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| 1 | 社交网络舆情意见领袖研究:蝴蝶图示、甄别及影响力评价显示文摘[目的/意义]社交媒体环境下意见领袖与受众社群间形成了自运转、自循环的范围舆情系统,有效甄别意见领袖并评价其影响力对加强网络舆情管控具有实践意义。[方法/过程]结合OCA扩展理论、群际关系理论、舆情场势理论以及SIC理论,通过系统动力学分析意见领袖作用、前因变量及其动因机制,构建意见领袖影响力评价体系的一般性框架,提出一种变权重灰色关联度的意见领袖甄别算法,并以舆情话题'11·3留日女生遇害案'进行实证研究。[结果/结论]'蝴蝶图示'架构了意见领袖作用与前因变量的因果关系及反馈回路,揭示了舆情系统内社群生态与意见领袖作用协同演化的内在机理;本文提出的理论模型具有多维度测度、权重集科学、算法性能优越等特点,适用于社交网络中意见领袖形成的动态过程。 | 郭勇 高歌 王天勇 Harris Wu 周世玉 | 2019 | 图书情报工作2019，63，14： | 31 |
| 2 | Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature显示文摘BACKGROUND Alopecia areata is a hair loss disease associated with genetics,autoimmunity,and other factors.There is an intriguing link between alopecia areata and gut dysbiosis.Fecal microbiota transplantation(FMT)has been recommended to treat Clostridium difficile(previously known as Clostridioides difficile)infection,and has also shown potentials in the treatment of inflammatory bowel disease,irritable bowel syndrome,and non-alcohol fatty liver disease.CASE SUMMARY An 86-year-old man,with a history of sigmoid colon carcinoma,suffered from recurrent abdominal pain and distension,and diarrhea for six months,with inappetence.At admission,he was also diagnosed with depression.Upon physical examination,the patient presented with a 1.5 cm×2.0 cm alopecia areata on his right occiput.Due to the negative results of laboratory testing,capsule endoscopy,and colonoscopy,the patient was diagnosed with noninfectious diarrhea,depressive disorder,and patchy alopecia areata.Considering that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis,he was given six rounds of FMT.His diarrhea improved remarkably one month after FMT,with improved appetite and disappearance of abdominal pain,distension,and depressive symptoms.Surprisingly,he reported new hair growth on the affected region of his scalp,with some of his white hair gradually turning to black,without taking any other therapies for alopecia areata before and after FMT.CONCLUSION FMT might act as a potential therapy for patients who suffer from alopecia areata.Large and well-designed studies are required to confirm the role of FMT in alopecia areata. | Wen-Rui Xie Xiao-Ya Yang Harry Hua-Xiang Xia Li-Hao Wu Xing-Xiang He | 2019 | World Journal of Clinical Cases2019，7，19： | 13 |
| 3 | Investigation of free amino acid, total phenolics,antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea显示文摘To find novel functional beverages from folk teas, 33 species of frequently used non-Camellia tea(plants other than Camellia) were collected and compared with Camellia tea(green tea, pu-erh tea and black tea) for the first time. Data are reported here on the quantities of 20 free amino acids(FAAs) and three purine alkaloids(measured by UHPLC), total polyphenols(measured by Folin-Ciocalteu assay), and antioxidant activity(DPPH). The total amounts of FAAs in non-Camellia tea(0.62–18.99 mg/g) are generally less than that of Camellia tea(16.55–24.99 mg/g). However, for certain FAAs, the quantities were much higher in some non-Camellia teas, such as γ-aminobutyric acid in teas from Ampelopsis grossedentata, Isodon serra and Hibiscus sabdariffa. Interestingly, theanine was detected in tea from Potentilla fruticosa(1.16±0.81 mg/g). Furthermore, the content of polyphenols in teas from A. grossedentata, Acer tataricum subsp. ginnala are significantly higher than those from Camellia tea;teas from I. serra, Pistacia chinensis and A. tataricum subsp. ginnala have remarkable antioxidant activities similar to the activities from green tea(44.23 μg/m L). Purine alkaloids(caffeine, theobromine and theophylline) were not detected in non-Camellia teas. The investigation suggest some non-Camellia teas may be great functional natural products with potential for prevention of chronic diseases and aging,by providing with abundant polyphenols, antioxidants and specific FAAs. | Wu Bi Chunnian He Yunyun Ma Jie Shen Linghua Harris Zhang Yong Peng Peigen Xiao | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 11 |
| 4 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 5 | Sustainability of China's Growth Model A Productivity Perspective显示文摘 | Harry X. Wu | 2016 | China & World Economy2016，24，5： | 10 |
