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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 3 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 4 | Long-term monitoring and source apportionment of PM_(2.5)/PM_(10) in Beijing,China显示文摘During 2001-2006,PM2.5 (particle matter with aerodynamic diameter less than 2.5 microns) and PM10 (particle matter with aerodynamic diameter less than 10 microns) were collected at the Beijng Normal University (BNU) site,China,and in 2006,at a background site in Duolun (DL).The long-term monitoring data of elements,ions,and black carbon showed that the major constituents of PM2.5 were black carbon (BC) crustal elements,nitrates,ammonium salts,and sulfates.These five major components accounted for 20%-80% of the total PM2.5.During this period,levels of Pb and S in PM remained rather high,as compared with the levels in other large cities in the world.Source apportionment results suggest that there were 6 common sources for PM2.5 and PM10,i.e.,soil dust,vehicular emission,coal combustion,secondary aerosol,industrial emission,and biomass burning.Coal combustion was the largest contributor of PM2.5 with a percentage of 16.6%,whereas soil dust played the most important role in PM10 with a percentage of 27%.In contrast,only three common types of sources could be resolved at the background DL site,namely,soil dust,biomass combustion,and secondary aerosol from combustion sources. | Hailin WANG Zhengping HAO | 2008 | Journal of Environmental Sciences2008，20，11： | 65 |
| 5 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 6 | The Structure of Ore-controlling Strain and Stress Fields in the Shangzhuang Gold Deposit in Shandong Province,China显示文摘Shangzhuang 改变岩石的类型金牌矿石存款位于中间的片断并且在 Jiaodong 金省的西北的部分由 Wang'ershan 差错地区控制了,中国。在 Shangzhuang 存款的变丑进化,紧张的结构和压力地和它的控制矿石的效果在这份报纸被讨论。变丑进化主要经历了四个阶段,这被揭示:早可锻的变丑,第二 NE 惹人注目水平简单砍,第三 NE 惹人注目的压缩砍和最后的 NW 惹人注目的压缩。矿化作用发生在在的第三个阶段期间最大的主要压力逐渐地从 NE 的 transited 到 NW。 3-D 压力地的数字模拟证明在最大的主要压力是NE惹人注目的条件上,在差错地区的破裂发展被赞成,当时当最大的主要压力是NW惹人注目的时,差错地区是相对 extensional 和它对形成矿石的液体的流入和炮兵阵地合适。压缩砍紧张地被类型结构在矿化作用期间描绘,积极的花结构,等等。Orebodies 等距离地主要位于 dilatational 空格,它在不可分的有压缩性的情形是分布式的。并且在差错态度变化的地方, dilatational 空格被开发或砍联合系统发展。在全面压缩砍应力地里,紧张地在多重规模忍受自我类似,包括 orebody,矿石存款和 orefield。结构的自我类似在各种各样的规模在一样的规模和破裂的类似的形状包括破裂的 subequidistant 分发。由于特殊地质的结构,然而, orebodies 主要在 Shangzhuang 存款位于挂的墙它与在 Jiaodong 金省的大多数存款不同。在存款的控制矿石的压力和紧张地的分析为寻求的沉积物提供一个重要基础。 | DENG Jun WANG Qingfei YANG Liqiang ZHOU Lei GONG Qingjie YUAN Wanming XU Hao GUO Chunying LIU Xiangwei | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 41 |
| 7 | Molecular and Biochemical Evidence for Phenylpropanoid Synthesis and Presence of Wall-linked Phenolics in Cotton Fibers显示文摘The mature cotton (Gossypium hirsutum L.) fiber is a single cell with a typically thickened secondary cell wall. The aim of this research was to use molecular, spectroscopic and chemical techniques to investigate the possible occurrence of previously overlooked accumulation of phenolics during secondary cell wall formation in cotton fibers. Relative quantitative reverse transcription-polymerase chain reaction analysis showed that GhCAD6 and GhCAD1 were predominantly expressed among seven gene homologs, only GhCAD6 was up-regulated during secondary wall formation in cotton fibers. Phylogenic analysis revealed that GhCAD6 belonged to Class I and was proposed to have a major role in monolignol biosynthesis, and