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| 1 | Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer显示文摘 | Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao | 2018 | Nano Research2018，11，5： | 4 |
| 2 | Magnetoresponsive nanozyme:magnetic stimulation on the nanozyme activity of iron oxide nanoparticles显示文摘The iron oxide nanoparticles(IONPs)that combine the nanozyme activity and magnetothermal properties have attracted significant interest for various biomedical applications.However,the effect of magnetic stimulation in fine-tuning the nanozyme activities remains unclear.Here,we have constructed a series of IONPs with different magneto-thermal conversion abilities,and systematically study the effect of magnetic field stimulation on the peroxidase(POD)activity of IONPs.The results show that POD activity is effectively amplified via an in situ alternating magnetic field(AMF)stimulation with no solution temperature rise,and the degree of activity enhancement is closely related to the magnetic heating ability of the IONPs,confirming the origin of activity enhancement arises from the local magnetothermal effect.As the first report to prove magnetothermal regulation on nanozyme activity and to shed lights on the underlying correlation between activity enhancement and the intrinsic specific absorption rate(SAR),this work is expected to provide important support for future design of new magnetoresponsive nanozymes in various practical applications. | Yuan He Xiaoyong Chen Ye Zhang Yanyun Wang Mengyao Cui Galong Li Xiaoli Liu Haiming Fan | 2022 | Science China(Life Sciences)2022，65，1： | 3 |
| 3 | Enhancement of Fe3O4/Au Composite Nanoparticles Catalyst in Oxidative Degradation of Methyl Orange Based on Synergistic Effect显示文摘Fe 3 O 4/Au nanoparticles (Fe 3 O 4/Au NP ) 催化剂被采用 H 2 O 2 作为氧化剂。评估 Fe 3 O 4/Au nanoparticles,不同降级条件被调查例如催化剂的数量, H 2 O 2 集中和 pH 价值。基于我们的数据,甲基橘子在一短时间完全被降级。提高的催化活动和增加的氧化率常数可以被归功于到 synergistic H 2 O 2 到哦激进,它是强壮的氧化种类之一。而且, Fe 3 O 4/Au nanoparticles 展出了令人满意为潜在的工业申请再循环性能。 | Qin Gao Yan Xing Mingli Peng Yongshuai Liu Zhiyi Luo Yanyan Jin Haiming Fan Kebin Li Chao Chen Yali Cui | 2017 | Chinese Journal of Chemistry2017，35，9： | 2 |
| 4 | Optimization of surface coating on Fea 04 nanoparticles for high performance magnetic hyperthermia agents 显示文摘 | Liu Xiaoli Fan Haiming Yi Jiabao | 2012 | J Mater Chem2012，22，： | 1 |
| 5 | A hierarchical porous carbon membrane from polyacrylonitrile/polyvinylpyrrolidone blending membranes: Preparation,characterization and electrochemical capacitive performance显示文摘Novel hierarchical porous carbon membranes were fabricated through a simple carbonization procedure of well-defined blending polymer membrane precursors containing the source of carbon polyacrylonitrile(PAN) and an additive of polyvinylpyrrolidone(PVP), which was prepared using phase inversion method. The as-fabricated materials were further used as the active electrode materials for supercapacitors.The effects of PVP concentration in the casting solution on structure feature and electrochemical capacitive performance of the as-prepared carbon membranes were also studied in detail. As the electrode material for supercapacitor, a high specific capacitance of 278.0 F/g could be attained at a current of 5 m A/cm2 and about 92.90% capacity retention could be maintained after 2000 charge/discharge cycles in 2 mol/L KOH solution with a PVP concentration of 0.3 wt% in the casting solution. The facile hierarchical pore structure preparation method and the good electrochemical capacitive performance make the prepared carbon membrane particularly promising for use in supercapacitor. | Huili Fan Fen Ran Xuanxuan Zhang Haiming Song Wenxia Jing Kuiwen Shen Lingbin Kong Long Kang | 2014 | Journal of Energy Chemistry2014，23，6： | 1 |
