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| 1 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 2 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 3 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 4 | Late Quaternary glacial chronology on the eastern slope of Gongga Mountain,eastern Tibetan Plateau,China显示文摘The Gongga Mountain is the largest area of modern glaciation in the Hengduan Mountains and,with a summit elevation of 7556 m,is the highest mountain on the eastern margin of the Tibetan Plateau.During the Quaternary glacial-interglacial cycles the Gongga Mountain was extensively and repeatedly glaciated,and glacial landforms and outwash deposits from multiple glaciations are well-preserved in valleys,in basins,and on piedmonts.To constrain the glacial chronology of the eastern slope of Gongga Mountain,sample sites were selected based on the distribution and weathering of glacial tills,relationships among glacial deposits,and soil development on moraines.Dating of the tills and glaciofluvial deposits was undertaken with electron spin resonance(ESR) and optically stimulated luminescence(OSL).The ages of the glacial deposits can be divided into four clusters:2.2±0.5,11.9±0.6,35.9±2.7-58.0±6.3 and 119.2±15.9-194.2±32.8 ka.Five glacial advances in this region have been identified,which are equivalent in age to the Little Ice Age(LIA),Neoglaciation,marine oxygen isotope stage(MIS) 2,mid-MIS3,and MIS6.The largest local last glacial maximum(LGML) occurred on Gongga Mountain during mid-MIS3,characterized by a cold-humid climate,rather than the global Last Glacial Maximum(LGMG) of MIS2.The Gongga,Nanmenguangou(NMGG) and Yajiageng Glaciations occurred during the late part of the last glacial cycle,the middle of the last glacial cycle and the penultimate glacial cycle,respectively.On the basis of geomorphological,sedimentological,and compositional characteristics,landforms of the Moxi Platform and terraces can be grouped by facies and geochronology.In combination with the dating results,this analysis indicates the basal part of the Moxi Platform between Xinxin and the Moxi Hotel is correlative with the till of the Nanguanmen Glaciation(mid-MIS3).This basal unit has occasional lenses of glaciofluvial sandy gravel and lacustrine sediments.The remainder of the Moxi Platform and the terraces beside the platform are glaciofluvial deposits occasionally mixed with debris flow deposits and range in age from MIS3 to Holocene. | WANG Jie PAN BaoTian ZHANG GuoLiang CUI Hang CAO Bo GENG HaoPeng | 2013 | Science China Earth Sciences2013，56，3： | 11 |
| 5 | Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in Young Female Population: A Single-center Study显示文摘 | Pei-Na Meng Chen Xu Wei You Zhi-Ming Wu Du-Jiang Xie Hang Zhang Chang Pan Fei Ye | 2017 | Chinese Medical Journal2017，，13： | 10 |
| 6 | Precipitation Behavior of V-N Microalloyed Steels during Normalizing显示文摘The precipitation behavior of V-N microalloyed steel during normalizing process was studied by physicochemical phase analysis and transmission electron microscopy(TEM). The effect of precipitation behavior on mechanical properties was investigated by theoretical calculations. The results showed that 32.9% of V(C,N) precipitates remained undissolved in the austenite during the soaking step of the normalizing process. These precipitates prevented the growth of the austenite grains. During the subsequent cooling process, the dissolved V(C,N) re-precipitated and played a role in precipitation strengthening. The undissolved V(C,N) induced intragranular ferrite nucleation and refined the ferrite grains. Consequently, compared with hot-rolled steel, the normalized steel exhibited increased grain-refining strengthening but diminished precipitation strengthening, leading to an improvement of the impact energy at the expense of about 40 MPa yield strength. | Tao PAN Xi-yang CHAI Jin-guang WANG Hang SU Cai-fu YANG | 2015 | Journal of Iron and Steel Research(International)2015，22，11： | 9 |
