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52篇 您的检索式:作者名="Haiqing Yang"
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1Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only.Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao 2019Cell Research2019,29,2:16
2TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang 2016Cell Research2016,26,9:13
3Therapeutic effect of nerve growth factor on cerebral infarction in dogs using the hemisphere anomalous volume ratio of diffusion-weighted magnetic resonance imaging显示文摘A model of focal cerebral ischemic infarction was established in dogs through middle cerebral artery occlusion of the right side.Thirty minutes after occlusion,models were injected with nerve growth factor adjacent to the infarct locus.The therapeutic effect of nerve growth factor against cerebral infarction was assessed using the hemisphere anomalous volume ratio,a quantitative index of diffusion-weighted MRI.At 6 hours,24 hours,7 days and 3 months after modeling,the hemisphere anomalous volume ratio was significantly reduced after treatment with nerve growth factor. Hematoxylin-eosin staining,immunohistochemistry,electron microscopy and neurological function scores showed that infarct defects were slightly reduced and neurological function significantly improved after nerve growth factor treatment.This result was consistent with diffusion-weighted MRI measurements.Experimental findings indicate that nerve growth factor can protect against cerebral infarction,and that the hemisphere anomalous volume ratio of diffusion-weighted MRI can be used to evaluate the therapeutic effect.Yong Wang Hui Zhang Zhe Wang Zuojun Geng Huaijun Liu Haiqing Yang Peng Song Qing Liu 2012Neural Regeneration Research2012,7,24:9
4Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications.Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng 2021Bioactive Materials2021,6,1:6
5Intercalibration of international and domestic ^(40)Ar/^(39)Ar dating standards显示文摘Four international standards, Ga1550, MMhb-1, Lp-6, Bern 4M, and one domestic standard BT-1 have been intercalibrated. The repeated measurements on MMhb-1 with different mass demonstrate that MMhb-1 is inhomogeneous in age and its average age is 519.8 Ma. The results of Bern 4M and Lp-6 reflect that they have an invariable value of 40Ar*/39Ark (F) and the ages we obtained are consensus with their K-Ar age: Lp-6=127.7Ma; Bern 4M=18.2 Ma. Analyses of BT-1 age spectra, Ca/K and Cl/K spectra as well as inverse isochrons indicate that the sample is homogeneous and invariable and keeps close chemically, with its trapped argon isotope composition close to the at- mosphere. The dating results show that age values are reproducible and steady, total fusion age, step-heating age, plateau age and isochron age are in accord with each other within the error range (2σ). Therefore, we recommend 28.7 Ma as the calibrated age of BT-1. We also discuss the variation in neutron flux gradients of Beijing 49-2 reactor. It was found that the neutron flux gradient varies considerably, and more monitors (standard samples) are needed to fix the trend of variation. The coefficient of the 49-2 reactor that transfers the ratio of production rate of 37ArCa/39ArK into Ca/K ratio is 1.78. This is different from that reported earlier, 2.0, which may be caused by the reconstruction of the reactor.WANG Fei HE Huaiyu ZHU Rixiang SANG Haiqing WANG Yinglan YANG Liekun 2006Science China Earth Sciences2006,49,5:6
