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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 3 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 4 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 5 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 6 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 7 | Enhanced Strength and Ductility Due to Microstructure Refinement and Texture Weakening of the GW102K Alloy by Cyclic Extrusion Compression显示文摘The cyclic extrusion compression(CEC) was applied to severely deform the as-extruded GW102K(Mg–10.0Gd–2.0Y–0.5Zr, wt%) alloy at 350, 400, and 450 °C, respectively. The microstructure, texture, and grain boundary character distribution of the CECed alloy were investigated in the present work. The mechanical properties were measured by uniaxial tension at room temperature. The crack initiation on the longitudinal section near the tensile fracture-surface was investigated by high-resolution scanning electron microscopy(SEM). The result shows that the microstructure was dramatically refined by dynamic recrystallization(DRX). The initial fiber texture was disintegrated and obviously weakened. The 8-passes/350 °C CECed alloy exhibited yield strength of 318 MPa with an elongation-to-fracture of 16.8%, increased by 41.3% and 162.5%, respectively. Moreover, the elongation-to-fracture of the 8-passes/450 °C CECed alloy significantly increased more than 3 times than that of the received alloy. The cracks were mainly initiated at twin boundaries and second phase/matrix interfaces during tensile deformation. The microstructure refinement was considered to result in the dramatically enhanced of the strength and ductility. In addition, the texture randomization during CEC is beneficial for enhancing ductility. The standard positive Hall–Petch relationships have been obtained for the CECed GW102 K alloy. | Jinbao Lin Xinyi Wang Weijie Ren Xuexia Yang Qudong Wang | 2016 | Journal of Materials Science & Technology2016，32，8： | 9 |
| 8 | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis显示文摘最近的研究在嗅觉的薄板 propria 作为居民干细胞的一种新类型识别了嗅觉的 ecto 间充质的干细胞(OE-MSCs ) 。然而,它仍然保持不清楚是否 OE-MSCs 拥有任何 immunoregulatory 功能。在这研究,我们发现老鼠 OE-MSCs 比骨头表示了更高转变的生长因素贝它和 interleukin-10 层次导出髓的 MSC。在文化, OE-MSCs 经由直接压制受动器 T 房间增长并且增加规章的 T (Treg ) 房间扩大施加了他们的抑制免疫力的能力。在有导致骨胶原的关节炎的老鼠, OE-MSCs 的采纳转移显著地压制了关节炎发作和疾病严厉,它被增加的 Treg 房间伴随并且在 vivo 减少了 Th1/Th17 房间回答。一起拿,我们的调查结果在调整 T 房间回答识别了 OE-MSCs 的新奇功能,显示那 OE-MSCs 可以为风湿性关节炎和另外的自体免疫的疾病的处理代表新房间治疗。 | Ke Rui Zhijiang Zhang Jie Tian Xiang Lin Xiaohui Wang Jie Ma Xinyi Tang Huaxi Xu Liwei Lu Shengjun Wang | 2016 | Cellular & Molecular Immunology2016，13，3： | 8 |
| 9 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 10 | Changes of Petroleum Acid Distribution Characterized by FT-ICR MS in Heavy Acidic Crude Oil after True Boiling Point Distillation显示文摘The molecular transformations of carboxylic acids in heavy acidic SL crude before and after true boiling point distillation were examined by ultra-high resolution negative-ion electrospray ionization(ESI) Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS). The acid class(heteroatom number), type(z numbers) and carbon number distributions were positively characterized. It was found out that the total acid number(TAN) of SL crude decreased after true boiling point distillation, and the abundance of O2 class in mass spectra was also found to be reduced from 67.6% to 34.5% in SL TBP mixed crude as measured by MS spectra, indicating to a potential carboxylic acid decomposition. However, it was interesting that the carboxylic acids type distribution in both oils was almost the same although their relative abundance in SL TBP mixed crude turned to be much lower, suggesting that various petroleum carboxylic acid types have the similar thermal decomposition reaction behavior. Furthermore, for each O2 type of acids in SL TBP mixed crude, the abundance of carboxylic acids with carbon number higher than 35 was reduced