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| 1 | Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis显示文摘Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes.AMP-activated protein kinase (AMPK), a cellular energy sensor, plays regulatory roles in multiple biological processes. Although afew studies have shed light on AMPK regulating cancer metastasis, the inside epigenetic mechanisms remain unknown. Herein weshow that AMPK activation by metformin relieves the repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1)during EMT processes and inhibits lung cancer metastasis. PHF2, a H3K9me2 demethylase, was identified to interact with AMPKα2.Genetic deletion of PHF2 aggravates lung cancer metastasis and abolishes the H3K9me2 downregulation and anti-metastasis effectof metformin. Mechanistically, AMPK phosphorylates PHF2 at S655 site, enhancing PHF2 demethylation activity and triggering thetranscription of CDH1. Furthermore, the PHF2-S655E mutant that mimics AMPK-mediated phosphorylation status further reducesH3K9me2 and suppresses lung cancer metastasis, while PHF2-S655A mutant presents opposite phenotype and reverses the antimetastasiseffect of metformin. PHF2-S655 phosphorylation strikingly reduces in lung cancer patients and the higherphosphorylation level predicts better survival. Altogether, we reveal the mechanism of AMPK inhibiting lung cancer metastasis viaPHF2 mediated H3K9me2 demethylation, thereby promoting the clinical application of metformin and highlighting PHF2 as thepotential epigenetic target in cancer metastasis. | Ying Dong Hao Hu Xuan Zhang Yunkai Zhang Xin Sun Hanlin Wang Weijuan Kan Min-jia Tan Hong Shi Yi Zang Jia Li | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 2 | Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer显示文摘 | Yue Liu Jinghong Xu Yurong Jiao Yeting Hu Chenghao Yi Qiong Li Zhou Tong Xiaowei Wang Lifeng Hu Qian Xiao Jun Li Kefeng Ding Hanlin L. Wang | 2014 | BioMed Research International2014，，： | 1 |
| 3 | Multi-Panel Extra-Large Scale MIMO Based Joint Activity Detection and Channel Estimation for Near-Field Massive IoT Access显示文摘The extra-large scale multiple-input multiple-output(XL-MIMO)for the beyond fifth/sixth generation mobile communications is a promising technology to provide Tbps data transmission and stable access service.However,the extremely large antenna array aperture arouses the channel near-field effect,resulting in the deteriorated data rate and other challenges in the practice communication systems.Meanwhile,multi-panel MIMO technology has attracted extensive attention due to its flexible configuration,low hardware cost,and wider coverage.By combining the XL-MIMO and multi-panel array structure,we construct multi-panel XL-MIMO and apply it to massive Internet of Things(IoT)access.First,we model the multi-panel XL-MIMO-based near-field channels for massive IoT access scenarios,where the electromagnetic waves corresponding to different panels have different angles of arrival/departure(AoAs/AoDs).Then,by exploiting the sparsity of the near-field massive IoT access channels,we formulate a compressed sensing based joint active user detection(AUD)and channel estimation(CE)problem which is solved by AMP-EM-MMV algorithm.The simulation results exhibit the superiority of the AMP-EM-MMV based joint AUD and CE scheme over the baseline algorithms. | Zhen Gao Hanlin Xiu Yikun Mei Anwen Liao Malong Ke Chun Hu Mohamed-Slim Alouini | 2023 | China Communications2023，20，5： | 1 |
| 4 | In-depth understanding of ionic liquid assisted perovskite film formation mechanism for two-step perovskite photovoltaics显示文摘Ionic liquids(ILs)have been widely applied in the one-step fabrication of perovskite with noticeable enhancement in the device performance.However,in-depth mechanism of ionic-liquid-assisted perovskite film formation is not well understood for also important two-step perovskite fabrication method,with better control of crystallization behavior.In this work,we introduced ionic liquid methylammonium formate(MAFa)into organic salt to produce perovskite film via a two-step method.Systematic investigations on the influence of MAFa on the perovskite thin film formation mechanism were performed.Ionic liquid is shown to assist lowering the perovskite