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| 1 | Acute inflammation stimulates a regenerative response in the neonatal mouse heart显示文摘 | Chunyong Han Yu Nie Hong Lian Rui Liu Feng He Huihui Huang Shengshou Hu | 2015 | Cell Research2015，25，10： | 26 |
| 2 | Simulation on dissolute and dust dispersion in comprehensive mechanized heading face with forced-exhaust ventilation显示文摘 | NIE Wen CHENG Wei-min HAN Li ZHOU Sheng-ju YU Yan-bin ZHAO Shan-shan | 2011 | Journal of Coal Science & Engineering(China)2011，17，3： | 21 |
| 3 | Antimony(V) removal from water by hydrated ferric oxides supported by calcite sand and polymeric anion exchanger显示文摘We fabricated and characterized two hybrid adsorbents originated from hydrated ferric oxides(HFOs) using a polymeric anion exchanger D201 and calcite as host. The resultant adsorbents(denoted as HFO-201 and IOCCS) were employed for Sb(V) removal from water. Increasing solution pH from 3 to 9 apparently weakened Sb(V) removal by both composites, while increasing temperature from 293 to 313 K only improved Sb(V) uptake by IOCCS. HFO-201 exhibited much higher capacity for Sb(V) than for IOCCS in the absence of other anions in solution. Increasing ionic strength from 0.01 to 0.1 mol/L NaNO3would result in a significant drop of the capacity of HFO-201 in the studied pH ranges; however, negligible effect was observed for IOCCS under similar conditions. Similarly, the competing chloride and sulfate pose more negative effect on Sb(V) adsorption by HFO-201 than by IOCCS, and the presence of silicate greatly decreased their adsorption simultaneously, while calcium ions were found to promote the adsorption of both adsorbents. XPS analysis further demonstrated that preferable Sb(V) adsorption by both hybrids was attributed to the inner sphere complexation of Sb(V) and HFO, and Ca(II) induced adsorption enhancement possibly resulted from the formation of HFO-Ca-Sb complexes. Column adsorption runs proved that Sb(V) in the synthetic water could be effectively removed from 30 μg/L to below 5 μg/L(the drinking water standard regulated by China), and the effective treatable volume of IOCCS was around 6 times as that of HFO-201, implying that HFO coatings onto calcite might be a more effective approach than immobilization inside D201. | Yangyang Miao Feichao Han Bingcai Pan Yingjie Niu Guangze Nie Lu Lv | 2014 | Journal of Environmental Sciences2014，26，2： | 20 |
| 4 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 5 | Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention显示文摘 | LIU Xiao-li WANG Zhi-jian YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie | 2012 | Chinese Medical Journal2012，，6： | 12 |
| 6 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 7 | Microcrack analysis of Sanya grantite fragments from rockburst tests显示文摘Fractures running along a plane reflect the cracking progress.In this paper uniaxial and rockburst tests on a group of granite specimens from Sanya province are described.Scanning electron microscopic imaging was used to characterize the fragments.Fractal fracture mechanics were used to analyze the microcracks in terms of both the crack type and the mineral constituent.A statistical analysis showed that the area of inter-granular cracking exceeds that of intra-granular cracking.Several types of crack were observed in the cracked areas.The percentage of intra-granular cracks in fragments from rockburst tests exceeds that from uniaxial compression tests.The results also showed that feldspar deformation was the main cause of fracture and that the consolidation along quartz grain boundaries was another weak area in the granite.Cracking along quartz grains had enough energy to enter the quartz crystal in the rockburst samples.All these results contribute to further research on rockburst mechanics. | HE, Manchao NIE, Wen HAN, Liqiang LING, Lijing | 2010 | Mining Science and Technology2010，20，2： | 11 |
| 8 | Attention-based encoder-decoder model for answer selection in question answering显示文摘问答技术的重要挑战之一就是解决问题与答案之间的语义空白。机器翻译模型已经被证明能有效的提升解决问题与答案之间的语义空白。本文提出了一种基于注意机制的深度神经网络模型来解决问答系统中的答案选择任务。该模型采用了基于双向长短时记忆(Long short-term memory,LSTM)的编码解码模型,编码解码模型是一个被证明再机器翻译领域取得了突出的成绩。我们还在模型中应用了注意力机制来提升模型的效果。本文在一个公开数据集上验证了实验的有效性,同时通过结合该模型显著提高了问答系统的性能在TREC 2015 liveQA的任务中。 | Yuan-ping NIE Yi HAN Jiu-ming HUANG Bo JIAO Ai-ping LI | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，4： | 11 |