greatly, especially for those with carbon number higher than 60, the mass peaks of which were nearly totally removed, indicating that the large carboxylic acid molecules in heavy fractions decomposed more significantly because of longer heating time during the true boiling point distillation process. As a result, the reduction of TAN may be caused by the thermal decomposition of carboxylic acids especially those with high carbon number, suggesting that quick distillation or much lower pressure is required to avoid the thermal decomposition. | Liu Yingrong Zhang Qundan Wang Wei Liu Zelong Zhu Xinyi Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 8 |
| 11 | Cooperative Jamming for Physical Layer Security in Hybrid Satellite Terrestrial Relay Networks显示文摘To integrate the satellite communications with the LTE/5G services, the concept of Hybrid Satellite Terrestrial Relay Networks(HSTRNs) has been proposed. In this paper, we investigate the secure transmission in a HSTRN where the eavesdropper can wiretap the transmitted messages from both the satellite and the intermediate relays. To effectively protect the message from wiretapping in these two phases, we consider cooperative jamming by the relays, where the jamming signals are optimized to maximize the secrecy rate under the total power constraint of relays. In the first phase, the Maximal Ratio Transmission(MRT) scheme is used to maximize the secrecy rate, while in the second phase, by interpolating between the sub-optimal MRT scheme and the null-space projection scheme, the optimal scheme can be obtained via an efficient one-dimensional searching method. Simulation results show that when the number of cooperative relays is small, the performance of the optimal scheme significantly outperforms that of MRT and null-space projection scheme. When the number of relays increases, the performance of the null-space projection approaches that of the optimal one. | Su Yan Xinyi Wang Zongling Li Bin Li Zesong Fei | 2019 | China Communications2019，16，12： | 7 |
| 12 | Characteristics and techniques of GaN-based micro-LEDs for application in next-generation display显示文摘Due to the excellent optoelectronic properties,fast response time,outstanding power efficiency and high stability,micro-LED plays an increasingly important role in the new generation of display technology compared with LCD and OLED display.This paper mainly introduces the preparation methods of the GaN-based micro-LED array,the optoelectronic characteristics,and several key technologies to achieve full-color display,such as transfer printing,color conversion by quantum dot and local strain engineering. | Zhou Wang Xinyi Shan Xugao Cui Pengfei Tian | 2020 | Journal of Semiconductors2020，41，4： | 7 |
| 13 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 14 | Superior CO2 uptake on nitrogen doped carbonaceous adsorbents from commercial phenolic resin显示文摘In this study,N-doped porous carbons were produced with commercial phenolic resin as the raw material,urea as the nitrogen source and KOH as the activation agent.Different from conventional carbonization-nitriding-activation three-step method,a facile two-step process was explored to produce N-incorporated porous carbons.The as-obtained adsorbents hold superior CO2 uptake,i.e.5.01 and 7.47 mmol/g at 25℃and 0℃under 1 bar,respectively.The synergistic effects of N species on the surface and narrow micropores of the adsorbents decide their CO2 uptake under 25℃and atmospheric pressure.These phenolic resin-derived adsorbents also possess many extremely promising CO2 adsorption features like good recyclability,quick adsorption kinetics,modest heat of adsorption,great selectivity of CO2 over N2 and outstanding dynamic adsorption capacity.Cheap precursor,easy preparation strategy and excellent CO2 adsorption properties make these phenolic resin-derived N-doped carbonaceous adsorbents highly promising in CO2 capture. | Shenfang Liu Linli Rao Pupu Yang Xinyi Wang Linlin Wang Rui Ma Limin Yue Xin Hu | 2020 | Journal of Environmental Sciences2020，32，7： | 6 |
