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| 1 | Nestin:A novel angiogenesis marker and possible target for tumor angiogenesis显示文摘Abnormal vasculature,termed tumor vessels,is a hallmark of solid tumors.The degree of angiogenesis is associated with tumor aggressiveness and clinical outcome.Therefore,exact quantification of tumor vessels is useful to evaluate prognosis.Furthermore,selective detection of newly formed tumor vessels within cancer tissues using specific markers raises the possibility of molecular targeted therapy via the inhibition of tumor angiogenesis.Nestin,an intermediate filament protein,is reportedly expressed in repair processes,various neoplasms,and proliferating vascular endothelial cells.Nestin expression is detected in endothelial cells of embryonic capillaries,capillaries of the corpus luteum,which replenishes itself by angiogenesis,and proliferating endothelial progenitor cells,but not in mature endothelial cells.Therefore,expression of nestin is relatively limited to proliferating vascular endothelial cells and endothelial progenitor cells.Nestin expression is also reported in blood vessels within glioblastoma,prostate cancer,colorectal cancer,and pancreatic cancer,and its expression is more specific for newly formed blood vessels than other endothelial cell markers.Nestin-positive blood vessels form smaller vessels with high proliferation activity in tumors.Knockdown of nestin in vascular endothelial cells suppresses endothelial cell growth and tumor formation ability of pancreatic cancers in vivo.Using nestin to more accurately evaluate microvessel density in cancer specimens may be a novel prognostic indicator.Furthermore,nestin-targeted therapy may suppress tumor proliferation via inhibition of angiogenesis in numerous malignancies,including pancreatic cancer.In this review article,we focus on nestin as a novel angiogenesis marker and possible therapeutic target via inhibition of tumor angiogenesis. | Yoko Matsuda Masahito Hagio Toshiyuki Ishiwata | 2013 | World Journal of Gastroenterology2013，19，1： | 16 |
| 2 | Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis显示文摘Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological conditions, nestin is expressed in repair processes in the CNS, muscle, liver, and infarcted myocardium. Furthermore, increased nestin expression has been reported in various tumor cells, including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanoma, dermatofibrosarcoma protuberances, and thyroid tumors. Nestin is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors; however, the roles of nestin in cancer cells have not been well characterized. Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers. These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis. It has received a lot of attention recently as a cancer stem cell marker in various cancer cells including brain tumors, malignant rhabdoid tumors, and uterine, cervical, prostate, bladder, head and neck, ovarian, testicular, and pancreatic cancers. The purpose of this review is to clarify the roles of nestin in cancer cells and in tumor angiogenesis, and to examine the association between nestin and cancer stem cells. Nestin has the potential to serve as a molecular target for cancers with nestin-positive cancer cells and nestin-positive tumor vasculature. | Toshiyuki Ishiwata Yoko Matsuda Zenya Naito | 2011 | World Journal of Gastroenterology2011，17，4： | 11 |
| 3 | Electricity producing property and bacterial community structure in microbial fuel cell equipped with membrane electrode assembly显示文摘 | Owen Rubaba Yoko Araki Shuji Yamamoto Kei Suzuki Hisatoshi Sakamoto Atsunori Matsuda Hiroyuki Futamata | 2013 | Journal of Bioscience and Bioengineering2013，，1： | 1 |
| 4 | Japan's Jishu-bosai-soshlki community activlties:analysis o{ its role in participatory community disaster risk management 显示文摘 | Robert Bajek Yoko Matsuda Norio Okada | 2008 | Nat Hazards2008，，44： | 1 |
| 5 | Expres-sion and roles of Lumican,a small leucine - rich proteoglycan,ingastrointestinal and other cancers显示文摘 | Toshiyuki Ishiwata Masahito Hagio Yoko Matsuda | 2012 | J Gastroenterol Hepatol Res2012，，5： | 1 |
| 6 | Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells显示文摘 | Yoko Matsuda Masahito Hagio Tomoko Seya Toshiyuki Ishiwata | 2012 | Molecular Cancer Therapeutics2012，，9： | 1 |
