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| 1 | Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation显示文摘Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration.However,it remains challenging to control the inflammatory response and tolerance at systemic levels without causing toxicity to injured tissues.Mesenchymal stem cells(MSCs) possess potent immunomodulatory properties and facilitate tissue repair by releasing exosomes,which generate a suitable microenvironment for inflammatory resolution.Exosomes contain several effective bioactive molecules and act as a cell-cell communication vehicle to influence cellular activities in recipient cells.During this process,the horizontal transfer of exosomal microRNAs(miRNAs) to acceptor cells,where they regulate target gene expression,is of particular interest for understanding the basic biology of inflammation ablation,tissue homeostasis,and development of therapeutic approaches.In this review,we describe a signature of three specific miRNAs(miR-21,miR-146 a,and miR-181) present in human umbilical cord MSC-derived exosomes(MSC-EXO) identified microarray chip analysis and focus on the inflammatory regulatory functions of these immune-related miRNAs.We also discuss the potential mechanisms contributing to the resolution of wound inflammation and tissue healing. | Dongdong Ti Haojie Hao Xiaobing Fu Weidong Han | 2016 | Science China(Life Sciences)2016，59，12： | 24 |
| 2 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
| 3 | Microenvironment-induced myofibroblast-like conversion of engrafted keratinocytes显示文摘Myofibroblasts,recognized classically by-smooth muscle actin(-SMA)expression,play a key role in the wound-healing process,promoting wound closure and matrix deposition.Although a body of evidence shows that keratinocytes explanted onto a wound bed promote closure of a skin injury,the underlying mechanisms are not well understood.The basal layer of epidermis is rich in undifferentiated keratinocytes(UKs).We showed that UKs injected into granulation tissue could switch into-SMA positive cells,and accelerate the rate of skin wound healing.In addition,when the epidermis sheets isolated from foreskin cover up the wound bed or are induced in vitro,keratinocytes located at the basal layers or adjacent sites were observed to convert into myofibroblast-like cells.Thus,UKs have a potential for myofibroblastic transition,which provides a novel mechanism by which keratinocyte explants accelerate skin wound healing. | LI MeiRong TI DongDong HAN WeiDong FU XiaoBing | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 4 | Adaptive T cell immunotherapy in cancer显示文摘Impaired tumor-specific effector T cells contribute to tumor progression and unfavorable clinical outcomes. As a compensatoryT cell-dependent cancer immunoediting strategy, adoptive T cell therapy (ACT) has achieved encouraging therapeutic results,and this strategy is now on the center stage of cancer treatment and research. ACT involves the ex vivo stimulation and expansionof tumor-infiltrating lymphocytes (TILs) with inherent tumor reactivity or T cells that have been genetically modified to expressthe cognate chimeric antigen receptor or T cell receptor (CAR/TCR), followed by the passive transfer of these cells into alymphodepleted host. Primed T cells must provide highly efficient and long-lasting immune defense against transformed cellsduring ACT. Anin-depth understanding of the basic mechanisms of these living drugs can help us improve upon currentstrategies and design better next-generation T cell-based immunotherapies. From this perspective, we provide an overview ofcurrent developments in different ACT strategies, with a focus on frontier clinical trials that offer a proof of principle. Meanwhile,insights into the determinants of ACT are discussed, which will lead to more rational, potent and widespread applicationsin the future. | Dongdong Ti Miaomiao Bai Xiaolei Li Jianshu Wei Deyun Chen Zhiqiang Wu Yao Wang Weidong Han | 2021 | Science China(Life Sciences)2021，64，3： | 2 |
| 5 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 6 | Mechanical pain sensitivity of deep tissues in children--possible develop- ment of myofascial trigger points in children 显示文摘 | Han TI Hong CZ Kuo FC | 2012 | BMC Musculoskelet Disord2012，13，4： | 1 |
