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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Efficacy and safety of intravenous recombinant tissue plasminogen activator in mild ischaemic stroke:a meta-analysis显示文摘The benefits and safety of intravenous recombinant tissue plasminogen activator(IV-tPA)for patients with mild ischaemic stroke(MIS)are still unclear.The objective of this meta-analysis was to evaluate the efficacy and safety of IV-tPA as treatment for patients with MIS.We performed a systematic literature search across MEDLINE,Embase,Central,Global Health and Cumulative Index to Nursing and Allied Health Literature(CINAHL),from inception to 10 November 2016,to identify all related studies.Where possible,data were pooled for meta-analysis with odds ratio(OR)and corresponding 95%confidence interval(CI)using the fixed-effects model.MIS was defined as having National Institutes of Health Stroke Scale score of≤6.We included seven studies with a total of 1591 patients based on the prespecified inclusion and exclusion criteria.The meta-analysis indicated a high odds of excellent functional outcome based on the modified Rankin Scale or Oxfordshire Handicap Score 0-1(OR=1.43;95%CI 1.14 to 1.79;P=0.002,I2=35%)in patients treated with IV-tPA compared with those not treated with IV-tPA(74.8%vs 67.6%).There was a high risk of symptomatic intracranial haemorrhage(sICH)with IV-tPA treatment(OR=10.13;95%CI 1.93 to 53.02;P=0.006,I2=0%)(1.9%vs 0.0%)but not mortality(OR=0.78;95%CI 0.43 to 1.43;P=0.43,I2=0%)(2.4%vs 2.9%).Treatment with IV-tPA was associated with better functional outcome but not mortality among patients with MIS,although there was an increased risk of sICH.Randomised trials are warranted to confirm these findings. | Shoujiang You Anubhav Saxena Xia Wang WeeYong Tan Qiao Han Yongjun Cao Chun-Feng Liu | 2018 | Stroke & Vascular Neurology2018，3，1： | 24 |
| 3 | Analytical validation of GMEX rapid point- of care CYP2C19 genotyping system for the CHANCE-2 trial显示文摘Background and purpose Rapid genotyping is useful for guiding early antiplatelet therapy in patients with high-risk nondisabling ischaemic cerebrovascular events(HR-NICE).Conventional genetic testing methods used in CYP2C19 genotype-guided antiplatelet therapy for patients with HR-NICE did not satisfy the needs of the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events(CHANCE)-2 trial.Therefore,we developed the rapid-genotyping GMEX(point-of care)system to meet the needs of the CHANCE-2 trial.Methods Healthy individuals and patients with history of cardiovascular diseases(n=408)were enrolled from six centres of the CHANCE-2 trial.We compared the laboratory-based genomic test results with Sanger sequencing test results for accuracy verification.Next,we demonstrated the accuracy,timeliness and clinical operability of the GMEX system compared with laboratory-based technology(YZY Kit)to verify whether the GMEX system satisfies the needs of the CHANCE-2 trial.Results Genotypes reported by the GMEX system showed 100%agreement with those determined by using the YZY Kit and Sanger sequencing for all three CYP2C19 alleles(*2,*3 and*17)tested.The average result’s turnaround times for the GMEX and YZY Kit methods were 85.0(IQR:85.0-86.0)and 1630.0(IQR:354.0-7594.0)min(p<0.001),respectively.Conclusions Our data suggest that the GMEX system is a reliable and feasible point-of care system for rapid CYP2C19 genotyping for the CHANCE-2 trial or related clinical and research applications. | Xia Meng Anxin Wang Guojun Zhang Siying Niu Wei Li Sifei Han Fang Fang Xingquan Zhao Kehui Dong Zening Jin Huaguang Zheng Kelin Chen Hao Li Chengyuan Yang Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 4 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 5 | Benefit Evaluation of the Deep Peak-regulation Market in the Northeast China Grid显示文摘In the Northeast China Grid(NCG),the percentage of wind power has reached nearly 20%of the total installed generation capacity,which causes increasing demands for deep peak-regulation capacity(DPC)during the operation of power systems.The shortage of DPC has become a significant problem in the NCG which may lead to wind curtailments and affect the security of power systems as well as the heating needs for inhabitants.In order to cope with this DPC shortage issue,the deep peak-regulation market(DPM)was established and has been running steadily in the past few years in NCG.This paper elaborates on the roles of the market players and the operational processes of the DPM,of which the advancements in terms of management mechanism are summarized.Moreover,benefits of the DPM for social harmony,environmental protection and economic efficiency are analyzed,for which relevant evaluation indices are proposed.A five-unit simulation system is constructed to illustrate the operation and benefits of the DPM.And focusing on comparisons with the previous Two Rules,the case study of Liaoning Power Grid verifies further that the DPM is feasible and able to bring more benefits to grids. | Hongyan Ma Zheng Yan Mingjie Li Dong Han Xiao Han Yiqun Song Ping Wei Gang Li Yongjun Liu | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 6 |
