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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Review on the Research and Practice of Deep Learning and Reinforcement Learning in Smart Grids显示文摘Smart grids are the developmental trend of power systems and they have attracted much attention all over the world.Due to their complexities,and the uncertainty of the smart grid and high volume of information being collected,artificial intelligence techniques represent some of the enabling technologies for its future development and success.Owing to the decreasing cost of computing power,the profusion of data,and better algorithms,AI has entered into its new develop-mental stage and AI 2.0 is developing rapidly.Deep learning(DL),reinforcement learning(RL)and their combination-deep reinforcement learning(DRL)are representative methods and relatively mature methods in the family of AI 2.0.This article introduces the concept and status quo of the above three methods,summarizes their potential for application in smart grids,and provides an overview of the research work on their application in smart grids. | Dongxia Zhang Xiaoqing Han Chunyu Deng | 2018 | CSEE Journal of Power and Energy Systems2018，4，3： | 44 |
| 3 | Synchronization of two coupled exciters in a vibrating system of spatial motion显示文摘纸建议调查二的同步的一条分析途径在空间运动的一个颤动的系统联合了 exciters。为二 exciters 的平均尖速度介绍骚乱参数,我们推出二 exciters,联合矩阵的惯性在是对称的尖速度的非维的联合方程并且联合矩阵的僵硬在一个非反响的颤动系统是反对称的。阶段角度的联合余弦效果将引起对二台马达起作用限制二 exciters 之间的阶段差别的增加以及在跑期间支撑它二 exciters 的对称的转矩的动态典型表演处理的联合的分析。它身体上解释二 exciters 的自我同步的怪癖。颤动的阶段角度的余弦效果由每 exciter 愿望减少使它惯性的时刻激动。每 exciter 的惯性的剩余时刻代表它惯性的相对时刻。 exciters 是二 exciters 的惯性的相对非维的时刻都比乘他们的产品的零和四伟大的二的同步的稳定性条件比他们阶段角度的联合余弦效果的系数的平方大,它等价于联合矩阵的惯性是积极的明确并且所有它的元素是积极的。数字结果证明颤动的系统的结构能保证同步操作的稳定性条件。关键词频率俘获-稳定性-同步-颤动的系统-振动同步传播工程被辽宁省学院科学和研究( 2008S095 )支持,中国的国家自然科学基础的关键工程( 50535010 , 50805020 )并且中国( 2007AA04Z442 )的高技术研究和开发节目。 | Chunyu Zhao Hongtao Zhu Yimin Zhang Bangchun Wen | 2010 | Acta Mechanica Sinica2010，26，3： | 25 |
| 4 | Control theorem of a universal uniform-rotating magnetic vector for capsule robot in curved environment显示文摘For realizing non-contact steering swimming of a capsule robot in curved environment filled with viscous liquid,based on spatial orthogonal superposition theorem of alternating magnetic vectors,an innovative physical method is proposed,which employs three-axis orthogonal square Helmholtz coils fed with three phase sine currents to create a universal uniform magnetic spin vector as energy source.According to the antiphase sine current superposition theorem generalized in this paper,an effective control method for successively adjusting the orientation and the rotating direction of the universal magnetic spin vector is proposed.For validating its feasibility and controllability,three-axis Helmholtz coils,power source and an innovative capsule robot prototype were manufactured,experiments were conducted in both spiral pipe and animal intestine.It was demonstrated that the orientation and the rotational direction of the universal uniform-magnetic spin vector can be adjusted successively through digital control and steering swimming of the capsule robot in spiral intestine can be achieved successfully.The breakthrough of the universal rotating uniform-magnetic vector will push forward the development of modern physics and biomedical | ZHANG YongShun WANG Na DU ChunYu SUN Ying WANG DianLong | 2013 | Science China(Technological Sciences)2013，56，2： | 16 |
| 5 | Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems显示文摘To investigate the effects of Cd on tolerance and antioxidant activities of castor, two different castor(Ricinus communis L.) cultivars(Zibo No. 5 and Zibo No. 8) were used for a hydroponic experiment(0, 1 and 2 mg/L Cd) and a pot experiment using Cd-contaminated soil(34 mg/kg) with the addition of ethylenedinitrilotetraacetic acid(EDTA). The results indicated that there were significant differences between the two cultivars with respect to Cd uptake in shoots(113–248 mg/kg for Zibo No. 5 and 130–288 mg/kg Zibo No. 8), biomass tolerance indexes(64.9%–74.6% for Zibo No. 5 and 80.1%–90.9% for Zibo No. 8) in the hydroponic experiment and survival rates(0% for Zibo No. 5 and 100% for Zibo No. 8)determined by the addition of