维普中文期刊产品整合服务
385篇 您的检索式:作者名="HUGUES"
    题名 作者 年代 出处 被引量
120世纪60—70年代新博物馆运动思想和“生态博物馆”用词和概念的起源显示文摘本文回顾了20世纪60—70年代新博物馆运动思想和“生态博物馆”概念的源起,对于我们从国际大背景下深入理解生态博物馆这一新兴博物馆形态有所帮助。雨果.戴瓦兰 Hugues de Varine 张晋平 2005中国博物馆2005,,2:12
2生态博物馆和可持续发展显示文摘雨果·戴瓦兰(Hugues de Varine) 张晋平(译) 2005中国博物馆2005,,3:12
3Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish显示文摘到许多蛋白质的小 ubiquitin 相关的修饰词(相扑) 变化形式调整多样的细胞的过程,包括抄写,房间周期规定和染色体正直的维护。在 vivo 调查相扑 paralogs 的生物功能,我们在 zebrafish 的早开发使他们失去活性。当作为 Ubc9 缺乏的,为所有三相扑 paralogs 缺乏的 zebrafish 胚胎显示了严重缺点时,单个相扑 paralog 的损失与正常开发兼容。相扑缺乏的胚胎能被一个单个人或 zebrafish 相扑救。当关键时结构的基本离氨酸残余和 N 终端相扑的未组织的段是批评的为在 vivo 营救, SUMO2 的一致 K11 sumoylation 地点是非必需的,在这个潜在的地点上暗示那链形成为正常开发是非本质的。所有三相扑的 Inactivation 触发了 p53 依赖的 apoptosis, p53 的进一步的 inactivation 恢复了正常 zebrafish 开发。有趣地,我们也证明 p53 的主导的否定截断的形式,螖 1 13p53,显著地弄钝相扑在 vivo 的导致弄空的 p53 活动。一起拿,我们的结果建议相扑 paralogs 不可缺少,却冗余,在 zebrafish 的早发展。Hao Yuan Jun Zhou Min Deng Xi Liu Morgane Le Bras Hugues de The Sai Juan Chen Zhu Chen Ting Xi Liu Jun Zhu 2010Cell Research2010,20,2:4
4新博物馆学和去欧洲化博物馆学显示文摘雨果·戴瓦兰(Hugues de Varine) 张晋平(译) 2005中国博物馆2005,,3:4
5The Treatment of Peritoneal Carcinomatosis of Colorectal Cancer with Complete Cytoreductive Surgery and Hyperthermic Intraperitoneal Peroperative Chemotherapy (HIPEC) with Oxaliplatin: A Belgian Multicentre Prospective Phase II Clinical Study显示文摘Daphne Hompes André D’Hoore Eric Cutsem Steffen Fieuws Wim Ceelen Marc Peeters Kurt Speeten Claude Bertrand Hugues Legendre Joseph Kerger 2012Annals of Surgical Oncology2012,,7:3
6Conserved Cytochrome P450 Evolved in Seed Plants Regulates Flower Maturation显示文摘植物染色体的全球检查识别越过 taxa 并且在强壮的净化的选择下面在低拷贝维持的基因,它是可能的有必要功能。基于这个基本原理,我们调查了在种子植物早出现了并且在强壮的否定选择下面演变的低副本的 CYP715 细胞色素 P450 基因家庭的功能。Arabidopsis CYP715A1 在开花期之上在花芽的 tapetum 并且在花药细丝显示出限制织物特定的表情。cyp715a1 插入线在花粉 intine 免职的花瓣开发,和短暂改变显示出一个强壮的缺点。比较表达式分析揭示了涉及花粉开发,房间墙生物的续生说,荷尔蒙动态平衡,和花的 sesquiterpene 的基因的 downregulated 表达式生合成,特别 TPS21 和调整象 MYB21, MYB24,和 MYC2 那样的花的开发的几关键基因。因此,花的 sesquiterpene 排放在 cyp715a1 异种被压制。另外,花荷尔蒙介绍显示了 gibberellinhomeostasis 和 jasmonic 酸衍生物的周转的强壮的骚乱的修正。花瓣生长被活跃赤霉素 GA 3 或 jasmonoyl 异白氨酸的功能的类似物部分恢复, coronatine。CYP715 看起来作为花成熟的一个关键管理者工作,同步花瓣扩大和不稳定的排放。是一个重要决定因素 offlower 昆虫相互作用因此被期望。Zhenhua Liu Benoit Boachon RaphaelLugan Raquel Tavares Mathieu Erhardt Jerome Mutterer Valerie Demais Stephanie Pateyron Veronique Brunaud Toshiyuki Ohnishi Ales Pencik Patrick Achard Fan Gong Peter Hedden Daniele Werck-Reichhart Hugues Renault 2015Molecular Plant2015,8,12:3
7CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse 2012Eur J Immunol2012,,12:2
8脑功能定位和连接性及可塑性概念在幕上低级别胶质瘤术中应用的研究(英文)显示文摘手术是脑内可切除性病变,尤其是脑肿瘤的首选治疗方法之一。然而,由于许多肿瘤具有侵袭性,尤其是(低级别)胶质瘤,病灶常侵犯脑功能区;另外由于个体之间存在解剖和功能的变异,故需应用脑功能定位方法定位脑功能区皮质及皮质下边界,用以个体化指导切除范围。除术前可采用功能成像(fMRI)进行术前计划外,切除肿瘤过程中还可应用术中电刺激,当需定位病人的语言区和其他认知功能区时,可使用局部麻醉。术中电刺激是一种确定脑功能区皮质及皮质下结构简单、准确、可信度高的安全方法,具有以下特点:①切除肿瘤前可定位每一个病人的功能区皮质;②了解被病灶侵犯区域,如辅助运动区、岛叶、运动前皮质、缘上回及角回的的病理生理功能;③在整个切除病灶过程中,可持续定位皮质下结构,用以了解解剖与功能的联系(皮质-皮质环及皮质-皮质下环路);④利用皮质重复电刺激可实时研究短期可塑性机制;⑤可根据功能界线进行病灶切除,以最大程度切除病灶,并尽量减小术后永久性功能障碍的风险,提高效益/风险比。此外,术中电刺激还可与围手术期各种功能神经影像技术相结合,如fMRI、PET、脑磁图(MEG)、矢量专题信息(digitalthematicinformation,DTI),用以提高术前计划的可靠性。Hugues Duffau 2004中国微侵袭神经外科杂志2004,9,7:2
9Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de 2013Lancet Neurology2013,,8:2
10Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids显示文摘Alexandre Louvet Emmanuel Diaz Sébastien Dharancy Hugues Coevoet Frédéric Texier Thierry Thévenot Pierre Deltenre Valérie Canva Christophe Plane Philippe Mathurin 2007Journal of Hepatology2007,,3:2
11Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics显示文摘Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain.Thibaud Thiollier Caisheng Wu Gregory Porras Erwan Bezard Qin Li Jinlan Zhang Hugues Contamin 2018Animal Models and Experimental Medicine2018,1,4:2
12Nephron-sparing Surgery Is Equally Effective to Radical Nephrectomy for T1BN0M0 Renal Cell Carcinoma: A Population-based Assessment显示文摘Maxime Crépel Claudio Jeldres Paul Perrotte Umberto Capitanio Hendrik Isbarn Shahrokh F. Shariat Daniel Liberman Maxine Sun Giovanni Lughezzani Philippe Arjane Hugues Widmer Markus Graefen Francesco Montorsi Jean-Jacques Patard Pierre I. Karakiewicz 2010Urology2010,,:2
13Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance 显示文摘Shalom S Mark AW Hugues L 2003JAC2003,51,:1
14Bioshale FP6 European project: exploiting black shale ores using biotechnologies? 显示文摘D'HUGUES P NORRIS P R HALLBERG K SANCHEZ F LANGWALDT J GROTOWSKI A CHMIELEWSKI T GROUDEV S Bioshale consortium 2007Minerals Engineering2007,21,:1
15Mesh optimization显示文摘HUGUES H TONY D TOM D 1994Computer Aided Geometric Design1994,11,2:1
16Cardiac sodium channel Na v 1.5 and interacting proteins: Physiology and pathophysiology显示文摘Hugues Abriel 2009Journal of Molecular and Cellular Cardiology2009,,1:1
17Maternal experience during epiduralor combined spinal epidural anesthesia for cesarean section:a prozpective,randmized trial显示文摘Stephanie JD Mchael JP Hugu W 1997Aneth Analg1997,85,:1
18Usefulness of tricuspid annular displacement(TAD) to identify right ventricular dysfunction in normotensive patients with acute pulmonary embolism显示文摘Hugues T Yaici K Latcu DG 2011Ann Cardiol Angeiol(Paris)2011,60,1:1
19Evo- lution of the bacterial population during the batch bi- oleaching of a eobaltiferous pyrite in a suspended-solids bubble column and comparison with a mechanically agi- tated reactor显示文摘Foucher S Battaglia-Brunet F d'Hugues P 2003Hydrometallurgy2003,71,1:1
20A PSO-based global MPPT technique for distributed PV power generation显示文摘Hugues R Fabrizio D Julien F 2015IEEE Transactions on Industrial Electronics2015,62,2:1
返回顶部 每页显示:
共20页 首页 上一页 第1页 下一页 末页 /20 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费