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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Application and Residue Pollution of Mulching Films in Xinjiang显示文摘In order to study current situation of application,recycling and residue pollution of mulching films in Xinjiang,and accurately grasp pollution degree of residue of mulching films,this paper made an empirical analysis on residue of mulching films in 31 typical counties and cities in Xinjiang. Results indicate that( i) use of mulching films in Xinjiang is wide and there is great difference in use and residue recycling between cities and counties. Planting area and planting structure jointly influence use of mulching films,and the use of mulching films is significantly correlated with recycling of mulching films,but not correlated with recycling rate of mulching films.( ii) There are significant differences in distribution of residue of mulching films,highest in North Xinjiang and South Xinjiang,followed by East Xinjiang,and the lowest in West Xinjiang.( iii) There are significant differences in distribution of residue of mulching films between different crop fields. Residue of mulching films in cotton field is the key problem of pollution. | Mingdong ZHOU Hong HOU Hegan DONG Haiying SU Xiaohui QIN | 2016 | Asian Agricultural Research2016，8，1： | 1 |
| 3 | Effect of chlorine content of chlorophenols on their adsorption by mesoporous SBA-15显示文摘Studies on the effect of the chlorine content of chlorophenols(CPs) on their adsorption from aqueous solution by mesoporous SBA-15 are important in understanding the mechanisms of CP adsorption.In this study,three CPs with different degrees of chlorine content(i.e.,2-chlorophenol,2,6-dichlorophenol and 2,4,6-trichlorophenol) were investigated.The effects of parameters such as temperature and solution pH were studied.The results showed that CP adsorption by SBA-15 increased with increasing number of chlorine substituents and depended strongly on the temperature and solution pH.Thermodynamic parameters such as Gibbs free energy change(G 0),enthalpy change(H 0) and entropy change(S 0) were also calculated.By comparison of the adsorption coefficient of CPs with varying physical-chemical properties(size,hydrophobicity and electron density),we propose that hydrophobic interactions between CPs and the SBA-15 surface,as well as electron donor-acceptor(EDA) complexes between oxygen of the siloxane surface of SBA-15(e-donor) and the π-system of the CPs(e-acceptor),were dominant adsorption mechanisms. | Qingdong Qin Ke Liu Dafang Fu Haiying Gao | 2012 | Journal of Environmental Sciences2012，24，8： | 1 |
| 4 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 5 | Single-component and three-component fuel cells 显示文摘 | Bin Zhu Rizwan Raza Haiying Qin Liangdong Fan | 2011 | Journal of Power Sources2011，196，： | 1 |
| 6 | Fuel eells based on electrolyte and non-electrolyte separators 显示文摘 | Bin Zhu Rizwan Raza Haiying Qin Qinghua Liu Liangdong Fan | 2011 | Energy & Environmental Science2011，4，： | 1 |
| 7 | Roles of Tet2 in meiosis, fertility and reproductive aging显示文摘Dear Editor,Ten-eleven translocation(Tet)enzymes play important roles in DNA demethylation involved in various biological processes including stem cell pluripotency and differentiation,and tumorigenesis(Dawlaty et al.,2013;Wu and Zhang,2017).Tet2 deficiency or mutation leads to severe hematopoietic defects or myeloid malignancies in mice(Delhommeau et al.,2009;Ko et al.,2010;Moran-Crusio et al.,2011).Restoration of TET2 blocks aberrant self-renewal and leukemia progression in patients possessing TET2 mutations(Cimmino et al.,2017). | Huasong Wang Linlin Liu Mo Gou Guian Huang Chenglei Tian Jiao Yang Haiying Wang Qin Xu Guo_Liang Xu Lin Liu | 2021 | Protein & Cell2021，12，7： | 0 |
| 8 | Single-cell transcriptomics reveals cell type diversity of human prostate显示文摘Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic tissues.Here,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular compositions.We identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune function.In addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and aging.These results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development. | Yang Chen Peng Zhang Jinling Liao Jiwen Cheng Qin Zhang Tianyu Li Haiying Zhang Yonghua Jiang Fangxing Zhang Yanyu Zeng Linjian Mo Haibiao Yan Deyun Liu Qinyun Zhang Chunlin Zou Gong-Hong Wei Zengnan Mo | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 9 | Production of phenolic compounds