GhCAD1 belonged to Class Ⅲ and was proposed to have a compensatory mechanism for monolignol biosynthesis. Amino acid sequence comparison showed that the cofactor binding sites of GhCADs were highly conserved with high similarity and identity to bona fide cinnamyl alcohol dehydrogenases. The substrate binding site of GhCAD1 is different from GhCAD6. This difference was confirmed by the different catalytic activities observed with the enzymes. Cell wall auto-fluorescence, Fourier transform infrared spectroscopy (FTIR), high-performance liquid chromatography (HPLC) and chemical analyses confirmed that phenolic compounds were bound to the cell walls of mature cotton fibers. Our findings may suggest a potential for genetic manipulation of cotton fiber properties, which are of central importance to agricultural, cotton processing and textile industries. | Ling Fan Wei-Jun Shi Wen-Ran Hu Xinn-Ynn Hao Dong-Mei Wang Hui Yuan Hong-Ying Yan | 2009 | Journal of Integrative Plant Biology2009，51，7： | 47 |
| 8 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 9 | Grain-size features of a Miocene loess-soil sequence at Qinan: Implications on its origin显示文摘In this study, grain-size of 507 bulk samples from the QA-I Miocene loess-soil sequence at Qinan were analyzed, and the grain-size features are compared with those of typical Quaternary loess and soil samples, representative lacustrine and fluvial samples. The results indicate that the grain-size distribution pattern of the Miocene loess is essentially similar to that of Quaternary loess, but greatly differs from the lacustrine and fluvial sediments. Loess layers are regularly coarser than soil layers, indicating cyclical climate changes. Median grain-size along the 253.1 m sequence varies from 6 to 13 μm and the >63 μm fraction represents only 5.3% in maximum, 0.9% in average. Long-term grain-size variations are consistent with the loess accumulation rate at Qinan and with the eolian mass accumulation rate in the North Pacific. These features firmly indicate an eolian origin of the studied sequence, and also reveal a coeval changes between the long-term changes of eolian grain-size and continental aridity in the dust source regions. | QIAO Yansong1,3, GUO Zhengtang2,1, HAO Qingzhen1, YIN Qiuzhen1, YUAN Baoyin1 & LIU Tungsheng1 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 3. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China | 2006 | Science China Earth Sciences2006，49，7： | 33 |
| 10 | Gastric cancer incidence and mortality in Zhuanghe,China,between 2005 and 2010显示文摘AIM:To investigate the incidence and mortality of gastric cancer(GC) in Zhuanghe region,northeast China and the influencing factors for their changing trends.METHODS:All new cancer cases and deaths registered from 2005 to 2010 in Zhuanghe County were reviewed.The annual GC cases,constituent ratio,crude rates,age-standardized rates,their sex and age distribution and temporal trends were assessed.The method of annual percentage change(APC) was used to estimate the trends of GC.RESULTS:Altogether 2634 new cases of GC and 1722 related deaths were registered,which accounted for 21.04% and 19.13% of all cancer-related incidence and deaths,respectively.The age-standardized incidence rate steadily decreased from 57.48 in 2005 to 44.53 in 2010 per 10 5 males,and from 18.13 to 14.70 per 10 5 females,resulting in a APC of-5.81% for males and-2.89% for