EDTA in the pot experiment, suggesting that Zibo No. 8 has higher tolerance than Zibo No. 5. Moreover, the castor cultivars have low bioconcentration factors(4.80% for Zibo No. 5 and 5.43% for Zibo No. 8) and low translocation factors(<1%).Consequently, Zibo No. 8 can participate in Cd phytostabilization in highly Cd-polluted areas. The results indicated that glutathione(GSH) as a non-enzymatic antioxidant, and antioxidant enzymes including superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(GPX), were cultivar- and dose-dependent. The higher tolerance of Zibo No. 8compared with Zibo No. 5 can be attributed to the higher GSH levels in the root and higher GPX activity in the leaf. | Hanzhi Zhang Qingjun Guo Junxing Yang Tongbin Chen Guangxu Zhu Marc Peters Rongfei Wei Liyan Tian Chunyu Wang Deyun Tan Jie Ma Gangming Wang Yingxin Wan | 2014 | Journal of Environmental Sciences2014，26，10： | 15 |
| 6 | Integrating TM and Ancillary Geographical Data with Classification Trees for Land Cover Classification of Marsh Area显示文摘The main objective of this research is to determine the capacity of land cover classification combining spec- tral and textural features of Landsat TM imagery with ancillary geographical data in wetlands of the Sanjiang Plain, Heilongjiang Province, China. Semi-variograms and Z-test value were calculated to assess the separability of grey-level co-occurrence texture measures to maximize the difference between land cover types. The degree of spatial autocorrelation showed that window sizes of 3×3 pixels and 11×11 pixels were most appropriate for Landsat TM im- age texture calculations. The texture analysis showed that co-occurrence entropy, dissimilarity, and variance texture measures, derived from the Landsat TM spectrum bands and vegetation indices provided the most significant statistical differentiation between land cover types. Subsequently, a Classification and Regression Tree (CART) algorithm was applied to three different combinations of predictors: 1) TM imagery alone (TM-only); 2) TM imagery plus image texture (TM+TXT model); and 3) all predictors including TM imagery, image texture and additional ancillary GIS in- formation (TM+TXT+GIS model). Compared with traditional Maximum Likelihood Classification (MLC) supervised classification, three classification trees predictive models reduced the overall error rate significantly. Image texture measures and ancillary geographical variables depressed the speckle noise effectively and reduced classification error rate of marsh obviously. For classification trees model making use of all available predictors, omission error rate was 12.90% and commission error rate was 10.99% for marsh. The developed method is portable, relatively easy to im- plement and should be applicable in other settings and over larger extents. | NA Xiaodong ZHANG Shuqing ZHANG Huaiqing LI Xiaofeng YU Huan LIU Chunyue | 2009 | Chinese Geographical Science2009，19，2： | 14 |
| 7 | Observation of mega-dune evaporation after various rain events in the hinterland of Badain Jaran Desert, China显示文摘The formation mechanisms of the mega-dunes and lakes in the hinterland of Badain Jaran Desert,China,is the focus of extensive academic research in the field of geoscience,and an often debated topic is whether atmospheric precipitation on the mega-dune can infiltrate to recharge groundwater.In the present study,the probability distribution functions and the return period analysis of extreme daily precipitation based on long-term precipitation records for the southern margin of Badain Jaran Desert and 2-year observation of hinterland precipitation were used to classify precipitation in the desert region.The data of automatic weather station and eddy covariance system in the desert hinterland were used to analyze evaporation on the mega-dune surface after various rain events.The results showed that the rain events in the desert could be divided into three categories.The first is conventional precipitation(CP),which is below 5 mm,accounting for roughly 90%of all rain events in the desert.The second and third categories are ordinary annual maximum(OAM)and extreme precipitation(EP),in which precipitation is roughly 20 mm and more than 40 mm,respectively.The atmospheric