| 9 | Study on interaction between microtubule associated protein tau and prion protein显示文摘Microtubule-associated protein tau is considered to play roles in many neurodegenera-tive diseases including some transmissible spongiform encephalopathies.To address the possible molecular linkage of prion protein(PrP) and tau,a GST-fusion segment of human tau covering the three-repeat region and various PrP segments was used in the tests of GST pull-down and immuno-precipitation.We found tau protein interacted with various style prion proteins such as native prion protein(PrPC) or protease-resistant isoform(PrPSc) .Co-localization signals of tau and PrP were found in the CHO cell tranfected with both PrP and tau gene.The domain of interaction with tau was located at N-terminal of PrP(residues 23 to 91) .The evidence of molecular interactions between PrP and tau protein highlights a potential role of tau in the biological function of PrP and the pathogenesis of TSEs. | HAN Jun1,ZHANG Jin1,2,YAO Hailan1,3,WANG Xiaofan1,LI Feng1,CHEN Lan1,4,GAO Chen1,GAO Jianmei1,NIE Kai1,ZHOU Wei1 & DONG Xiaoping11.State Key Laboratory for Infectious Diseases Prevention and Control,National Institute for Viral Disease Control and Pre-vention,Chinese Center for Disease Control and Prevention,Beijing 100052,China 2.School of Medicine,Xi’an Jiao-Tong University,Xi’an 710061,China 3.Tong-Ji Medical College,Hua-Zhong University of Science and Technology,Wuhan 430030,China 4.National Laboratory of Medical Molecular Biology,Institute of Basic Medical Science,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China | 2006 | Science China(Life Sciences)2006，49，5： | 10 |
| 10 | Spatial Distribution of Soil Organic Matter and Nutrients in the Pear Orchard Under Clean and Sod Cultivation Models显示文摘The soil organic matter and nutrients are fundamental for the sustainability of pear production, but little is known about the spatial distribution of soil organic matter and nutrients in a pear orchard. With the soil of the pear (cv. Dangshansu on P.betulifolia Bunge. rootstock) orchard under clean and sod cultivation models as test materials, the experiment was conducted to evaluate spatial variability of soil organic matter (SOM), total nitrogen (STN), total phosphorus (STP), total potassium (STK), available nitrogen (SAN), and available potassium (SAK) in and between rows at different soil depths (0-60 cm). The SOM, STN, STP, STK, SAN and SAK of the different soil layers under the two tillage models were different in the vertical direction. The SOM, STN, STP and SAN in the 0-20 cm soil layer were higher than those in the 20-40 and 40-60 cm soil layers. The STK of 40-60 cm soil layer was higher than that in the 0-20 and 20-40 cm soil layers. The STK increased with the depth of soil in the vertical direction in the clean cultivated pear orchard. Variability of the SOM, STN, STP, STK, SAN and SAK of sample sites in between rows of the same soil layer was found in the pear orchard soil in the horizontal direction under clean and sod cultivation management systems, except that STK of all sites did not show the difference in identical soil layers in the pear orchard under clean cultivation. The sod cultivation model improved the SOM, STN, and STK in the 0-20 cm soil layer in the pear orchard, and the three components increased by 12.8, 12.7 and 7.3% compared to clean cultivation, respectively. The results can be applicable to plan collection of orchard soil samples, assess orchard soil quality, and improve orchard soil management practices. | XU Ling-fei ZHOU Peng HAN Qing-fang LI Zhi-hui YANG Bao-ping NIE Jun-feng | 2013 | Journal of Integrative Agriculture2013，12，2： | 10 |