females over the entire period.The magnitude of APC in GC mortality amounted to-11.09% and-15.23%,respectively,as the agestandardized mortality rate steadily decreased from 42.08 in 2005 to 23.71 in 2010 per 10 5 males,and from 23.86 to 10.78 per 10 5 females.Females had a significantly lower incidence(a male/female ratio 2.80,P < 0.001) and mortality(a male/female ratio 2.30,P < 0.001).In both genders,the peak incidence and mortality occurred in the 80-84 years age group.The age-standardized mortality/incidence ratio also decreased from the peak of 0.73 in 2005 to 0.53 in 2010 for males,and from 1.32 to 0.73 for females.CONCLUSION:Encouraging declines of incidence and mortality of GC were observed in Zhuanghe region between 2005 and 2010,possibly due to the economic development and efficient GC control strategies. | Jing-Jing Jing Jin-Kuan Hao Li-Na Wang Yun-Ping Wang Li-Hua Sun Yuan Yuan | 2012 | World Journal of Gastroenterology2012，18，11： | 32 |
| 11 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 12 | Dendritic Cell-Derived Exosomes Stimulate Stronger CD8^+ CTL Responses and Antitumor Immunity than TVimor Cell-Derived Exosomes显示文摘从树枝状的细胞(DC ) 和肿瘤细胞导出的 Exosomes (EXO ) 被用来在动物模型并且在临床的试用刺激 antitumor 免疫者回答。然而,有不,一起, antitumor 免疫者回答的 stimulatory 效率的比较由这二支通常使用的 EXO 疫苗导致了。在这研究,我们选择了房间表示学习 EXO 的特征从一个 transfected EG7 肿瘤导出的显型 ovalbumin (卵) 和由流动 cytometry 的搏动卵的 DC。我们在在 EXO 的这二种类型之间的卵特定的有免疫力的回答的正式就职比较了 stimulatory 效果。我们发现卵搏动蛋白质的导出 DCovA 的 EXO (EXODC ) 能更高效地在 vivo 刺激天真的卵特定的 CD8+ T 房间增长和区别进细胞毒素的 T 淋巴细胞,并且比 EG7 肿瘤导致更有效的 antitumor 免疫导出房间的 EXO (EXOEG7 ) 。另外,我们阐明了在 EXO 的 stimulatory 效果被主人 DC 送到 T 房间回答的 EXO 疫苗的主人 DC 的重要角色。因此,导出 DC 的 EXO 可以在 antitumor 免疫的正式就职代表一支更有效的基于 EXO 的疫苗。 | Siguo Hao Ou Bai Jinying Yuan Mabood Qureshi Jim Xiang | 2006 | Cellular & Molecular Immunology2006，3，3： | 30 |
| 13 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 14 | Solvothermal-Assisted Exfoliation Process to Produce Graphene with High Yield and High Quality显示文摘Monolayer and bilayer graphene sheets have been produced by a solvothermal-assisted exfoliation process in a highly polar organic solvent,acetonitrile,using expanded graphite(EG)as the starting material.It is proposed that the dipole-induced dipole interactions between graphene and acetonitrile facilitate the exfoliation and dispersion of graphene.The facile and effective solvothermal-assisted exfoliation process raises the low yield of graphene reported in previous syntheses to 10 wt%12 wt%.By means of centrifugation at 2000 rpm for 90 min,monolayer and bilayer graphene were separated effectively without the need to add a stabilizer or modifi er.Electron diffraction and Raman spectroscopy indicate that the resulting graphene sheets are high quality products without any signifi cant structural defects. | Wen Qian Rui Hao Yanglong Hou Yuan Tian Chengmin Shen Hongjun Gao Xuelei Liang | 2009 | Nano Research2009，2，9： | 28 |
| 15 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 16 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 17 | Clinical Characteristics of Patients with Diabetic Nephropathy on Maintenance Hemodialysis: A Multicenter Cross-sectional Survey in Anhui Province, Eastern China显示文摘 | Hu Chen De-Guang Wang Liang Yuan Gui-Ling Liu Heng-Jie He Juan Wang Sen Zhang Li Hao | 2016 | Chinese Medical Journal2016，，11： | 24 |