formation enthalpy upon the density functional theory(DFT)calculation,leading to an accelerated crystallization process evidenced by in-situ UV-Vis absorption measurement.A gradient up-down distribution of ionic liquid has been confirmed by timeof-flight SIMS.Importantly,besides the surface passivation,we found the HCOO-can diffuse into the perovskite crystals to fill up the halide vacancies,resulting in significant reduction of trap states.Uniform perovskite films with significantly larger grains and less defect density were prepared with the help of MAFa IL,and the corresponding device efficiency over 23%was obtained by two-step process with remarkably improved stability.This research work provides an efficient strategy to tune the morphology and opto-electronic properties of perovskite materials via ionic-liquid-assisted two-step fabrication method,which is beneficial for upscaling and application of perovskite photovoltaics. | Fei Wang Patrick Wai-Keung Fong Zhiwei Ren Hai-Lun Xia Kang Zhou Kai Wang Jiajie Zhu Xiaoxi Huang Xiao-Yuan Liu Hao Wang Yumeng Shi Haoran Lin Quanyao Zhu Gang Li Hanlin Hu | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 5 | Room-temperature multiple ligands-tailored SnO_(2) quantum dots endow in situ dual-interface binding for upscaling efficient perovskite photovoltaics with high V_(OC)显示文摘The benchmark tin oxide(SnO_(2))electron transporting layers(ETLs)have enabled remarkable progress in planar perovskite solar cell(PSCs).However,the energy loss is still a challenge due to the lack of“hidden interface”control.We report a novel ligand-tailored ultrafine SnO_(2) quantum dots(QDs)via a facile rapid room temperature synthesis.Importantly,the ligand-tailored SnO_(2) QDs ETL with multi-functional terminal groups in situ refines the buried interfaces with both the perovskite and transparent electrode via enhanced interface binding and perovskite passivation.These novel ETLs induce synergistic effects of physical and chemical interfacial modulation and preferred perovskite crystallization-directing,delivering reduced interface defects,suppressed non-radiative recombination and elongated charge carrier lifetime.Power conversion efficiency(PCE)of 23.02%(0.04 cm^(2))and 21.6%(0.98 cm^(2),V_(OC) loss:0.336 V)have been achieved for the blade-coated PSCs(1.54 eV E_(g))with our new ETLs,representing a record for SnO_(2) based blade-coated PSCs.Moreover,a substantially enhanced PCE(V_(OC))from 20.4%(1.15 V)to 22.8%(1.24 V,90 mV higher V_(OC),0.04 cm^(2) device)in the blade-coated 1.61 eV PSCs system,via replacing the benchmark commercial colloidal SnO_(2) with our new ETLs. | Zhiwei Ren Kuan Liu Hanlin Hu Xuyun Guo Yajun Gao Patrick W.K.Fong Qiong Liang Hua Tang Jiaming Huang Hengkai Zhang Minchao Qin Li Cui Hrisheekesh Thachoth Chandran Dong Shen Ming-Fai Lo Annie Ng Charles Surya Minhua Shao Chun-Sing Lee Xinhui Lu Frédéric Laquai Ye Zhu Gang Li | 2021 | Light(Science & Applications)2021，10，12： | 0 |
| 6 | Achieving Tunable Cold/Warm White‑Light Emission in a Single Perovskite Material with Near‑Unity Photoluminescence Quantum Yield显示文摘Single materials that exhibit efficient and stable white-light emission are highly desirable for lighting applications.This paper reports a novel zero-dimensional perovskite,Rb_(4)CdCl_(6):Sn^(2+),Mn^(2+),which demonstrates exceptional white-light properties including adjustable correlated color temperature,high color rendering index of up to 85,and near-unity photoluminescence quantum yield of 99%.Using a co-doping strategy involving Sn^(2+)and Mn^(2+),cyan-orange dual-band emission with complementary spectral ranges is activated by the self-trapped excitons and d-d transitions of the Sn^(2+)and Mn^(2+)centers in the Rb_(4)CdCl_(6)host,respectively.Intriguingly,although Mn^(2+)ions doped in Rb_(4)CdCl_(6)are difficult to excite,efficient Mn^(2+)emission can be realized through an ultra-high-efficient energy transfer between Sn^(2+)and Mn^(2+)via the formation of adjacent exchange-coupled Sn–Mn pairs.Benefiting from this efficient Dexter energy transfer process,the dual emission shares the same optimal excitation wavelengths of the Sn^(2+)centers and suppresses the non-radiative vibration relaxation significantly.Moreover,the relative intensities of the dual-emission components can be modulated flexibly by adjusting the fraction of the Sn^(2+)ions to the Sn–Mn pairs.This co-doping approach involving short-range energy transfer represents a promising avenue for achieving high-quality white light within a single material. | Bo Zhou Aixuan Du Dong Ding Zexiang Liu Ye Wang Haizhe Zhong Henan Li Hanlin Hu Yumeng Shi | 2023 | Nano-Micro Letters2023，15，11： | 0 |