precipitation of CP and OAM evaporated from the megadune surface in 1–3 days and 3–4 weeks,respectively.Following an EP event,the mega-dune evaporation was negatively influenced by the upper dry sand layer,and a lengthy period was required for its complete removal.The accumulative evaporation and accumulative precipitation of all three types of rain events indicated that local atmospheric precipitation had no significant contribution to recharging the groundwater system in the hinterland of Badain Jaran Desert.This research will benefit comprehensive elucidation of the formation mechanism of lakes in the hinterland of Badain Jaran Desert. | Ning Ma Naiang Wang Liqiang Zhao Zhenyu Zhang Chunyu Dong Shiping Shen | 2014 | Chinese Science Bulletin2014，59，2： | 14 |
| 8 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 9 | Synchronization of the four identical unbalanced rotors in a vibrating system of plane motion显示文摘A new mechanism is proposed to implement the synchronization of the four unbalanced rotors in a vibrating system, which consists of a main rigid frame (MRF) and two accessorial rigid frames (ARF). An analytical approach is developed to study the coupling dynamic characteristics of the four unbalanced rotors, which converts the problem of synchronization of the four unbalanced rotors into the existence and the stability of zero solutions for the non-dimensional differential equations of the angular velocity disturbance parameters (NDDEDP). The stability of zero solutions of the NDDEDP is decomposed into that of its generalized system and a system of the three first order differential equations for the disturbance parameters of the phase differences. The coupling dynamic characteristic of the four unbalanced rotors includes the inertia coupling, the stiffness coupling of angular velocity and the load torque coupling. The non-dimensional inertia coupling matrix is symmetric, the non dimensional matrix of the stiffness coupling of angular velocity is antisymmetric and its diagonal elements are all negative. Hence, the general system of the NDDEDP automatically satisfies the generalized Lyapunov equations when the non-dimensional inertia coupling matrix is positive definite and its elements are all positive. Using Routh-Hurwitz criterion the condition of stability of differential equations for the disturbance parameters of the phase differences is obtained. The load torque coupling makes the vibrating system have the dynamic characteristic of selecting motions and self-synchronization of the four unbalanced rotors arises from the dynamic characteristic of selecting motion of the vibrating system. When the two coefficients of coupling cosine effect of phase angles are all greater than 0 and the three indexes of synchronization are all far greater than 1, the vibrating system can implement an elliptical motion of the main rigid frame required in engineering. Numeric results show that the structural parameters of the proposed mechanism can guarantee the non-dimensional inertia matrix to be always positive definite. Computer simulation is carried out to verify the results of the theoretical investigation. | ZHAO ChunYu, WEN BangChun & ZHANG XueLiang School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110004, China | 2010 | Science China(Technological Sciences)2010，53，2： | 12 |
| 10 | A point mutation resulting in a 13 bp deletion in the coding sequence of Cldf leads to a GA-deficient dwarf phenotype in watermelon显示文摘The dwarf architecture is an important and valuable agronomic trait in watermelon breeding and has the potential to increase fruit yield and reduce labor cost in crop cultivation.However,the molecular basis for dwarfism in watermelon remains largely unknown.In this study,a recessive dwarf allele(designated as Cldf(Citrullus lanatus dwarfism))was fine mapped in a 32.88 kb region on chromosome 09 using F2 segregation populations derived from reciprocal crossing of a normal line M08 and a dwarf line N21.Gene annotation of the corresponding region revealed that the Cla015407 gene encoding a gibberellin 3β-hydroxylase functions as the best possible candidate gene for Cldf.Sequence analysis showed that the fourth polymorphism site(a G to A point mutation)at the 3′AG splice receptor