|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity显示文摘The aim of this study was to develop an intravenous clarithromycin lipid emulsion(CLE)with good stability and excellent antibacterial activity. The CLE was prepared by the thinfilm dispersed homogenization method. The interaction between clarithromycin(CLA) and cholesteryl hemisuccinate(CHEMS) was confirmed by DSC, FT-IR and^1H NMR analysis. The interfacial drug loading, thermal sterilization, freeze–thaw stability, and in vitro and in vivo antibacterial activity were investigated systematically. DSC, FT-IR and^1H NMR spectra showed that CHEMS(CLA: CHEMS, M ratio 1:2) could interact with CLA through H-bonding and a hydrogen-bonded ion pair. The CHEMS was found necessary to maintain the stability of CLE.Ultracentrifugation showed that almost 88% CLA could be loaded into the interfacial layer.The optimized CLE formulation could withstand autoclaving at 121 °C for 10 min and remain stable after three freeze–thaw cycles. The in vitro susceptibility test revealed that the CLA–CHEMS ion-pair and CLE have similar activity to the parent drug against many different bacterial strains. The in vivo antibacterial activity showed that the ED50 of intravenous CLE was markedly lower than that of CLA solution administrated orally. CLE exhibited pronounced antibacterial activity and might be a candidate for a new nanocarrier for CLA with potential advantages over the current commercial formulation. | Haoyu Gong Sicong Geng Qi Zheng Puxiu Wang Lifeng Luo Xiuzhi Wang Yan Zhang Yu Zhang Haibing He Xing Tang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 2 | Prevention of Mother-to-Child Transmission of HIV-1 Using Highly Active Antiretroviral Therapy in Rural Yunnan, China显示文摘 | Zengquan Zhou Kathrine Meyers Xia Li Qingling Chen Haoyu Qian Yunfei Lao Elvin Geng Yishan Fan Shaomin Yang Michael Chiu David D Ho | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，： | 1 |
| 3 | Epitaxial fabrication of AgTe monolayer on Ag(111)and the sequential growth of Te film显示文摘Transition-metal chalcogenides(TMCs)materials have attracted increasing interest both for fundamental research and industrial applications.Among all these materials,two-dimensional(2D)compounds with honeycomb-like structure possess exotic electronic structures.Here,we report a systematic study of TMC monolayer AgTe fabricated by direct depositing Te on the surface of Ag(111)and annealing.Few intrinsic defects are observed and studied by scanning tunneling microscopy,indicating that there are two kinds of AgTe domains and they can form gliding twin-boundary.Then,the monolayer AgTe can serve as the template for the following growth of Te film.Meanwhile,some Te atoms are observed in the form of chains on the top of the bottom Te film.Our findings in this work might provide insightful guide for the epitaxial growth of 2D materials for study of novel physical properties and for future quantum devices. | Haoyu Dong Le Lei Shuya Xing Jianfeng Guo Feiyue Cao Shangzhi Gu Yanyan Geng Shuo Mi Hanxiang Wu Yan Jun Li Yasuhiro Sugawara Fei Pang Wei Ji Rui Xu Zhihai Cheng | 2021 | Frontiers of physics2021，16，6： | 0 |
| 4 | Microwave-assisted Synthesis of Al_(4)SiC_(4) and Its Effect on Properties of MgO-C Refractories显示文摘Al_(4)SiC_(4) was synthesized from Al powder, silicon carbide, and graphite by microwave sintering, and characterized by XRD and SEM. Then the synthesized material was added to the magnesia carbon refractory brick to study its effect on the oxidation resistance, apparent porosity, bulk density, elastic modulus, and modulus of rupture. It is found that Al_(4)SiC_(4) can be synthesized by microwave sintering at 1 300 ℃ and the addition of Al_(4)SiC_(4)-containing material as an antioxidant can enhance the oxidation resistance of the magnesia carbon refractory brick. | WANG Li LIU Shijie WEI Haoyu GUO Yanyan GENG Shangrui YAN Miaoxin QIN Feng GUO Yusen Ma Juanjuan DONG Binbin | 2024 | China's Refractories2024，33，1： | 0 |