| 7 | Ionic liquid engineering enabled in-plane orientated 1D perovskite nanorods for efficient mixed-dimensional perovskite photovoltaics显示文摘Mixed-dimensional engineering of perovskite material has been demonstrated as a facile and promising strategy to improve both photovoltaic performance and long-term stability of perovskite solar cells(PSCs).In this study,we report an in-plane preferred orientation of 1D perovskite induced by an ionic liquid(IL)of 1-(3-cyanopropyl)-3-methylimidazolium chloride(CPMIMCl)for the first time via sequential deposition approach,leading to a mixed dimensional perovskite thin films.The generated one-dimensional(1D)CPMIMPbI3 with in-plane orientation resides at the grain boundaries of three-dimensional(3D)perovskite can be appreciably observed from the morphology level,leading to creation of high-quality films with large grain size with more efficient defect passivation.Moreover,the dispersion of IL in the bulk phase of perovskite material allows for the formation of 1D perovskite for multiple level passivation to inhibit non-radiative recombination and optimize carrier transport.This IL engineering strategy not only yields a mixed-dimensional perovskite heterostructure with in-plane orientation 1D perovskite nano-rods but also significantly improves the opto-electronic property with suppressed trap states.As a result,the CPMIMCl-treated PSCs show an enhanced photovoltaic performance with a champion power conversion efficiency(PCE)up to 24.13%.More importantly,benefiting from the hydrophobicity of formed 1D perovskite and defects suppression,the corresponding PSC demonstrates an excellent longterm stability and maintain 97.1%of its pristine PCE at 25C under 50%RH condition over 1000 h.This research provides an innovative perspective for employing the low dimensional engineering to optimize the performance and stability of photovoltaic devices. | Fei Wang Dawei Duan Kang Zhou YZBXue Xiao Liang Xianfang Zhou Chuangye Ge Chao Zhou Jin Xiang Jiajie Zhu Quanyao Zhu Haoran Lin Yumeng Shi Yonghua Chen Gang Li Hanlin Hu | 2023 | InfoMat2023，5，8： | 0 |
| 8 | Contributions of Chinese scholars to body donation research in international journals显示文摘Anatomical dissectionis an important part of human anatomy course and relies much on cadavers.Body donation is the primary source of cadavers used in ana tomical dissection course in China.This study aimed to systematically review the contributions of Chinese scholars to body donation research in international journals,in the 100^(th) anniversary of the foundation of Chinese Society for Anatomical Sciences.The search was conducted on May 12,2020.The searching strategy was(body or anatomy or anatomical or cadaver or cadaveric)and(donate or donation or bequest or gift or gifting)and(China or Hong Kong or Macao or Taiwan).Only English articles focusing on body donation research were included.A total of 578 articles were retrieved. | Zhang Hanlin Tang Keyun Hu Xinzhi Wang Yuanzhuo Liu Runzhu Ma Chao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 9 | Efficient energy transfer in organic light-emitting transistor with tunable wavelength显示文摘Key challenges in the development of organic light-emitting transistors(OLETs)are blocking both scientific research and practical applications of these devices,e.g.,the absence of high-mobility emissive organic semiconductor materials,low device efficiency,and color tunability.Here,we report a novel device configuration called the energy transfer organic light-emitting transistor(ET-OLET)that is intended to overcome these challenges.An organic fluorescent dye-doped polymethyl methacrylate(PMMA)layer is inserted below the conventional high-mobility organic semiconductor layer in a single-component OLET to separate the functions of the charge transport and light-emitting layers,thus making the challenge to essentially