| 7 | Effect of Tempering Temperature on Microstructure and Mechanical Properties of Steel Containing Ni of 9%显示文摘Mechanical properties of quenching,intercritical quenching and tempering (QLT) treated steel containing Ni of 9% were evaluated from specimens subject to various tempering temperatures. The detailed microstructures of steel containing Ni of 9% at different tempering temperatures were observed by optical microscope (OM) and transmission electron microscope (TEM). The volume fraction of austenite was estimated by XRD. The results show that high strength and cryogenic toughness of steel containing Ni of 9% are obtained when the tempering temperature are between 540 and 580 ℃. The microstructure keeps the dual phase lamellar structure after the intercritical quenching and there is cementite created in the Ni-rich constituents when tempering temperature is 540 ℃. When tempering temperatures are between 560 and 580 ℃,the reversed austenites (γ′) grow up and the dual phase lamellar structure is not clear. The γ′ becomes instable at 600 ℃. When tempered at temperature ranging from 500 to 520 ℃,the increase of dislocation density in the lamellar matrix makes both tensile strength and yield strength decrease. When tempered at 540 ℃ and higher temperature,the yield strength decreases continuously because the C and alloying elements in the matrix are absorbed by the cementite and the γ′,so the yield ratio is decreased by the γ′. There are two toughness mechanisms at different tempering temperatures. One is that the precipitation of cementite absorbs the carbon in the steel which plays a major role in improving cryogenic toughness at lower temperature. Another is that the γ′ and the purified matrix become major role at higher tempering temperature. When the tempering temperature is 600 ℃,the stability of γ′ is decreased quickly,even the transformation takes place at room temperature,which results in a sharp decrease of Charpy-V impact energy at 77 K. The tempering temperature range is enlarged by the special distribution of cementite and the lamellar structure. | ZHAO Xi-qing PAN Tao WANG Qing-feng SU Hang YANG Cai-fu YANG Qing-xiang | 2011 | Journal of Iron and Steel Research(International)2011，18，5： | 9 |
| 8 | A comprehensive analysis of the response of the fungal community structure to long-term continuous cropping in three typical upland crops显示文摘Certain agricultural management practices are known to affect the soil microbial community structure;however,knowledge of the response of the fungal community structure to the long-term continuous cropping and rotation of soybean,maize and wheat in the same agroecosystem is limited.We assessed the fungal abundance,composition and diversity among soybean rotation,maize rotation and wheat rotation systems and among long-term continuous cropping systems of soybean,maize and wheat as the effect of crop types on fungal community structure.We compared these fungal parameters of same crop between long-term crop rotation and continuous cropping systems as the effect of cropping systems on fungal community structure.The fungal abundance and composition were measured by quantitative real-time PCR and Illumina MiSeq sequencing.The results revealed that long-term continuous soybean cropping increased the soil fungal abundance compared with soybean rotation,and the fungal abundance was decreased in long-term continuous maize cropping compared with maize rotation.The long-term continuous soybean cropping also exhibited increased soil fungal diversity.The variation in the fungal community structure among the three crops was greater than that between long-term continuous cropping and rotation cropping.Mortierella,Guehomyces and Alternaria were the most important contributors to the dissimilarity of the fungal communities between the continuous cropping and rotation cropping of soybean,maize and wheat.There were 11 potential pathogen and 11 potential biocontrol fungi identified,and the relative abundance of most of the potential pathogenic fungi increased during the long-term continuous cropping of all three crops.The relative abundance of most biocontrol fungi increased in long-term continuous soybean cropping but decreased in long-term continuous maize and wheat cropping.Our results indicate that the response of the soil fungal community structure to long-term continuous cropping varies based upon crop types. | LIU Hang PAN Feng-juan HAN Xiao-zeng SONG Feng-bin ZHANG Zhi-ming YAN Jun XU Yan-li | 2020 | Journal of Integrative Agriculture2020，19，3： | 8 |