| 7 | Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer显示文摘 | Yoko Matsuda Toshiyuki Ishiwata Kazuya Yamahatsu Kiyoko Kawahara Masahito Hagio Wei-Xia Peng Tetsushi Yamamoto Nando Nakazawa Tomoko Seya Yoshiharu Ohaki Zenya Naito | 2011 | Cancer Letters2011，，2： | 1 |
| 8 | Secre-ted 70kda lumican stimulates growth and inhabits invasion of hu-man pancreatic cancer显示文摘 | Tetsushi Yamamoto Yoko Matsuda Kiyoko Kawahara | 2012 | Cancer Lett2012，320，1： | 1 |
| 9 | Esophageal function worsens with long duration of diabetes显示文摘 | Fumihiko Kinekawa Fumiyoshi Kubo Kazuya Matsuda Mitsuyoshi Kobayashi Yasuo Furuta Yoko Fujita Hiroki Okada Tomie Muraoka Hideo Yamanouchi Hideyuki Inoue Yoshihito Uchida Tsutomu Masaki | 2008 | Journal of Gastroenterology2008，，5： | 1 |
| 10 | The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy显示文摘 | Shinichiro Ochi Masao Abe Cheng Li Yoko Mori Takashi Ishimaru Yuta Yoshino Kiyohiro Yamazaki Takaaki Mori Ryuji Fukuhara Satoshi Tanimukai Seiji Matsuda Kenichi Yoshida Shu-ichi Ueno | 2014 | Neuroscience Letters2014，，： | 1 |
| 11 | Hemodynamic assessment of the left gastric vein in patients with esophageal varices with color Doppler EUS: Factors affecting development of esophageal varices显示文摘 | Shoryoku Hino Hiroshi Kakutani Keiichi Ikeda Yujiro Uchiyama Kazuki Sumiyama Akira Kuramochi Yoko Kitamura Koji Matsuda Hiroshi Arakawa Muneo Kawamura Katsunori Masuda Hiroaki Suzuki | 2002 | Gastrointestinal Endoscopy2002，，4： | 1 |
| 12 | Chromosomal Instability (CIN) Phenotype, CIN High or CIN Low, Predicts Survival for Colorectal Cancer显示文摘 | Toshiaki Watanabe Takashi Kobunai Yoko Yamamoto Keiji Matsuda Soichiro Ishihara Keijiro Nozawa Hideki Yamada Tamuro Hayama Eisuke Inoue Junko Tamura Hisae Iinuma Takashi Akiyoshi Tetsuichiro Muto | 2012 | Journal of Clinical Oncology2012，，18： | 1 |
| 13 | Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4显示文摘 | Kiyoshi Kikuchi Salunya Tancharoen Fumiyo Matsuda Kamal Krishna Biswas Takashi Ito Yoko Morimoto Yoko Oyama Kazunori Takenouchi Naoki Miura Noboru Arimura Yuko Nawa Xiaojie Meng Binita Shrestha Shinichiro Arimura Masahiro Iwata Kentaro Mera Hisayo Sameshi | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 14 | Peer education by medical students in a public health course显示文摘 | Tsurugi Yoko Yamamoto Mieko Matsuda Shinya | 2002 | Japan Journal of USEH2002，24，3： | 1 |
| 15 | Edaravone: A new therapeutic approach for the treatment of acute stroke显示文摘 | Kiyoshi Kikuchi Ko-ichi Kawahara Naohisa Miyagi Hisaaki Uchikado Terukazu Kuramoto Yoko Morimoto Salunya Tancharoen Naoki Miura Kazunori Takenouchi Yoko Oyama Binita Shrestha Fumiyo Matsuda Yoshihiro Yoshida Shinichiro Arimura Kentaro Mera Ko-ichi Tada Na | 2010 | Medical Hypotheses2010，，6： | 1 |
| 16 | A triterpene and saponin from roots of flex pubescens 显示文摘 | Kazuyuki l-Iidaka Miyoko Ito Yoko Matsuda | 1987 | Phytochemistry1987，26，7： | 1 |
| 17 | Potential of edaravone for neuroprotection in neurologic diseases thatdo not involve cerebral infarction (Review)显示文摘 | Kiyoshi Kikuchi Ko-ichi Kawahara Hisaaki Uchikado Naohisa Miyagi Terukazu Kuramoto Tomoya Miyagi Yoko Morimoto Takashi Ito Salunya Tancharoen Naoki Miura Kazunori Takenouchi Yoko Oyama Binita Shrestha Fumiyo Matsuda Yoshihiro Yoshida Shinihiro Arimura Ken | 2011 | Experimental and Therapeutic Medicine2011，，5： | 1 |
| 18 | New triterpene saponins from llex pubescens 显示文摘 | Kazuyuki Hidaka Miyoko ho Yoko Matsuda | 1987 | Chem Pharm Bull1987，35，2： | 1 |
| 19 | Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses显示文摘Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type. | Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno | 2024 | Cancer Communications2024，44，2： | 0 |
| 20 | Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury显示文摘有感染由针棍子损害引起了的一个丙肝病毒(HCV ) 的一个 29 岁的护士与在尖锐肝炎的发作以后开始大约一年的干扰素贝它被对待。有一般疲劳,黄疸,和腹水的症状的耐心的发达尖锐丙肝在针棍子损害以后的 4 wk。当这些症状被介绍时,病人由人工授精是怀孕的。她希望了继续她的怀孕。在交货以后,生物化学的肝酶回到了正常层次。不过, HCV RNA 是积极的,病理学的发现显示了前进到慢性。遗传型是有低病毒的负担的 1b。在 600 万个单位的剂量的干扰素贝它的每日的静脉注射被开始并且继续八个星期。没有严重不利效果, HCV 被根除。在尖锐丙肝,推迟治疗被认为减少功效,但是干扰素贝它治疗是为在长期的阶段的丙肝感染的有用治疗之一。 | Takayuki Kogure Yoshiyuki Ueno Noriatsu Kanno Koji Fukushima Yoko Yamagiwa Futoshi Nagasaki Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Masashi Ninomiya Tooru Shimosegawa | 2006 | World Journal of Gastroenterology2006，12，29： | 0 |
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