4篇
您的检索式：作者名="Haolong Yang"
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| 1 | Mitochondria Redistribution in Enterovirus A71 Infected Cells and Its Effect on Virus Replication显示文摘Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host mitochondria are crucial for virus replication and pathogenicity.In this study,it was observed that EV-A71 infection resulted in a perinuclear redistribution of the mitochondria.The mitochondria rearrangement was found to require the microtubule network,the dynein complex and a low cytosolic calcium concentration.Subsequently,the EV-A71 non-structural protein 2BC was identified as the viral protein capable of inducing mitochondria clustering.The protein was found localized on mitochondria and interacted with the mitochondrial Rho GTPase 1(RHOT1)that is a key protein required for attachment between the mitochondria and the motor proteins,which are responsible for the control of mitochondria movement.Additionally,suppressing mitochondria clustering by treating cells with nocodazole,EHNA,thapsigargin or A23187 consistently inhibited EV?A71 replication,indicating that mitochondria recruitment played a crucial role in the EV-A71 life cycle.This study identified a novel function of the EV-A71 2BC protein and provided a potential model for the regulation of mitochondrial motility in EV-A71 infection. | Yang Yang Haolong Cong Ning Du Xiaodong Han Lei Song Wenliang Zhang Chunrui Li Po Tien | 2019 | Virologica Sinica2019，34，4： | 2 |
| 2 | Effect of Crystallographic Orientations on Electrical Properties of Sputter-deposited Nickel Oxide Thin Films显示文摘 | Chen Haolong Yang Yaosheng | 2008 | Thin Solid Films2008，516，16： | 1 |
| 3 | Photo‐Responsive Self‐Assembly of an Azobenzene‐Ended Surfactant‐Encapsulated Polyoxometalate Complex for Modulating Catalytic Reactions显示文摘 | Yang Yang Liang Yue Haolong Li Eamonn Maher Yongguang Li Yizhan Wang Lixin Wu Vivian Wing‐Wah Yam | 2012 | Small2012，，20： | 1 |
| 4 | A Fire Escape Simulation System Based on the Dijkstra Algorithm显示文摘Despite the support of all kinds of fire prevention measures and high-tech fire prevention equipment,fires still occur frequently because of both anthro-pogenic factors and natural disasters.This issue has drawn the attention of schools,all levels of government,and other organizations.Many types of organi-zations carry out fire drills throughout the year.Because this kind of drill cannot anticipate the specific circumstances of each fire,which are generally far more complicated than drills,most people cannot correctly choose the optimal escape route from real fires.Thus,a fire-scene virtual simulation system based on the Dijkstra algorithm is here proposed to address such problems as casualties caused by frequent fires and the inability of most people to correctly choose a fire escape route.This virtual fire escape simulation system uses Maya to carry out 3D recon-struction of the fire scene,the Unity engine to conduct interactive function design,and the Dijkstra algorithm to calculate the best escape route.The results of the example indicate that the simulation system solves the problems of the traditional simulation system,such as stiffness,lack of intelligence,and poor simulation. | Haolong Yang Chunqiang Hu Guwei Li Jingchun Fan | 2021 | Computer Systems Science & Engineering2021，39，12： | 0 |
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