6Laser step-heating ^(40)Ar/^(39)Ar dating on young volcanic rocks显示文摘An attempt was made to use CO_2 laser step-heating method to date the late Pleistocene basaltic groundmass (DF-2) from Tengchong volcanic field. Among the fourteen heating steps, ten define a good inverse isochron (MSWD = 1.4) with an age of 32.2 ± 7.1 ka (2 σ).The inverse isochron also shows that the initial argon isotopic ratio is 297.1±2.0 (2σ) which is the same as the atmospheric argon at the 2σ error level. Study indicates that it is a useful means to date young volcanic groundmass with low K content by using CO_2 laser step-heating ^(40)Ar/^(39)Ar method.WANG Fei HE Huaiyu ZHU Rixiang YANG Liekun SANG Haiqing WANG Yinglan 2006Chinese Science Bulletin2006,51,23:4
7Constant Volume Spray Auto-ignition Study of Alkanes显示文摘Spray auto-ignition experiments were carried out in a constant volume combustion chamber for some pure alkanes(n-paraffins with different chain length, cyclohexane, n-butyl cyclohexane, and isooctane) and blends of n-decane with Standard Blended Fuel(isooctane/n-heptane) and product gasoline. Test results showed that the reaction activity of n-paraffins was relatively high. Meanwhile, the auto-ignition characteristics differed significantly with the molecular structures of alkanes. Adding different volume fractions of n-decane to Standard Blended Fuel and product gasoline could improve the fuel reaction activity at varying degree. Finally, functional groups effects were used to simulate the relationship between the molecular topology and the auto-ignition quality.Wang Jun Yang He Song Haiqing Tian Huayu Wang Pengfei 2019China Petroleum Processing & Petrochemical Technology2019,21,1:4
8Microelectrode array recordings of excitability of low Mg^(2+)-induced acute hippocampal slices显示文摘Neuronal connections can be detected by neuronal network discharges in hippocampal neurons cultured on multi-electrodes. However, the multi-electrode-array (MEA) has not been widely used in hippocampal slice culture studies focused on epilepsy. The present study induced spontaneous synchronous epileptiform activity using low Mg2+ artificial cerebrospinal fluid on acute hippocampal slices to record hippocampal discharges with MEA. Results showed that burst duration and average number of spikes in a burst were significantly greater in the CA3 compared with dentate gyrus and CA1 areas. In Schaffer cut-off group, CA1 area discharges disappeared, but synchronous discharges remained in the CA3 area. Moreover, synchronous discharge frequency in the Schaffer cut-off group was similar to control. However, burst duration and average number of spikes in a burst were significantly decreased compared with control (P < 0.05). Results demonstrated that highest neuronal excitability occurred in the CA3 area, and synchronous discharges induced by low Mg2+ originated from the CA3 region.Fan Yang Xinwei Gong Haiqing Gong Puming Zhang Peiji Liang Qinchi Lu 2010Neural Regeneration Research2010,5,20:3
9DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11.Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo 2022Acta Pharmaceutica Sinica B2022,12,1:3
10Bi_2Se_3/C Nanocomposite as a New Sodium-Ion Battery Anode Material显示文摘Bi_2Se_3 was studied as a novel sodium-ion battery anode material because of its high theoretical capacity and high intrinsic conductivity. Integrated with carbon,Bi_2Se_3/C composite shows excellent cyclic performance and rate capability. For instance, the Bi_2Se_3/C anode delivers an initial capacity of 527 mAh g^(-10) at 0.1 A g^(-1) and maintains 89% of this capacity over 100 cycles. The phase change and sodium storage mechanism are also carefully investigated.Lixin Xie Ze Yang Jingying Sun Haiqing Zhou Xiaowei Chi Hailong Chen ANDy X.Li Yan Yao Shuo Chen 2018Nano-Micro Letters2018,10,3:2
