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| 1 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 2 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 3 | Structure, regulation and function of PKB/AKT—a major therapeutic target显示文摘 | Masahito Hanada Jianhua Feng Brian A Hemmings | 2004 | BBA - Proteins and Proteomics2004，，1： | 2 |
| 4 | Activation of gibberellin biosynthesis and response pathways by low temperature during imbibition of Arabidopsis thaliana seeds 显示文摘 | Yamauchi Y Ogawa M Kuwahara A Hanada A Kamiya Y Yamaguchi Y | 2004 | Plant Cell2004，16，： | 1 |
| 5 | Bcl-2 gene hypomethylation and high level expression in B-cell chronic lymphocytic leukemia显示文摘 | Hanada M Delia D Aiello A | 2013 | {H}Blood2013，，05： | 1 |
| 6 | Dexmedetomi- dine was safety used for sedation during spinal anesthesi- a in a very elderly patient 显示文摘 | Kanisaua T Hanada S Kurosawa A | 2010 | J Anesth2010，24，6： | 1 |
| 7 | Renal function and periodontal disease in elderly Japanese 显示文摘 | Yoshihara A Deguchi T Hanada N Miyazaki H | 2007 | J Periodontol2007，78，： | 1 |
| 8 | CIS3/SOCS3/SSI3 plays a negative regulatory role in STA3'3 activation and intestinal inflam- mation 显示文摘 | Suzuki A Hanada T Mitsuyama K | 2001 | J Exp Med2001，193，4： | 1 |
| 9 | A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults 显示文摘 | Yoshihara A Seida Y Hanada N | 2004 | J Clin Periodontol2004，31，8： | 1 |
| 10 | Inhibition of shoot branching by new terpenoid plant hormones显示文摘 | Umehara M Hanada A Yoshida S | 2008 | Nature2008，455，： | 1 |
| 11 | CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestional inflammation显示文摘 | Suzuki A Hanada T Mit suyama K | 2001 | Exp Med2001，193，4： | 1 |
| 12 | High-temperature strength and room-temperature toughness of Nb-W-Si-B alloys prepared by arc-melting显示文摘 | SHA J B HIRAI H TABARU T KITAHARA A UENO H HANADA S | 2004 | Mater Sci Eng A2004，364，12： | 1 |
| 13 | CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation显示文摘 | Suzuki A Hanada T Mitsuyama K | 2001 | J Exp Med2001，193，4： | 1 |
| 14 | Self-compatible peach (Prunus persica) has mutant versions of the S haplotypes found in self-incompatible Prunus species显示文摘 | Tao R A Watari T Hanada | 2007 | Plant Mol Biol2007，63，： | 1 |
| 15 | The relationship between morphological changes of the condyle and condylar position in the glenoid fossa 显示文摘 | Tsuruta A Yamada K Hanada K | 2004 | J Orofae Pain2004，18，： | 1 |
| 16 | Cibberellin biosynthesis and response during Arabidopsis seed germination 显示文摘 | Ogawa M Hanada A Yamauehi Y | 2003 | The Plant Cell2003，15，： | 1 |
| 17 | Biological Control of Neotropical Aquatic Weeds with Fungi显示文摘 | BARRETO R R CHARUDATTAN A P HANADA R | 2000 | Crop Protection2000，19，： | 1 |
| 18 | Tubulogenesis by microvascular endothelial cells is mediated by vascular endothelial growth factor (VEGF) in renal cell carcinoma显示文摘 | Nakagawa M Emoto A Hanada T | 1997 | Br J Urol1997，79，5： | 1 |
| 19 | Structure, regulation and func- tion of PKB/AKT-a major therapeutic target 显示文摘 | Hanada M Feng J Hemmings B A | 2004 | Biochem Biophys Acta2004，1697，12： | 1 |
| 20 | Penetration of zona-free eggs by spermatozoa of different species 显示文摘 | HANADA A CHANG MC | 1972 | Biol Reprod1972，6，： | 1 |
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