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| 1 | Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis显示文摘Ovarian cancer is the second leading cause of death in women with gynecological malignancy in China.Circular RNAs are a class of noncoding regulatory RNAs reported to be involved in cancer development and progression.Previous studies,including our own,have indicated that hsa_circ_0007444 is downregulated in ovarian cancer tissues.This study aims to elucidate the function and mechanism of hsa_circ_0007444 in ovarian cancer progression.The expression of hsa_circ_0007444 is determined by quantitative real-time PCR(qRT-PCR).Cell proliferation,invasion,migration and apoptosis are examined by cell counting-kit 8(CCK-8),transwell and flow cytometry assays.Tumor growth and metastasis are assessed in vivo using Balb/c nude mouse xenograft model and tail vein injection model.And the mechanism of action of hsa_circ_0007444 is analysed by RNA-binding protein immunoprecipitation(RIP),luciferase reporter and rescue assays.hsa_circ_0007444 is downregulated in ovarian cancer tissues and cell lines compared with that in normal ovarian tissues and normal epithelial cell line.Gain-and loss-of-function results indicate that hsa_circ_0007444 inhibits cell proliferation,invasion,migration and increases cell apoptosis of ovarian cancer cells in vitro,and inhibits tumor growth and lung metastasis in vivo.Mechanistically,hsa_circ_0007444 can interact with AGO2 and sponge miR-23a-3p,thereby upregulating DICER1 expression,which is an important tumor suppressor in ovarian cancer.And miR-23a-3p mimics can rescue the inhibitory effect of hsa_circ_0007444 on ovarian cancer cell proliferation,invasion and migration.Therefore,hsa_circ_0007444 can inhibit ovarian cancer progression through the hsa_circ_0007444/miR-23a-3p/DICER1 axis. | Min Zhang Yu Sun Hanzi Xu Yaqian Shi Rong Shen Fang Teng Juan Xu Xuemei Jia | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 2 | 术中超声在冷循环射频治疗肝脏肿瘤中的作用(英文)显示文摘目的将在肝的癌的凉爽尖端的射频脱离(RFA ) 探索 intraoperative ultrasonography (IOUS ) 的可行性和效率。肝的癌的 31 个病人在这被注册的方法学习。在哆开的, 开放的, 切开, 切断电路, 断电外科的凉爽尖端的射频脱离的过程, IOUS 被使用,指导并且监视 RFA 在的过程估计肝的损害即时。在 intraoperative ultrasonography 的指导下面的结果,在所有病人的户外 surgical RFA 顺利继续。七另外的肝的损害被发现那没在外科手术前的成像被检测。外科手术前的 MRI 报导的假积极局灶性损害被 IOUS 精确地排除。结论 Intraoperative ultrasonography 比在发现损害错过的平常的成像技术优异,避免象胆汁管和容器的损害那样的复杂并发症。显然从而监视即时 RFA 过程优化肝的癌的治疗。 | Wentao Kong Weiwei Zhang Ningyi Shao Hanzi Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 3 | Functional genomics of Brassica napus:Progresses,challenges,and perspectives显示文摘Brassica napus,commonly known as rapeseed or canola,is a major oil crop contributing over 13%to the stable supply of edible vegetable oil worldwide.Identification and understanding the gene functions in the B.napus genome is crucial for genomic breeding.A group of genes controlling agronomic traits have been successfully cloned through functional genomics studies in B.napus.In this review,we present an overview of the progress made in the functional genomics of B.napus,including the availability of germplasm resources,omics databases and cloned functional genes.Based on the current progress,we also highlight the main challenges and perspectives in this field.The advances in the functional genomics of B.napus contribute to a better understanding of the genetic basis underlying the complex agronomic traits in B.napus and will expedite the breeding of high quality,high resistance and high yield in B.napus varieties. | Zengdong Tan Xu Han Cheng Dai Shaoping Lu Hanzi He Xuan Yao Peng Chen Chao Yang Lun Zhao Qing-Yong Yang Jun Zou Jing Wen Dengfeng Hong Chao Liu Xianhong Ge Chuchuan Fan Bing Yi Chunyu Zhang Chaozhi Ma Kede Liu Jinxiong Shen Jinxing Tu Guangsheng Yang Tingdong Fu Liang Guo Hu Zhao | 2024 | Journal of Integrative Plant Biology2024，66，3： | 0 |
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