11Effects of different amino acid levels and a carvacrol-thymol blend on growth performance and intestinal health of weaned pigs显示文摘Background:Over the past years,antibiotic growth promoter had been restricted in animal husbandry production in many countries because of antimicrobial resistance and foodborne antibiotic residues.However,the problems of poor intestinal health and low growth efficiency of piglets have not been solved completely in an antibiotic-free diet,and it is urgent to explore alternatives to antimicrobial growth promoters.Methods:Here,a total of 532 weaned pigs were assigned to one of 4 treatments,the low amino acid(AA)level diet(d 1 to d 14 is 1.35%,d 15 to d 42 is 1.25%)(Low AA),the low AA level diet supplementation with a carvacrol-thymol blend(50 mg carvacrol and 50 mg thymol/kg of diet)(CB)(Low AA+CB),the high AA level diet(d 1 to d 14 is 1.50%,d 15 to d 42 is 1.40%)(High AA),and the high AA level diet supplementation with a CB(High AA+CB),respectively.Then we measured growth performance and intestinal health indicators of weaned pigs.Results:Results showed that high AA level significantly reduced plasma urea nitrogen,plasma Interleukin-6(IL-6)and fecal lipocalin-2 contents(P<0.05),significantly increased the relative abundance of fecal Lactobacillus and Enterococcus,and had a trend to increase the fecal secretory immunoglobulin A(sIgA)and mucin 2(MUC 2)contents(P<0.05)in piglets,thereby alleviating the diarrhea of piglets and reducing the feed conversion ratio(FCR)of piglets during d 1~14 after weaning.Dietary supplementation with CB significantly increased the activity of plasma antioxidant enzymes T-SOD and GSH-px(P<0.05),while significantly reduced plasma malondialdehyde(MDA),plasma interleukin-1β(IL-1β),plasma endotoxin and D-lactic acid contents(P<0.05).Meanwhile,CB significantly decreased fecal lipocalin-2 contents and the abundance of fecal Escherichia coli(P<0.05).Thus,we hypothesis that dietary supplementation with CB significantly increased the average daily gain(ADG)of piglets(P<0.05)during d 1~14 after weaning through promoting intestinal health.Conclusion:These results suggest that high AA level and dietary supplementation with CB improved the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity.Yanan Wang Zhipeng Yang Yuanfei Zhou Jiajian Tan Haiqing Sun Defa Sun Yuyun Mu Jian Peng Hongkui Wei 2022Journal of Animal Science and Biotechnology2022,13,5:2
12Boosting pH-Universal Hydrogen Evolution of Molybdenum Disulfide Particles by Interfacial Engineering显示文摘The design of high-efficiency non-noble and earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is highly paramount for water splitting and renewable energy systems.Molybdenum disulfide(MoS_(2))with abundant edge sites can be utilized as a promising alternative,but its catalytic activity is greatly related to the pH values,especially in an alkaline environment due to the extremely high energy barriers for water adsorption and dissociation steps.Here we report an exceptionally efficient and stable electrocatalyst to improve the sluggish HER process of layered MoS_(2)particles in different pH electrolytes,especially in base.The electrocatalyst is constructed by in situ growing selenium-doped MoS_(2)(Se-MoS_(2))nanoparticles on three-dimensional cobalt nickel diselenide(mCo_(0.2)Ni_(0.8)Se_(2))nanostructured arrays.Due to the large number of active edge sites of Se-MoS_(2)particles exposed at the surface,robust electrical conductivity and large surface area of mCo_(0.2)Ni_(0.8)Se_(2)support,and strong interfacial interactions between Se-MoS_(2)and mCo_(0.2)Ni_(0.8)Se_(2),this hybrid catalyst shows very outstanding catalytic HER properties featured by low overpotentials of 30 and 122 mV at 10 and 100 mA/cm^(2)with good operational stability in base,respectively,which outperforms most of inexpensive catalysts consisting of layered MoS_(2),transition metal selenides and sulfides,and it performs as well as noble Pt catalysts.Meanwhile,this electrocatalyst is also very active in neutral and acidic electrolytes,requiring low overpotentials of 93 and 94 mV at 10 mA/cm^(2),respectively,demonstrating its superb pH universality as a HER electrocatalyst with excellent catalytic durability.This study provides a straightforward strategy to construct an efficient non-noble electrocatalyst for driving the HER kinetics in different electrolytes.Liling Liao Lun Yang Gang Zhao Haiqing Zhou Fengming Cai Yi Li Xiuzhang Wang Fang Yu 2021Chinese Journal of Chemistry2021,39,2:2