| 9 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 10 | Assessment of different biomarkers provides valuable diagnostic standards in the evaluation of the risk of acute rejection显示文摘尖锐拒绝(AR ) 是为长期的拒绝在的一个强壮的风险因素肾移植接受者。AR 事件的精确、及时的诊断为疾病控制和预后是很重要的。因此,客观地评估了病人的有免疫力的地位在移植以后的治疗的地里是必要的。这纵的研究在外部血 mononuclear 房间( PBMC )和活体检视在 sera ,CD4+ T 房间的细胞内部的腺苷 triphosphate ( iATP )版本水平,和 granzyme B/perforin 表示调查了五 biomarkers ,人的白血球抗原( HLA ) -G5 和 sCD30 水平的实用性,总共肾的移植的 84 个案例的检测 AR 和 biomarkers 的决定。数据证明接受者与临床或证明的活体检视拒绝显著地增加了 CD4+ T 房间的 iATP 版本水平,并且提高了 sCD30,但是与稳定的接枝功能与个人相比在 sera 降低了 HLA-G5 水平。granzyme B 和 perforin 的表示层次也在 PBMC 和 AR 病人的接枝活体检视被提高。一起拿,我们鉴别 HLA-G5 的 sCD30, iATP, granzyme B, perforin,和 downregulation 的 upregulation 能提供珍贵诊断标准在 AR 的风险识别那些接受者。并且 iATP 可以比为预言接枝拒绝事件的其它是更好的 biomarker。 | Jin Zheng Xiaoming Ding Xiaohui Tian Zhankui Jin Xiaoming Pan Hang Yan Xinshun Feng Jun Hou Heli Xiang Li Ren Puxun Tian Wujun Xue | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 11 | Interlayer engineering for titanium clad steel by hot roll bonding显示文摘 | Xi-yang Chai Tao Pan Feng Chai Xiao-bing Luo Hang Su Zhi-gang Yang Cai-fu Yang | 2018 | Journal of Iron and Steel Research(International)2018，25，7： | 8 |
| 12 | Kinetics simulation and experimental observation of fine microstructure of 9%Ni cryogenic steel processed by QLT heat treatment显示文摘Thermo-Calc and Dictra commercial calculation software programs have been used to simulate the formation of fine microstructure of 9%Ni cryogenic steel processed by quench–lamellarize–temper(QLT)heat treatment.The calculations show many compositional fluctuations in each single-martensite lath after QLT treatment;the peak concentrations of carbon and nickel reach about 0.40%and 18%,respectively.The width of the C or Ni element-enriched zone increases when the critical lamellarizing temperature decreases or the temper temperature increases.Extending the temper time has a similar effect on the element profiles.The simulation results are in accordance with the observed fine microstructures. | Tao Pan Jing Zhu Caifu Yang Hang Su | 2014 | Chinese Science Bulletin2014，59，15： | 8 |
| 13 | Numerical simulation of microstructure evolution during directional solidification process in directional solidified (DS) turbine blades显示文摘Directional solidified(DS) turbine blades are widely used in advanced gas turbine engine. The size and orientation of columnar grains have great influence on the high temperature property and performance of the turbine blade. Numerical simulation of the directional solidification process is an effective way to investigate the grain's growth and morphology,and hence to optimize the process. In this paper,a mathematical model was presented to study the directional solidified microstructures at different withdrawal rates. Ray-tracing method was applied to calculate the temperature variation of the blade. By using a Modified Cellular Automation(MCA) method and a simple linear interpolation method,the mushy zone and the microstructure evolution were studied in detail. Experimental validations were carried out at different withdrawal rates. The calculated cooling curves and microstructure agreed well with those experimental. It is indicated that the withdrawal rate affects the temperature distribution and growth rate of the grain directly,which determines the final size and morphology of the columnar grain. A moderate withdrawal rate can lead to high quality DS turbine blades for industrial application. | ZHANG Hang XU QingYan TANG Ning PAN Dong LIU BaiCheng | 2011 | Science China(Technological Sciences)2011，54，12： | 7 |
| 14 | A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia显示文摘 | Hong GAN Zhenhua SONG Peiwei XU Hang SU Yingying PAN Min ZHAO Dengtang LIU | 2018 | 上海精神医学2018，30，3： | 6 |
| 15 | Berberine treats atherosclerosis via a vitamine-like effect downregulating Choline-TMA-TMAO production pathway in gut microbiota显示文摘Trimethylamine-N-oxide(TMAO)derived from the gut microbiota is an atherogenic metabolite.This study investigates whether or not berberine(BBR)could reduce TMAO production in the gut microbiota and treat atherosclerosis.Effects of BBR on TMAO production in the gut microbiota,as well as on plaque development in atherosclerosis were investigated in the culture of animal intestinal bacterial,HFD-fed animals and atherosclerotic patients,respectively.We found that oral BBR in animals lowers TMAO biosynthesis in intestine through interacting with the enzyme/co-enzyme of choline-trimethylamine lyase(CutC)and flavincontaining monooxygenase(FMO)in the gut microbiota.This action was performed by BBR’s metabolite dihydroberberine(a reductive BBR by nitroreductase in the gut microbiota),via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway.Oral BBR decreased TMAO production in animal intestine,lowered blood TMAO and interrupted plaque formation in blood vessels in the HFD-fed hamsters.Moreover,21 patients with atherosclerosis exhibited the average decrease of plaque score by 3.2%after oral BBR(0.5 g,bid)for 4 months(^(*)P<0.05,n=21);whereas the plaque score in patients treated with rosuvastatin plus aspirin,or clopidogrel sulfate or ticagrelor(4 months,n=12)increased by 1.9%.TMA and TMAO in patients decreased by 38 and 29%in faeces(^(*)P<0.05;^(*)P<0.05),and 37 and 35%in plasma(^(***)P<0.001;^(*)P<0.05),after 4 months on BBR.BBR might treat atherosclerotic plaque at least partially through decreasing TMAO in a mode of action similar to that of vitamins. | Shu-Rong Ma Qian Tong Yuan Lin Li-Bin Pan Jie Fu Ran Peng Xian-Feng Zhang Zhen-Xiong Zhao Yang Li Jin-Bo Yu Lin Cong Pei Han Zheng-Wei Zhang Hang Yu Yan Wang Jian-Dong Jiang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 6 |