site of the intron leads to a 13 bp deletion in the coding sequence of Cldf in dwarf line N21 and thus results in a truncated protein lacking the conserved domain for binding 2-oxoglutarate.In addition,the dwarf phenotype of Cldf could be rescued by exogenous GA3 application.Phylogenetic analysis suggested that the small multigene family GA3ox(GA3 oxidase)in cucurbit species may originate from three ancient lineages in Cucurbitaceae.All these data support the conclusion that Cldf is a GA-deficient mutant,which together with the cosegregated marker can be used for breeding new dwarf cultivars. | Chunhua Wei Chunyu Zhu Liping Yang Wei Zhao Rongxue Ma Hao Li Yong Zhang Jianxiang Ma Jianqiang Yang Xian Zhang | 2019 | Horticulture Research2019，6，1： | 12 |
| 11 | Multi-scale analysis to uncover habitat use of red-crowned cranes: Implications for conservation显示文摘 | Chunyue LIU Hongxing JIANG Shuqing ZHANG Chunrong LI Yunqiu HOU Fawen QIAN | 2013 | Current Zoology2013，59，5： | 12 |
| 12 | Direction of arrival estimation and signal recovery based on single snapshot compressed sensing in frequency domain显示文摘Direction of arrival(DOA) estimation and signal recovery is the base of the underwater target localization,tracking and recognition.Based on the compressed sensing theory,a method for DOA estimation and source signal recovery is proposed using the single snapshot processing of the received array signal in frequency domain.The received array signal are transformed to frequency domain,and the single snapshot data in frequency domain are regarded as the measured data of the compressed sensing.According to the frequency,searching orientation and array manifold,the overcomplete array manifold is constructed as the sensing matrix of the compressed sensing.Both the target signal and power of the searching orientation are estimated by the basis pursuit method to complete DOA estimation and signal recovery.Simulation results show that the proposed method has a number of advantages over the minimum variance distortionless response(MVDR) method,including improved robustness to noise,fewer requirement in number of sensors and snapshots.And the correlation coefficient of the signal reaches up to 0.89.Experiment results in real environments verify that the proposed method performs more effectively in the detection of weak targets than the MVDR method and can be applied to real sonar system. | KANG Chunyu LI Qianyan ZHANG Xinhua LI Jun | 2016 | Chinese Journal of Acoustics2016，35，2： | 10 |
| 13 | FLECH:A Danish market solution for DSO congestion management through DER flexibility services显示文摘Future electric power systems will face new operational challenges due to the high penetration of distributed energy resources(DERs).In Denmark,distribution system operator(DSO)expects a significant congestion increased in distribution grids.In order to manage these congestions and mobilize the DERs as economically efficient as possible in the future distribution grid,the brand new notion of flexibility clearing house(FLECH)is proposed in this paper.With the aggregator-based offers,the proposed FLECH market has the ability to promote small scale DERs(upto 5 MW)for actively participating in trading flexibility services,which are stipulated accommodating the various requirements of DSO.Accordingly,the trading setups and processes of the FLECH market are also illustrated in detail.A quantitative example is utilized to illustrate the formulation and classification of flexibility services provided by the DERs in the proposed FLECH market. | Chunyu ZHANG Yi DING Niels Christian NORDENTOFT Pierre PINSON JacobØSTERGAARD | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 10 |
| 14 | Facile construction of carbon dots via acid catalytic hydrothermal method and their application for target imaging of cancer cells显示文摘为了解决高温度或长反应的问题,在碳点(CD ) 的热水的合成预定,一个新奇方法基于支持的碳化由盐酸催化作用在现在的工作被开发的酸。催化的碳点的酸(ACD ) 在 200 虪箳椰嬑郢 G | Zhenggang Wang Boshi Fu Siwei Zou Bo Duan Chunyu Chang Bai Yang Xiang Zhou Lina Zhang | 2016 | Nano Research2016，9，1： | 8 |
