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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Detection of Eperythrozoon suis DNA from swine blood by whole organism DNA hybridizations显示文摘 | Oberst R D Hall S M Schoneweis D A | 1990 | Vet Microb1990，24，： | 1 |
| 4 | Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo显示文摘 | Brain S D | 1999 | Br J Pharmacol1999，26，1： | 1 |
| 5 | Characterization of randomly-obtained matrix attachment regions (MARs) from higher plants显示文摘 | Michalowski S M Alien G C Hall G E Thompson W F Spiker S | 1999 | Biochemistry1999，38，12： | 1 |
| 6 | Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturtion of homologous single-stranded DNA显示文摘 | Hall S D Kane M F Kolodner R D | 1993 | J Bacteriol1993，175，： | 1 |
| 7 | Remodeling of the pulmonary arteries during recovery from pulmonary hypertension induced by neonatal hypoxia显示文摘 | Hall S M Hislop A A Wu Z S | 2004 | J Pahtol2004，203，： | 1 |
| 8 | Freezing point de- pression of NaC1-KCI-H20 solutions 显示文摘 | Hall D L Sterner S M and Bodner R J | 1988 | Economic Geology1988，100，5： | 1 |
| 9 | Recovery after open versus laparoscopic pyloromyotomy for pyloric stenosis:a double-blind multicentre randomised controlled trial显示文摘 | Hall NJ Pacilli M Eaton S | | 0，，9661： | 1 |
| 10 | Guideline for the management of nonmusele invasive bladder cancer (stages Ta, T1, and Tis): 2007 Update显示文摘 | Hall M C Chang S S Dalbagni G | 2007 | J Urol2007，178，6： | 1 |
| 11 | Calculation of lipophilieity of a large, diverse dataset of antieancer platinum complexes and the relation to cellular uptake 显示文摘 | Oldfield S P Hall M D Platts J A | 2007 | Journal of medicinal chemistry2007，50，21： | 1 |
| 12 | Detection of Epery throzoon suis DNA from swine blood by whole organism DNA hybridizations 显示文摘 | Oberst R D Hall S M Schoneweis D A | 1990 | Vet Microbiol1990，24，2： | 1 |
| 13 | Isolation of infective and non-infective Eperythrozoon suis bodies from the whole blood of infected swine显示文摘 | Hall S M Cipriano J A Schoneweis D A | 1988 | Vet Rec1988，123，： | 1 |
| 14 | The release of spinal prostaglandin E2 and the effect of nitric oxide synthetase inhibition during strychnine-induced allodynia显示文摘 | MILNE B HALL S R SULLIVAN M E | 2004 | Anesth Analg2004，93，3： | 1 |
| 15 | The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord显示文摘 | HALL S M | 1972 | J Cell Sci1972，10，2： | 1 |
| 16 | Generalized Flory equations of state for hard heteronuclear chain molecules 显示文摘 | Gulati H S Wichert J M Hall C K | 1996 | Journal of Chemical Physics1996，104，13： | 1 |
| 17 | Freezing point depression of NaCl-KCl-H2O solutions显示文摘 | Hall D L Sterner S M Bodnar R J | 1988 | Economic Geology1988，83，： | 1 |
| 18 | Subpicosecond spin relaxation in GaAsSb multiple quantum wells显示文摘 | Hall K C Leonard S W Direl H M | 1999 | Appl Phys Lett1999，75，： | 1 |
| 19 | Freezing point depression of NaC1-KCI-HzO solutions显示文摘 | HALL D L STERNER S M BODNAR R J | 1988 | Economic Geology1988，83，： | 1 |
| 20 | Regeneration of adult axons in white matter tracts of the central nervous system显示文摘 | Davies S J Fitch M T Memberg S P Hall A K Raisman G Silver J | 1997 | Nature1997，390，： | 1 |
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