13T-cell vaccination leads to suppression of intrapancreatic Th17 cells through Stat3-mediated RORyt inhibition in autoimmune diabetes显示文摘有使失去活性的 autoreactive T 房间的免疫是改善的一条有效治疗学的途径自体免疫的疾病,当调整 autoreactive T 房间的内在的机制完全没被理解时。这研究测试了 T 房间种痘(TCV ) 禁止的假设在通过 Th17 房间的抑制的老鼠的自体免疫的糖尿病。结果显示出在类型 1 糖尿病(T1D ) 的减少的多糖症作为与控制相比由多重低剂量的 streptozotocin (MLD-STZ ) 导致了的那个 TCV 处理,保存了健康胰腺的小岛的数字并且增加了在小岛的胰岛素的生产。进一步的学习表明 TCV 显著地减少了在通过 mRNA 的显著抑制渗入淋巴细胞(IPL ) 的 intrapancreatic 的 -17 和 IL-23 retinoic 铺平的两 interleukin (IL ) 的生产酸相关的孤儿受体 γ t (RORγ t ) 并且信号变换器和抄写 3 的使活跃之物(Stat3 ) phosphorylation。导致 TCV 的 Th17 抑制的角色进一步在 sub-diabetogenic 老鼠与极化的 Th17 房间在采纳转移实验被验证,它类似于 anti-IL-17 抗体处理的效果。一起,我们的学习证明 intrapancreatic Th17 房间抑制和健康小岛保藏由 TCV 在 T1D 的处理起一个重要作用。Min Wang Liu Yang Xiaoyan Sheng Weilei Chen Haiqing Tang Hongguang Sheng Beili Xi Ying Qin Zang 2011Cell Research2011,21,9:2
14Studies on the properties of surface and edges of N-layer graphenes显示文摘Graphene, a new two-dimensional carbon material, is a rising star of physics, chemistry and materials science. In this work, we report the recent experimental researches on the Raman spectra and the temperature-dependent features of graphenes and car- bon nanoscrolls, which are evolved from graphene and have an open tubular structure. The layer-dependent Raman enhancing characteristics of n-layer graphenes for crystal violet, and the thickness-dependent morphologies of gold on n-layer graphenes are also systematically investigated. Meanwhile, the aggregations of ferromagnetic and paramagnetic atoms at edges of gra- phenes and graphite are observed and the mechanisms are discussed.CHEN MinJiang ZHOU HaiQing QIU CaiYu YANG HuaiChao YU Fang SUN LianFeng 2011Science China(Physics,Mechanics & Astronomy)2011,54,10:2
15A ratiometric fluorescent probe for the detection of hypochlorous acid in living cells and zebra fish with a long wavelength emission显示文摘A ratiometric fluorescence probe,NClO,for the rapid and selective detection of HClO had been designed and synthesized based on a 1,8-naphthalimide derivative.Probe NClO displayed a red emission(λmax=615 nm).In the presence of HClO,the solution of probe NClO gave off a strong green fluorescence(λem,max=520 nm)with a rapid response(within seconds).This probe had been applied to image HClO in living cells and zebra fish.Haiqing Xiong Long He Yun Zhang Jingpei Wang Xiangzhi Song Zhaoguang Yang 2019Chinese Chemical Letters2019,30,5:2
16Application of image texture for the sorting of tea categories using multi-spectral imaging technique and support vector machine显示文摘Di Wu Haiqing Yang Xiaojing Chen Yong He Xiaoli Li 2008Journal of Food Engineering2008,,4:1
17Application of image texture for the sorting of tea categories using multi- spectral imaging technique and support vector mac- hine 显示文摘Wu Di Yang Haiqing Chen Xiaojing 2008Journal of Food Engineering2008,88,4:1
18Systematic Review and Meta‐Analysis: Circulating miRNAs for Diagnosis of Hepatocellular Carcinoma显示文摘Jing‐Tao Huang Song‐Mei Liu Haiqing Ma Ying Yang Xuan Zhang Huanhuan Sun Xiaoyan Zhang Jianqing Xu Jin Wang 2016J. Cell. Physiol2016,,2:1
19Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs).Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li 2023Genomics, Proteomics & Bioinformatics2023,21,4:1
20Application of image texture for the sorting of tea categories using multi-spectral imaging technique and support vector machine 显示文摘Di Wu Haiqing Yang Xiaojing Chen 2008Journal of food engineering2008,3,:1
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