|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Exploring and exploiting genetics and genomicsfor sweetpotato improvement: Status andperspectives显示文摘Sweetpotato(Ipomoea batatas(L.)Lam.)is one of the most important root crops cultivated worldwide.Because of its adaptability,high yield potential,and nutritional value,sweetpotato has become an important food crop,particularly in developing countries.To ensure adequate crop yields to meet increasing demand,it is essential to enhance the tolerance of sweetpotato to environmental stresses and other yield-limiting factors.The highly heterozygous hexaploid genome of I.batatas complicates genetic studies and limits improvement of sweetpotato through traditional breeding.However,application of next-generation sequencing and high-throughput genotyping and phenotyping technologies to sweetpotato genetics and genomics research has provided new tools and resources for crop improvement.In this review,we discuss the genomics resources that are available for sweetpotato,including the current reference genome,databases,and available bioinformatics tools.We systematically review the current state of knowledge on the polyploid genetics of sweetpotato,including studies of its origin and germplasm diversity and the associated mapping of important agricultural traits.We then outline the conventional and molecular breeding approaches that have been applied to sweetpotato.Finally,we discuss future goals for genetic studies of sweetpotato and crop improvement via breeding in combination with state-of-the-art multi-omics approaches such as genomic selection and gene editing.These approaches will advance and accelerate genetic improvement of this important root crop and facilitate its sustainable global production. | Mengxiao Yan Haozhen Nie Yunze Wang Xinyi Wang Robert Jarret Jiamin Zhao Hongxia Wang Jun Yang | 2022 | Plant Communications2022，3，5： | 2 |
| 3 | Engineered stem cells by emerging biomedical stratagems显示文摘Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable disorders.As the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical applications.Despite the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are unstable.To optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell therapies.This review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future development.We begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical research.Finally,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications. | Jinglin Wang Xiaoxuan Zhang Hanxu Chen Haozhen Ren Min Zhou Yuanjin Zhao | 2024 | Science Bulletin2024，69，2： | 0 |
| 4 | Incidence and risk factors of in-hospital venous thromboembolism in non-oncological urological inpatients:A single center experience显示文摘Objective To determine incidence and risk factors for venous thromboembolism(VTE)development of in-hospital VTE in urological inpatients who underwent non-oncological surgery in a tertiary hospital in China.Methods Consecutive 1453 inpatients who were admitted to a non-oncological urological ward in the tertiary hospital from January 1,2018 to December 31,2018 were enrolled in the study,and the VTE events were diagnosed by ultrasound or computed tomographic pulmonary angiography.Patients’occurrence of VTE and characteristics which may contribute to the development of VTE were collected and analyzed as incidence and risk factors.Results The incidence of VTE in non-oncological urological inpatients is 2.3%.In our cohort,patients who experienced previous VTE(adjusted odds ratios[aOR]14.272,95%CI 3.620-56.275),taking anticoagulants or antiplatelet agents before admission(aOR 10.181,95%CI 2.453-42.256),D-dimer(max)≥1μg/mL(aOR 22.456,95%CI 6.468-77.967),lower extremity swelling(aOR 10.264,95%CI 2.242-46.994),chest symptoms(aOR 79.182,95%CI 7.132-879.076),operation time of more than or equal to 180 min(aOR 10.690,95%CI 1.356-84.300),and Caprini score(max)of more than or equal to 5(aOR 34.241,95%CI 1.831-640.235)were considered as risk factors for VTE.Conclusion In this study,we found that the incidence of VTE in non-oncological surgery was about 2.3%,which was higher than some previous studies.Risk factors could be used for early detection and diagnosis of VTE. | Zhao Wang Kaixuan Li Quan Zhu Haozhen Li Ziqiang Wu Xuesong Liu Zhengyan Tang | 2023 | Asian Journal of Urology2023，10，4： | 0 |
| 5 | Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy显示文摘Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects.Currently,the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy.For this purpose,stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection,prolonged blood circulation,specific tumor accumulation,and controlled release profile of nucleic acid drugs.Besides,synergistic therapy could be achieved when combined with other therapeutic regimens.This review summarizes recent advances in various stimuliresponsive nanocarriers for gene delivery.Particularly,the nanocarriers responding to endogenous stimuli including pH,reactive oxygen species,glutathione,and enzyme,etc.,and exogenous stimuli including light,thermo,ultrasound,magnetic field,etc.,are introduced.Finally,the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed.The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable. | Qingfei Zhang Gaizhen Kuang Wenzhao Li Jinglin Wang Haozhen Ren Yuanjin Zhao | 2023 | Nano-Micro Letters2023，15，3： | 0 |
