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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 3 | 大塑性变形6013铝合金的时效特性与力学性能(英文)显示文摘利用X射线衍射分析(XRD)、差示扫描量热法(DSC)和拉伸试验,研究不同温度等通道转角挤压(ECAP)和常规静态时效处理后6013 Al-Mg-Si铝合金的微观结构、时效行为、析出动力学以及力学性能。XRD测得的ECAP变形后合金的平均晶粒尺寸在66-112 nm范围内,平均位错密度在1.20×10^14-1.70×10^14 m^-2范围内。DSC分析表明,由于ECAP后试样比常规时效处理试样拥有更细小的晶粒和更高的位错密度,因此,ECAP变形后合金的析出动力学更快。与未变形合金相比,ECAP后试样的屈服强度和抗拉强度都得到了显著提高。室温ECAP后试样的强度达到最大,其屈服强度是静态峰时效屈服强度的1.6倍。细晶强化、位错强化以及由于ECAP过程中的动态析出而产生的析出相强化,是ECAP合金获得高强度的几种主要强化机制。 | 刘满平 蒋婷慧 王俊 刘强 吴振杰 Ying-da YU Pl C.SKARET Hans J.ROVEN | 2014 | Transactions of Nonferrous Metals Society of China2014，24，12： | 8 |
| 4 | An efficient descriptor model for designing materials for solar cells显示文摘An efficient descriptor model for fast screening of potential materials for solar cell applications is presented.It works for both excitonic and non-excitonic solar cells materials,and in addition to the energy gap it includes the absorption spectrum(α(E))of the material.The charge transport properties of the explored materials are modelled using the characteristic diffusion length(Ld)determined for the respective family of compounds.The presented model surpasses the widely used Scharber model developed for bulk heterojunction solar cells.Using published experimental data,we show that the presented model is more accurate in predicting the achievable efficiencies.To model both excitonic and non-excitonic systems,two different sets of parameters are used to account for the different modes of operation.The analysis of the presented descriptor model clearly shows the benefit of includingα(E)and Ld in view of improved screening results. | Fahhad H Alharbi Sergey N Rashkeev Fedwa El-Mellouhi Hans P Lüthi Nouar Tabet Sabre Kais | 2015 | npj Computational Materials2015，，1： | 3 |
| 5 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 6 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 7 | Transcatheter closure of membranous ventricular septal defects with a new nitinol prosthesis in a natural swine model显示文摘 | Gu X P Han Y M Titus J L | 2000 | Cathete Cardiovasc Intervent2000，50，4： | 2 |
| 8 | Proinflammatory cytokines cause NO dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells显示文摘 | Han X Fink M P Delude R L | 2003 | Shock2003，19，3： | 1 |
| 9 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 10 | Roles of SM22ct in cellular plasticity and vascular diseases 显示文摘 | Dong L H Lv P Han M | 2012 | Cardiovas Hematol Disord Drug Targets2012，12，2： | 1 |
| 11 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 12 | Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species显示文摘 | Chen S L Yao H Han J P | 2010 | PLoS ONE2010，5，1： | 1 |
| 13 | Microbial degradation of quinQline by immobilized cells of Burkholderia pickettii 显示文摘 | Wang J L Quan X C Han L P | 2002 | Water Res2002，36，9： | 1 |
| 14 | Efficient transformation of Actinidia arguta by reducing the strength of basal salts in the medium to alleviate callus browning显示文摘 | Han M L Gleave A P Wang T C | 2010 | Plant B iotechnology Reporter2010，4，： | 1 |
| 15 | Banana polyphenol oxidase: occurrence and change of polypheno| o~idase activity in some banana cultivars during fruit development 显示文摘 | YangC P NongZR LuJL LU L Xu J S Han YZ Li Y J Fujita S | 2004 | Food Science Technology2004，10，1： | 1 |
| 16 | Inhibitory effects of P-alkyl-benzoic acids on the activity of polyphenoloxidase from potato(Solanum tuberosum) 显示文摘 | LIN M KE L HAN P | 2010 | Food Chemistry2010，119，2： | 1 |
| 17 | Improving wireless phys- ical layer security via cooperating relays显示文摘 | DONG L HAN Z PETROPULU A P | 2010 | IEEE Transactions on Signal Processing2010，58，3： | 1 |
| 18 | Hydrodynamic lubrication of micro-dimple texture surface using three-dimensional CFD 显示文摘 | Han J Fang L Sun J P | 2010 | Tribology Transactions2010，53，6： | 1 |
| 19 | Improving wireless physi- cal layer security via cooperating relays 显示文摘 | DONG L HAN Z PETROPULU A P | 2010 | IEEE Trans on Signal Processing2010，58，3： | 1 |
| 20 | 查看详情显示文摘 | Ju L P Han K L Zhang J Z H | | 0，，： | 1 |
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