| 11 | Effect of replacing antibiotics using multi-enzyme preparations on production performance and antioxidant activity in piglets显示文摘The study was conducted to investigate the effects of replacing antibiotics using multi-enzyme preparations on growth performance,coefficient of total tract apparent digestibility,digestive enzyme activity,and antioxidant property in piglets.A total of 160 piglets((21.35±0.22)kg)were randomly assigned to five dietary treatments:1)basal diet supplemented with antibiotics(AC),2)antibiotic diet supplemented with 0.5 g kg^(–1) multi-enzyme preparations(AC+0.5EP),3)antibiotic diet supplemented with 1.5 g kg^(–1) multi-enzyme preparations(AC+1.5EP),4)basal diet supplemented with a half dosage of antibiotics and 1.5 g kg^(–1) multi-enzyme preparations(AH+1.5EP),and 5)basal diet supplemented with 1.5 g kg^(–1) multienzyme preparations(BC+1.5EP).The results showed that AC+1.5EP significantly improved the feed efficiency,apparent digestibility of ether extract(EE)and crude ash(CA),lipase activity in pancreas and duodenum content,maltase and lactase activity in jejunum and ileum mucosa,glutathione peroxidase(GSH-Px)concentration in serum and liver,and decreased malondialdehyde(MDA)concentration in serum and liver compared with piglets receiving AC(P<0.05).Piglets receiving BC+1.5EP showed no significant difference in growth performance(P>0.05)but had lower MDA concentration than piglets receiving AC(P<0.05).The apparent digestibility of EE and crude fiber(CF),duodenal lipase activity,jejunum mucosa maltase,and ileum mucosa lactase activity of piglets receiving AH+1.5EP or BC+1.5EP were significantly improved compared with piglets receiving AC(P<0.05).These results indicated an additive growth promotion effect between antibiotics and multi-enzyme preparations on piglets,and the multi-enzyme preparations may be used as substitutes for antibiotics for improving piglet production performance and health status. | HAN Xin-yan YAN Feng-ying NIE Xin-zheng XIA Wei CHEN Sha ZHANG Xiao-xu QIAN Li-chun | 2017 | Journal of Integrative Agriculture2017，16，3： | 9 |
| 12 | Application of 3D-computed tomography angiography technology in large meningioma resection显示文摘Objective:To discuss the role of 3D-computed tomography angiography(3D-CTA) technology in reducing injuries of large meningioma surgery.Methods:3D-CTA preoperative examinations were done in 473 patients with large meningioma(simulated group).The images were analyzed by 30 post-processing workstation.By observing the major intracranial blood vessels,venous sinus,and the compression and invasion pattern in the nerve region,assessing risk level of the surgery,simulating the surgical procedures,the surgical removal plan,surgical routes and tumor blood-supplying artery embolisation plan were performed.Two hundred and fifty seven large meningioma patients who didn’t underwent 3D-CTA preoperative examination served as control group.The incidence of postoperative complications,intraoperative blood transfusion and the operation time were compared between these two groups.Results:Compared with the control group,the Simpson’s grade 1 and 11 resection rate was 80.3%(380/473),similar with that of the control(81.3%,209/257).The incidence of postoperative complications in 3D-CTA simulated group was 37.0%which was significantly lower than that(48.2%) of the control(P<0.01). The intraoperative blood supply for simulated group and the control was(523.4±208.1) mL and (592.0±263.3) mL,respectively,with significant difference between two groups(P<0.01).And the operation time[(314.8±106.3)]min was significantly lower in simulated group than that in the control[(358.4±147.9) min](P<0.01).Conclusions:Application of 3D-CTA imaging technology in risk level assessment before large-scaled meningioma resection could assist in the rational planning of tumor resectin,surgical routes,and is helpful in reducing injuries and complications and enhancing the prognosis of the patients. | Jian-Qiang Chen Yin Guan Gang Li Xiao-Hua Li Yue-Fu Zhan Xiang-Yin Li Liu Nie Xiang-Jun Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 9 |
| 13 | DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1显示文摘Micro sate Hite instability(MSI) defines a subtype of colorectal cancer(CRC) with typical clinicopathologic characteristics. CRCs with MSI(MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlying mechanism remains incompletely understood. Our previous study has identified the microRNA(miRNA) expression profile in MSI CRCs. In this study, three miRNAs(miR-181 a, miR-135 a and miR-302 c) were validated by qRT-PCR to be dramatically decreased in 67 CRC samples. Proliferation and apoptosis assays demonstrated that miR-181 a/135 a/302 c function as tumor suppressors via repressing PLAG1/IGF2 signaling. Moreover, we presented compelling evidence that restoration of miR-181 a/135 a/302 c expression promoted sensitivity of MSI CRC cells to 5-FU treatment. miR-181 a/135 a/302 c exerted their effect on chemoresistance through attenuating PLAG1 expression. Notably, the hypermethylation status of MSI CRC accounts for the decrements of miR-181 a/135 a/302 c. Our results contribute to a better understanding of the mechanism of chemo?resistance in MSI CRCs, and provide a clue for digging the bio markers and therapeutic targets for CRC patients. | Lu Shi Xiang Li Zhiqiang Wu Xiaolei Li Jing Nie Mingzhou Guo Qian Mei Weidong Han | 2018 | Journal of Genetics and Genomics2018，45，4： | 9 |
