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| 1 | Functional dyspepsia:The role of visceral hypersensitivity in its pathogenesis显示文摘功能,或非溃疡,消化不良(FD ) 是为到胃的肠学的工作分派的最普通的原因之一。它与重要病态被联系并且损害了生命的质量。许多当局相信那机能性消化不良和急躁的肠症候群代表一样的疾病过程的光谱的部分。FD 的病理生理学仍然保持不清楚但是几个理论包括内脏的超敏性,胃的马达机能障碍, Helicobacter pylori 感染和精神分析被建议了社会因素。在这评论,迄今为止,我们在 FD 的原因论为内脏的超敏性的角色看证据。 | John Keohane Eamonn M M Quigley | 2006 | World Journal of Gastroenterology2006，12，17： | 35 |
| 2 | The UCR Time Series Archive显示文摘The UCR time series archive–introduced in 2002,has become an important resource in the time series data mining community,with at least one thousand published papers making use of at least one data set from the archive.The original incarnation of the archive had sixteen data sets but since that time,it has gone through periodic expansions.The last expansion took place in the summer of 2015 when the archive grew from 45 to 85 data sets.This paper introduces and will focus on the new data expansion from 85 to 128 data sets.Beyond expanding this valuable resource,this paper offers pragmatic advice to anyone who may wish to evaluate a new algorithm on the archive.Finally,this paper makes a novel and yet actionable claim:of the hundreds of papers that show an improvement over the standard baseline(1-nearest neighbor classification),a fraction might be mis-attributing the reasons for their improvement.Moreover,the improvements claimed by these papers might have been achievable with a much simpler modification,requiring just a few lines of code. | Hoang Anh Dau Anthony Bagnall Kaveh Kamgar Chin-Chia Michael Yeh Yan Zhu Shaghayegh Gharghabi Chotirat Ann Ratanamahatana Eamonn Keogh | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 26 |
| 3 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 4 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 5 | Changing face of irritable bowel syndrome显示文摘最近的年在我们急躁的肠症候群(IBS ) 的理解见证巨大的进步。这是在个人并且为折磨的个人的社会工作与重要症状和缺陷联系的真正全球的疾病,是明显的。在我们内脏 flora-mucosal 相互作用,伤寒神经系统和大脑勇气轴的理解的进展至少在 IBS 在症状的致病导致了实质的进步并且向这混乱的基本病原学提供了一些提示,在一些潜水艇人口。我们盼望治疗将针对病理生理学并且也许的一时间,甚至到主要病原学。同时,一个模型基于为肠的发炎的一个主要角色服役集成各种各样的海滨,它贡献 IBS 的演讲。 | Eamonn MM Quigley | 2006 | World Journal of Gastroenterology2006，12，1： | 6 |
| 6 | Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses显示文摘 | Siobhain M. O’Mahony Julian R. Marchesi Paul Scully Caroline Codling Anne-Marie Ceolho Eamonn M.M. Quigley John F. Cryan Timothy G. Dinan | 2009 | Biological Psychiatry2009，，3： | 4 |
| 7 | A Global Perspective on Irritable Bowel Syndrome: A Consensus Statement of the World Gastroenterology Organisation Summit Task Force on Irritable Bowel Syndrome显示文摘 | Eamonn M. M. Quigley Hussein Abdel-Hamid Giovanni Barbara Shobna J. Bhatia Guy Boeckxstaens Roberto De Giorgio Michel Delvaux Douglas A. Drossman Amy E. Foxx-Orenstein Francisco Guarner Kok-Ann Gwee Lucinda A. Harris A. Pali S. Hungin Richard H. Hunt John | 2012 | Journal of Clinical Gastroenterology2012，，5： | 4 |
| 8 | Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘 | Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling | 2006 | Gastroenterology2006，，2： | 3 |
| 9 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Circulation2008，，18： | 3 |
| 10 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 11 | Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies显示文摘 | Fergus Shanahan Eamonn M.M. Quigley | 2014 | Gastroenterology2014，，： | 3 |
| 12 | A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome显示文摘 | Caroline Codling Liam O’Mahony Fergus Shanahan Eamonn M. M. Quigley Julian R. Marchesi | 2010 | Digestive Diseases and Sciences2010，，2： | 3 |
| 13 | Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease显示文摘 | Kevin Whelan Eamonn M.M. Quigley | 2013 | Current Opinion in Gastroenterology2013，，2： | 3 |
| 14 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 15 | The Gut Microbiota and the Liver Pathophysiological and Clinical Implications显示文摘 | Eamonn M .M. Quigley Catherine Stanton Eileen F. Murphy | 2012 | Journal of Hepatology2012，，： | 2 |
| 16 | Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome显示文摘 | Paul J. Kennedy Gerard Clarke Eamonn M.M. Quigley John A. Groeger Timothy G. Dinan John F. Cryan | 2011 | Neuroscience and Biobehavioral Reviews2011，，1： | 2 |
| 17 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 18 | 温度测量系统对ADC的要求显示文摘引言
适用于温度测量的温度传感器有好几种。为具体应用选择适当的温度传感器取决于待测温度范围以及所需要的精度。系统精度取决于温度传感器的精度以及用于将传感器输出数字化的模数转换器(ADC)的性能。多数情况下,传感器的信号幅度相当小,需要一种高分辨率的ADC。∑-△ADC分辨率高,通常包含温度测量系统所需的内置电路,如激励电流源。本文讨论不同类型的温度传感器(热电偶、电阻式温度检测器(RTD)、热敏电阻以及热敏二极管)以及连接传感器和ADC所需要的电路,还介绍对ADC的性能要求。 | Mary Mc Carthy Eamonn Dillon | 2006 | 世界电子元器件2006，，8： | 2 |
| 19 | IBD Around the world: Comparing the epidemiology, diagnosis, and treatment: Proceedings of the World Digestive Health Day 2010 – Inflammatory bowel disease task force meeting显示文摘 | Daniel C.Baumgart Charles N.Bernstein ZaighamAbbas Jean F.Colombel Andrew S.Day GeertD’Haens IrisDotan Khean L.Goh ToshifumiHibi Richard A.Kozarek Eamonn M.M.Quigley WalterReinisch Bruce E.Sands Jose D.Sollano A. HillarySteinhart FlávioSteinwurz Morten H. | 2011 | Inflamm Bowel Dis2011，，2： | 2 |
| 20 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Journal of the American College of Cardiology2008，，18： | 2 |
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