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| 1 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 2 | Research on a Multi-grid Model for Passenger Evacuation in Ships显示文摘In order to enhance the authenticity and accuracy of passenger evacuation simulation in ships, a new multi-grid model was proposed on the basis of a traditional cellular automata model. In the new model finer lattices were used, interaction of force among pedestrians or between pedestrians and constructions was considered, and static floor fields in a multi-level exit environment were simplified into cabin and exit static floor fields. Compared with the traditional cellular automata model, the multi-grid model enhanced the continuity of the passengers'track and the precision of the boundary qualifications. The functions of the dislocation distribution of passengers as well as partial overlap of tracks due to congestion were realized. Furthermore, taking the typical cabin environment as an example, the two models were used to analyze passenger evacuation under the same conditions. It was found that the laws of passenger evacuation simulated by the two models are similar, while the simulation's authenticity and accuracy are enhanced by the multi-grid model. | Miao Chen Duanfeng Han Haipeng Zhang | 2011 | Journal of Marine Science and Application2011，10，3： | 4 |
| 3 | Enormous enhancement in electrical performance of few-layered MoTe2 due to Schottky barrier reduction induced by ultraviolet ozone treatment显示文摘Doping can improve the band alignment at the metal-semiconductor interface to modify the corresponding Schottky barrier,which is crucial for the realization of high-performance logic components.Here,we systematically investigated a convenient and effective method,ultraviolet ozone treatment,for p-type doping of MoTe2 field-effect transistors to enormously enhance the corresponding electrical performance.The resulted hole concentration and mobility are near 100 times enhanced to be〜1.0×10^13 cm^-2 and 101.4 cm^2/(V·s),respectively,and the conductivity is improved by 5 orders of magnitude.These values are comparable to the highest ones ever obtained via annealing doping or non-lithographic fabrication methods at room temperature.Compared with the pristine one,the photoresponsivity(522 mA/W)is enhanced approximately 100 times.Such excellent performances can be attributed to the sharply reduced Schottky barrier because of the surface charge transfer from MoTe2 to MoOx(x<3),as proved by photoemission spectroscopy.Additionally,the p-doped devices exhibit excellent stability in ambient air.Our findings show significant potential in future nanoelectronic and optoelectronic applications. | Xiaoming Zheng Xueao Zhang Yuehua Wei Jinxin Liu Hang Yang Xiangzhe Zhang Shitan Wang Haipeng Xie Chuyun Deng Yongli Gao Han Huang | 2020 | Nano Research2020，13，4： | 3 |
| 4 | Who may benefit from lower dosages of intravenous tissue plasminogen activator? Results from a cluster data analysis显示文摘background The risk of symptomatic intracranial haemorrhage(sICH)after thrombolysis is low but severe.Lower dose of alteplase may reduce the risk of sICH.We aim to identify subsets of patients who could benefit from lower dose of alteplase compared with standard dose.Methods Data from two observational registries were pooled together.A total of 3479 patients who had acute ischaemic stroke were entered into the interaction tree model.The response variable was the rate of sICH per the definition of the National Institute of Neurological Disorders and Stroke Study.Clinical improvement was measured by the National Institutes of Health Stroke Scale(NIHSS)and defined as NIHSS 0 or 1 or an improvement of more than 4 points(within 7 days or at discharge).Rare event logistic regression was performed to analyse the OR of safety outcome.results To optimise the interaction effect between tissue plasminogen activator(tPA)dosage(standard/lower)and patient subgroups,three subgroups based on the severity of stroke were identified:(1)NIHSS≤4,(2)NIHSS between 5 and 14,and(3)NIHSS≥15.The estimated difference of OR of having sICH was 2.71(95%CI 0.80 to 7.69,p=0.10)for mild,0.13(95%CI 0.02 to 0.68,p=0.01)for moderate,and 0.65(95%CI 0.19 to 2.55,p=0.52)for severe,respectively.In addition,patients who had moderate stroke treated with lower dose had comparable efficacy outcome(OR 1.23,95%CI 0.71 to 2.13,p=0.45).Conclusion Our analysis demonstrated that in patients who had moderate stroke,lower doses of alteplase are associated with significant sICH reduction and non-inferior performance in efficacy,compared with those in the standard dose group. | Yi Dong Ye Han Haipeng Shen Yilong Wang Frank Ma Hao Li Yongjun Wang Qiang Dong | 2020 | Stroke & Vascular Neurology2020，5，4： | 3 |