| 6 | Emerging role of natural products in cancer immunotherapy显示文摘Cancer immunotherapy has become a new generation of anti-tumor treatment,but its indications still focus on several types of tumors that are sensitive to the immune system.Therefore,effective strategies that can expand its indications and enhance its efficiency become the key element for the further development of cancer immunotherapy.Natural products are reported to have this effect on cancer immunotherapy,including cancer vaccines,immune-check points inhibitors,and adoptive immune-cells therapy.And the mechanism of that is mainly attributed to the remodeling of the tumorimmunosuppressive microenvironment,which is the key factor that assists tumor to avoid the recognition and attack from immune system and cancer immunotherapy.Therefore,this review summarizes and concludes the natural products that reportedly improve cancer immunotherapy and investigates the mechanism.And we found that saponins,polysaccharides,and flavonoids are mainly three categories of natural products,which reflected significant effects combined with cancer immunotherapy through reversing the tumor-immunosuppressive microenvironment.Besides,this review also collected the studies about nano-technology used to improve the disadvantages of natural products.All of these studies showed the great potential of natural products in cancer immunotherapy. | Songtao Dong Xiangnan Guo Fei Han Zhonggui He Yongjun Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 7 | In Situ Investigation of Dynamic Silver Crystallization Driven by Chemical Reaction and Diffusion显示文摘Rational synthesis of materials is a long-term challenging issue due to the poor understanding on the formation mechanism of material structure and the limited capability in controlling nanoscale crystallization.The emergent in situ electron microscope provides an insight to this issue.By employing an in situ scanning electron microscope,silver crystallization is investigated in real time,in which a reversible crystallization is observed.To disclose this reversible crystallization,the radicals generated by the irradiation of electron beam are calculated.It is found that the concentrations of radicals are spatiotemporally variable in the liquid cell due to the diffusion and reaction of radicals.The fluctuation of the reductive hydrated electrons and the oxidative hydroxyl radicals in the cell leads to the alternative dominance of the reduction and oxidation reactions.The reduction leads to the growth of silver crystals while the oxidation leads to their dissolution,which results in the reversible silver crystallization.A regulation of radical distribution by electron dose rates leads to the formation of diverse silver structures,confirming the dominant role of local chemical concentration in the structure evolution of materials. | Ting Liu Xiangyu Dou Yonghui Xu Yongjun Chen Yongsheng Han | 2020 | Research2020，，1： | 4 |
| 8 | Mineral phase and structure changes during roasting of fine-grained carbonaceous gold ores and their effects on gold leaching efficiency显示文摘While roasting has been widely applied to reduce the negative effect of carbonaceous matters on gold extraction from fine-grained carbonaceous gold ores, the phase and structure changes of minerals during roasting and their in fluences on the leachi ng rate of gold have not been fully understood. This limits the extraction of carbonaceous gold deposits. The current work examines the oxidation process of a fine-grained carbonaceous gold ore during roasting using a range of techniques including X-ray diffraction (XRD), seanning electron microscopy (SEM), Energy Dispersive Spectrometer (EDS) analysis and pore structure analysis together with gold leaching tests. The results show that during the process of oxidative roasting, the carbonaceous matters (organic carbon and graphitic carbon) and pyrite were completely decomposed at 600 ℃ with the carbonaceous components burned and pyrite oxidized into hematite. At 650 ℃, while dolomite was decomposed into calcia, magnesia, calcium sulfate etc., the calcine structure became loose and porous, leading to a high gold leaching rate from the roasted product. Above 750 ℃, the porous calcite structure started to collapse along with the agglomeration, leading to the secondary encapsulation of gold particles, which contributed to the sharp drop in the gold leaching rate of the roasted product. This study suggests optimum phase and structure changes of minerals during roasting to achieve maximum gold extraction from fine-grained carbonaceous gold deposits. | Jianping Jin Yuexin Han Hui Li Yangyang Huai Yongjun Peng Xiaotian Gu Wei Yang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 4 |