| 6 | Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease显示文摘BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their metabolites.AIM To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)dependency.METHODS Patients with recurrent NERD and PPI dependency at the First Affiliated Hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without WMT.The endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier function.RESULTS In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI group.In 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after treatment.Only one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 wk.CONCLUSION This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence. | Ya-Mei Zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu Harry Hua-Xiang Xia Min Zhang Xing-Xiang He Li-Hao Wu | 2021 | World Journal of Gastroenterology2021，27，6： | 7 |
| 7 | Inheritance of growth and survival in two 9-year-old, open-pollinated progenies of an advanced breeding population of Chinese firs in southeastern China显示文摘Tree growth traits(tree height,DBH and stem volume) and survival from two 9-year-old,open-pollinated progeny tests of Chinese fir were investigated for heritability,genotype 9 environment interaction,age-age genetic correlation and selection efficiency.The 97 and 79 families planted at two sites were collected from the thirdcycle seed orchard.Individual heritability was estimated between 0.05 and 0.21 for tree height,DBH,and volume and between 0.45 and 1.0 for survival.Family heritability was between 0.20 and 1.14.Significant genotype 9 environment interaction was observed for the three growth traits.Type B genetic correlation was between 0.41 and 0.67 with an increasing trend as tree grows.High age-age genetic correlation was observed with correlation reaching 0.9 after age 4 for height,DBH,and volume.The genetic gains were estimated at 3.26,3.39 and 5.98 % for tree height,DBH,and volume with 10 % selection intensity.The implication for advanced tree breeding in Chinese fir is discussed. | Renhua Zheng Zhou Hong Shunde Su Liming Bian Hui Xiao Jisen Shi Harry X. Wu | 2016 | Journal of Forestry Research2016，27，5： | 6 |
| 8 | Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis显示文摘 | Kit Yee Chan Wei Wang Jing Jing Wu Li Liu Evropi Theodoratou Josip Car Lefkos Middleton Tom C Russ Ian J Deary Harry Campbell Wei Wang Igor Rudan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 5 |
| 9 | Spatial and temporal variations in prehistoric human settlement and their influencing factors on the south bank of the Xar Moron River, Northeastern China显示文摘 | Xin JIA Shuangwen YI Yonggang SUN Shuangye WU Harry F. LEE Lin WANG Huayu LU | 2017 | Frontiers of Earth Science2017，11，1： | 5 |
| 10 | The Development of Modern Pesticides显示文摘The present paper deals with agrochemicals. The low toxicities to mammals and wild lives, greater selectivity against target organisms, and high levels of activity are particular features of many modern agrochemicals. It is suggested that integrated pest management(IPM), by means of a combination of biological and chemical controls has met with some success and the present approach is to optimize the use of chemicals rather than to eliminate them. | Harry R. Hudson 1, WU Jun 2,* and XU Wei-liang 21. Division of Chemistry, School of Biological and Applied Sciences, University of North London, London N7 8DB, UK 2. Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China | 2002 | Chemical Research in Chinese Universities2002，18，4： | 4 |
| 11 | 利用染色体步移PCR检测辐射松的单核苷酸多态性显示文摘用染色体步移技术(chromosome walking)的基本原理以辐射松(Pinus radiata)肌动蛋白基因(actin)为例,利用获得的EST序列设计定向引物,向上游和下游进行了染色体序列的步移.获得了包括启动子、5′端非编码区和编码区及3′端非编码区辐射松肌动蛋白基因基因组序列2154 bp.通过对200株不同辐射松个体进行PCR扩增及测序,共获得了21个SNPs,其中启动子区域3个,编码区15个,3′端非编码区4个.实验结果为今后染色体步移技术在基因非编码区SNP的检测提供了理论与技术参考. | 李伟 李慧 陈晓阳 WU Harry | 2007 | 西北植物学报2007，27，8： | 4 |
| 12 | A framework for the regional critical zone classi?cation: the case of the Chinese Loess Plateau显示文摘The concept of the Earth’s Critical Zone(CZ)—the near-surface heterogeneous environment of our planet—was originally defined to include the land surface,vegetation canopy, rivers, lakes and shallow seas (1)CZ accommodates interactions among air, water, soil, rock and living organisms, and determines the availability of life-sustaining resources needed for the well-being and sustainability of human society. Therefore, there are new opportunities for integrative. | Yihe Lü Jian Hu Bojie Fu Paul Harris Lianhai Wu Xiaolin Tong Yingfei Bai Alexis J.Comber Alexis J.Comber | 2019 | National Science Review2019，6，1： | 4 |
