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| 1 | 溃疡性结肠炎内镜下严重度指数(UCEIS评分)与Mayo内镜评分(MES)用于预测急性重症结肠炎患者行肠切除术的比较研究显示文摘背景溃疡性结肠炎内镜下严重度指数(UCEIS)和Mayo内镜评分(MES)都是溃疡性结肠炎(UC)内镜下严重程度的客观评估方法,然而,对于这两种评分方法能否用于筛选出需要行结肠切除术的急性重症结肠炎患者,目前仍不明了。方法:对2012年1月至2016年5月间连续收治的ASC患者进行回顾性分析。提取并分析入组患者的人口统计资料、既往治疗史、疾病特征资料、实验室指标、药物治疗及内镜评估等资料。主要结局指标是住院和随访期间需行结肠切除术的患者比例。结果:92例患者纳入研究,其中37例(40.2%)需行结肠切除术。多因素分析显示,UCEIS评分是需行结肠切除术的独立预测因素(OR=3.25,95%CI:1.77~5.97;P<0.001)。UCEIS评分的ROC曲线下面积为0.85;以7分作为最佳阈值,其预测需行结肠切除术的敏感度为60.3%,特异度为85.5%。UCEIS评分对于需要行结肠切除术的预测价值优于MES评分,后者曲线下面积仅为0.65。当UCEIS评分≥7分时,有80%的ASC患者最终需行结肠切除术。结论:预测ASC患者的肠切除风险,UCEIS评分优于MES评分。对于USEIS≥7分的患者,由于其药物治疗失败风险较高,因此,可考虑早期行结肠切除术。 | Tingbin Xie Tenghui Zhang Chao Ding Xujie Dai Yi Li Zhen Guo Yao Wei Jianfeng Gong Weiming Zhu Jieshou Li | 2018 | Gastroenterology Report2018，6，1： | 6 |
| 2 | Mild hyperthermia synergized chemotherapy by Bi_(2)Se_(3)/MoSe_(2)nanosaucers for cancer treatment with negligible thermal resistance显示文摘Harsh photothermal temperatures(>50℃)caused heating damage to the normal tissues and induced thermal resistance in cancer cells,which significantly limited the safety and efficacy of photothermal therapy(PTT)in cancer treatment.Mild hyperthermia(<42℃)combined with chemotherapy might solve this issue.Herein,a novel transition metal dichalcogenides nanostructure,namely,Bi_(2)Se_(3)/MoSe_(2)nanosaucers(BMNSs),was designed to produce mild photo-hyperthermia(mPTT)and combined with chemotherapy to improve the overall antitumor efficacy.The BMNSs were constituted by Bi_(2)Se_(3)hexagonal nanoplates and enclosed with MoSe_(2)nanosheets evenly.While the MoSe_(2)moiety endowed the nanoplatform with excellent photothermal efficacy,the Bi_(2)Se_(3)substrates provided large specific surface area to anchor more doxorubicin(DOX)molecules as chemotherapeutic agent.Under the stimuli of mPTT/tumor acidic microenvironment,the tumor-specific drug release and the enhanced chemotherapy could be realized,showing impressive therapeutic outcomes against 4T1 cells.The synergetic therapeutic mechanism might be attributed to the mPTT induced cell membrane permeability,and interestingly,the expression of heat shock proteins 70 was not elevated obviously after the synergetic therapy,thus to avoid the tumor thermal resistance and further improve the therapeutic effect.The in vivo anti-tumoral performance of the BMNSs was further studied and complete tumor eradication was achieved without any recurrence and biotoxicity.Not only demonstrating a paradigm of high therapeutic efficacy of mild hyperthermia and synergistic chemotherapy for precise cancer therapy,our findings proved that the cancer therapeutic effect can be improved with minimal side effects through exquisite designing of the microstructures and the physiochemical properties of the nanoplatform. | Fei Gao Tingbin Zhang Yuqing Miao Huijun Ma Hui Guo Ruyi Jin Zhi Li Haifang Wang Haiming Fan Lingyun Zhao | 2022 | Nano Research2022，15，9： | 1 |
| 3 | Seasonal snow cover patterns explain alpine treeline elevation better than temperature at regional scale显示文摘Unprecedented modern rates of warming are expected to advance alpine treelines to higher elevations,but global evidence suggests that current treeline dynamics are influenced by a variety of factors.Seasonal snow cover has an essential impact on tree recruitment and growth in alpine regions,which may in turn influence current treeline elevation;however,little research has been conducted on its role in regional treeline formation.Based on 11,804treeline locations in the eastern Himalayas,we extracted elevation,climate,and topographic data for treeline and snowline.Specifically,we used linear and structural equation modelling to assess the relationship between these environmental factors and treeline elevation,and the climate-snow-treeline interaction mechanism.The results showed that the treeline elevation increased with summer temperature and permanent or seasonal snowline elevation,but decreased with snow cover days and spring temperature at the treeline positions(P<0.001).Importantly,spring snowline elevation(33.4%)and