| 5 | Aluminum and Activated Alumina Powder Additions on Microwave Synthesis of Al_(4)SiC_(4)显示文摘Aiming at improving the properties of magnesia carbon materials,silicon aluminum carbide(Al_(4)SiC_(4))containing materials were prepared using industrial aluminum powder,silicon carbide powder,and graphite as raw materials,and activated alumina powder as an additive,mixing thoroughly,pressing into cylinders and then firing at 1200℃for 30 min in a carbon embedded atmosphere by the microwave method.The effects of the aluminum powder addition(20%and 24%,by mass)and activated alumina powder addition(0,3%,5%and 7%,by mass)on the microwave synthesis of Al_(4)SiC_(4) as well as the effect of the obtained Al_(4)SiC_(4) containing material on the properties of magnesia carbon bricks were studied.The results show that:compared with the samples with 20%aluminum powder,those with 24%aluminum powder generate more Al_(4)SiC_(4).With the activated alumina powder addition increasing from 0 to 7%,the amount of Al_(4)SiC_(4) generated increases first and then decreases.Compared with the sample without activated alumina powder,the samples with activated alumina powder show lower bulk density and higher apparent porosity.With the activated alumina powder addition increasing from 3%to 7%,the bulk density of the samples increases first and then decreases,while the apparent porosity of the samples shows an opposite trend.The optimal additions are 24%aluminum powder and 5%activated alumina powder,and Al_(4)SiC_(4) synthesized in this sample has a hexagonal plate structure.With the synthesized Al_(4)SiC_(4) containing material added,the magnesia carbon brick has slightly increased cold modulus of rupture,basically the same modulus of elasticity and improved oxidation resistance. | WANG Li LIU Shijie WEI Haoyu MA Juanjuan DONG Binbin GENG Shangrui YAN Miaoxin QIN Feng GUO Yusen | 2024 | China's Refractories2024，33，1： | 0 |
| 6 | Label distribution learning for scene text detection显示文摘Recently,segmentation-based scene text detection has drawn a wide research interest due to its flexibility in describing scene text instance of arbitrary shapes such as curved texts.However,existing methods usually need complex post-processing stages to process ambiguous labels,i.e.,the labels of the pixels near the text boundary,which may belong to the text or background.In this paper,we present a framework for segmentation-based scene text detection by learning from ambiguous labels.We use the label distribution learning method to process the label ambiguity of text annotation,which achieves a good performance without using additional post-processing stage.Experiments on benchmark datasets demonstrate that our method produces better results than state-of-the-art methods for segmentation-based scene text detection. | Haoyu MA Ningning LU Junjun MEI Tao GUAN Yu ZHANG Xin GENG | 2023 | Frontiers of Computer Science2023，17，6： | 0 |
| 7 | Dietary xanthophyll improved growth,antioxidant,pigmentation and meat quality in the southern catfish(Silurus soldatovi meridionalis Chen)显示文摘Xanthophyll has multiple physiological functions to improve the quality of farmed animals.The present study aimed to investigate the effects of xanthophyll on the growth performance,antioxidation,immunity,pigmentation and meat quality of southern catfish(Silurus soldatovi meridionalis Chen).Juvenile southern catfish(18.35±0.04 g)were randomly allocated into 24 cages(30 juveniles per cage),and fed diets with different dietary xanthophyll levels(at 14,42,80,108,126 and 152 mg/kg,dry matter of diet)twice daily for 8 weeks.Results indicated that the diet with 80 mg/kg xanthophyll induced a higher specific growth rate(SGR),feed efficiency ratio and protein productive value.Moreover,the 80 mg/kg xanthophyll diet also increased complement 3,immunoglobulin M(IgM)and lysozyme content more than the other groups.The mRNA expression level of inflammation-related genes and antioxidant enzyme activities further confirmed the effects of 80 mg/kg dietary xanthophyll on improving immune response.The present study also found that the 126 mg/kg xanthophyll diet significantly enhanced the content of total carotenoids and xanthophyll,hydroxyproline,collagen and amino acid in muscle.The diet with 126 mg/kg xanthophylls also induced lower drip loss,thawing loss,centrifugal loss,cooking loss and higher muscle adhesiveness,cohesiveness,springiness,gumminess and chewiness than the other treatments.In conclusion,quadratic regression model analysis based on SGR and IgM revealed that the optimum xanthophyll level in the diet was 86.78 and 84.63 mg/kg,respectively.Moreover,broken line regression analysis based on xanthophyll content in dorsal skin and chewiness in muscle demonstrated that the optimal xanthophyll level was between 89.73 and 108.66 mg/kg in the diet of southern catfish(S.soldatovi meridionalis Chen). | Chaoqun He Haoyu Geng Yawen Qin Peng Yang Wenqiang Wang Kangsen Mai Fei Song | 2023 | Animal Nutrition2023，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员