in catalytic pyrolysis of bagasse lignin in the presence of Ca_(0.5)Pr_(0.5)FeO_(3)显示文摘Herein,sodium dodecylbenzene sulfonate(SDBS)was used as a template to control the synthesis of Ca_(0.5)Pr_(0.5)FeO_(3).Its microstructure,composition,and morphology were detected via X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FT-IR),and scanning electron microscopy(SEM).The properties of catalyzing bagasse lignin(BL)pyrolysis were determined by thermogravimetric analysis(TG)test and evaluation of a fixed bed alumina microreactor.The results show that the sample Ca_(0.5)Pr_(0.5)FeO_(3)regulated by SDBS has a cubic crystal phase,and the addition of SDBS does not cause phase transition.Moreover,when the SDBS concentration is 0.10 mol/L,the particle size is 200-500 nm and the specific surface area is 11.26 m^(2)/g.The yields of gas,liquid,and solid products in the BL catalytic pyrolysis are 39.58 wt%,26.76 wt%and 32.36 wt%,respectively.The contents of CO_(2)and CO decrease from 54.07%and 4.98%to 45.29%and 3.23%,respectively.The liquid products are mainly guaiacol,syringol,and phenol,and the total selectivity of phenols is 83.67%,accompanied by a small amount of non-aromatic oxygen-containing compounds(five-membered ring(furan)or ester).Compared with the BL pyrolysis and Ca_(0.5)Pr_(0.5)FeO_(3)catalytic pyrolysis products,the selectivity of guaiacol compounds increases by43.26%,while those of syringol compounds and phenylketones decrease by 30.08%and 3.39%,respectively.The selectivity of 2,6-dimethoxyphenol is 28.37%.After five catalytic pyrolysis-regeneration cycles,the characteristic peaks of the catalyst do not change significantly and the particles are uniform,suggesting that the catalyst has good crystal phase stability and regeneration stability. | Hongjing Han Qin Ge Mei Zhang Yanguang Chen Haiying Wang Yanan Zhang Yizhen Wang Hua Song Chunlei Zhang | 2022 | Journal of Rare Earths2022，40，2： | 0 |
| 10 | Les systèmes de valeurs clans Une Saison en Enfer显示文摘A la différence des Illuminations, Une Saison en Enfer est la seule de ses oeuvres que Rimbaud air lui-meme intitulée et publiée comme un ensemble, Ce fait suffit à justifier une lecture globale qui considère les neuf textes d’Une Sqaison en Enfer comme un tout(bien que, selon les historiens de Rimbaud, ils n’aient pas étéécrits à la suite ni dans une meme intention initiale), lecture qui s’arrete sur certains lieux récurrents pour faire apparaitreun réseau de sens sous-tendu | QIN Haiying | 1989 | 法国研究1989，，2： | 0 |
| 11 | Amperometric Biosensors Sensitive to Organic Peroxides Based on Immobilization of Redox Organic Dyes and Horseradish Peroxidase in Polyester Ionomer Film显示文摘Peroxides Based on Immobilization of Redox Organic Dyes and Horseradish Peroxidase in Polyester Ionomer FilmTX1IntroductionOrg... | Liu Haiying Yan Shaohua Qin Yiqin Wang Zhaojin (School of Chemistry and Chemical Engineering) | 1998 | Advances in Manufacturing1998，，4： | 0 |
| 12 | Anti-lipid-oxidation effects and edible safety evaluation of the oil extracted by a supercritical CO_(2) process from coix seed fermented by Monascus purpureus显示文摘The physicochemical properties and composition of coix seed oil produced by Monascus purpureus fermentation and supercritical CO_(2)extraction were determined.Anti-lipid-oxidation and edible safety were evaluated using a cholesterol-fish oil model,acute oral toxicity assay,and genetic toxicity assay in vitro and in vivo,respectively.The results show that the extraction oil from fermented coix seed(FCS-O)had good physicochemical quality and abundant active components with physiological function.In particular,γ-tocotrienol,γ-oryzanol,coixenolide and oleic acid concentrations reached 72.83μg/g,745.96μg/g,9.65 mg/g and 316.58 mg/100 g DW,respectively.The FCS-O exhibited higher antioxidant capability in inhibiting lipid oxidation and peroxidation.Compared to the blank control,the concentrations of 7-ketocholestreol and peroxide only were 8.42μg/mL and 16.16 mmol/kg at 168 h of oxidation(P<0.01).In addition,the FCS-O has been confirmed to be a very safe edible oil,with no acute toxicity(LD50>10 g/kg bw,considered actually non-toxic)and no induced mutagenicity,cytotoxicity or genotoxicity.These results serve as a good safety reference for future application of the oil from fermented coix seed.The development and utilization of this kind of oil will be beneficial as a food,food ingredient,nutritional supplement,or natural food antioxidant to promote good health function. | Haiying Zeng Anran Zhu Shengling He Mingjun Wu Muhammad Mazhar Anyan Wen Na Liu Likang Qin Song Miao | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 13 | The Analysis of the Influence Factors of TBT on the Export of Agricultural Products in China显示文摘 | Qingbo Qin Haiying Ren | 2006 | Journal of Systems Science and Information2006，4，1： | 0 |
