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| 1 | MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer显示文摘 | Hongxia Deng Yanan Guo Haojun Song Bingxiu Xiao Weiliang Sun Zhong Liu Xiuchong Yu Tian Xia Long Cui Junming Guo | 2013 | Gene2013，，： | 5 |
| 2 | Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats显示文摘OBJECTIVE: To investigate the changes in the neuronal microenvironment of the middle cerebral artery(MCA) territory induced by Jing-well points bloodletting acupuncture(WPBA) and to explore the neuroprotective mechanism of WPBA in stroke.METHODS: Adult male Sprague Dawley(n = 32)rats were randomly divided into four groups of eight animals each: WPBA-thalamus group(WT),WPBA-caudate nucleus group(WC), sham-control thalamus group(ST) and sham-control caudate nucleus group(SC). Animals in the WT and WC groups received 2 μL of the extracellular tracer gadolinium-diethylene triamine pentaacetic acid(Gd-DTPA)injected into the thalamus or caudate nucleus, respectively, and 12 Jing-well points in the distal ends of the rats' digits were used for WPBA. Although 2 μL of Gd-DTPA was injected into the thalamus or caudate nucleus, respectively, for animals in the two sham groups(ST and SC), no acupuncture or bloodletting was performed. Brain extracellular space and interstitial fluid flow parameters were measured using Gd-DTPA-enhanced magnetic resonance imaging.RESULTS: The brain interstitial fluid flow speed was decreased in the thalamus after WPBA, with a significantly lower Gd-DTPA clearance rate and longer half-life of Gd-DTPA in the thalamus of treated rats than those in sham-control rats [WPBA-treated rats' clearance rate,(7.47 ± 3.15) × 10^(-5)/s(P = 0.009);half-life,(1.52 ± 0.13) h, P = 0.000]. By contrast, no significant changes in brain extracellular space and interstitial fluid flow parameters were detected in the caudate nucleus after WPBA(P = 0.649). In addition, no differences in the morphology of the brain extracellular space or the final distribution of the traced brain interstitial fluid were demonstrated between the WT and WC groups(P = 0.631, P = 0.970,respectively).CONCLUSION: The WPBA decreased the speed of the local thalamic ISF flow in rats, which is assumed to be a beneficial protection by down-modulated the metabolic rate of the attacked neurons under stroke. | FuYu LiYuliang GuoJia Liu Bin Liu Huipo Zhang Weibo Sun Wanli GaoYajuan Ren Qiushi Han Haojun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 3 |
| 3 | lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis显示文摘 | Chunjing Xu Yongfu Shao Tian Xia Yunben Yang Jiawei Dai Lin Luo Xinjun Zhang Weiliang Sun Haojun Song Bingxiu Xiao Junming Guo | 2014 | Tumor Biology2014，，10： | 1 |
| 4 | FCM- based model selection algorithms for eetermining the number of clusters 显示文摘 | Sun Haojun Wang Shengrui Jiang Qingshan | 2004 | Pattern Recognition2004，37，10： | 1 |
| 5 | FCM- based Model Selection Algorithms for Determining the Number of Clusters 显示文摘 | SUN Haojun WANG Shengrui JING Qingshan | 2004 | Pattern Recognition2004，37，10： | 1 |
| 6 | FCM-Based Model Selection Algorithms for Detem in ing the Number of Clusters显示文摘 | Sun Haojun Wang Shengrui Jiang Qingshan | | 0，，： | 1 |
| 7 | FCM-Based Model Selection Algorithms for Determining the Number of Clustes 显示文摘 | Haojun Sun Shengrui Wang Qingshan Jing | 2004 | Pattern Recognition (S0031-3203)2004，37，10： | 1 |
| 8 | FCM-Based model selection algorithms for determining the number of cluster显示文摘 | SUN Haojun WANG Shengrui JIANG Qingshan | 2004 | Pattern Recognition(S0031-3203)2004，37，10： | 1 |
| 9 | FCM-based ModelSelection Algorithms for Determining the Number of Clusters显示文摘 | Sun Haojun Wang Shengrui Jiang Qingshan | 2004 | Pattern Recognition2004，37，10： | 1 |
| 10 | FCM-based Model Selection Algorithms for Determining the Number of Cluster显示文摘 | Sun Haojun Wang Shenrui Jiang Qingshan | 2004 | Pattern Recognition2004，37，10： | 1 |
| 11 | FCM-based model selection algorithm for determining the number of clusters 显示文摘 | SUN Haojun WANG Shengrui JIANG Qingshan | 2004 | Pattern Recognition2004，10，37： | 1 |
| 12 | FCM-based model selection algorithms for determining the number of clusters显示文摘 | Sun Haojun Wang Shengrui Jiang Qingshan | 2004 | Pattern Recognition2004，37，10： | 1 |
| 13 | FCM - Based Model Selection Mgorithms for Determining the Number of Clusters显示文摘 | Haojun Sun Shengrui Wang Qingshan Jiang | 2004 | Pattern Recognition ~2004，37，： | 1 |
