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| 1 | Fractional differential approach to detecting textural features of digital image and its fractional differential filter implementation显示文摘This paper mainly discusses fractional differential approach to detecting textural features of digital image and its fractional differential filter. Firstly,both the geometric meaning and the kinetic physical meaning of fractional differential are clearly explained in view of information theory and kinetics,respectively. Secondly,it puts forward and discusses the definitions and theories of fractional stationary point,fractional equilibrium coefficient,fractional stable coefficient,and fractional grayscale co-occurrence matrix. At the same time,it particularly discusses fractional grayscale co-occurrence matrix approach to detecting textural features of digital image. Thirdly,it discusses in detail the structures and parameters of n×n any order fractional differential mask on negative x-coordinate,positive x-coordinate,negative y-coordinate,positive y-coordinate,left downward diagonal,left upward diagonal,right downward diagonal,and right upward diagonal,respectively. Furthermore,it discusses the numerical implementation algorithms of fractional differential mask for digital image. Lastly,based on the above-mentioned discussion,it puts forward and discusses the theory and implementation of fractional differential filter for digital image. Experiments show that the fractional differential-based image operator has excellent feedback for enhancing the textural details of rich-grained digital images. | PU YiFei WANG WeiXing ZHOU JiLiu WANG YiYang JIA HuaDing | 2008 | Science in China(Series F)2008，51，9： | 50 |
| 2 | A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma显示文摘 | ZHAN Hai-lun GAO Xin PU Xiao-yong LI Wei LI Zhi-jian ZHOU Xiang-fu QIU Jian-guang | 2012 | Chinese Medical Journal2012，，21： | 48 |
| 3 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 4 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 5 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 6 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 7 | Water isotope variations in the snow pack and summer precipitation at July 1 Glacier, Qilian Mountains in northwest China显示文摘This paper presents the stable isotope data of the snow pack and summer precipitation collected at the July 1 Glacier, Qilian Mountains in northwest China and analyses their relationships with meteorologi- cal factors. On an event scale, there is no temperature effect on the δ 18O values in the summer pre- cipitation, whereas the amount effect is shown to be clear. By tracing the moisture transport history and comparing the precipitation with its isotopic composition, it is shown that this amount effect not only reflects the change in moisture trajectory, which is related to the monsoon activities, but is also associated with the cooling degree of vapor in the cloud, the evaporation of falling raindrops and the isotopic exchange between the falling drops and the atmospheric vapor. As very little precipitation occurs in winter, the snow pack profile mainly represents the precipitation in the other three seasons. There are low precipitation δ 18O ratios in summer and high ratios in spring and autumn. The Meteoric Water Line (MLW) for the summer precipitation is δ D = 7.6 δ 18O + 13.3, which is similar to that at Delingha, located in the south rim of the Qilian Mountains. The MWL for the snow pack is δ D = 10.4 δ 18O + 41.4, showing a large slope and intercept. The deuterium excess (d) of the snow pack is positively correlated with δ 18O, indicating that both d and δ 18O decrease from spring to summer and increase from early autumn to early spring. This then results in the high slope and intercept of the MWL. Sea- sonal fluctuations of d in the snow pack indicate the change of moisture source and trajectory. During spring and autumn, the moisture originates from continental recycling or rapid evaporation over rela- tively warm water bodies like Black, Caspian and Aral Seas when the dry westerly air masses pass over them, hence very high d values in precipitation are formed. During summer, the monsoon is responsi- ble for the low d values. This indicates that the monsoon can reach the western part of the Qilian Mountains. | ZHOU ShiQiao NAKAWO Masayoshi SAKAI Akiko MATSUDA Yoshihiro DUAN KeQin PU JianChen | 2007 | Chinese Science Bulletin2007，52，21： | 21 |
| 8 | Genome Analysis of the Ancient Tracheophyte Selaginella tama#scina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance显示文摘 | Zhichao Xu Tianyi Xin Dorothea Bartels Ying Li Wei Gu Hui Yao Sai Liu Haoying Yu Xiangdong Pu Jianguo Zhou Jiang Xu Caicai xi Hetian Lei Jingyuan song Shilin Chen | 2018 | Molecular Plant2018，11，7： | 20 |