| 6 | Mild hyperthermia synergized chemotherapy by Bi_(2)Se_(3)/MoSe_(2)nanosaucers for cancer treatment with negligible thermal resistance显示文摘Harsh photothermal temperatures(>50℃)caused heating damage to the normal tissues and induced thermal resistance in cancer cells,which significantly limited the safety and efficacy of photothermal therapy(PTT)in cancer treatment.Mild hyperthermia(<42℃)combined with chemotherapy might solve this issue.Herein,a novel transition metal dichalcogenides nanostructure,namely,Bi_(2)Se_(3)/MoSe_(2)nanosaucers(BMNSs),was designed to produce mild photo-hyperthermia(mPTT)and combined with chemotherapy to improve the overall antitumor efficacy.The BMNSs were constituted by Bi_(2)Se_(3)hexagonal nanoplates and enclosed with MoSe_(2)nanosheets evenly.While the MoSe_(2)moiety endowed the nanoplatform with excellent photothermal efficacy,the Bi_(2)Se_(3)substrates provided large specific surface area to anchor more doxorubicin(DOX)molecules as chemotherapeutic agent.Under the stimuli of mPTT/tumor acidic microenvironment,the tumor-specific drug release and the enhanced chemotherapy could be realized,showing impressive therapeutic outcomes against 4T1 cells.The synergetic therapeutic mechanism might be attributed to the mPTT induced cell membrane permeability,and interestingly,the expression of heat shock proteins 70 was not elevated obviously after the synergetic therapy,thus to avoid the tumor thermal resistance and further improve the therapeutic effect.The in vivo anti-tumoral performance of the BMNSs was further studied and complete tumor eradication was achieved without any recurrence and biotoxicity.Not only demonstrating a paradigm of high therapeutic efficacy of mild hyperthermia and synergistic chemotherapy for precise cancer therapy,our findings proved that the cancer therapeutic effect can be improved with minimal side effects through exquisite designing of the microstructures and the physiochemical properties of the nanoplatform. | Fei Gao Tingbin Zhang Yuqing Miao Huijun Ma Hui Guo Ruyi Jin Zhi Li Haifang Wang Haiming Fan Lingyun Zhao | 2022 | Nano Research2022，15，9： | 1 |
| 7 | Redox modulated hydrogelation of a self-assembling short peptide amphiphile显示文摘Hydrogels resulting from the self-assembly of small peptides are smart nanobiomaterials as their nanostructuring can be readily tuned by environmental stimuli such as pH,ionic strength and temperature,thereby favoring their practical applications.This work reports experimental observations of formation of peptide hydrogels in response to the redox environment.Ac-I 3 K-NH 2 is a short peptide amphiphile that readily self-assembles into long nanofibers and its gel formation occurs at concentrations of about 10 mmol/L.Introduction of a Cys residue into the hydrophilic region leads to a new molecule,Ac-I 3 CGK-NH 2,that enables the formation of disulfide bonds between self-assembled nanofibers,thus favoring cross-linking and promoting hydrogel formation.Under oxidative environment,Ac-I 3 CGK-NH 2 formed hydrogels at much lower concentrations(even at 0.5 mmol/L).Furthermore,the strength of the hydrogels could be easily tuned by switching between oxidative and reductive conditions and time.However,AFM,TEM,and CD measurements revealed little morphological and structural changes at molecular and nano dimensions,showing no apparent influence arising from the disulfide bond formation. | CAO ChangHai CAO MeiWen FAN HaiMing XIA DaoHong XU Hai LU Jian R | 2012 | Chinese Science Bulletin2012，57，33： | 1 |
| 8 | Decentralized domestic wastewater treatment using intermittently aerated vertical flow constructed wetlands: impact of influent strengths 显示文摘 | WU Haiming FAN Jinlin ZHANG Jian | 2015 | Bioresource Technology2015，176，： | 1 |
| 9 | Tuna- ble magnetoplasmons for efficient terahertz modulator and isolator by gated monolayer graphene 显示文摘 | Zhou Yixuan Xu Xinlong Fan Haiming | 2013 | Physical Chemistry Chemical Physics2013，15，14： | 1 |
| 10 | Growth and Function of Urban Cultural Space Seen from Guangfu Morning Tea Culture显示文摘Morning tea culture taking Guangzhou as the core and the Pearl River Delta as the traffic area is taken as the research object.The evolution of the way of morning tea is analyzed,and internal and external conditions for the formation of urban cultural space are analyzed,and the growth and function of urban cultural space are explored.Through theoretical sampling method and grounded theory method,taking social media views as data source,the dimensions of the cultural space of Guangfu morning tea are explored,and the dimensions involved in the construction of cultural space of Guangfu morning tea are discussed,and the relationship between the cultural space of morning tea and human being is understood,to better explore how to construct the cultural space of morning tea,and find out the growth dimension of urban cultural space.The growth and function of urban cultural space are examined from the perspective of urban cultural space,thereby providing suggestions for the development of urban cultural space. | GUO Xudong CHEN Fang FAN Xiaowen CHEN Haiming | 2021 | Journal of Landscape Research2021，13，3： | 0 |