| 7 | Molecular recognition and complexation thermodynamics of dye guest mole-cules by modified cyclodextrins and calixarenesulfonates显示文摘 | LIU Yu HAN Bao Hang CHEN Yun Ti | 2002 | J Phys Chem B2002，106，： | 1 |
| 8 | New titanium alloys for biomaterials:a study of mechanical and corrosion properties and cytotoxicity显示文摘 | Kim TI Han JH Lee IS | 1997 | Biomed Mater Eng1997，，7： | 1 |
| 9 | Imperforate anus:US determination of the type with infracoccygeal approach显示文摘 | Han TI Kim IO Kim WS | 2003 | Radiology2003，228，1： | 1 |
| 10 | Reliability of the Supraspinatus Muscle Thickness Measurement by Ultrasonography显示文摘 | Yi TI Han IS Kim JS | | 0，，04： | 1 |
| 11 | Inducing immunogenic cell death in immuno-oncological therapies显示文摘Immunotherapy has revolutionized cancer treatment and substantially improved patient outcomes with respect to multiple types of tumors.However,most patients cannot benefit from such therapies,mainly due to the intrinsic low immunogenicity of cancer cells(CCs)that allows them to escape recognition by immune cells of the body.Immunogenic cell death(ICD),which is a form of regulated cell death,engages in a complex dialogue between dying CCs and immune cells in the tumor microenvironment(TME),ultimately evoking the damage-associated molecular pattern(DAMP)signals to activate tumor-specific immunity.The ICD inducers mediate the death of CCs and improve both antigenicity and adjuvanticity.At the same time,they reprogram TME with a“cold-warmhot”immune status,ultimately amplifying and sustaining dendritic cell-and T cell-dependent innate sensing as well as the antitumor immune responses.In this review,we discuss how to stimulate ICD based upon the biological properties of CCs that have evolved under diverse stress conditions.Additionally,we highlight how this dynamic interaction contributes to priming tumor immunogenicity,thereby boosting anticancer immune responses.We believe that a deep understanding of these ICD processes will provide a framework for evaluating its vital role in cancer immunotherapy. | Dongdong Ti Xin Yan Jianshu Wei Zhiqiang Wu Yao Wang Weidong Han | 2022 | Chinese Journal of Cancer Research2022，34，1： | 1 |
| 12 | Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells显示文摘 | Li TI Han S Cubbage M | 2002 | Eur J Immunol2002，32，10： | 1 |
| 13 | Risk factors for esophageal and gastric cancers in Shanxi Province, China: A case–control study显示文摘 | Ying Gao Nan Hu Xiao You Han Ti Ding Carol Giffen Alisa M. Goldstein Philip R. Taylor | 2011 | Cancer Epidemiology2011，，6： | 1 |
| 14 | Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the O ne M illion T aiwanese S creening P rogram显示文摘 | Han‐Mo Chiu Sam Li‐Sheng Chen Amy Ming‐Fang Yen Sherry Yueh‐Hsia Chiu Jean Ching‐Yuan Fann Yi‐Chia Lee Shin‐Liang Pan Ming‐Shiang Wu Chao‐Sheng Liao Hsiu‐Hsi Chen Shin‐Lan Koong Shu‐Ti Chiou | 2015 | Cancer2015，，18： | 1 |
| 15 | Renal doppler ultrasound exami- nation of ureteral obstruction in rabbits : effects of different sites and degrees of obstruction on renal resistive index 显示文摘 | Kim WS Han TI Kim SH | 2004 | Invest Radiol2004，39，9： | 1 |
| 16 | New titanium alloys forn biomaterials: a study of mechanical and corrosion properties and cytotoxicity 显示文摘 | Kim TI Han JH Lee IS | 1997 | Biomed Mater Eng1997，7，4： | 1 |
| 17 | Causes and consequences of epigenetic regulation in wound healing显示文摘 | Dongdong Ti Meirong Li Xiaobing Fu Weidong Han | 2014 | Wound Repair Regen2014，，： | 1 |
| 18 | The role of hubs in the adoption process显示文摘 | Ti Goldenberg J Han S Lehmann D R | 2009 | Journal of Marketing2009，73，2： | 1 |
| 19 | Impaired Erythropoietin Response to Anemia in Patients with Lymphocytic Malignancies显示文摘Patients with lymphocytic malignancies like Non-Hodgkin's lymphoma (NHL), multiple myeloma (MM), and chronic lymphocytic leukemia (CLL) are often complicated with anemia. In this prospective study, we devised a carefully controlled erythropoietin (Epo) level measurement in anemic or non-anemic patients with lymphocytic malignancies, in order to determine whether the response of Epo was decreased in anemic patients. | Bing Han Yuan-kai Shi Jun Zhu Xiao-hui He Ning-jing Lin Shu-lan Li Ti Shen | 2007 | Chinese Medical Sciences Journal2007，22，3： | 1 |
| 20 | Mechanical pain sensitivity ofdeep tissues in children - possible development ofmyofascial trigger points in children 显示文摘 | Han TI Hong CZ Kuo FC | 2012 | BMC MusculoskeletDisord2012，13，： | 1 |
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