| 9 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 10 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 11 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 12 | Coherent beam combining of high powerfiber lasers: Progress and prospect显示文摘The recent research progress of coherent beam combining of high power fiber lasers is reviewed. Key technologies like coherently combinable fiber laser, phase control of multiple beams and beam tilling are specially analyzed. Prospects for single coherently combinable high power fiber amplifier, beam tilling and target-in-the-loop control for propagation in real atmosphere are presented. | LIU ZeJin ZHOU Pu XU XiaoJun WANG XiaoLin MA YanXing | 2013 | Science China(Technological Sciences)2013，56，7： | 16 |
| 13 | Development status of high power fiber lasers and their coherent beam combination显示文摘High-power fiber laser has been emerged great potential in a wide range of applications and becomes a robust candidate for high energy solid state laser system. To further increase the output brightness of single-channel fiber laser, high-brightness pump sources and high-power-handling passive components should be fabricated and utilized in the fiber laser systems, in addition to the advanced techniques for multiple nonlinear effects managements. The state-of-the-art high power fiber lasers are reviewed, in terms of narrow-linewidth fiber lasers, broadband fiber lasers and fiber lasers at 2 μm. Coherent beam combining is a promising technique to obtain higher output power while maintaining excellent beam quality simultaneously,which breaks through the bottlenecks of single-channel fiber laser. Based on a series of key techniques for coherent beam combining, high-power coherent beam combining of fiber lasers could be enabled with high combining efficiency. In this paper, we review the progress of high-power fiber lasers and their coherent beam combining in the recent decade, particularly the relevant work in our group. The future prospects of fiber lasers and coherent beam combining technique are also discussed. | Zejin LIU Xiaoxi JIN Rongtao SU Pengfei MA Pu ZHOU | 2019 | Science China(Information Sciences)2019，62，4： | 15 |
| 14 | 1.3 kW monolithic linearly polarized single-mode master oscillator power amplifier and strategies for mitigating mode instabilities显示文摘We report on the high-power amplification of a 1064 nm linearly polarized laser in an all-fiber polarizationmaintained master oscillator power amplifier,which can operate at an output power level of 1.3 kW.The beam quality(M^2) was measured to be <1.2 at full power operation.The polarization extinction rate of the fiber amplifier was measured to be above 94% before mode instabilities(MIs) set in,which reduced to about 90% after the onset of MI.The power scaling capability of strategies for suppressing MI is analyzed based on a semianalytical model,the theoretical results of which agree with the experimental results.It shows that mitigating MI by coiling the gain fiber is an effective and practical method in standard double-cladding large mode area fiber,and,by tight coiling of the gain fiber to the radius of 5.5 cm,the MI threshold can be increased to three times higher than that without coiling or loose coiling.Experimental studies have been carried out to verify the idea,which has proved that MI was suppressed successfully in the amplifier by proper coiling. | Rumao Tao Pengfei Ma Xiaolin Wang Pu Zhou Zejin Liu | 2015 | Photonics Research2015，3，3： | 15 |
| 15 | 腹腔镜前列腺癌切除术:中国单一研究机构对126例患者最少三年的肿瘤和功能性随访结果显示文摘本文评估了在中国最大样本的腹腔镜前列腺癌切除术对126例患者最少三年的肿瘤和功能性随访结果。从2000年10月到2004年5月,126例患者(平均年龄62.5岁,56.78岁之间)接受了腹腔镜前列腺癌根治术,其前列腺癌特异性抗原平均水平为13.4ng/mL,Gleason评分6分,27例患者接受了单侧或双侧勃起神经保留术,29例患者接受了盆腔淋巴结清扫术。生化复发定义为PSA〉0.2ngmL^-1。Logistic和Cox多元回归模型用于比较临床病理参数和无生化复发进展(bPFS)之间的关系。平均手术时间为250分钟(110—660分钟),平均失血量354毫升(150-1100毫升)。无转为开放手术。4例主要并发症,包括直肠损伤2例,输尿管损伤1例和活动性出血1例。总体的切缘阳性率(PSM)为20.6%以及与病理分期相关。在超过3年(平均4.6年)的随访中,98.4%的患者能够控尿,2例患者腹压增加时需要尿垫。在3年的随访中,22例(81.5%)患者接受勃起神经保留的患者术后恢复了勃起功能。3年的随访期间,总体的生存率为100%,无生化复发率为81.0%。本研究为中国首次报道大于三年的腹腔镜前列腺癌根治术的结果,与以前文献报道的开放手术和腹腔镜手术具有相似的肿瘤随访结果和发病率。 | Xin Gao Jian-Hua Zhou Liao-Yuan Li Jian-Guang Qiu Xiao-Yong Pu | 2009 | Asian Journal of Andrology2009，11，5： | 13 |