integrate the high mobility and emissive functions within a single organic semiconductor in a conventional OLET or multilayer OLET unnecessary.In this architecture,there is little change in mobility,but the external quantum efficiency(EQE)of the ET-OLET is more than six times that of the conventional OLET because of the efficient Förster resonance energy transfer,which avoids exciton-charge annihilation.In addition,the emission color can be tuned from blue to white to green-yellow using the sourcedrain and gate voltages.The proposed structure is promising for use with electrically pumped organic lasers. | Ke Zhou Jian Tang Shaofan Fang Ke Jiang Fangxu Yang Deyang Ji Jing Xiang Jie Liu Huanli Dong(✉) Cheng Han Hanlin Hu Xiaotao Zhang Wenping Hu Yumeng Shi | 2022 | Nano Research2022，15，4： | 0 |
| 10 | Recent progress of scalable perovskite solar cells and modules显示文摘The rapid development of perovskite solar cells(PSCs)over the past decade makes it the most promising next generation photovoltaic technology.Splendid progress in efficiency and stability has been demonstrated in laboratory level,while endeavours are extremely required to enable successful transfer of the printable PSC technology to industry scale toward commercialization.In this work,recent progresses on upscaling of PSCs are systematically reviewed.Starting with the traditional PSC structure,we have analyzed the specially designed configuration for perovskite solar modules(PSMs).The comprehensive overview and assessment are provided for the technologies engineering in large-scale preparation,including both solution processing and vapor-phase deposition methods.Considering the promoting effect of material engineering to scale up PSMs,the application of additive engineering,solvent engineering and interface engineering on the stability and efficiency of PSMs is systematacially discussed.Moreover,the effect of current packaging technology of PSMs on device lifetime and environmental friendliness is emphasized.At last,we propose the prospects and challenges of PSMs commercialization in the future to meet the requirements for next generation photovoltaic industry. | Fei Wang Yu Han Dawei Duan Chuangye Ge Hanlin Hu Gang Li | 2022 | Energy Reviews2022，1，2： | 0 |
| 11 | Highly specific characterization and discrimination of monosodium urate crystals in gouty arthritis based on aggregation-induced emission luminogens显示文摘Existing technologies used to detect monosodium urate(MSU)crystals for gout diagnosis are not ideal due to their low sensitivity and complexity of operation.The purpose of this study was to explore whether aggregation-induced emission luminogens(AIEgens)can be used for highly specific imaging of MSU crystals to assist in the diagnosis of gout.First,we developed a series of luminogens(i.e.,tetraphenyl ethylene(TPE)-NH_(2),TPE-2NH_(2),TPE-4NH_(2),TPE-COOH,TPE-2COOH,TPE-4COOH,and TPE-Ketoalkyne),each of which was then evenly mixed with MSU crystals.Next,optimal fluorescence imaging of each of the luminogens was characterized by a confocal laser scanning microscope(CLSM).This approach was used for imaging standard samples of MSU,hydroxyapatite(HAP)crystals,and mixed samples with 1:1 mass ratio of MSU/HAP.We also imaged samples from mouse models of acute gouty arthritis,HAP deposition disease,and comorbidities of interest.Subsequently,CLSM imaging results were compared with those of compensated polarized light microscopy,and we assessed the biosafety of TPE-Ketoalkyne in the RAW264.7 cell line.Finally,CLSM time series and three-dimensional imaging were performed on MSU crystal samples from human gouty synovial fluid and tophi.As a promising candidate for MSU crystal labeling,TPE-Ketoalkyne was found to detect MSU crystals accurately and rapidly in standard samples,animal samples,and human samples,and could precisely distinguish gout from HAP deposition disease.This work demonstrates that TPE-Ketoalkyne is suitable for highly specific and timely imaging of MSU crystals in gouty arthritis and may facilitate future research on MSU crystal-related diseases. | Wenjuan Wang Guiquan Zhang Ziyi Chen Hanlin Xu Bohan Zhang Rong Hu Anjun Qin Yinghui Hua | 2023 | Bio-Design and Manufacturing2023，6，6： | 0 |
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