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您的检索式：作者名="HUIBO HONG"
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| 1 | Functions and mechanisms of protein lysine butyrylation(Kbu):Therapeutic implications in human diseases显示文摘Post-translational modifications(PTM)are covalent modifications of proteins or peptides caused by proteolytic cleavage or the attachment of moieties to one or more amino acids.PTMs play essential roles in biological function and regulation and have been linked with several diseases.Modifications of protein acylation(Kac),a type of PTM,are known to induce epigenetic regulatory processes that promote various diseases.Thus,an increasing number of studies focusing on acylation modifications are being undertaken.Butyrylation(Kbu)is a new acylation process found in animals and plants.Kbu has been recently linked to the onset and progression of several diseases,such as cancer,cardiovascular diseases,diabetes,and vascular dementia.Moreover,the mode of action of certain drugs used in the treatment of lymphoma and colon cancer is based on the regulation of butyrylation levels,suggesting that butyrylation may play a therapeutic role in these diseases.In addition,butyrylation is also commonly involved in rice gene expression and thus plays an important role in the growth,development,and metabolism of rice.The tools and analytical methods that could be utilized for the prediction and detection of lysine butyrylation have also been investigated.This study reviews the potential role of histone Kbu,as well as the mechanisms underlying this process.It also summarizes various enzymes and analytical methods associated with Kbu,with the goal of providing new insights into the role of Kbu in gene regulation and diseases. | Qianqian Xue Yanyan Yang Hong Li Xiaoxin Li Lu Zou Tianxiang Li Huibo Ma Hongzhao Qi Jianxun Wang Tao Yu | 2023 | Genes & Diseases2023，10，6： | 0 |
| 2 | Quantum microwave photonics in radio-over-fiber systems显示文摘As the main branch of microwave photonics,radio-over-fiber technology provides high bandwidth,low-loss,and long-distance propagation capability,facilitating wide applications ranging from telecommunication to wireless networks.With ultrashort pulses as the optical carrier,a large capacity is further endowed.However,the wide bandwidth of ultrashort pulses results in the severe vulnerability of high-frequency radio frequency(RF)signals to fiber dispersion.With a time-energy entangled biphoton source as the optical carrier combined with the singlephoton detection technique,a quantum microwave photonics method in radio-over-fiber systems is proposed and demonstrated experimentally.The results show that it not only realizes unprecedented nonlocal RF signal modulation with strong resistance to the dispersion but also provides an alternative mechanism to distill the RF signal out from the dispersion effectively.Furthermore,the spurious-free dynamic ranges of the nonlocally modulated and distilled RF signals have been significantly improved.With the ultra-weak detection and the high-speed processing advantages endowed by the low-timing-jitter single-photon detection,the quantum microwave photonics method opens new possibilities in modern communication and networks. | YAQING JIN YE YANG HUIBO HONG XIAO XIANG RUNAI QUAN TAO LIU SHOUGANG ZHANG NINGHUA ZHU MING LI RUIFANG DONG | 2022 | Photonics Research2022，10，7： | 0 |
| 3 | Surpassing the classical limit of the microwave photonic frequency fading effect by quantum microwave photonics显示文摘With energy-time entangled biphoton sources as the optical carrier and time-correlated single-photon detection for high-speed radio frequency(RF)signal recovery,the method of quantum microwave photonics(QMWP)has presented the unprecedented potential of nonlocal RF signal encoding and efficient RF signal distilling from the dispersion interference associated with ultrashort pulse carriers.In this paper,its capability in microwave signal processing and prospective superiority are further demonstrated.Both QMWP RF phase shifting and transversal filtering functionality,which are the fundamental building blocks of microwave signal processing,are realized.Besides good immunity to the dispersion-induced frequency fading effect associated with the broadband carrier in classical MWP,a native two-dimensional parallel microwave signal processor is provided.These results well demonstrate the superiority of QMWP over classical MWP and open the door to new application fields of MWP involving encrypted processing. | YAQING JIN YE YANG HUIBO HONG XIAO XIANG RUN'AI QUAN TAO LIU NINGHUA ZHU MING LI SHOUGANG ZHANG RUIFANG DONG | 2023 | Photonics Research2023，11，6： | 0 |
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