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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 3 | Renal function as a predictor of outcome in a broad spectrum of patients with heart failure显示文摘 | HANS L HILLEG E DOROTHEA N | 2006 | Circulation2006，113，： | 1 |
| 4 | Molecular basis for the herbicide resistance of roundup ready crops显示文摘 | Todd F Han H J Healy-Fried M L Fischer M Schnbrunn E | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，，13： | 1 |
| 5 | An uhrastrac-tural analysis of the prototype single step adhesive appliedon enamel and dentin surfaces显示文摘 | HAN L CRUE E FUKUSHIMA M | 2004 | Dent Mater2004，23，3： | 1 |
| 6 | Vehicle routing under time-dependent travel times: the impact of congestion avoidance显示文摘 | A L Kok E W Hans J M J Schutten | 2012 | Computers & Operations Research2012，39，5： | 1 |
| 7 | A Delay Systems Method for Designing Event-triggered Controllers of Networked Control Systems 显示文摘 | Yue D Tian E G Han Q L | 2013 | IEEE Transactions on Automatic Control2013，58，2： | 1 |
| 8 | DNA methylation regulatesMicroRNA expression显示文摘 | Han L Witmer PD Casey E | 2007 | Cancer Biol Ther2007，6，8： | 1 |
| 9 | Four prodator- prey models with infectious diseases 显示文摘 | HAN L T MA Z E HETHCOTE H W | 2001 | Mathl Comput Modelling2001，34，： | 1 |
| 10 | Effects of race-earth elements Gd and Y on the solid solution strengthening of Mg alloys显示文摘 | GAO L CHEN R S HAN E H | 2009 | Journal of Alloys and Compounds2009，481，12： | 1 |
| 11 | 显示文摘 | Do L Han E Yamamoto N | 1996 | Mol Cryst Liq Cryst1996，280，： | 1 |
| 12 | Prostaglandin E2-bisphosphonate conjugates:potential agents for treatment of osteoporosis显示文摘 | Gil L Han Y Opas E E | 1999 | Bioorg Med Chem1999，7，： | 1 |
| 13 | Expandable metal stents for the palliation of malignant gastroduodenal obstruction显示文摘 | Rudeean R Hans -Ulrich L Ruth E | 2001 | Cardiovasc Intervent Radiol2001，24，5： | 1 |
| 14 | Effects of rare-earth elements Gd and Y on the solid solution strengthening of Mg alloys 显示文摘 | Gao L Chen R S Han E H | 2009 | Journal of Alloys and Compounds2009，481，1： | 1 |
| 15 | Calpain system regulates muscle mass and glucose transporter GLUT4 turnover显示文摘 | Otani K Han D H Ford E L | 2004 | Biological chemistry2004，278，20： | 1 |
| 16 | Solid solution strengthe-ning behaviors in binary Mg - Y single phase alloys显示文摘 | Gao L Chen R S Han E H | 2009 | Journal of Alloys and Compounds2009，，： | 1 |
| 17 | Application of dispersive liquid-liquid microextraction for the analysis of organophosphorus pesticides in watermelon and cucumber显示文摘 | Zhao E C Zhao W T Han L J | | 0，，1： | 1 |
| 18 | e-Mye-induced, long, noneoding H19 affeets cell proliferation and prediets a poor prognosis in patients with gastric cancer显示文摘 | Zhang E B Han L Yin D D | 2014 | Med Oneol2014，31，： | 1 |
| 19 | Development of the pen tile matrix color AMLCD sub-pixel architecture and rendering algorithms 显示文摘 | Brown E C H Credelle T L Han S | 2003 | Journal of the SID2003，11，1： | 1 |
| 20 | Ultra - compact di?rectional couplers and Mach - Zehnder interferometers employing surface plasmon polaritons 显示文摘 | HAN Z H LIU L FORSBERG E | 2006 | Opt Commun2006，259，： | 1 |
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