| 18 | Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis显示文摘瞄准:为了探索 Diammonium 的反煽动性的机制,在 ulcerative 的一个老鼠模型的 Glycyrrhizinate 由乙酸导致了。方法:Spragur-Dawley 雌老鼠被划分成四个组:Diammonium Glycyrrhizinate 组,地塞米松组,乙酸控制和正常控制组。结肠的发炎被疾病活动索引,粗野词法损坏,组织学的损害和结肠的 myeloperoxidase 活动评估。Immunohistochemistry 被用来在结肠的粘膜检测 NF-kappaB, TNF-alpha 和 ICAM-1 的表示。结果:把控制,显示出的两 Diammonium Glycyrrhizinate 和地塞米松比作乙酸重要反煽动性的效果(P <
0.01 ) 。在结肠的粘膜的 NF-kappaB, TNF-alpha 和 ICAM-1 的表示比在乙酸组在 Diammonium Glycyrrhizinate 组和地塞米松组是显著地更低的。结论:Diammonium Glycyrrhizinate 能在 ulcerative 的一个老鼠模型减少煽动性的损害。这可以在结肠的粘膜经由 NF-kappaB, TNF-alpha 和 ICAM-1 的抑制发生。 | Hao Yuan Wan-Sheng Ji Ke-Xiang Wu Jian-Xin Jiao Liang-Hua Sun Yong-Tang Feng | 2006 | World Journal of Gastroenterology2006，12，28： | 23 |
| 19 | Source apportionment for urban PM_(10) and PM_(2.5) in the Beijing area显示文摘Airborne particulate matter (PM2.5 and PM10) samples were collected at the Beijing Normal University sampling site in the urban area of Beijing, China in dry and wet seasons during 2001―2004. Concen-trations of 23 elements and 14 ions in particulate samples were determined by ICP-AES and IC, re-spectively. Source apportionment results derived from both Positive Matrix Factorization (PMF) and Chemical Mass Balance (CMB) models indicate that the major contributors of PM2.5 and PM10 in Beijing are: soil dust, fossil fuel combustion, vehicle exhausts, secondary particulate, biomass burning and some industrial sources. We have identified both regional common sources, such as vehicular emis-sions, particulate of secondary origin and biomass burning, as well as country-specific problems, such as sand storms and soil dust that should be addressed for effective air quality control. | ZHANG Wei GUO JingHua SUN YeLe YUAN Hui ZHUANG GuoShun ZHUANG YaHui HAO ZhengPing | 2007 | Chinese Science Bulletin2007，52，5： | 22 |
| 20 | Using Interrupted Time Series Design to Analyze Changes in Hand, Foot, and Mouth Disease Incidence during the Declining Incidence Periods of 2008-2010 in China显示文摘Objective To identify patterns of hand, foot and mouth disease (HFMD) incidence in China during declining incidence periods of 2008, 2009, and 2010. Methods Reported HFMD cases over a period of 25 months were extracted from the National Disease Reporting System (NDRS) and analyzed. An interrupted time series (ITS) technique was used to detect changes in HFMD incidence rates in terms of level and slope between declining incidence periods of the three years. Results Over 3.58 million HFMD cases younger than 5 years were reported to the NDRS between May 1, 2008, and May 31, 2011. Males comprised 63.4% of the cases. ITS analyses demonstrated a significant increase in incidence rate level (P<0.0001) when comparing the current period with the previous period. There were significant changes in declining slopes when comparing 2010 to 2009, and 2010 to 2008 (all P<0.005), but not 2009 to 2008. Conclusion Incremental changes in incidence rate level during the declining incidence periods of 2009 and 2010 can potentially be attributed to a few factors. The more steeply declining slope in 2010 compared with previous years could be ascribed to the implementation of more effective interventions and preventive strategies in 2010. Further investigation is required to examine this possibility. | YU Shi Cheng HAO Yuan Tao ZHANG Jing XIAO Ge Xin LIU Zhuang ZHU Qi MA Jia Qi WANG Yu | 2012 | Biomedical and Environmental Sciences2012，25，6： | 23 |
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