sixty-six patients were enrolled in this study,and ultimately 384 cases were analyzed for safety,including 267 cases in the darbepoetin alfa group and 117 cases in the epoetin alfa group.There were 211 cases in the per-protocol set,including 152 cases in the darbepoetin alfa group and 59 cases in the epoetin alfa group.The changes in the average Hb concentrations from the baseline to the end of the evaluation period were-0.07 and-0.15 g/dl in the darbepoetin alfa group and epoetin alfa group respectively.The difference between the two groups was 0.08 g/dl(95%confidence interval[CI]:-0.22 to 0.39),and the lower limit of the 95%CI was-0.22>-1.0 g/dl.The average Hb concentrations of the two groups were 10.88-11.43 g/dl(darbepoetin alfa)and 10.91-11.38 g/dl(epoetin alfa)during the study period of Weeks 0-28,with the maintenance rates of the target Hb concentration ranging within 71%-87%and 78%-95%in the darbepoetin alfa group and epoetin alfa group respectively.During the period of comparison between the two groups,the incidence of AEs in the darbepoetin alfa group was 61.42%,while in the epoetin alfa group it was 56.41%.All of the adverse events and reactions in the study were those commonly associated with hemodialysis.Conclusion:The overall efficacy and safety of darbepoetin alfa for the treatment of Chinese renal anemia patients undergoing hemodialysis are consistent with those of epoetin alfa. | Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 1 |
| 16 | Photocatalytic performance of α -, β -, and γ -Ga 2 O 3 for the destruction of volatile aromatic pollutants in air显示文摘 | Yidong Hou Ling Wu Xinchen Wang Zhengxin Ding Zhaohui Li Xianzhi Fu | 2007 | Journal of Catalysis2007，，： | 1 |
| 17 | A solution on identification and rearing files in smallhold production 显示文摘 | Xiong Benhai Fu Runting Lin Zhaohui | 2009 | Computer and Computing Technologies in Agriculture 2/springer2009，，3： | 1 |
| 18 | Targeting xa13, a recessive gene for bacterial blight resistance in rice显示文摘 | Zhaohui Chu Binying Fu Hong Yang Caiguo Xu Zhikang Li A. Sanchez Y. J. Park J. L. Bennetzen Qifa Zhang Shiping Wang | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 19 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 20 | Rapid determination of aflatoxins in corn and peanuts 显示文摘 | FU Zhaohui HUANG Xuexiang MIN Shungeng | 2008 | J Chromatogr A2008，1209，12： | 1 |
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