| 14 | FCM - Based Model Selection Algorithms for Deteming the Number of Clusters 显示文摘 | Haojun Sun Shengrui Wang Qingshan Jiang | 2004 | Pattern Recognition2004，，37： | 1 |
| 15 | Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics显示文摘 | Haojun Zhang Tingting Zhao Yuewen Gong Xi Dong Weiku Zhang Sifan Sun Hua Wang Yanting Gu Xiaoguang Lu Meihua Yan Ping Li | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 16 | FCM-based model selection algorithm for determining the numberof cluster显示文摘 | SUN Haojun WANG Shengrui JIANG Qingshan | 2004 | Pattem Recognition2004，37，10： | 1 |
| 17 | Establishment of a prognostic scoring model for regional recurrent nasopharyngeal carcinoma after neck dissection显示文摘Objective:The main aim of this study was to establish a scoring model to predict risk of progression and survival in patients with regionally recurrent nasopharyngeal carcinoma(NPC).Methods:Three hundred and forty-eight patients subjected to neck dissection from 2003 to 2017 were included for study.Clinicopathologic information for each patient was analyzed.Independent prognostic factors were selected using the Cox proportional hazards model and incorporated into the scoring model.Concordance index(C-index)and calibration curves were used to verify discrimination and calibration,respectively and the results validated using bootstrap resampling.Results:Microscopic positive lymph node>2[hazard ratio(HR),2.19;95%confidence interval(CI),1.30–3.68;P=0.003],extranodal extension(HR,2.75;95%CI,1.69–4.47;P<0.001),and lower neck involvement(HR,1.78;95%CI,1.04–3.04;P=0.034)were identified from multivariate analysis as independent factors for overall survival(OS).A qualitative 4-point scale was generated to stratify patients into 4 risk groups for predicting OS and progression-free survival(PFS).The novel scoring model demonstrated enhanced discrimination(C-index=0.69;95%CI,0.62–0.76)relative to the original recurrent tumor-node-metastasis(rTNM)staging system(C-index=0.56;95%CI,0.50–0.62),and was internally validated with a bootstrap-adjusted C-index of 0.70.The calibration curve showed good agreement between predicted probabilities and actual observations.Conclusions:The scoring system established in this study based on a large regionally recurrent NPC cohort fills a gap regarding assessment of risk and prediction of survival outcomes after neck dissection in this population and could be further applied to identify high-risk patients who may benefit from more aggressive intervention. | Xiaoyun Li Chao Lin Jinjie Yan Qiuyan Chen Xuesong Sun Sailan Liu Shanshan Guo Liting Liu Haojun Xie Qingnan Tang Yujing Liang Ling Guo Hao Li Xuekui Liu Xiang Guo Linquan Tang Haiqiang Mai | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 18 | Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis显示文摘Multiple sclerosis(MS)is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration.Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described.However,with the innovation of technology in glial cell research,we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS.In this review,we focus on the role of glial cells,including microglia,astrocytes,and oligodendrocytes,in the pathogenesis of MS.We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss. | Ye Sun Haojun Yu Yangtai Guan | 2023 | Neuroscience Bulletin2023，39，3： | 0 |
| 19 | Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification显示文摘Signal amplification is an important issue in DNA nanotechnology and molecular diagnostics.In this work,we report a strategy for the catalytic self-assembly of spherical nucleic acids(SNAs)programmed by two-layer cascaded DNA circuits through integrating an entropy-driven catalytic network,a catalytic hairpin assembly circuit,and a facile SNA assembly-based reporter system.This integrated system could implement^100,000-fold signal amplification in the presence of 1 pM of input target.Possessing powerful amplification ability of nucleic acid signal,our strategy should be of great potential in fabricating more robust dynamic networks to be applied for signal transduction,DNA computing,and nucleic acid-based diagnostics. | Xiang Li Dongbao Yao Junxiang Zhou Xiang Zhou Xianbao Sun Bing Wei Chengxu Li Bin Zheng Haojun Liang | 2020 | Science China Chemistry2020，63，1： | 0 |
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