| 15 | Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection显示文摘Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity,promoting the development of LRRK2 kinase inhibitors as therapeutics.Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise.However,nearly all inhibitors are ATP competitive—some with unwanted side effects and unclear clinical outcome—alternative types of LRRK2 inhibitors are lacking.Herein we identify 5′-deoxyadenosylcobalamin(AdoCbl),a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity.Multiple assays show that AdoCbl directly binds LRRK2,leading to the alterations of protein conformation and ATP binding in LRRK2.STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain.Furthermore,we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization.Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue,and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C.elegans and D.melanogaster expressing LRRK2 disease variants.Finally,AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models.Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism,which can be harnessed to develop new LRRK2-based PD therapeutics in the future. | Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue | 2019 | Cell Research2019，29，4： | 7 |
| 16 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 17 | Visible Light Accelerated Vinyl C-H Arylation in Pd-Catalysis:" Application in the Synthesis of ortho Tetra-substituted Vinylarene Atropisomers显示文摘在有 diaryliodonium 盐的乙烯基 arenes 的催化钯的 arylation 的可见轻加速的 C-H functionalization 反应当另外的 photosensitizer 不在时被报导。运动同位素效果(k H /k D ) 从 3.6 被改变(在黑暗下面) 到 1.1 当由可见的光照耀时,它显示 C-H functionalization 步是在黑暗下面决定步的率并且显著地由可见的光的照耀加速了。最后 ortho 的合成有高 enantiospecificity 的代替 tetra 的 vinylarene atropisomers 经由这个协议被认识到。 | Jia Feng Bin Li Julong Jiang Mingkai Zhang Wenbai Ouyang Chunyu Li Yao Fu Zhenhua Gu | 2018 | Chinese Journal of Chemistry2018，36，1： | 7 |
| 18 | Mesenteric lymph reperfusion may exacerbate brain injury in a rat model of superior mesenteric artery occlusion shock显示文摘BACKGROUND:The intestinal lymphatic pathway and intestinal ischemia/reperfusion are mainly involved in mesenteric lymph duct ligation or drainage;moreover,intervention by reducing the lymph liquid reflux might relieve lung and other organ dysfunction induced by intestinal ischemia/reperfusion;however,research addressing mesenteric lymph reperfusion (MLR) and brain injury has not yet to be reported.OBJECTIVE:To observe the effect of MLR on brain tissue in a rat model of superior mesenteric artery occlusion (SMAO) shock,and to explore the molecular mechanism of MLR.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment at a neuro-pathophysiology level was performed at the Institute of Microcirculation,Hebei North University;Department of Pathophysiology,Basic Medical College;Department of Pathology,the First Hospital of Hebei North University between December 2007 and March 2009.MATERIALS:Adenosine triphosphate (ATP) standard was provided by the National Institute for the Control of Pharmaceutical and Biological Products;lactic acid (LA),superoxide dismutase (SOD),malonaldehyde (MDA),nitrogen monoxidum (NO),nitric oxide synthase (NOS),myeloperoxidase (MPO) and ATPase assay kits were provided by Nanjing Jiancheng Bioengineering Institute,China.METHODS:A total of 24 male Wistar rats were randomly divided into four groups.In the sham-surgery group (n=6),both the mesenteric lymph duct and the superior mesenteric artery were not blocked;in the MLR group (n=6),the mesenteric lymph duct was occluded for 1 hour followed by 2-hour reperfusion;in the SMAO group (n=6),the superior mesenteric artery was occluded for 1 hour followed by 2-hour reperfusion;in the MLR + SMAO group (n=6),both the mesenteric lymph duct and superior mesenteric artery were occluded for 1 hour followed by 2-hour reperfusion.MAIN OUTCOME MEASURES:Mean arterial blood pressure prior to and following ischemia/reperfusion;brain tissue morphology levels of LA,MDA,SOD,NO,NOS,MPO,ATPase and ATP following reperfusion.RESULTS:MLR did not cause changes in mean arterial blood pressure,brain tissue morphology,LA,MDA,NO,ATP,SOD,NOS,MPO and ATPase.However,SMAO caused a rapid decrease and gradual increase of mean arterial blood pressure.Neuronal necrosis,degeneration and swelling were observed in brain tissue.Contents of MDA,NO,LA and ATP as well as activities of NOS and MPO were significantly increased (P < 0.05),but activities of SOD and