| 6 | Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing显示文摘Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical properties.Substituted alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge transport.Here,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain length.Most importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification properties.These results indicate that asymmetric side-chain engineering opens a route for breath healthcare. | Xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang Danfeng Zhi Haozhen Zhao Zhenjie Ni Ye Zou Xike Gao Fengjiao Zhang | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 7 | Developing tissue engineering strategies for liver regeneration显示文摘The regenerative function of liver can be destroyed by viral infection,drug poisoning and tumorigenesis,resulting in irreversible damage.Numerous approaches in promoting liver repair intend to replace liver transplantation,which is faced with a shortage of donors.Owing to the significant advantages in cell programming and bioscaf-fold engineering,liver tissue engineering is considered to be the most promising alternative for mimicking liver microstructure,maintaining hepatic function or implanting whole liver.Cell sources gradually develop from pri-mary hepatocytes,tumor cells,stem cell-induced cells to multiple cell coculture formats,spheroids and organoids,which have realized the improvement of cell function,overcome the problem of large-scale cell expansion and avoid the risk of immune rejection.Scaffolds,biocompatible materials are applied as cell carriers,and decel-lularized scaffolds and three-dimensional bioprinting liver pipeline structures are also used to accelerate cell colonization and proliferation.We enumerate sufficient research concerning liver tissue engineering in this re-view,including single and multiple cell sources,implantable and extracorporeal scaffold materials,and so on,providing critical conclusions and future implications of tissue engineering in liver regenerative applications. | Jinglin Wang Danqing Huang Hang Yu Yi Cheng Haozhen Ren Yuanjin Zhao | 2022 | Engineered Regeneration2022，3，1： | 0 |
| 8 | An empirical study on classification of patent life patterns显示文摘With the theoretical framework of patent information life cycle,this research studies the relationship between patents' life patterns and technological development stages of the relevant field,using life status in patent information life cycle as the research dimension. Data of patents issued in the field of wireless charging are retrieved from the United States Patent and Trademark Office Library. Citation information about these patents is also collected. By analyzing the temporal citation count data of patent information,the patents' life patterns using the RSD/P classification method are classified. This study found that the emergence of different life patterns of patent information has strong connection with the technological stage in which the patent information is located,and sleeping beauty patents have high hidden values. In the stage of technological development,attention should be paid to the identification of non-stationary patents. Rapid identification of high-value patents,i. e.,patents with certain life pattern,is instrumental to accelerate the development of technologies. This study provides a viable approach for identifying high-value patents of emerging technologies through empirical research. | 望俊成 Lin Hui Shi Bingfan Zhou Xiaodan Zhang Xuanxuan Zhao Haozhen | 2018 | High Technology Letters2018，24，4： | 0 |
| 9 | Recent progress of fat reduction strategies for emulsion type meat products显示文摘With the continuous improvement of living standards,people’s demand for meat products is increasing.However,the high fat content in traditional meat products will result in additional chronic diseases,causing harm to human health.Hence,there exists an urgent need for research on fat reduction technology of meat products.Recently,physical modification technologies and protein/carbohydrate/lipid/complexbased fat substitutes have gained great interest in reducing animal fat,which can simultaneously improve the technological and sensory properties of meat products.In this thriving field,many newly presented works lack comprehensive summary and critical comparison.Therefore,this paper reviews the latest research progress on the application of physical technologies and fat substitutes in fat-reduced meat products,highlighting their advantageous and disadvantageous in reducing total fat,improving the fatty acid profile and modifying technological and sensory properties of products.Finally,future trends are proposed with the aim to provide new insight into the development of quality fatsubstituted meat products. | Haozhen Zhang Weiyi Zhang Xianming Zeng Xue Zhao Xinglian Xu | 2022 | Food Materials Research2022，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员