| 15 | The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant显示文摘The anthocyanin content in apple skin determines its red coloration,as seen in a Fuji apple mutant.Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant.A novel R2R3-MYB transcription factor,MdMYB90-like,was uncovered as the key regulatory gene for enhanced coloration in the mutant.The expression of MdMYB90-like was 21.3 times higher in the mutant.MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis.MdMYB90-like bound to the promoters of both structural genes(MdCHS and MdUFGT)and other transcription factor genes(MdMYB1 and MdbHLH3)in the yeast one-hybrid system,electrophoretic mobility shift assay,and dual-luciferase assay.Transgenic analysis showed that MdMYB90-like was localized in the nucleus,and its overexpression induced the expression of other anthocyanin-related genes,including MdCHS,MdCHI,MdANS,MdUFGT,MdbHLH3,and MdMYB1.The mutant had reduced levels of DNA methylation in two regions(−1183 to−988 and−2018 to−1778)of the MdMYB90-like gene promoter,which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin. | Chao Sun Chunming Wang Wang Zhang Shuai Liu Weiyao Wang Xinyi Yu Tao Song Maxwell Yu Weichang Yu Shenchun Qu | 2021 | Horticulture Research2021，8，1： | 6 |
| 16 | Variations in organic carbon loading of surface sediments from the shelf to the slope of the Chukchi Sea,Arctic Ocean显示文摘The content of organic carbon(OC) normalized to the specific surface area(SSA) of sediment is widely used to trace variations in OC loading(OC/SSA).This study presents observations of OC/SSA of surface sediments collected in the Chukchi Sea,a typical Arctic marginal sea.Shelf sediments exhibit much higher OC/SSA values than slope sediments in the study area.Compared with OC/SSA values reported from the East Siberian Shelf and Mackenzie River,the slope sediments possess lower OC loading.This abrupt decrease in OC/SSA is mostly related to the lower primary production on slope as well as possible oxidization processes.The results of linear regression analysis between OC and SSA indicate a sedimentary source rock for the OC in the Chukchi Sea sediments.Moreover,shelf sediments with low SSA possess a larger rock OC fraction than slope sediments do.The dataset of the present study enables a more thorough understanding of regional OC cycling in the Chukchi Sea. | LI Zhongqiao WANG Xinyi JIN Haiyan JI Zhongqiang BAI Youcheng CHEN Jianfang | 2017 | Acta Oceanologica Sinica2017，36，8： | 6 |
| 17 | In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus显示文摘As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with antibiotics may provide synergistic antibacterial activity. The aim of the study was to evaluate in vitro and in vivo activity of D-serine alone and in combination withβ-lactams against methicillin-resistant Staphylococcus aureus(MRSA) strains, and to explore the possible sensitization mechanisms. The activity of D-serine, β-lactams alone and in combinations was evaluated both in vitro by standard MICs, time–kill curves and checkerboard assays, and in vivo by murine systemic infection model as well as neutropenic thigh infection model. An in vitro synergistic effect was demonstrated with the combination of D-serine and β-lactams against MRSA standard and clinical strains.Importantly, the combinations enhanced the therapeutic efficacy in the animal models as compared toβ-lactam alone groups. Initial mechanism study suggested possible revision of D-alanine-D-alanine residue to D-alanine-D-serine in peptidoglycan by adding of D-alanine in the medium, which may cause decreased affinity to PBPs during transpeptidation. In conclusion, D-serine had synergistic activity in combination with β-lactams against MRSA strains both in vitro and in vivo. Considering the relatively good safety of D-serine alone or in combination with β-lactams, D-serine is worth following up as new anti-MRSA infection strategies. | Qing Wang Yuemeng Lv Jing Pang Xue Li Xi Lu Xiukun Wang Xinxin Hu Tongying Nie Xinyi Yang Yan Q.Xiong Jiandong Jiang Congran Li Xuefu You | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 6 |