| 11 | Programmable endonuclease combined with isothermal polymerase amplification to selectively enrich for rare mutant allele fractions显示文摘Liquid biopsy is a highly promising method for non-invasive detection of tumor-associated nucleic acid fragments in body fluids but is challenged by the low abundance of nucleic acids of clinical interest and their sequence homology with the vast background of nucleic acids from healthy cells.Recently,programmable endonucleases such as clustered regularly interspaced short palindromic repeats(CRISPR)associated protein(Cas)and prokaryotic Argonautes have been successfully used to remove background nucleic acids and enrich mutant allele fractions,enabling their detection with deep next generation sequencing(NGS).However,the enrichment level achievable with these assays is limited by futile binding events and off-target cleavage.To overcome these shortcomings,we conceived a new assay(Programmable Enzyme-Assisted Selective Exponential Amplification,PASEA)that combines the cleavage of wild type alleles with concurrent polymerase amplification.While PASEA increases the numbers of both wild type and mutant alleles,the numbers of mutant alleles increase at much greater rates,allowing PASEA to achieve an unprecedented level of selective enrichment of targeted alleles.By combining CRISPR-Cas9 based cleavage with recombinase polymerase amplification,we converted samples with0.01%somatic mutant allele fractions(MAFs)to products with 70%MAFs in a single step within 20 min,enabling inexpensive,rapid genotyping with such as Sanger sequencers.Furthermore,PASEA's extraordinary efficiency facilitates sensitive real-time detection of somatic mutant alleles at the point of care with custom designed Exo-RPA probes.Real-time PASEA'performance was proved equivalent to clinical amplification refractory mutation system(ARMS)-PCR and NGS when testing over hundred cancer patients'samples.This strategy has the potential to reduce the cost and time of cancer screening and genotyping,and to enable targeted therapies in resource-limited settings. | Junman Chen Tian Qiu Michael G.Mauk Zheng Su Yaguang Fan Dennis J.Yuan Qinghua Zhou Youlin Qiao Haim H.Bau Jianming Ying Jinzhao Song | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 12 | Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss显示文摘Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO. | Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni | 2022 | Bone Research2022，10，4： | 0 |
| 13 | Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy显示文摘Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,and the efficacy of these drugs increased our confidence that immunomodulation was a viable way of treating cancer.The basis of immunotherapy is to break the immune escape of the tumor and resolve the immune suppressive microenvironment of tumors.Nanomaterial-mediated dynamic therapy(NDT)is an emerging immuno-regulatable type for tumor therapy,whose effects are mediated by increased cellular levels of reactive oxygen species(ROS).ROS is a potent trigger of immunogenic cell death,and this process initiates antitumor immunity.Nanomaterials for use in NDT can be engineered to interact with almost all cell types in the tumor microenvironment to remodel this environment.In this review,we systematically examined the effects of NDT on four major cell types in the tumor microenvironment,namely tumor cells,lymphocytes,myeloid cells,and tumor stromal cells.We believe that this review will improve researchers’understanding of the anti-tumor immunity triggered by NDT,and provide ideas and inspiration for how optimally designed NDT schemes can be used to target the cells in the tumor microenvironment. | Wangbo Jiao Yao Feng Chen Liang Qiaoyi Lu Haiming Fan Xing-Jie Liang Xiaoli Liu | 2023 | Nano Research2023，16，12： | 0 |
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