| 9 | Information diffusion network inferring and pathway tracking显示文摘Network diffusion, such as spread of ideas, rumors, contagious disease, or a new type of behaviors, is one of the fundamental processes within networks. Designing effective strategies for influence spread maximization, rumor spread minimization, or epidemic immunization has attracted considerable research attention. However, a key challenge is that many times we can only observe the trace of contagion spreading across network, but the underlying network structure is unknown and the transmission rates between node pairs are unclear to us. In this paper, given the observed information cascades, we aim to address two problems:diffusion network structure inferring and information diffusion pathways tracking. We propose a novel probabilistic model called Network Inferring from Multidimensional Features of Cascades(NIMFC) which takes into account heterogeneous features, including temporal and topological features of cascades, node attributes, and information content, to infer the latent network structure and transmission rates of edges. Also, based on the inferred network structure, we may track diffusion pathways of a cascade in social networks. We use blocked coordinate descent method to learn a sparse estimation of the latent network. Our proposed model NIMFC is evaluated both on large synthetic and real-world data sets, and experimental results show that our method significantly outperforms state-of-the-art models both in terms of recovering the latent network structure and information pathway tracking. | ZHOU DongHao HAN WenBao WANG YongJun YUAN BaoDi | 2015 | Science China(Information Sciences)2015，58，9： | 3 |
| 10 | Who may benefit from lower dosages of intravenous tissue plasminogen activator? Results from a cluster data analysis显示文摘background The risk of symptomatic intracranial haemorrhage(sICH)after thrombolysis is low but severe.Lower dose of alteplase may reduce the risk of sICH.We aim to identify subsets of patients who could benefit from lower dose of alteplase compared with standard dose.Methods Data from two observational registries were pooled together.A total of 3479 patients who had acute ischaemic stroke were entered into the interaction tree model.The response variable was the rate of sICH per the definition of the National Institute of Neurological Disorders and Stroke Study.Clinical improvement was measured by the National Institutes of Health Stroke Scale(NIHSS)and defined as NIHSS 0 or 1 or an improvement of more than 4 points(within 7 days or at discharge).Rare event logistic regression was performed to analyse the OR of safety outcome.results To optimise the interaction effect between tissue plasminogen activator(tPA)dosage(standard/lower)and patient subgroups,three subgroups based on the severity of stroke were identified:(1)NIHSS≤4,(2)NIHSS between 5 and 14,and(3)NIHSS≥15.The estimated difference of OR of having sICH was 2.71(95%CI 0.80 to 7.69,p=0.10)for mild,0.13(95%CI 0.02 to 0.68,p=0.01)for moderate,and 0.65(95%CI 0.19 to 2.55,p=0.52)for severe,respectively.In addition,patients who had moderate stroke treated with lower dose had comparable efficacy outcome(OR 1.23,95%CI 0.71 to 2.13,p=0.45).Conclusion Our analysis demonstrated that in patients who had moderate stroke,lower doses of alteplase are associated with significant sICH reduction and non-inferior performance in efficacy,compared with those in the standard dose group. | Yi Dong Ye Han Haipeng Shen Yilong Wang Frank Ma Hao Li Yongjun Wang Qiang Dong | 2020 | Stroke & Vascular Neurology2020，5，4： | 3 |
| 11 | Lattice Effect on Magnetic and Electrical Properties of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)Films显示文摘Lattice effect on magnetic and electrical transport properties of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)films prepared by RF magnetron sputtering technique were investigated.With the decrease of the average ions radius ,the structure of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)targets transit from the rhombohedral phase to the orthorhombic phase,and the Curie temperature reduces rapidly with the decrease of .The electrical properties show that films are the metallic state which can be fitted to the formula:ρ(T)=ρ0+ρ1T^2+ρ2T^(4.5) at low temperatures.The temperature range of the ferromagnetic metallic state becomes narrow with the decrease of.The phenomenon can be explained by the lattice effect. | Li'an HAN Huaping YANG Yongjun HE | 2008 | Journal of Materials Science & Technology2008，24，5： | 2 |
| 12 | Therapeutic Effect of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells in a Rat Model of Stroke显示文摘 | Wenbin Liao Jiang Xie Jian Zhong Yongjun Liu Lei Du Bin Zhou Jie Xu Pengxia Liu Shaoguang Yang Jiming Wang Zhibo Han Zhong Chao Han | 2009 | Transplantation2009，，3： | 2 |
