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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | High Power Linearly Polarized Raman Fiber Laser With Stable Temporal Output显示文摘We demonstrate a high power linearly polarized Raman fiber laser(RFL)pumped by an amplified spontaneous emission(ASE)source.Temporal-stable operation of RFL could be ensured owing to the employment of ASE,which mitigates the inherent intensity noise compared with the classic scheme adopting laser oscillator as pump source.In this experiment,the RFL has up to 119.5W output power,with central wavelength of 1129.2nm,and full width at half maximum(FWHM)linewidth of about 4.18nm.The polarization extinction ratio(PER)of the Raman laser is about 23dB.Moreover,this laser has excellent long-term and short-term stabilities in terms of the output power and time domain. | Jiaxin SONG Hanshuo WU Jun YE Jiangming XU Hanwei ZHANG Pu ZHOU | 2019 | Photonic Sensors2019，9，1： | 4 |
| 3 | Somatic mutations in renal cell carcinomas from Chinese patients revealed by targeted gene panel sequencing and their associations with prognosis and PD-L1 expression显示文摘Dear Editor, Renal cell carcinoma (RCC) is among the most common human cancers in the United States, with approximately 63,990 new patients and 14,400 deaths annually [1]. However, RCC is not among the top 10 malignancies in China in terms of incidence and mortality [2]. The clini-cal and molecular features of RCC differ among distinct pathological types, mainly clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PRCC), and chromophobe renal cell carcinoma (ChRCC). The most common subtype of RCC is ccRCC worldwide. Accord-ing to The Cancer Genome Atlas (TCGA), the somatic mutation landscape of RCC has been revealed by whole- exome sequencing (WES) or whole-genome sequencing (WGS). In our previous WES study, we validated most of the significantly mutated genes reported by the TCGA and identified several novel somatically altered genes [3]. The TCGA study showed that only somatic mutations in BRCA1-associated protein 1 (BAP1) were associated with patients’ poor survival outcomes among all significantly mutated genes [4]. In our previous WES study, BAP1 was somatically mutated in 2 of 15 ccRCC samples [3]. Never-theless, all of these RCC patients lacked follow-up infor-mation. Hence, further analysis is needed to determine whether there are any somatically mutated genes associ-ated with the prognosis of Chinese patients with RCC. However, WES or WGS is time-consuming and costly. Furthermore, compared with targeted sequencing, WES was more likely to generate false positives and false nega-tives due to insufficient base coverage [5]. | Jie Wang Jianzhong Xi Hanshuo Zhang Juan Li Yuchao Xia Ruibin Xi Zhijun Xi | 2019 | Cancer Communications2019，39，1： | 1 |
| 4 | Statement on Establishment of Public Health Protection Guideline for Cold Spells—China显示文摘Cold spells are extreme weather events characterized by the invasion of cold air from high latitudes into the middle and low latitudes,resulting in significant cooling.Cold spells have various adverse health effects,including epidermal damage,respiratory tract spasms,respiratory immune abnormalities,acute cardiopulmonary diseases,and exacerbation of urinary and endocrine disorders.In response to the frequent cold spells in recent years. | Tiantian Li Qinghua Sun Chen Chen Qing Wang Jie Ban Runmei Ma Yi Zhang Lijun Pan Yuanyuan Liu Qiutong Li Leyao Chang Hanshuo Zhang Yirong Liu Miaoyou Niu Xiangxiang Wei Lin Wang | 2024 | China CDC weekly2024，6，5： | 0 |
| 5 | Oral cancer overexpressed 1 (ORAOVI): A regulator for cell growth and tumor angiogenesis in oral squamous cell carcinoma显示文摘 | Qian Ming Chen Lu Jiang Xin Zeng Hanshuo Yang Zhi Wang Jun Shen Jingping Bai Yuanyuan Zhang Feng Gao Min Zhou | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 6 | Investigation on extreme frequency shift in silica fiber-based high-power Raman fiber laser显示文摘In this paper, we experimentally investigated the extreme frequency shift in high-power Raman fiber laser(RFL). The RFL was developed by using a pair of fiber Bragg gratings with fixed and matched central wavelength(1120 nm)combined with a piece of 31-m-long polarization maintaining(PM) passive fiber adopted as Raman gain medium.The pump source was a homemade high-power, linearly polarized(LP) wavelength-tunable master oscillator power amplifier(MOPA) source with ~25 nm tunable working range(1055–1080 nm). High-power and high-efficiency RFL with extreme frequency shift between the pump and Stokes light was explored. It is found that frequency shift located within 10.6 THz and 15.2 THz can ensure efficient Raman lasing, where the conversion efficiency is more than 95% of the maximal value, 71.3%. In addition, a maximum output power of 147.1 W was obtained with an optical efficiency of71.3%, which is the highest power ever reported in LP RFLs to the best of our knowledge. | Jiaxin Song Hanshuo Wu Jun Ye Hanwei Zhang Jiangming Xu Pu Zhou Zejin Liu | 2018 | High Power Laser Science and Engineering2018，6，2： | 0 |
| 7 | Virtual electromagnetic environment modeling based data augmentation for drone signal identification显示文摘Radio frequency(RF)-based drone identification technologies have the advantages of long effective distances and low environmental dependence,which has become indispensable for drone surveillance systems.However,since drones operate in unlicensed frequency bands,a large number of co-frequency devices exist in these bands,which brings a great challenge to traditional signal identification methods.Deep learning techniques provide a new approach to complete endto-end signal identification by directly learning the distribution of RF data.In such scenarios,due to the complexity and high dynamics of the electromagnetic environments,a massive amount of data that can reflect the various propagation conditions of drone signals is necessary for a robust neural network(NN)for identifying drones.In reality,signal acquisition and labeling that meet the above requirements are too costly to implement.Therefore,we propose a virtual electromagnetic environment modeling based data augmentation(DA)method to improve the diversity of drone signal data.The DA method focuses on simulating the spectrograms of drone signals transmitted in real-world environments and randomly generates extra training data in each training epoch.Furthermore,considering the limited processing capability of RF receivers,we modify the original YOLOv5s model to a more lightweight version.Without losing the identification performance,more hardware-friendly designs are applied and the number of parameters decreases about 10-fold.For performance evaluation,we utilized a universal software radio peripheral(USRP)X310 platform to collect RF signals of four drones in an anechoic chamber and a practical wireless scenario.Experiment results reveal that the NN trained with augmented data performs as well as that trained with practical data in the complex electromagnetic environment. | Hanshuo Zhang Tao Li Yongzhao Li Zhijin Wen | 2023 | Journal of Information and Intelligence2023，1，4： | 0 |
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