| 14 | Mapping of a Wheat Resistance Gene to Yellow Mosaic Disease by Amplified Fragment Length Polymorphism and Simple Sequence Repeat Markers显示文摘Wheat (Triticum aestivum L.) yellow mosaic virus (WYMV) is transmitted by a fungal vector through soil and causes serious wheat yield losses due to yellow mosaic disease, with yellow-streaked leaves and stunted plants. In the present study, the amplified fragment length polymorphisms (AFLP) and simple sequence repeat (SSR) were used to identify the molecular linkages with the resistance gene against WYMV. Bulked segregant analysis was performed with an F2 population derived from the cross of cultivar Ningmai 9 (resistant) × cultivar Yangmai 10 (susceptible). By screening among the resistant or susceptible parents, the F2 pools and the individuals in the F2 population with 64 combined selective AFLP primers(EcoRI/MseI) or 290 reported SSR primers, a polymorphic DNA segment (approximately 120 bp) was amplified using the primer pair E2/M5, and an SSR marker (approximately 180 bp) was located on wheat chromosome 2A using the primer Xgwm328. Analysis with MAPMAKER/Exp Version 3.0b (Whitehead institute for Biomedical Research, Cambridge, MA, USA) indicated that these two markers were dominantly associated with the resistance gene at distances of 5.4 cM or 17.6 cM, respectively. The resistance gene to WYMV derived from Ningmai 9, is temporarily named YmNM, and was mapped to wheat chromosome 2A. | Wei-Hua LIU Huan NIE Zhen-Tian HE Xiu-Lan CHEN Yue-Peng HAN Jin-Rong WANG Xin LI Cheng-Gui HAN Jia-Lin YU | 2005 | Journal of Integrative Plant Biology2005，47，9： | 8 |
| 15 | Decellularized aorta of fetal pigs as a potential scaffold for small diameter tissue engineered vascular graft显示文摘为心血管的织物工程的背景,从猪的 acellularized biomaterials 广泛地被调查了。当为小直径织物的支架设计了下胎儿的猪的主动脉的脉管的 graft.Methods,我们的目的是学习胎儿的猪(DAFP ) 的 decellularized 主动脉的机械性质和 biocompatibility 决定它的潜力被搬迁房间使用胰岛素, ribonuclease 和 desoxyribonuclease。DAFP 的机械性质被张力的压力紧张和爆炸压力分析评估。对房间粘附和相容性的评价被播种猪的大动脉的 endothelial 房间进行。在 vivo 评估 biocompatibility, DAFP 为 2, 4 和 8 weeks.Results 组织化学皮下地被植入进成年男 Sprague Dawley 老鼠,扫描 DAFP 的电子显微镜学检查揭示了保存得很好的细胞外的矩阵蛋白质和多孔的三维的结构。与新鲜主动脉相比, DAFP 有类似的最终的张力的力量,轴的依从和爆炸压力。在 vitro 的房间文化研究证明猪的大动脉的 endothelial 房间与优秀房间生存能力在 DAFP 的表面上粘住并且增殖。Subdermal 培植证明 DAFP 没几乎显示出任何免疫学的反应并且在 DAFP 有的整个后续 period.Conclusion 期间展出最小的石灰化为小直径织物用作脚手架的潜力设计了脉管的接枝。 | LIU Guo-feng HE Zhi-juan YANG Da-ping HAN Xue-feng GUO Tie-fang HAO Chen-guang MA Hui NIE Chun-lei | 2008 | Chinese Medical Journal2008，，15： | 7 |
| 16 | Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells显示文摘Iron is an essential trophic element that is required for cell viability and differentiation, especially in oligodendrocytes, which consume relatively high rates of energy to produce myelin. Multiple iron metabolism proteins are expressed in the brain including transferrin receptor and ferritin-H. However, it is still unknown whether they are developmentally regulated in oligodendrocyte lineage cells for myelination. Here, using an in vitro cultured differentiation model of oligodendrocytes, we found that both transferrin receptor and ferritin-H are significantly upregulated during oligodendrocyte maturation, implying the essential role of iron in the development of oligodendrocytes. Additional different doses of Fe3+ in the cultured medium did not affect oligodendrocyte precursor cell maturation or ferritin-H expression but decreased the expression of the transferrin receptor. These results indicate that upregulation of both transferrin receptor and ferritin-H contributes to maturation and myelination of oligodendrocyte precursor cells. | Yunxia Li Qiang Guan Yuhui Chen Hongjie Han Wuchao Liu Zhiyu Nie | 2013 | Neural Regeneration Research2013，8，1： | 7 |