| 16 | Long-term surface water changes and driving cause in Xiong'an,China:from dense Landsat time series images and synthetic analysis显示文摘China's government statement recently reported the plan of constructing Xiong'an New Area, which aims to phase out some extra capital functions from Beijing and to explore an innovative urban development mode with the priority in eco-environmental protection. The New Area is located in the semi-arid North China Plain(NCP) and is home to NCP's largest natural freshwater wetland, Baiyangdian Lake. A comprehensive realization of surface water dynamics would be crucial for policy-makers to outline a sustainable environment development strategy for New Area. In this study, we used a total of 245 time slices of cloud-free Landsat images to document the continuous changes of water bodies within Xiong'an City during 1984-2016 and to provide detailed evidence of water presence and persistency states and changes under the influences of climate change and human actions. Our results reveal that the New Area water body areas varied dramatically during the past 33 years, ranging from 0.44 km^2 in April 1988 to317.85 km^2 in February 1989. The change of surface water area was not characterized by a monotonically decreasing tendency. The evolution processes can be divided into four sub-stages: the first extreme desiccation in mid-1980 s, the wet stage with the most extensive inundation areas and strong inter-annual fluctuations from late-1988 to late 1999, another desiccation stage in early 2000 s, and the overall recovering stage between 2007 and 2016. We also mapped the maximum water inundation extents and frequencies of all-season, pre-wet season(February-May) and post-wet season(September-December) for the 33 years and different sub-periods. Although there is good agreement between time series of surface water area evolution in the New Area and station-based precipitation and evaporation variations, multiple lines of evidences reviewed in previous research indicate that the degraded Baiyangdian Lake was also tightly associated with human activities from various aspects, including dam construction, groundwater extraction, agricultural irrigation, etc. We highlighted the current status of exploring the driving mechanism of surface water changes and existing problems, and then offer recommendations. | Chunqiao Song Linghong Ke Hang Pan Shengan Zhan Kai Liu Ronghua Ma | 2018 | Science Bulletin2018，63，11： | 6 |
| 17 | A first attempt of inferior vena cava filter successfully guided by a mixed-reality system: a case report显示文摘Pulmonary embolism(PE)is one of the fatal heart attacks,and lower limbs deep vein thrombosis(DVT)is the most common reason for PE.Inferior vena cava filter(IVCF)implantation is a most prevention for PE.But it may carry a high risk of injury because of the radiation and contrast agent.Patients with nephrotic syndrome(NS)or some other renal diseases may prone to thrombosis due to the excretion of protein C and protein S overmuch.So,it is necessary to develop a new therapy without contrast agent.Mixed-reality(MR)is a new technology as a guidance of inferior vena cava filter implantation exposed under no X-ray and required no contrast agent. | Hang ZHU Yao LI Chi WANG Qiu-Yang LI Zheng-Yang XU Xin LI Abudureyimu Abudulitipujiang Ji-Xing PAN Er-Long FAN Jun GUO Yun-Dai CHEN | 2019 | Journal of Geriatric Cardiology2019，16，7： | 5 |