| 13 | Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial显示文摘Objective:Coronavirus disease 2019(COVTD-19)is often accompanied by gastrointestinal symptoms,which are related to gut microbiota dysbiosis(GMD).Whether washed microbiota transplantation(WMT)is an effective treatment for COV1D-19 patients suspected of having GMD by restoring the gut microbiota is unknown.This study is designed to explore the efficacy and safety of WMT in COVID-19 patients suspected of having GMD.Methods:This is a randomized,multicenter,single-blind prospective study.COVID-19 patients suspected of having GMD will be randomly divided to receive routine treatment only or to receive routine treatment and WMT.The frequency of WMT will be once a day for three consecutive days.Laboratory and imaging examinations will be performed at admission,1 and 2 weeks after treatment,and on the day of discharge.Then a telephone follow-up will be conducted at 1st week,2nd week,and 6th month after discharge.The clinical efficacy and safety of WMT in COVD-19 patients suspected of having GMD and the effects of WMT on the organ function,homeostasis,inflammatory response,intestinal mucosal barrier function,and immunity of the patients will be evaluated.Results:By following the proposed protocol,WMT is expected to be efficacious and safe for the treatment of COVID-19 patients suspected of having GMD,and the therapeutic effect is expected to be associated with improvement of the intestinal mucosal barrier function,inflammatory response,and immunity.Conclusion:The findings from this study may offer a new approach for the prevention and treatment of COVID-19 patients suspected of having GMD. | Li-hao WU Zhi-ning YE Ping PENG Wen-rui XIE Jia-ting XU Xue-yuan ZHANG Harry Hua-xiang XIA Xing-xiang HE | 2021 | Current Medical Science2021，41，6： | 3 |
| 14 | Spatial analysis increases efficiency of progeny testing of Chinese fir显示文摘We used spatial, global trend and post-blocking analysis to examine the effectiveness of a progeny trial in a tree breeding program for Chinese fir(Cunninghamia lanceolata(Lamb.) Hook) on a hilly site with an environmental gradient from hill top to bottom. Diameter at breast height(DBH) and tree height data had significant spatial auto-correlations among rows and columns. Adding a firstorder separable autoregressive term more effectively modelled the spatial variation than did the incomplete block(IB)model used for the experimental design. The spatial model also accounted for effects of experimental design factors and greatly reduced residual variances. The spatial analysis relative to the IB analysis improved estimation of genetic parameters with the residual variance reduced 13 and 19%for DBH and tree height, respectively; heritability increased35 and 51% for DBH and tree height, respectively; and genetic gain improved 3–5%. Fitting global trend and postblocking did not improve the analyses under IB model. The use of a spatial model or combined with a design model is recommended for forest genetic trials, particularly with global trend and local spatial variation of hilly sites. | Liming Bian Renhua Zheng Shunde Su Huazhong Lin Hui Xiao Harry Xiaming Wu Jisen Shi | 2017 | Journal of Forestry Research2017，28，3： | 3 |
| 15 | Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes显示文摘 | Eric J. Kunkel Judie Boisvert Kristine Murphy Mark A. Vierra Mark C. Genovese Andrew J. Wardlaw Harry B. Greenberg Martin R. Hodge Lijun Wu Eugene C. Butcher James J. Campbell | 2002 | The American Journal of Pathology2002，，1： | 2 |
| 16 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，： | 2 |
| 17 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 18 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，5： | 2 |
| 19 | Household Income Determination and Regional Income Differential in Rural China显示文摘 | Xin Meng Harry X Wu | 1998 | Asian Economic Journal1998，，1： | 1 |
| 20 | Schwann cellss and astrocytes induce synapse formation by spinal motor neurons in culture显示文摘 | Ullian EM Harris BT Wu A | | 0，，02： | 1 |
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