| 14 | Epizootiological surveillance of porcine circoviruses in free-ranging wild boars in China显示文摘Four species of porcine circoviruses(PCV1–4)have been reported to circulate in Chinese domestic pigs,while the epizootiology of these viruses in free-ranging wild boars in China remains unknown.In this study,tissue and serum samples collected from diseased or apparently healthy wild boars between 2018 and 2020 in 19 regions of China were tested for the prevalence of PCV1–4 infections.Positive rates of PCV1,PCV2,and PCV3 DNA in the tissue samples of Chinese wild boars were 1.6%(4/247),58.3%(144/247),and 10.9%(27/247)respectively,with none positive for PCV4.Sequence analysis of viral genome showed that the four PCV1 strains distributed in Hunan and Inner Mongolia shared 97.5%–99.6%sequence identity with global distributed reference strains.Comparison of the ORF2 gene sequences showed that 80 PCV2 strains widely distributed in 18 regions shared 79.5%–100%sequence identity with reference strains from domestic pigs and wild boars,and were grouped into PCV2a(7),PCV2b(31)and PCV2d(42).For PCV3,17 sequenced strains shared 97.2%–100%nucleotide identity at the genomic level and could be divided into PCV3a(3),PCV3b(2)and PCV3c(12)based on the phylogeny of ORF2 gene sequences.Serological data revealed antibody positive rates against PCV1 and PCV2 of 11.4%(19/167)and 53.9%(90/167)respectively.The data obtained in this study improved our understanding about the epidemiological situations of PCVs infection in free-ranging wild boars in China and will be valuable for the prevention and control of diseases caused by PCVs infection. | Wenjie Gong Haiying Du Tong Wang Heting Sun Peng Peng Siyuan Qin Haidong Geng Zheng Zeng Wangwang Liang Hongquan Ling Changchun Tu Zhongzhong Tu | 2023 | Virologica Sinica2023，38，5： | 0 |
| 15 | Direct Electron Transfer Reactions of Glucose Oxidase and D-Amino Acid Oxidase at a Glassy Carbon Electrode in Organic Media显示文摘DirectElectronTransferReactionsofGlucoseOxidaseandD┐AminoAcidOxidaseataGlasyCarbonElectrodeinOrganicMediaWeiJianjunQinYiqinLi... | Wei Jianjun Qin Yiqin Liu Haiying(School of Chemistry and Chemical Engineering) Deng Jiaqi(Fudan University) | 1998 | Advances in Manufacturing1998，，1： | 0 |
| 16 | Integrative proteomic-transcriptomic analysis revealed the lifestyles of Lactobacillus paracasei H4-11 and Kluyveromyces marxianus L1-1 under co-cultivation conditions显示文摘Compared with the rice-acid soup inoculated with single starter,the synergistically intensifi ed rice-acid soup inoculated with Lactobacillus paracasei H4-11(L.paracasei H4-11)and Kluyveromyces marxianus L1-1(K.marxianus L1-1)contained more fl avor compounds.Organic acids mainly included L-lactic acid and the main volatile fl avor component was ethyl acetate.Moreover,the signal intensity of astringency and bitterness and the total concentration of volatile sulfur compounds were reduced.The combined analysis results of RNA sequencing(RNA-seq)technology and 4D label-free quantitative(4D LFQ)proteomics explained the fl avor formation pathways in rice-acid soup inoculated with L.paracasei H4-11 and K.marxianus L1-1.In L.paracasei H4-11,L-lactate dehydrogenase,phosphoglucomutase,acetate kinase,alcohol dehydrogenase and acetyl-CoA were up-regulated and D-lactate dehydrogenase and N-Acetyltransferase were down-regulated.In K.marxianus L1-1,Acetyl-CoA,acetaldehyde dehydrogenase,acyl-coenzyme A,N-acetyltransferase,and L-lactate dehydrogenase were up-regulated and hexokinase,alcohol dehydrogenase,and alcohol O-acetyltransferase were down-regulated.The above up-regulation and down-regulation synergistically promoted the formation of characteristic fl avor compounds(mainly L-lactic acid and ethyl acetate).Enzyme-linked immunoassay(ELISA)and parallel reaction monitoring(PRM)quantitative analysis respectively verifi ed that 5 key metabolic enzymes and 27 proteins in L.paracasei H4-11 and K.marxianus L1-1 were associated with the characteristic fl avor of rice-acid soup,as confi rmed by the quantitative results of 4D LFQ. | Na Liu Likang Qin Haiying Zeng Anyan Wen Song Miao | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
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