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| 1 | MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma显示文摘MicroRNAs(miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma(HCC),as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR-182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC. | Chenggang Wang Ren Ren Haolin Hu Changjun Tan Miao Han Xiaolin Wang Yun Zheng | 2014 | Chinese Journal of Cancer Research2014，26，1： | 13 |
| 2 | Co-seismic responses of water wells in Jiangsu province to 2008 Wenchuan and 2011 Japan earthquakes显示文摘Co-seismic water-level and temperature changes of the 2008 magnitude-8.0 Wenchuan and the 2011 magnitude-9.0 Japan earthquakes recorded at 10 observation wells in Jiangsu province are presented and analyzed. The data show that water level responded more regularly with earthquake magnitude and distance than water temperature. The response was different for wells located in different tectonic units, being weaker in central and northern plain, which has a relatively thick surface layer of loess, than southern Jiangsu, which is hilly. | Jiang Haolin Zheng Jiangrong | 2011 | Geodesy and Geodynamics2011，2，3： | 1 |
| 3 | Optimized weak measurement of orbital angular momentum-induced beam shifts in optical reflection显示文摘Tiny but universal beam shifts occur when a polarized light beam is reflected upon a planar interface.Although the beam shifts of Gaussian beams have been measured by the weak measurement technique, the weak measurement for orbital angular momentum(OAM)-induced spatial shifts of vortex beams is still missing.Here, by elaborately choosing the preselection and postselection states, the tiny OAM-induced Goos–H?nchen and Imbert–Fedorov shifts are amplified at an air–prism interface. The maximum shifts along directions both parallel and perpendicular to the incident plane are theoretically predicted and experimentally verified with optimal preselection and postselection states. These maximum shifts can be used to determine the OAM of vortex beams. | Wenjin Long Jintao Pan Xinyi Guo Xiaohe Liu Haolin Lin Huadan Zheng Jianhui Yu Heyuan Guan Huihui Lu Yongchun Zhong Shenhe Fu Li Zhang Wenguo Zhu Zhe Chen | 2019 | Photonics Research2019，7，11： | 1 |
| 4 | Metal-Free Synthesis of Benzo[a]phenanthridines from Aromatic Aldehydes,Cyclohexanones,and Aromatic Amines显示文摘A three-component synthesis of benzo[a]phenanthridines from aromatic aldehydes,cyclohexanones,and aromatic amines has been developed,which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[a]phenanthridines in satisfactory yields.The present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as ligand by further modification.With the advantages of readily available starting materials,transition-metal-free conditions,gram-scale synthesis,and broad substrate scope,this three-component protocol provides an efficient approach for the preparation of diverse benzo[a]phenanthridines. | Pingyu Jiang Zhifei Shan Shanping Chen Quanyuan Wang Shuxin Jiang Haolin Zheng Guo-Jun Deng | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 5 | Sulfurized hematite for photo-Fenton catalysis显示文摘A hematite/amorphous sulfur composite was prepared via simple heating hematite and α-sulfur in Teflon-lined autoclave at low temperature. The composite was characterized by X-ray diffraction(XRD), Raman spectrum,Thermal Gravity Analysis(TGA), Transmission Electron Microscopy(TEM) and X-ray photoelectron spectroscopy(XPS). The results revealed that an allotrope sulfur at 5-37% weight percent was found in the composite.After sulfuration, S_n^(2-) or S_2^(2-) was doped in the lattice of hematite, large amounts of OH and SO_4 were adsorbed on the surface of hematite. Hematite/amorphous sulfur composite had superior photo-Fenton activities than pure hematite. This work also demonstrated that amorphous sulfur also had the activity of photo-Fenton catalysis. OH^-and SO_4 radicals facilitated dye adsorption and acted as a bridge to link H_2 O_2. Moreover, SO_4 radicals on hematite served as electron trapping center that can receive photo-induced electron from conduction band of hematite and transfer it to the adsorbed H_2 O_2, increasing the rate of photo-Fenton reaction eventually. | Yaping Zhang Kaituo Dong Zheng Liu Haolin Wang Shengxiang Ma Anyu Zhang Ming Li Lianqing Yu Yan Li | 2017 | Progress in Natural Science:Materials International2017，27，4： | 0 |
| 6 | Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur显示文摘An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed.This cascade reaction involving alcohol oxidation,nitro reduction,and oxidative annulation was achieved in a one-pot.The present protocol was started from mono-functionalized indoles and readily available benzylic alcohols/aldehydes,affording a variety of functionalized indolo[2,3-c]quinolines in satisfactory yields. | Rong Li Shuxin Jiang Haolin Zheng Hanwen Lei Zhi Huang Shanping Chen Guo-Jun Deng | 2022 | Green Synthesis and Catalysis2022，3，1： | 0 |