| 5 | A Novel Time-aware Frame Adjustment Strategy for RFID Anti-collision显示文摘Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyzes the deficiencies of the state-of-the-arts algorithms and proposes a novel sub-frame-based algorithm with adaptive frame breaking policy to lower the tag identification time for EPC global C1 Gen2 UHF RFID standard.Through the observation of slot statistics in a sub-frame,the reader estimates the tag quantity and efficiently calculates an optimal frame size to fit the unread tags.Only when the expected average identification time in the calculated frame size is less than that in the previous frame size,the reader starts the new frame.Moreover,the estimation of the proposed algorithm is implemented by the look-up tables,which allows dramatically reduction in the computational complexity.Simulation results show noticeable throughput and time efficiency improvements of the proposed solution over the existing approaches. | Haipeng Chen Kexiong Liu Chunyang Ma Yu Han Jian Su | 2018 | Computers, Materials & Continua2018，，11： | 2 |
| 6 | A numerical study on the axial crushing response of hybrid puhruded and ±45° braided tubes 显示文摘 | Han Haipeng Taheri Farid Pegg Neil Lu You | 2007 | Composite Structures2007，80，2： | 1 |
| 7 | Quasi-- static and Dynamic Crushing Behaviors of Aluminum and Steel Tubes with a Cutout显示文摘 | Han Haipeng Taheri F Pegg N | 2007 | Thin--walled Structures2007，45，3： | 1 |
| 8 | Theoretical studies on anisotro-py of the first hyperpolarizabilities in one-and two-dimen-sionai charge transfer molecules:Role of frequency disper-sion显示文摘 | Li Haipeng Han Kui | 2007 | Chem Phys Lett2007，444，13： | 1 |
| 9 | The first hyperpolarizabilities of hemicyanine cationic derivatives studied by finite-field (FF)calculations显示文摘 | Li Haipeng Han Kui | 2006 | J Mol Struct2006，767，13： | 1 |
| 10 | Numerical and experimental investigations of the response of aluminum cylinders with a cutout subject to axial compression 显示文摘 | Han Haipeng Chen Jinquan Taheri Farid Pegg Neil | 2006 | Thin-Walled Structures2006，44，： | 1 |
| 11 | Numerical and experimental investigations of the response of aluminum cylinders with a cutout subject to axial compression 显示文摘 | Han Haipeng Chen Jinquan Taheri Farid Pegg Neil | 2006 | Thin-Walled Structures2006，44，： | 1 |
| 12 | Lamin A/C Modulate Apoptosis of Rat Vascular Smooth Muscle Cells During Cyclic Stretch Application显示文摘Objective The apoptosis of vascular smooth muscle cells(VSMCs)influenced by abnormal cyclic stretch is crucial for vascular remodeling during hypertension.We explored that the causes of mechano-responsive lamin A/C changingin aonormai cyclic stretcn and its roles in VSMC apoptosis.Methods and results Our previous vascular proteomics study revealed that LaminA/C is mechano-sensitive molecule.When VSMCs are subjected to cyclic stretch,the expression of LaminA/C is significantly changed which participates dysfunctions of VSMCs during hypertension.However,the molecular mechanism involved in regulation of LaminA/C expression and the role of LaminA/C in the VSMC apoptosis during cyclic stretch application are still unclear.In the present study,VSMCs were subjected to different amplitudes of cyclic steetch in vitro:5%cyclic stretch(physiological strain)or 15%cyclic stretch(pathological strain).The expression of 2 different selective cleavage isomers of LaminA/C,i.e.LaminA and LaminC,and the apoptosis of VSMCs were detected.The results showed that compared with 5%group,15%cyclic stretch significantly decreased the expression of LaminA and LaminC,and promoted