| 13 | Light-induced irreversible structural phase transition in trilayer graphene显示文摘A crystal structure has a profound influence on the physical properties of the corresponding material.By synthesizing crystals with particular symmetries,one can strongly tune their properties,even for the same chemical configuration(compare graphite and diamond,for instance).Even more interesting opportunities arise when the structural phases of crystals can be changed dynamically through external stimulations.Such abilities,though rare,lead to a number of exciting phenomena,such as phase-change memory effects.In the case of trilayer graphene,there are two common stacking configurations(ABA and ABC)that have distinct electronic band structures and exhibit very different behaviors.Domain walls exist in the trilayer graphene with both stacking orders,showing fascinating new physics such as the quantum valley Hall effect.Extensive efforts have been dedicated to the phase engineering of trilayer graphene.However,the manipulation of domain walls to achieve precise control of local structures and properties remains a considerable challenge.Here,we experimentally demonstrate that we can switch from one structural phase to another by laser irradiation,creating domains of different shapes in trilayer graphene.The ability to control the position and orientation of the domain walls leads to fine control of the local structural phases and properties of graphene,offering a simple but effective approach to create artificial two-dimensional materials with designed atomic structures and electronic and optical properties. | Jianyu Zhang Jinsen Han Gang Peng Xi Yang Xiaoming Yuan Yongjun Li Jianing Chen Wei Xu Ken Liu Zhihong Zhu Weiqi Cao Zheng Han Jiayu Dai Mengjian Zhu Shiqiao Qin Kostya S.Novoselov | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 14 | Numerical simulation of icing effects on static flow field around blade airfoil for vertical axis wind turbine显示文摘Icing on blade surface of the straight-bladed vertical axis wind turbine(SB-VAWT)set in cold regions is a serious problem.To study the performance effects of icing on SB-VAWT,numerical simulations were carried out on the ice accretion on NACA 0015 airfoil which was always used for blade airfoil of SB-VAWT by CFD methods based on 2D steady incompressible N-S Equation.The morphology and procedure of icing on blade airfoil were obtained under different wind speeds,attack angles of blade and water flow flux in wind.The static flow fields,especially the static pressure fields around blade airfoil with or without icing on it were computed.The aerodynamic characteristics including the lift and drag force coefficients of blade airfoil were also calculated.The results indicated that icing caused the static pressure field changed greatly and led to the increasing of drag force and reducing the aerodynamic performance. | Li Yan Chi Yuan Han Yongjun Li Shengmao Tagawa Kotaro | 2011 | International Journal of Agricultural and Biological Engineering2011，4，3： | 2 |
| 15 | Facile Synthesis of Fe3Pt-Ag Nanocomposites for Catalytic Reduction of Methyl Orange显示文摘 | HAN Donglai LI Boxun XING Guoliang ZHANG Yuanyuan CHEN Yue SUN Yantao ZHANG Yongjun LIU Yang YANG Jinghai | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 16 | Physical and Numerical Simulation for Inner Crack Healing in Metals显示文摘The research purpose on the healing of inner crack in metallic materials is to provide an effective approach for improving their properties and prolonging their lifetime. The crack healing process of 20MnMo steel with inner pre-crack was analyzed. It was found that all inner cracks could be healed in different degree. There were very fine ferrite grains in healing region. The micro-crack healing process in single crystal of BBC-Fe was simulated by the molecule dynamics method, which showed that the critical temperature of crack healing in BBC-Fe is 673K. There were micro-voids, dislocations and twins left after crack healing. | Jingtao HAN Dongbin WEI Yongjun ZHANG | 2004 | 上海交通大学学报2004，38，z2： | 1 |
| 17 | Static/dynamic contact FEA and experimental study for tooth profile modification of helical gears显示文摘 | WU Yongjun WANG Jianjun HAN Qinkai | 2012 | Journal of Mechanical Science and Technology2012，26，5： | 1 |
| 18 | Growth and charactefization of dumbbell -shaped MgO nanowhiskers显示文摘 | Chen Yongjun Li Jianbao Han Yongsheng | 2003 | Ceramics International2003，29，： | 1 |
| 19 | Contact finite element method for dynamic meshing characteristics analysis of continuous engaged gear drives显示文摘 | Wu Yongjun Wang Jianjun Han Qinkai | 2012 | Journal of Mechanical Science and Technology2012，26，6： | 1 |
| 20 | Static/dynamic contact FEA and experimental study for tooth profile modification of helical gears显示文摘 | Wu Yongjun Wang Jianjun Han Qinkai | 2012 | Journal of Mechanical Science and Technology2012，26，5： | 1 |
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