| 18 | Potential association of long noncoding RNA HA117 with tetralogy of Fallot显示文摘Tetralogy of Fallot(TOF)is a congenital heart disease characterized by abnormal cardiomyocyte differentiation in the right ventricular outflow tract(RVOT),and HA117 is a novel long noncoding RNA(lncRNA)with anti-differentiation roles.To investigate the potential association of HA117 with TOF,we collected 84 RVOT tissues from patients with TOF.We determined the expression of HA117 in RVOT samples from TOF patients and collected clinical data to conduct a cross-sectional and short-term follow-up study.McGoon ratio,Nakata index,and left ventricular end-diastolic volume index(LVEDVI)were negatively correlated with the expression of HA117 based on subgroup analysis,correlation analysis and logistic regression analysis.Additionally,cardiopulmonary bypass(CPB)time and ICU stay were longer in patients with higher expression of HA117 than in patients with lower expression of HA117.Furthermore,percentage improvement in SPO2 was significantly reduced in patients with increased HA117 expression at 6 months after surgery.Our results suggested that the increased expression of the novel lncRNA HA117 is a risk factor for unfavorable McGoon ratio,Nakata index and LVEDVI in TOF patients.Additionally,an increased expression of HA117 might lead to adverse short-term outcomes in TOF patients. | Quan Wang Zhili Wang Chun Wu Zhengxia Pan Li Xiang Hang Liu Xin Jin Kerong Tong Shulei Fan Xianqing Jin | 2018 | Genes & Diseases2018，5，2： | 5 |
| 19 | Chemical formation and source apportionment of PM_(2.5) at an urban site at the southern foot of the Taihang mountains显示文摘The region along the Taihang Mountains in the North China Plain(NCP) is characterized by serious fine particle pollution. To clarify the formation mechanism and controlling factors, an observational study was conducted to investigate the physical and chemical properties of the fine particulate matter in Jiaozuo city, China. Mass concentrations of the water-soluble ions(WSIs) in PM_(2.5) and gaseous pollutant precursors were measured on an hourly basis from December 1, 2017, to February 27, 2018. The positive matrix factorization(PMF) method and the FLEXible PARTicle(FLEXPART) model were employed to identify the sources of PM_(2.5). The results showed that the average mass concentration of PM_(2.5) was 111 μg/m^(3) during the observation period. Among the major WSIs, sulfate, nitrate, and ammonium(SNA) constituted 62% of the total PM_(2.5) mass, and NO_(3)^(-) ranked the highest with an average contribution of 24.6%. NH_(4)^(+) was abundant in most cases in Jiaozuo. According to chemical balance analysis, SO_(2)-4, NO_(3)^(-), and Cl^(-) might be present in the form of(NH_4)_(2)SO_4, NH_4NO_3, NH_4Cl, and KCl. The liquid-phase oxidation of SO_(2) and NO_(2) was severe during the haze period. The relative humidity and pH were the key factors influencing SO_(4)^(2-) formation. We found that NO_(3)^(-) mainly stemmed from homogeneous gas-phase reactions in the daytime and originated from the hydrolysis of N_(2)O_5 in the nighttime, which was inconsistent with previous studies. The PMF model identified five sources of PM_(2.5) : secondary origin(37.8%), vehicular emissions(34.7%), biomass burning(11.5%), coal combustion(9.4%), and crustal dust(6.6%). | Xiaoyong Liu Mingshi Wang Xiaole Pan Xiyue Wang Xiaolong Yue Donghui Zhang Zhigang Ma Yu Tian Hang Liu Shandong Lei Yuting Zhang Qi Liao Baozhu Ge Dawei Wang Jie Li Yele Sun Pingqing Fu Zifa Wang Hong He | 2021 | Journal of Environmental Sciences2021，33，5： | 5 |
| 20 | The effects of diltiazem in renal transplantation patients treated with cyclosporine A显示文摘Objective:To investigate the effects of diltiazem and cyclosporine A(CsA)combination therapy on protecting the kidney,promoting graft functioning and improving post-transplanted kidney recovery.Methods:The blood concentrations of CsA,the condition of the post-transplant kidney,the rate of acute rejection(AR),as well as hepatic and renal toxicity in 636 cases of renal transplant recipients were determined after being treated by CsA,with or without diltiazem.Results:Compared with the control group which received CsA,mycophenolate mofetil(MMF) and prednisolone(Pred)but lacked diltiazem,the group receiving these agents together with diltiazem required reduced dosage of CsA(P<0.01),while blood concentrations of CsA were significantly increased(P<0.01);the recovery time of graft function was reduced from(6.2±1.5)d to(3.9±1.4)d(P<0.01),and the rate of AR was decreased from 13.2%to 7.9%(P<0.01).Conclusion:In renal transplantation patients treated with CsA and diltiazem,blood concentrations of CsA were increased while the dosage was decreased.This efficient combination therapy reduced patients'economic burden,at the same time retained kidney function,promoted graft function recovery and decreased hepatic and renal toxicity and the rate of AR. | Wujun Xue Yong Song Puxun Tian Xiaoming Ding Xiaoming Pan Hang Yan Jun Hou Xinshun Feng Heli Xiang Xiaohui Tian | 2010 | The Journal of Biomedical Research2010，24，4： | 4 |
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