the apoptosis of VSMCs.Using specific small interfering RNA(siRNA)transfection which targets on LMNA the encoding gene of LaminA/C,the expression of LaminA and LaminC in VSMCs was significantly decreased,and the apoptosis was significantly increased.In order to study the molecular mechanism involved in cyclic stretch regulating the expression of LaminA/C,we focused on the microRNA(miR).Bioinformatics analysis showed that the 3’untranslated region(3’UTR)of LMNA has two potential binding sites to miR-124-3p.Double luciferase reported system revealed that both sites have binding abilities to miR-124-3p.Under static condition,miR-124-3p inhibitor significantly up-regulated the expression levels of LaminA and LaminC,while the miR-124-3p mimics significantly down-regulated them.RT-PCR results showed that 15%cyclic stretch significantly up-regulated the expression of miR-124-3p compared with 5%cyclic stretch.Furthermore,in order to study the role of changeed LaminA/C in VSMC apoptosis,LMNA-specific siRNA was transfected to repress the expression of LaminA/C in VSMCs,and Protein/DNA microarray was used to detecte the activity of transcription factors.The transcription factors whose activity were changed significantly(increase or decrease more than 2 times)were analyzed by cluster analysis and ingenurity pathway analysis(IPA).Six transcription factors associated with apoptosis were screened,in which TP53 was activated by the specific siRNA transfection and the other 5 were inavtived,including TP53,CREB1,MYC,STAT1/5/6 and JUN.Using abdominal aorta coarctation hypertensive model,the change of miR-124-3p in VSMCs was explored in vivo.A marked increase of miR-124-3p in thoracic aorta was revealed compared with the sham-operated controls,and in situ FISH revealed that this increase was mainly in the VSMCs.Conclusions The present study suggest that abnormally increased cyclic stretch(15%)up-regulates the expression of miR-124-3p in VSMCs,which subsequently targets on the 3’UTR of LMNA and decreases the expression of nuclear envelope protein LaminA/C;the repressed LaminA/C may play an important role in the apoptosis of VSMCs by regulating the activity of virious transcription factors,such as TP53,CREB1,MYC,STAT1/5/6 and JUN.The present study may provide a new insight into understanding the molecular mechanisms of vascular remodeling. | Han Bao Haipeng Li Qian Shi Kai Huang Yingxin Qi | 2019 | 医用生物力学2019，34，A01： | 0 |
| 13 | Assessing non-point source pollution in an apple-dominant basin and associated best fertilizer management based on SWAT modeling显示文摘Investigating the impact of apple-dominated areas on nitrogen(N)and phosphorus(P)losses at a basin scale was essential for the sustainable development of apple industry in China.This study conducted a survey on fertilizer application and built a Soil and Water Assessment Tool(SWAT)model to quantita-tively analyze the N and P losses in the Qixia apple-dominated area.Additionally,the decreases in N and P losses through adjusting the fertilizer application modes were evaluated.Results showed that average N and P losses in the Wulong River Basin(WRB)were 44.4 and 0.365 kg ha^(-1)in 2011-2017,respectively,and apple orchards accounted for 733%and 51.4%of the total N and P losses in the basin.Under nine fertilizer scheduling scenarios,three fertilizer schedule scenarios,automatic fertilizer application(S-AUTO),'one shot'mode(S1),and regulated fertilizer application(S-BSD),had the lowest N and P losses in apple orchards.The decreases in N loss ranged from 20.6%to 26.1%at the subbasin scale and 14.8%-30.7%at the basin outlet when applying the S-AUTO,S1,and S-BSD fertilizer application modes in Qixia apple orchards and all apple orchards in the WRB.The reductions in P loss varied from 22.0%to 46.1%at the subbasin scale and 14.6%-25.6%at the basin outlet.In orchard-dominated basin,N and P losses can be effectively reduced by optimizing the orchard fertilizer scheduling strategies. | Yiwen Han Zhong Liu Yafei Chen Yingxuan Li Haipeng Liu Lianghong Song Yong Chen | 2023 | International Soil and Water Conservation Research2023，11，2： | 0 |
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