Na+-K+-ATPase were significantly decreased (P < 0.05).MLR aggravated neuronal damage in a rat model of SMAO shock.Following MLR,mean arterial blood pressure was significantly decreased (P < 0.05),contents of MDA and NO as well as activities of NOS and MPO were significantly increased (P < 0.05),but activities of Ca2+-ATPase,Mg2+-ATPase and Ca2+-Mg2+-ATPase as well as ATP content were significantly decreased (P < 0.05).CONCLUSION:MLR aggravates brain injury in a rat model of SMAO shock,which correlates with oxygen-derived free radical injury,NO synthesis and release,sequestration of neutrophilic granulocytes,decreasing activity of cell membrane pumps and energy metabolism dysfunction.Pathogenesis of the intestinal lymphatic pathway should be thoroughly investigated to prevent ischemia/reperfusion injury. | Zigang Zhao Chunyu Niu Aimin Shang Jiaming Tian Rui Han Chunhui Zhang Yuping Zhang Jing Zhang | 2010 | Neural Regeneration Research2010，5，9： | 7 |
| 19 | Integrated transcriptome and proteome analysis provides insight into chilling-induced dormancy breaking in Chimonanthus praecox显示文摘Chilling has a critical role in the growth and development of perennial plants.The chilling requirement(CR)for dormancy breaking largely depends on the species.However,global warming is expected to negatively affect chilling accumulation and dormancy release in a wide range of perennial plants.Here,we used Chimonanthus praecox as a model to investigate the CR for dormancy breaking under natural and artificial conditions.We determined the minimum CR(570 chill units,CU)needed for chilling-induced dormancy breaking and analyzed the transcriptomes and proteomes of flowering and non-flowering flower buds(FBs,anther and ovary differentiation completed)with different CRs.The concentrations of ABA and GA3 in the FBs were also determined using HPLC.The results indicate that chilling induced an upregulation of ABA levels and significant downregulation of SHORT VEGETATIVE PHASE(SVP)and FLOWERING LOCUS T(FT)homologs at the transcript level in FBs when the accumulated CR reached 570 CU(IB570)compared to FBs in November(FB.Nov,CK)and nF16(non-flowering FBs after treatment at 16℃for−300 CU),which suggested that dormancy breaking of FBs could be regulated by the ABA-mediated SVP-FT module.Overexpression in Arabidopsis was used to confirm the function of candidate genes,and early flowering was induced in 35S::CpFT1 transgenic lines.Our data provide insight into the minimum CR(570 CU)needed for chilling-induced dormancy breaking and its underlying regulatory mechanism in C.praecox,which provides a new tool for the artificial regulation of flowering time and a rich gene resource for controlling chilling-induced blooming. | Zhineng Li Ning Liu Wei Zhang Chunyu Wu Yingjie Jiang Jing Ma Mingyang Li Shunzhao Sui | 2020 | Horticulture Research2020，7，1： | 6 |
| 20 | Structural characteristics and magnetic properties of bulk nanocrystalline Fe_(84)Zr_2Nb_4B_(10) alloy prepared by mechanical alloying and spark plasma sintering consolidation显示文摘Magnetic properties of Fe84Zr2Nb4B10 sample were investigated. The sample was produced from nanocrystalline powders made by the mechanical alloying (MA) and consolidation using the spark plasma sintering (SPS) technique. Effects of milling time on phase transformation, structural characteristics, and magnetic properties of powders were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and physical property measure system (PPMS), respectively. Results show that nanostructured α-Fe supersaturated solid solution is obtained in the final MAed products. The saturation magnetization (Ms) increased with increasing milling time and became constant at 130 h, but the coercivity (Hc) increased firstly and then decreased. The consolidated bulk sample exhibited a high density of 6.893 g·cm-3, there was no phase change during SPS process, and the saturation magnetization and susceptibility of the SPSed bulk sample improved in comparison with the milled powders. The variation of magnetic parameters can be explained by nano-scale effect and Herzer model. | Tang, Cuiyong Xiao, Zhiyu Luo, Fei Wang, Jun Ma, Chunyu Zhang, Wen | 2012 | Rare Metals2012，31，3： | 6 |
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