| 16 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 17 | Fractional partial differential equation denoising models for texture image显示文摘In this paper,a set of fractional partial differential equations based on fractional total variation and fractional steepest descent approach are proposed to address the problem of traditional drawbacks of PM and ROF multi-scale denoising for texture image.By extending Green,Gauss,Stokes and Euler-Lagrange formulas to fractional field,we can find that the integer formulas are just their special case of fractional ones.In order to improve the denoising capability,we proposed 4 fractional partial differential equation based multiscale denoising models,and then discussed their stabilities and convergence rate.Theoretic deduction and experimental evaluation demonstrate the stability and astringency of fractional steepest descent approach,and fractional nonlinearly multi-scale denoising capability and best value of parameters are discussed also.The experiments results prove that the ability for preserving high-frequency edge and complex texture information of the proposed denoising models are obviously superior to traditional integral based algorithms,especially for texture detail rich images. | PU YiFei SIARRY Patrick ZHOU JiLiu LIU YiGuang ZHANG Ni HUANG Guo LIU YiZhi | 2014 | Science China(Information Sciences)2014，57，7： | 13 |
| 18 | Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization显示文摘许多研究建议了的背景 angiogenic 因素和 anti-angiogenic 因素表示的不平衡显著地作出贡献到 choroidal 的开发 neovascularization (CNV ) ,和超声 microbubble 联合系统能成功地增加基因 transfection 效率。这研究被设计调查调停超声的 microbubble 破坏是否,并且是否能有效地交付治疗学的 plasmid 进老鼠的视网膜导出上皮的因素( PEDF )能禁止的颜料的基因转移 CNV.Methods 人的网膜的颜料上皮的房间独自与超声或 plasmid 被孤立并且对待任何一个,或与接近 提高microbubble 的超声的可行性的 plasmid ,超声和 microbubbles 的联合提高 PEDFgene expressio 因为在 vivo 动物学习, CNV 被氩 lasgon 激光在老鼠导致。这些老鼠随机被分到五个组并且被灌输与 PEDF 的裸体 plasmid DNA 依附进的 microbubbles 对待立即的超声暴露(intravitreal 注射) 跟随的老鼠玻璃;与 PEDF 的裸体 plasmid DNA 灌输 liposomes 进玻璃(lipofectamine + PEDF ) ;灌输立即与超声照耀与 PEDF 依附进老鼠的轨道的 microbubbles (retrobular 注射) ;灌输 microbubbles 与 PEDF 属于进老鼠的大腿骨的静脉与立即暴露了到超声(静脉注射) 。没有任何处理的 CNV 老鼠用作控制。老鼠被牺牲,眼睛是在在处理以后的 7, 14,和 28 天的 enucleated。PEDF 的基因和蛋白质表示被量的即时 RT-PCR,西方的弄污和分别地染色的 immunofluorescence 检测。CNV 上的 PEDF 基因转移的效果被荧光黄宫底 angiography.Results 在房间实验显示出的 vitro 检验有超声照耀的那 microbubbles 能显著地独自作为与 microbubbles 或超声相比提高 PEDF 交货。在老鼠 CNV 模型, transfection 效率由 ultrasound/microbubbles 调停了由在在处理以后的 28 天的调停 lipofectamine 的基因转移比那显著地高。学习也证明与调停超声的 microbubbles 破坏的管理,老鼠的 CNV 被禁止 effectively.Conclusions Ultrasound-microbubble 技术能增加 PEDF 基因转移进老鼠的视网膜和 chorioid ,与 CNV 的发展的重要抑制联合,建议这个 noninvasive 基因转移方法可以为临床的基因治疗提供一个有用工具。 | ZHOU Xi-yuan LIAO Qing PU Yi-min TANG Yong-qiang GONG Xiao LI Jia XU Yan WANG Zhi-gang | 2009 | Chinese Medical Journal2009，，22： | 12 |
| 19 | Numerical study on ULF waves in a dipole field excited by sudden impulse显示文摘A three-dimensional numerical model is employed to investigate ULF waves ex-cited by the sudden impulse (SI) of the solar wind dynamic pressure interacting with a dipole magnetosphere. We focus on the solar wind-magnetosphere energy coupling through ULF waves, and the influences of the SI spectrum on the cavity mode structure and the energy deposition due to field line resonances (FLRs) in the magnetosphere. The numerical results show that for a given SI lasting for 1 min with amplitude of 50 mV/m impinging on the subsolar magnetopause, the total ULF energy transported from the solar wind to the magnetosphere is about the magni-tude of 1014 J. The efficiency of the solar wind energy input is around 1%, which depends little on the location of the magnetopause in the model. It is also found that the energy of the cavity mode is confined in the region near the magnetopause, whereas, the energy of the toroidal mode may be distributed among a few specific L-shells. With a given size of the model magnetosphere and plasma density distri-bution, it is shown that the fundamental eigenfrequency of the cavity mode and the central locations of the FLRs do not vary noticeably with the power spectrum of the SI. It is worth noting that the spectrum of the SI affects the excitation of higher harmonics of the global cavity mode. The broader the bandwidth of the SI is, the higher harmonics of cavity mode could be excited. Meanwhile, the corresponding FLRs regions are broadened at the same time, which implies that the global cavity modes and toroidal modes can resonate on more magnetic L-shells when more harmonics of the global cavity modes appear. | YANG Biao FU SuiYan ZONG QiuGang WANG YongFu ZHOU XuZhi PU ZuYin XIE Lun | 2008 | Science China(Technological Sciences)2008，51，10： | 12 |
| 20 | Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion显示文摘 | Wu, Han Zhou, Xu Fu, Gong-Bo He, Zhi-Ying Wu, Hong-Ping You, Pu Ashton, Charles Wang, Xin Wang, Hong-Yang Yan, He-Xin | 2017 | Cell Research2017，27，5： | 12 |
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