| 18 | Vertical displacement loading tides and self-attraction and loading tides in the Bohai, Yellow, and East China Seas显示文摘The loading tides are calculated by means of the Green's function method based on a high-resolution regional ocean tide model, the TOPO7.0 global ocean tide model, and the Gutenberg-Bullen A Earth model. The results show that the maximal amplitude of M2 vertical displacement loading (VDL) tide in the Bohai, Yellow, and East China Seas exceeding 28mm appears 150km off the Zhejiang coast; the second maximum exceeding 20mm appears in Inchon Bay; and the third maximum exceeding 14mm is located in the northeast of the North Yellow Sea. The maximal amplitudes of S2 VDL tide at the above three locations exceed 10, 8, and 4mm, respectively. The maximal amplitudes of the K1 and O1 VDL tides, exceeding 13 and 10 mm respectively, appear near the central and north Ryukyu Islands; the amplitudes tend to decease toward the inward areas. The phases of semidiurnal VDL tides are basically opposite to those of corresponding ocean tides. The phases of diurnal VDL tides are basically opposite to those of corresponding ocean tides in the most part of the East China Sea and the eastern part of the South Yellow Sea. This anti-phase relationship generally does not hold in the rest parts of the Bohai and Yellow Seas. The distribution patterns of self-attraction and loading (SAL) tides are very similar to those of VDL tides. The SAL tides have amplitudes about 1.2-1.7 times of the corresponding VDL tides and their phases are basically opposite to the corresponding VDL tides. The maximal amplitude of M2 SAL tide also appears off the Zhejiang coast, with a magnitude exceeding 42mm. | FANG GuoHong XU XiaoQing WEI ZeXun WANG YongGang WANG XinYi | 2013 | Science China Earth Sciences2013，56，1： | 6 |
| 19 | Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies显示文摘大多数病原体在人的 mucosal 表面开始他们的感染。因此, mucosal 种痘,通过特别口头或 intranasal 管理线路,高度为传染疾病被需要。同时,基于蛋白质的抗原提供一种更安全的选择给基于的整个病原体或 DNA 在疫苗的开发的。然而,在他们到达指向,相对低的 immunogenicity ,以及蛋白质抗原的低稳定性的地点以前, intranasally 或口头上地交付了蛋白质疫苗的唯一的 biopharmaceutical 障碍需要克服,要求有头脑、调整的 mucosal 疫苗明确的表达包括 immunostimulants 的选择,合适的疫苗的交货系统的鉴定,和准确作文和生产条件的决心。这评论试图提供蛋白质的新调查基于抗原的疫苗的明确的表达开发,包括 immunostimulants 和为 intranasal 和口头的政府的疫苗的交货系统的优化的用法。 | Shujing Wang Huiqin Liu Xinyi Zhang Feng Qian | 2015 | Protein & Cell2015，6，7： | 6 |
| 20 | Multi-level multi-area hybrid automatic voltage control system and its trial operation in Northeast China Grid显示文摘In order to coordinate automatic voltage control(AVC)systems of a large interconnected system,a multi-level multi-area hybrid automatic voltage control(MLMA-HAVC)system was constructed.This system began its trial operation in the Northeast China Grid in January 2010,and for the first time in China and abroad it realized automatic close-loop control of multi-area and multi-level interconnected power grid and multi-objective self-approaching optimization in aspects of security,high quality and economic operation.This system has three breakthroughs in theory and engineering application:1)Established the MLMA-HAVC theory to solve multi-objective optimization of large-scale system;2)proposed reactive power/voltage coordination control method to inhibit or further eliminate regional oscillations;3)presented advanced state estimation algorithm to guarantee acquisition of high reliability data.This paper summarizes the basic principle of MLMA-HAVC,and reports engineering realization of MLMA-HAVC system in the Northeast China Grid. | ZHANG XueMin MEI ShengWei SU XinYi WANG Gang JIA Wei SHAO GuangHui XU XingWei | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
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