seasonal snow cover days(21.1%)contributed the most to treeline elevation,outperforming the permanent snowline,temperature,precipitation,and light.Our results support the assertion that the temperature-moisture interaction affects treeline elevation in the eastern Himalayas,but we also found that the effects were strongly mediated by seasonal snow cover patterns.The increasing tendency of snow cover governed by climate humidification observed in the eastern Himalayas,is likely to limit future treeline advancement and may even cause treeline decline due to the mortality of the remaining old trees.Together,our findings highlight the role of seasonal snow cover patterns in determining treeline elevation in the eastern Himalayas,which should be considered when assessing the potential for treeline ascent in snow-mediated alpine systems elsewhere. | Mengyue Huang Guoyan Wang Xiaojuan Bie Yunqing Jiang Xiyue Huang Jing-Ji Li Songlin Shi Tingbin Zhang Pei-Hao Peng | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 4 | Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy显示文摘Focal epilepsy accounts for 60% of all forms of epilepsy, but the pathogenic mechanism is not well understood. In this study,three novel mutations in NPRL3(nitrogen permease regulator-like 3), c.937_945del, c.1514dup C and 6,706-bp genomic DNA(g DNA) deletion, were identified in three families with focal epilepsy by linkage analysis, whole exome sequencing(WES) and Sanger sequencing. NPRL3 protein is a component of the GATOR1 complex, a major inhibitor of m TOR signaling. These mutations led to truncation of the NPRL3 protein and hampered the binding between NPRL3 and DEPDC5, which is another component of the GATOR1 complex. Consequently, the mutant proteins enhanced m TOR signaling in cultured cells, possibly due to impaired inhibition of m TORC1 by GATOR1. Knockdown of nprl3 in Drosophila resulted in epilepsy-like behavior and abnormal synaptic development. Taken together, these findings expand the genotypic spectrum of NPRL3-associated focal epilepsy and provide further insight into how NPRL3 mutations lead to epilepsy. | Shiyue Du Sheng Zeng Li Song Hongying Ma Rui Chen Junyu Luo Xu Wang Tingbin Ma Xuan Xu Hao Sun Ping Yi Jifeng Guo Yaling Huang Mugen Liu Tao Wang Wei-Ping Liao Luoying Zhang Jing Yu Liu Beisha Tang | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 5 | Spatio-temporal Characteristics of Atmospheric Pollution and Cause Analysis of Haze Events in Sichuan Basin,China显示文摘This study analyzed the spatio-temporal variability of air quality data for six standard air pollutants(Particulate Matter 2.5(PM2.5),Particulate Matter 10(PM10),SO2,NO2,CO,and O3)in the Sichuan Basin(SCB),China from 2015 to 2018 in relation to the formation of haze using conventional meteorological data(temperature,wind speed,and relative humidity),satellite data(fire point data,vertical profiles of aerosol subtypes,and aerosol optical depth),planetary boundary layer height,and backward trajectories.The results indicated that the spatio-temporal evolution of the air quality index(AQI)had notable seasonality for the pollution severity in descending order:winter,spring,summer,and autumn.Autumn and winter severe haze events occurred in November and January,respectively,and were caused by higher local pollution emissions under stagnant air conditions.Spring severe haze events occurred in May and were caused by dust from Northwest China and local regions.Severe summer haze events occurred in July and were caused by local burning.Therefore,the analyses showed that local burning,stagnant meteorological conditions,air mass transport and anthropogenic pollution emissions played a key role in haze in the SCB.This study provides scientific insights for fully analyzing heavy air pollution in SCB,China,and also provides a scientific basis for pollution research in regions of complex terrain as basins and mountains. | WANG Xingjie GUO Ke LIANG Yuan ZHANG Tingbin WANG Guxi | 2021 | Chinese Geographical Science2021，31，3： | 0 |
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