| 17 | Soil Enzyme Activities on Eroded Slopes in the Sichuan Basin, China显示文摘Determining how soil erosion affects enzyme activity may enhance our understanding of soil degradation on eroded agricultural landscapes. This study assessed the changes in enzyme activity with slope position and erosion type by selecting water and tillage erosion-dominated slopes and performing analyses using the137 Cs technique. The137 Cs data revealed that soil loss occurred in the upper section of the two eroded slope types, while soil accumulation occurred in the lower section. The invertase activity increased downslope and exhibited a pattern similar to the137 Cs data. The spatial patterns of urease and alkaline phosphatase activities were similar to the137 Cs inventories on the water and tillage erosion-dominated slopes, respectively. On both the eroded slope types, the invertase activity and soil organic carbon content were correlated, but no correlation was observed between the alkaline phosphatase activity and total phosphorus content. Nevertheless, the urease activity was correlated with the total nitrogen content only on the water erosion-dominated slopes. The enzyme activity-to-microbial biomass carbon ratios indicated high activities of invertase and urease but low activity of phosphatase on the water erosion-dominated slopes compared with the tillage erosion-dominated slopes.Both the invertase activity and the invertase activity-to-microbial biomass carbon ratio varied with the slope position. Changes in the urease activity-to-microbial biomass carbon ratio were significantly affected by the erosion type. These suggested that the dynamics of the invertase activity were linked to soil redistribution on the two eroded slope types, whereas the dynamics of the urease and alkaline phosphatase activities were associated with soil redistribution only on the water or tillage erosion-dominated slopes, respectively. The erosion type had an obvious effect on the activities of invertase, urease and alkaline phosphatase. Soil redistribution might influence the involvement of urease in the N cycle and alkaline phosphatase in the P cycle. Thus, enzyme activity-to-microbial biomass ratios may be used to better evaluate microbiological activity in eroded soils. | NIE Xiaojun ZHANG Jianhui GAO Han | 2015 | Pedosphere2015，25，4： | 7 |
| 18 | A transition prediction method for flow over airfoils based on high-order dynamic mode decomposition显示文摘This article presents a novel approach for predicting transition locations over airfoils,which are used to activate turbulence model in a Reynolds-averaged Navier-Stokes flow solver.This approach combines Dynamic Mode Decomposition(DMD)with e^Ncriterion.The core idea is to use a spatial DMD analysis to extract the modes of unstable perturbations from a steady flowfield and substitute the local Linear Stability Theory(LST)analysis to quantify the spatial growth of Tollmien–Schlichting(TS)waves.Transition is assumed to take place at the stream-wise location where the most amplified mode’s N-factor reaches a prescribed threshold and a turbulence model is activated thereafter.To improve robustness,the high-order version of DMD technique(known as HODMD)is employed.A theoretical derivation is conducted to interpret how a spatial highorder DMD analysis can extract the growth rate of the unsteady perturbations.The new method is validated by transition predictions of flows over a low-speed Natural-Laminar-Flow(NLF)airfoil NLF0416 at various angles of attack and a transonic NLF airfoil NPU-LSC-72613.The transition locations predicted by our HODMD/e^Nmethod agree well with experimental data and compare favorably to those obtained by some existing methods■.It is shown that the proposed method is able to predict transition locations for flows over different types of airfoils and offers the potential for application to 3D wings as well as more complex configurations. | Mengmeng WU Zhonghua HAN Han NIE Wenping SONG Soledad Le CLAINCHE Esteban FERRER | 2019 | Chinese Journal of Aeronautics2019，32，11： | 7 |
| 19 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 20 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
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