| 7 | Analysis of Space-time Characteristics of Energy Field of Seismicity in Jiangsu and Its Neighboring Areas显示文摘The paper analyzes the variation characteristics of energy fields of seismicity 2.1≤M L ≤4.5 in Jiangsu and its neighboring areas during the period between January 1970 and December 2007.It also analyzes the variations of time 'weight' coefficients of the major typical energy fields,using random function theory with seismic energy fields as a space-time random function field based on Empirical Orthogonal Function (EOF) expansion methods.The results show that the expansion accuracy of the first seven typical fields is 0.9244.The strength of seismic energy varies remarkably in different tectonic blocks in the study area.High value areas are in middle and southern Jiangsu,and the south Yellow Sea.The distribution of the typical fields also shows that it is an area that affects most significantly the seismic energy fields of the study region.The time 'weight' coefficients of the first six typical fields vary with time,and the amplitude of the variations has strong temporal correlations with moderate-strong earthquakes in the region. | Wang Jun Sun Yejun Zhan Xiaoyan Zheng Jiangrong Jiang Haolin Huo Zhuqing | 2010 | Earthquake Research in China2010，24，4： | 0 |
| 8 | Ferroelectricity of hafnium oxide-based materials:Current status and future prospects from physical mechanisms to device applications显示文摘The finding of the robust ferroelectricity in HfO_(2)-based thin films is fantastic from the view point of both the fundamentals and the applications.In this review article,the current research status of the future prospects for the ferroelectric HfO_(2)-based thin films and devices are presented from fundamentals to applications.The related issues are discussed,which include:1)The ferroelectric characteristics observed in HfO_(2)-based films and devices associated with the factors of dopant,strain,interface,thickness,defect,fabrication condition,and more;2)physical understanding on the observed ferroelectric behaviors by the density functional theory(DFT)-based theory calculations;3)the characterizations of microscopic and macroscopic features by transmission electron microscopes-based and electrical properties-based techniques;4)modeling and simulations,5)the performance optimizations,and 6)the applications of some ferroelectric-based devices such as ferroelectric random access memory,ferroelectric-based field effect transistors,and the ferroelectric tunnel junction for the novel information processing systems. | Wanwang Yang Chenxi Yu Haolin Li Mengqi Fan Xujin Song Haili Ma Zheng Zhou Pengying Chang Peng Huang Fei Liu Xiaoyan Liu Jinfeng Kang | 2023 | Journal of Semiconductors2023，44，5： | 0 |
| 9 | Distribution and Controlling Factors of Dissolved Gaseous Mercury and Reactive Mercury in Seawater Near Yangtze River Estuary显示文摘Complex hydrocultural conditions in the estuary affect the migration and transformation of mercury.Using two voyages in July and October 2018,Dissolved Gaseous Mercury(DGM)and Reactive Mercury(RHg)were determined to explore the source,transformation and influence of DGM content in the adjacent waters of Yangtze River Estuary in summer and autumn.The results showed the contents of DGM and RHg in summer were higher than those in autumn,and both of them were higher than those in open sea.In summer and autumn,the Yangtze River brought a higher concentration of DGM,and different flow direction and runoff resulted in differences in the high value region of the surface.The emergence of low-oxygen zones in summer was conducive to the production of DGM.In autumn,windy weather allowed seawater disturbances to promote the release of mercury from the underlying sediments,especially in shallow sea in northwest.RHg showed a higher concentration in the offshore than in the open sea in summer,but there was no such trend in autumn,reflecting the influence of less runoff input.DGM is the main product of RHg reduction,and there was a significant positive correlation between DGM and RHg in summer(r=0.356,P<0.05),while the correlation between DGM and RHg was not significant in autumn due to the influence of light intensity,wind speed and nutrients.The exchange flux of mercury in the adjacent waters of the Yangtze River Estuary was higher than that in the open sea.There was no significant difference of the release flux of mercury in summer and autumn.This article highlighted that the input of mercury from the Yangtze River runoff promotes the release of mercury in seawater,and the hypoxic zone caused by eutrophication is conducive to the production of DGM. | YIN Pingping ZHENG Wen WANG Yan LIU Ruhai HE Xin SUN Haolin LI Dou | 2023 | Journal of Ocean University of China2023，22，5： | 0 |
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